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Conserved domains on  [gi|227908769|ref|NP_032769|]
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endonuclease III-like protein 1 isoform 1 [Mus musculus]

Protein Classification

endonuclease III( domain architecture ID 11415064)

endonuclease III is a DNA repair enzyme that has both DNA N-glycosylase and AP-lyase activities

EC:  4.2.99.18
Gene Symbol:  nth
Gene Ontology:  GO:0051539|GO:0140078

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
118-298 9.12e-63

Endonuclease III [Replication, recombination and repair];


:

Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 196.86  E-value: 9.12e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769 118 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVESILQTDDDTLGRLIYPVGFWRNKVKYIKQTTAILQQRYEGDIPASVA 197
Cdd:COG0177   21 FELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNIIALARILVEKYGGEVPETRE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769 198 ELVALPGVGPKMAHLAMAVAWGtISGIAVDTHVHRIANRLRWTKkmTKTPEETRKNLEEWLPRVLWSEVNGLLVGFGQQI 277
Cdd:COG0177  101 ELESLPGVGRKTANVVLNFAFG-KPAIAVDTHVHRVSNRLGLVP--GKDPEEVEKDLMKLIPKEYWGDLHHLLILHGRYI 177

                        170       180
                 ....*....|....*....|.
gi 227908769 278 CLPVHPRCQACLNKALCPAAQ 298
Cdd:COG0177  178 CKARKPKCEECPLADLCPYYG 198
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
118-298 9.12e-63

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 196.86  E-value: 9.12e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769 118 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVESILQTDDDTLGRLIYPVGFWRNKVKYIKQTTAILQQRYEGDIPASVA 197
Cdd:COG0177   21 FELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNIIALARILVEKYGGEVPETRE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769 198 ELVALPGVGPKMAHLAMAVAWGtISGIAVDTHVHRIANRLRWTKkmTKTPEETRKNLEEWLPRVLWSEVNGLLVGFGQQI 277
Cdd:COG0177  101 ELESLPGVGRKTANVVLNFAFG-KPAIAVDTHVHRVSNRLGLVP--GKDPEEVEKDLMKLIPKEYWGDLHHLLILHGRYI 177

                        170       180
                 ....*....|....*....|.
gi 227908769 278 CLPVHPRCQACLNKALCPAAQ 298
Cdd:COG0177  178 CKARKPKCEECPLADLCPYYG 198
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 126-275 2.78e-52

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 168.21  E-value: 2.78e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769   126 LSSQTKDQVTAGAMQRLRARGLTVESILQTDDDTLGRLIYPVGFWRNKVKYIKQTTAILQQRYEGDIPASVAELVALPGV 205
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769   206 GPKMAHLAMAVAWGtISGIAVDTHVHRIANRLRWTKKmTKTPEETRKNLEEWLPRVLWSEVNGLLVGFGQ 275
Cdd:smart00478  81 GRKTANAVLSFALG-KPFIPVDTHVLRIAKRLGLVDK-KSTPEEVEKLLEKLLPEEDWRELNLLLIDFGR 148
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 118-274 5.70e-46

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 152.40  E-value: 5.70e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769 118 YQVLLSLMLSSQTKDQVTAGAMQRLRAR-GLTVESILQTDDDTLGRLIYPVGFwRNKVKYIKQTTAILQQRYEGDI---P 193
Cdd:cd00056    1 FEVLVSEILSQQTTDKAVNKAYERLFERyGPTPEALAAADEEELRELIRSLGY-RRKAKYLKELARAIVEGFGGLVlddP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769 194 ASVAELVALPGVGPKMAHLAMAVAWGtISGIAVDTHVHRIANRLRWTKKmTKTPEETRKNLEEWLPRVLWSEVNGLLVGF 273
Cdd:cd00056   80 DAREELLALPGVGRKTANVVLLFALG-PDAFPVDTHVRRVLKRLGLIPK-KKTPEELEELLEELLPKPYWGEANQALMDL 157


                 .
gi 227908769 274 G 274
Cdd:cd00056  158 G 158
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 118-285 3.00e-44

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 149.07  E-value: 3.00e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769  118 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVESILQTDDDTLGRLIYPVGFWRNKVKYIKQTTAILQQRYEGDIPASVA 197
Cdd:TIGR01083  28 FELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLYRNKAKNIIELCRKLVERYGGEVPEDRE 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769  198 ELVALPGVGPKMAHLAMAVAWGtISGIAVDTHVHRIANRLRWTKkmTKTPEETRKNLEEWLPRVLWSEVNGLLVGFGQQI 277
Cdd:TIGR01083 108 ELVKLPGVGRKTANVVLNVAFG-IPAIAVDTHVFRVSNRLGLSK--GKDPIKVEEDLMKLVPREFWVKLHHWLILHGRYT 184


                  ....*...
gi 227908769  278 CLPVHPRC 285
Cdd:TIGR01083 185 CKARKPLC 192
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 122-260 1.38e-40

