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Conserved domains on  [gi|113865979|ref|NP_032620|]
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lactadherin isoform 1 precursor [Mus musculus]

Protein Classification

EGF_CA and FA58C domain-containing protein( domain architecture ID 11076406)

EGF_CA and FA58C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 310-462 8.45e-56

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 182.17  E-value: 8.45e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865979 310 EPLGLkNNTIPDSQMSASSSYKTwnlrafGWYPHLGRLDnqgKINAWTAQSNSAKEWLQVDLGTQRQVTGIITQGARDFG 389
Cdd:cd00057    1 EPLGM-ESGLADDQITASSSYSS------GWEASRARLN---SDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGG 70

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 113865979 390 HIQYVASYKVAHSDDGVQWTVYEEQGSSKVFQGNLDNNSHKKNIFEKPFMARYVRVLPVSWHNRITLRLELLG 462
Cdd:cd00057   71 SSEWVTSYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 152-302 7.46e-51

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 169.07  E-value: 7.46e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865979 152 LGMEGGAiADSQISASSVYMGfmglqRWGPELARLYRTgivNAWTASNYDSKPWIQVNLLRKMRVSGVMTQGASRAGRAE 231
Cdd:cd00057    3 LGMESGL-ADDQITASSSYSS-----GWEASRARLNSD---NAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGSSE 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 113865979 232 YLKTFKVAYSLDGRKFEFIQDEsGGDKEFLGNLDNNSLKVNMFNPTLEAQYIKLYPVSCHRGCTLRFELLG 302
Cdd:cd00057   74 WVTSYKVQYSLDGETWTTYKDK-GEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 68-106 2.26e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 2.26e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 113865979   68 CSPNPCYNDAKCLVTLDTqrgdifteYICQCPVGYSGIH 106
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGG--------YTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 28-57 5.02e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 5.02e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 113865979   28 CDSSLCLNGGTCLTGQdNDIYCLCPEGFTG 57
Cdd:pfam00008   1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTG 29
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 310-462 8.45e-56

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 182.17  E-value: 8.45e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865979 310 EPLGLkNNTIPDSQMSASSSYKTwnlrafGWYPHLGRLDnqgKINAWTAQSNSAKEWLQVDLGTQRQVTGIITQGARDFG 389
Cdd:cd00057    1 EPLGM-ESGLADDQITASSSYSS------GWEASRARLN---SDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGG 70

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 113865979 390 HIQYVASYKVAHSDDGVQWTVYEEQGSSKVFQGNLDNNSHKKNIFEKPFMARYVRVLPVSWHNRITLRLELLG 462
Cdd:cd00057   71 SSEWVTSYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 152-302 7.46e-51

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 169.07  E-value: 7.46e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865979 152 LGMEGGAiADSQISASSVYMGfmglqRWGPELARLYRTgivNAWTASNYDSKPWIQVNLLRKMRVSGVMTQGASRAGRAE 231
Cdd:cd00057    3 LGMESGL-ADDQITASSSYSS-----GWEASRARLNSD---NAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGSSE 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 113865979 232 YLKTFKVAYSLDGRKFEFIQDEsGGDKEFLGNLDNNSLKVNMFNPTLEAQYIKLYPVSCHRGCTLRFELLG 302
Cdd:cd00057   74 WVTSYKVQYSLDGETWTTYKDK-GEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 307-463 8.28e-39

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 137.26  E-value: 8.28e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865979   307 GCSEPLGLKNntipDSQMSASSSYktwnlrafgWYPHLGRLdNQGKINAWTAQSNSAKEWLQVDLGTQRQVTGIITQGAR 386
Cdd:smart00231   1 PCNEPLGLES----DSQITASSSY---------WAAKIARL-NGGSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRH 66

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 113865979   387 DFGHIQYvasYKVAHSDDGVQWTVYEEqGSSKVFQGNLDNNSHKKNIFEKPFMARYVRVLPVSWHNRITLRLELLGC 463
Cdd:smart00231  67 GNGDWVT---YKLEYSDDGVNWTTYKD-GNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 148-303 1.40e-35