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 138.19  E-value: 1.38e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769  122 LSLMLSSQTKDQVTAGAMQRLRAR-GLTVESILQTDDDTLGRLIYPVGFWRNKVKYIKQTTAILQQRYEGDIPASVAELV 200
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFEKfFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 227908769  201 A-LPGVGPKMAHLAMAVAWG-TISGIAVDTHVHRIANRLRWTKKmTKTPEETRKNLEEWLPR 260
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALGrPDPLPVVDTHVRRVLKRLGLIKE-KPTPKEVERELEELWPP 141
PRK10702 PRK10702
endonuclease III; Provisional
 118-294 1.82e-22

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 92.77  E-value: 1.82e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769 118 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVESILQTDDDTLGRLIYPVGFWRNKVKYIKQTTAILQQRYEGDIPASVA 197
Cdd:PRK10702  30 FELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIGLYNSKAENVIKTCRILLEQHNGEVPEDRA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769 198 ELVALPGVGPKMAHLAMAVAWGTISgIAVDTHVHRIANRLRWtkkmtkTPEETRKNLEEWLPRVLWSE----VNGLLVGF 273
Cdd:PRK10702 110 ALEALPGVGRKTANVVLNTAFGWPT-IAVDTHIFRVCNRTQF------APGKNVEQVEEKLLKVVPAEfkvdCHHWLILH 182

                        170       180
                 ....*....|....*....|.
gi 227908769 274 GQQICLPVHPRCQACLNKALC 294
Cdd:PRK10702 183 GRYTCIARKPRCGSCIIEDLC 203
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
118-298 9.12e-63

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 196.86  E-value: 9.12e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769 118 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVESILQTDDDTLGRLIYPVGFWRNKVKYIKQTTAILQQRYEGDIPASVA 197
Cdd:COG0177   21 FELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNIIALARILVEKYGGEVPETRE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769 198 ELVALPGVGPKMAHLAMAVAWGtISGIAVDTHVHRIANRLRWTKkmTKTPEETRKNLEEWLPRVLWSEVNGLLVGFGQQI 277
Cdd:COG0177  101 ELESLPGVGRKTANVVLNFAFG-KPAIAVDTHVHRVSNRLGLVP--GKDPEEVEKDLMKLIPKEYWGDLHHLLILHGRYI 177

                        170       180
                 ....*....|....*....|.
gi 227908769 278 CLPVHPRCQACLNKALCPAAQ 298
Cdd:COG0177  178 CKARKPKCEECPLADLCPYYG 198
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 126-275 2.78e-52

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 168.21  E-value: 2.78e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769   126 LSSQTKDQVTAGAMQRLRARGLTVESILQTDDDTLGRLIYPVGFWRNKVKYIKQTTAILQQRYEGDIPASVAELVALPGV 205
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769   206 GPKMAHLAMAVAWGtISGIAVDTHVHRIANRLRWTKKmTKTPEETRKNLEEWLPRVLWSEVNGLLVGFGQ 275
Cdd:smart00478  81 GRKTANAVLSFALG-KPFIPVDTHVLRIAKRLGLVDK-KSTPEEVEKLLEKLLPEEDWRELNLLLIDFGR 148
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 118-274 5.70e-46

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 152.40  E-value: 5.70e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769 118 YQVLLSLMLSSQTKDQVTAGAMQRLRAR-GLTVESILQTDDDTLGRLIYPVGFwRNKVKYIKQTTAILQQRYEGDI---P 193
Cdd:cd00056    1 FEVLVSEILSQQTTDKAVNKAYERLFERyGPTPEALAAADEEELRELIRSLGY-RRKAKYLKELARAIVEGFGGLVlddP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769 194 ASVAELVALPGVGPKMAHLAMAVAWGtISGIAVDTHVHRIANRLRWTKKmTKTPEETRKNLEEWLPRVLWSEVNGLLVGF 273
Cdd:cd00056   80 DAREELLALPGVGRKTANVVLLFALG-PDAFPVDTHVRRVLKRLGLIPK-KKTPEELEELLEELLPKPYWGEANQALMDL 157


                 .
gi 227908769 274 G 274
Cdd:cd00056  158 G 158
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 118-285 3.00e-44

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 149.07  E-value: 3.00e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769  118 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVESILQTDDDTLGRLIYPVGFWRNKVKYIKQTTAILQQRYEGDIPASVA 197
Cdd:TIGR01083  28 FELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLYRNKAKNIIELCRKLVERYGGEVPEDRE 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769  198 ELVALPGVGPKMAHLAMAVAWGtISGIAVDTHVHRIANRLRWTKkmTKTPEETRKNLEEWLPRVLWSEVNGLLVGFGQQI 277
Cdd:TIGR01083 108 ELVKLPGVGRKTANVVLNVAFG-IPAIAVDTHVFRVSNRLGLSK--GKDPIKVEEDLMKLVPREFWVKLHHWLILHGRYT 184


                  ....*...
gi 227908769  278 CLPVHPRC 285
Cdd:TIGR01083 185 CKARKPLC 192
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 122-260 1.38e-40

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 138.19  E-value: 1.38e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769  122 LSLMLSSQTKDQVTAGAMQRLRAR-GLTVESILQTDDDTLGRLIYPVGFWRNKVKYIKQTTAILQQRYEGDIPASVAELV 200
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFEKfFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 227908769  201 A-LPGVGPKMAHLAMAVAWG-TISGIAVDTHVHRIANRLRWTKKmTKTPEETRKNLEEWLPR 260
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALGrPDPLPVVDTHVRRVLKRLGLIKE-KPTPKEVERELEELWPP 141
PRK10702 PRK10702
endonuclease III; Provisional
 118-294 1.82e-22

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 92.77  E-value: 1.82e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769 118 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVESILQTDDDTLGRLIYPVGFWRNKVKYIKQTTAILQQRYEGDIPASVA 197
Cdd:PRK10702  30 FELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIGLYNSKAENVIKTCRILLEQHNGEVPEDRA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769 198 ELVALPGVGPKMAHLAMAVAWGTISgIAVDTHVHRIANRLRWtkkmtkTPEETRKNLEEWLPRVLWSE----VNGLLVGF 273
Cdd:PRK10702 110 ALEALPGVGRKTANVVLNTAFGWPT-IAVDTHIFRVCNRTQF------APGKNVEQVEEKLLKVVPAEfkvdCHHWLILH 182

                        170       180
                 ....*....|....*....|.
gi 227908769 274 GQQICLPVHPRCQACLNKALC 294
Cdd:PRK10702 183 GRYTCIARKPRCGSCIIEDLC 203
HP0602 COG2231
3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and ...
 138-298 8.23e-21

3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and repair];


Pssm-ID: 441832 [Multi-domain]  Cd Length: 220  Bit Score: 88.36  E-value: 8.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769 138 AMQRLRARG-LTVESILQTDDDTLGRLIYPVGFWRNKVKYIKQTTAILQQRYEGDI------PASV--AELVALPGVGPK 208
Cdd:COG2231   50 AIANLKEAGlLDPEALAALDPEELAELIRPSGFYNQKAKRLKNLARWLVERYGGGLeklkalPTEElrEELLSLKGIGPE 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769 209 MA--------HLAMAVawgtisgiaVDTHVHRIANRLRWTKKmTKTPEETRKNLEEWLPR--VLWSEVNGLLVGFGQQIC 278
Cdd:COG2231  130 TAdsillyafNRPVFV---------VDAYTRRIFSRLGLIEE-DASYDELQRLFEENLPPdvALYNEFHALIVEHGKEYC 199

                        170       180
                 ....*....|....*....|
gi 227908769 279 LPVhPRCQACLNKALCPAAQ 298
Cdd:COG2231  200 KKK-PKCEECPLRDLCPYGG 218
HHH pfam00633
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ...
 187-211 4.93e-08

Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 425789 [Multi-domain]  Cd Length: 30  Bit Score: 48.18  E-value: 4.93e-08
                          10        20
                  ....*....|....*....|....*
gi 227908769  187 RYEGDIPASVAELVALPGVGPKMAH 211
Cdd:pfam00633   1 SLEGLIPASVEELLALPGVGPKTAE 25
FES smart00525
iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); ...
 277-297 4.50e-04

iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3);


Pssm-ID: 197771 [Multi-domain]  Cd Length: 21  Bit Score: 36.76  E-value: 4.50e-04
                           10        20
                   ....*....|....*....|.
gi 227908769   277 ICLPVHPRCQACLNKALCPAA 297
Cdd:smart00525   1 ICTARKPRCDECPLKDLCPAY 21
ogg TIGR00588
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known ...
 173-268 5.93e-04

8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 211589 [Multi-domain]  Cd Length: 310  Bit Score: 40.66  E-value: 5.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769  173 KVKYIKQTTAILQQryEGDIPASVAE------------LVALPGVGPKMAHLAMAVAWGTISGIAVDTHVHRIANR---L 237
Cdd:TIGR00588 186 RARYIRETARALLE--EQGGRAWLQQirgasyedareaLCELPGVGPKVADCICLMGLDKPQAVPVDVHVWRIANRdypW 263

                          90       100       110
                  ....*....|....*....|....*....|..
gi 227908769  238 RWTKKMTKTP-EETRKNLEEwLPRVLWSEVNG 268
Cdd:TIGR00588 264 HPKTSRAKGPsPFARKELGN-FFRSLWGPYAG 294
AlkA COG0122
3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and ...
 148-257 1.75e-03

3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 439892 [Multi-domain]  Cd Length: 255  Bit Score: 39.10  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908769 148 TVESILQTDDDTLGRLiypvGFWRNKVKYIKQTTAI-------LQQRYEGDIPASVAELVALPGVGPKMAH-LAM----- 214
Cdd:COG0122  129 TPEALAAASEEELRAC----GLSRRKARYLRALARAvadgeldLEALAGLDDEEAIARLTALPGIGPWTAEmVLLfalgr 204

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 227908769 215 --AVAWGtisgiavDTHVHRIANRLRWTKKMTkTPEETRKNLEEW 257
Cdd:COG0122  205 pdAFPAG-------DLGLRRALGRLYGLGERP-TPKELRELAEPW 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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