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 128.78  E-value: 1.40e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865979   148 CSTQLGMEGgaiaDSQISASSVYmgfmglqrWGPELARLYRtGIVNAWTASNYDSKPWIQVNLLRKMRVSGVMTQGasRA 227
Cdd:smart00231   2 CNEPLGLES----DSQITASSSY--------WAAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGR--RH 66

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113865979   228 GRAEYLKTFKVaYSLDGRKFEFIQDesGGDKEFLGNLDNNSLKVNMFNPTLEAQYIKLYPVSCHRGCTLRFELLGC 303
Cdd:smart00231  67 GNGDWVTYKLE-YSDDGVNWTTYKD--GNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 323-460 7.85e-35

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 126.41  E-value: 7.85e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865979  323 QMSASSSYktwnlraFGWYPHLGRLDNQGKiNAWTAQSNSAKEWLQVDLGTQRQVTGIITQGARDfGHIQYVASYKVAHS 402
Cdd:pfam00754   1 QITASSSY-------SGEGPAAAALDGDPN-TAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD-GSNGYVTSYKIEYS 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865979  403 DDGVQWTVYeeqgSSKVFQGNLDNNSHKKNIFEKPFMARYVRVLPVSWH--NRITLRLEL 460
Cdd:pfam00754  72 LDGENWTTV----KDEKIPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNggNGIALRAEL 127
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 163-300 5.45e-27

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 104.84  E-value: 5.45e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865979  163 QISASSVYMGFmglqrwGPELARLyrTGIVN-AWTASNYDSKPWIQVNLLRKMRVSGVMTQGAsRAGRAEYLKTFKVAYS 241
Cdd:pfam00754   1 QITASSSYSGE------GPAAAAL--DGDPNtAWSAWSGDDPQWIQVDLGKPKKITGVVTQGR-QDGSNGYVTSYKIEYS 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 113865979  242 LDGRKFEFIQDEsggdkEFLGNLDNNSLKVNMFNPTLEAQYIKLYPVS--CHRGCTLRFEL 300
Cdd:pfam00754  72 LDGENWTTVKDE-----KIPGNNDNNTPVTNTFDPPIKARYVRIVPTSwnGGNGIALRAEL 127
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 68-106 2.26e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 2.26e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 113865979   68 CSPNPCYNDAKCLVTLDTqrgdifteYICQCPVGYSGIH 106
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGG--------YTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 69-108 1.28e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 1.28e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 113865979  69 SPNPCYNDAKCLVTLDTqrgdifteYICQCPVGYSGIHCE 108
Cdd:cd00054    7 SGNPCQNGGTCVNTVGS--------YRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 28-57 5.02e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 5.02e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 113865979   28 CDSSLCLNGGTCLTGQdNDIYCLCPEGFTG 57
Cdd:pfam00008   1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 26-60 1.45e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 1.45e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 113865979  26 DFCDS-SLCLNGGTClTGQDNDIYCLCPEGFTGLVC 60
Cdd:cd00054    3 DECASgNPCQNGGTC-VNTVGSYRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 310-462 8.45e-56

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 182.17  E-value: 8.45e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865979 310 EPLGLkNNTIPDSQMSASSSYKTwnlrafGWYPHLGRLDnqgKINAWTAQSNSAKEWLQVDLGTQRQVTGIITQGARDFG 389
Cdd:cd00057    1 EPLGM-ESGLADDQITASSSYSS------GWEASRARLN---SDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGG 70

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 113865979 390 HIQYVASYKVAHSDDGVQWTVYEEQGSSKVFQGNLDNNSHKKNIFEKPFMARYVRVLPVSWHNRITLRLELLG 462
Cdd:cd00057   71 SSEWVTSYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 152-302 7.46e-51

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 169.07  E-value: 7.46e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865979 152 LGMEGGAiADSQISASSVYMGfmglqRWGPELARLYRTgivNAWTASNYDSKPWIQVNLLRKMRVSGVMTQGASRAGRAE 231
Cdd:cd00057    3 LGMESGL-ADDQITASSSYSS-----GWEASRARLNSD---NAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGSSE 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 113865979 232 YLKTFKVAYSLDGRKFEFIQDEsGGDKEFLGNLDNNSLKVNMFNPTLEAQYIKLYPVSCHRGCTLRFELLG 302
Cdd:cd00057   74 WVTSYKVQYSLDGETWTTYKDK-GEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 307-463 8.28e-39

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 137.26  E-value: 8.28e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865979   307 GCSEPLGLKNntipDSQMSASSSYktwnlrafgWYPHLGRLdNQGKINAWTAQSNSAKEWLQVDLGTQRQVTGIITQGAR 386
Cdd:smart00231   1 PCNEPLGLES----DSQITASSSY---------WAAKIARL-NGGSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRH 66

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 113865979   387 DFGHIQYvasYKVAHSDDGVQWTVYEEqGSSKVFQGNLDNNSHKKNIFEKPFMARYVRVLPVSWHNRITLRLELLGC 463
Cdd:smart00231  67 GNGDWVT---YKLEYSDDGVNWTTYKD-GNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 148-303 1.40e-35

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 128.78  E-value: 1.40e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865979   148 CSTQLGMEGgaiaDSQISASSVYmgfmglqrWGPELARLYRtGIVNAWTASNYDSKPWIQVNLLRKMRVSGVMTQGasRA 227
Cdd:smart00231   2 CNEPLGLES----DSQITASSSY--------WAAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGR--RH 66

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113865979   228 GRAEYLKTFKVaYSLDGRKFEFIQDesGGDKEFLGNLDNNSLKVNMFNPTLEAQYIKLYPVSCHRGCTLRFELLGC 303
Cdd:smart00231  67 GNGDWVTYKLE-YSDDGVNWTTYKD--GNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 323-460 7.85e-35

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 126.41  E-value: 7.85e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865979  323 QMSASSSYktwnlraFGWYPHLGRLDNQGKiNAWTAQSNSAKEWLQVDLGTQRQVTGIITQGARDfGHIQYVASYKVAHS 402
Cdd:pfam00754   1 QITASSSY-------SGEGPAAAALDGDPN-TAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD-GSNGYVTSYKIEYS 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865979  403 DDGVQWTVYeeqgSSKVFQGNLDNNSHKKNIFEKPFMARYVRVLPVSWH--NRITLRLEL 460
Cdd:pfam00754  72 LDGENWTTV----KDEKIPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNggNGIALRAEL 127
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 163-300 5.45e-27

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 104.84  E-value: 5.45e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865979  163 QISASSVYMGFmglqrwGPELARLyrTGIVN-AWTASNYDSKPWIQVNLLRKMRVSGVMTQGAsRAGRAEYLKTFKVAYS 241
Cdd:pfam00754   1 QITASSSYSGE------GPAAAAL--DGDPNtAWSAWSGDDPQWIQVDLGKPKKITGVVTQGR-QDGSNGYVTSYKIEYS 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 113865979  242 LDGRKFEFIQDEsggdkEFLGNLDNNSLKVNMFNPTLEAQYIKLYPVS--CHRGCTLRFEL 300
Cdd:pfam00754  72 LDGENWTTVKDE-----KIPGNNDNNTPVTNTFDPPIKARYVRIVPTSwnGGNGIALRAEL 127
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 68-106 2.26e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 2.26e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 113865979   68 CSPNPCYNDAKCLVTLDTqrgdifteYICQCPVGYSGIH 106
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGG--------YTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 69-108 1.28e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 1.28e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 113865979  69 SPNPCYNDAKCLVTLDTqrgdifteYICQCPVGYSGIHCE 108
Cdd:cd00054    7 SGNPCQNGGTCVNTVGS--------YRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 28-57 5.02e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 5.02e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 113865979   28 CDSSLCLNGGTCLTGQdNDIYCLCPEGFTG 57
Cdd:pfam00008   1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 26-60 1.45e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 1.45e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 113865979  26 DFCDS-SLCLNGGTClTGQDNDIYCLCPEGFTGLVC 60
Cdd:cd00054    3 DECASgNPCQNGGTC-VNTVGSYRCSCPPGYTGRNC 37
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 67-108 5.33e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 34.76  E-value: 5.33e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 113865979  67 PCS-PNPCYNDAKCLVTLDTqrgdifteYICQCPVGYSG-IHCE 108
Cdd:cd00053    1 ECAaSNPCSNGGTCVNTPGS--------YRCVCPPGYTGdRSCE 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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