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Conserved domains on  [gi|160333372|ref|NP_032550|]
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lumican precursor [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-321 2.03e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 2.03e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372  71 LYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGKVFSKLKQLKKLHINYNNLTESVgplpKSLQDLQLTNNKIS 150
Cdd:COG4886   51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL----TNLESLDLSGNQLT 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 151 KLG-SFDGLVNLTFIYLQHNQLKEdaVSASLKGLKSLEYLDLSFNQMSKLPAGLP--TSLLTLYLDNNKISNIPDEyFKR 227
Cdd:COG4886  127 DLPeELANLTNLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGN 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 228 FTGLQYLRLSHNELADsgVPGNSFNISSLLELDLSYNKLKSIPTVNE--NLENYYLEVNELEKFDVKSFCKilgplsysK 305
Cdd:COG4886  204 LTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPELGNltNLEELDLSNNQLTDLPPLANLT--------N 273

                        250
                 ....*....|....*.
gi 160333372 306 IKHLRLDGNPLTQSSL 321
Cdd:COG4886  274 LKTLDLSNNQLTDLKL 289
LRRNT smart00013
Leucine rich repeat N-terminal domain;
37-71 2.35e-07

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 46.54  E-value: 2.35e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 160333372    37 CAPECNCPHsypTAMYCDDLKLKSVPMVPPGIKYL 71
Cdd:smart00013   2 CPAPCNCSG---TAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-321 2.03e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 2.03e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372  71 LYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGKVFSKLKQLKKLHINYNNLTESVgplpKSLQDLQLTNNKIS 150
Cdd:COG4886   51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL----TNLESLDLSGNQLT 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 151 KLG-SFDGLVNLTFIYLQHNQLKEdaVSASLKGLKSLEYLDLSFNQMSKLPAGLP--TSLLTLYLDNNKISNIPDEyFKR 227
Cdd:COG4886  127 DLPeELANLTNLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGN 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 228 FTGLQYLRLSHNELADsgVPGNSFNISSLLELDLSYNKLKSIPTVNE--NLENYYLEVNELEKFDVKSFCKilgplsysK 305
Cdd:COG4886  204 LTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPELGNltNLEELDLSNNQLTDLPPLANLT--------N 273

                        250
                 ....*....|....*.
gi 160333372 306 IKHLRLDGNPLTQSSL 321
Cdd:COG4886  274 LKTLDLSNNQLTDLKL 289
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
35-321 1.43e-14

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 74.81  E-value: 1.43e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372  35 PNCAPecncphSYPTAMYCDDLKLKSVPMVPPGIKYLYLRNNQIDHIDekafenvtdlqwlILDHNLLENSkIKGKVFSK 114
Cdd:PRK15387 217 PDCLP------AHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLP-------------VLPPGLLELS-IFSNPLTH 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 115 LKQLK----KLHINYNNLTeSVGPLPKSLQDLQLTNNKISKLGSFDGlvNLTFIYLQHNQLkedavsASLKGLKS-LEYL 189
Cdd:PRK15387 277 LPALPsglcKLWIFGNQLT-SLPVLPPGLQELSVSDNQLASLPALPS--ELCKLWAYNNQL------TSLPTLPSgLQEL 347

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 190 DLSFNQMSKLPAgLPTSLLTLYLDNNKISNIPdeyfKRFTGLQYLRLSHNELADSGV-PgnsfniSSLLELDLSYNKLKS 268
Cdd:PRK15387 348 SVSDNQLASLPT-LPSELYKLWAYNNRLTSLP----ALPSGLKELIVSGNRLTSLPVlP------SELKELMVSGNRLTS 416

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 160333372 269 IPTVNENLENYYLEVNELEKFDvKSFckilgpLSYSKIKHLRLDGNPLTQSSL 321
Cdd:PRK15387 417 LPMLPSGLLSLSVYRNQLTRLP-ESL------IHLSSETTVNLEGNPLSERTL 462
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 49-200 1.75e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.66  E-value: 1.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372  49 TAMYCDDLKLKSVPM--VPPGIKYLYLRNNQIDHIDekAFENVTDLQWLILDHNLLEnsKIKGkvFSKLKQLKKLHINYN 126
Cdd:cd21340    5 THLYLNDKNITKIDNlsLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIE--KIEN--LENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 127 ------------NLTE-------------------SVGPLPKSLQDLQLTNNKISKLGSFDGLVNLTFIYLQHNQLKE-D 174
Cdd:cd21340   79 risvveglenltNLEElhienqrlppgekltfdprSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDlE 158

                        170       180
                 ....*....|....*....|....*.
gi 160333372 175 AVSASLKGLKSLEYLDLSFNQMSKLP 200
Cdd:cd21340  159 ELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
66-128 5.17e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 5.17e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 160333372   66 PGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLenSKIKGKVFSKLKQLKKLHINYNNL 128
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
37-71 2.35e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 46.54  E-value: 2.35e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 160333372    37 CAPECNCPHsypTAMYCDDLKLKSVPMVPPGIKYL 71
Cdd:smart00013   2 CPAPCNCSG---TAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 37-66 3.00e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 46.08  E-value: 3.00e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 160333372   37 CAPECNCPHsypTAMYCDDLKLKSVPMVPP 66
Cdd:pfam01462   2 CPVPCHCSA---TVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-321 2.03e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 2.03e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372  71 LYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGKVFSKLKQLKKLHINYNNLTESVgplpKSLQDLQLTNNKIS 150
Cdd:COG4886   51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL----TNLESLDLSGNQLT 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 151 KLG-SFDGLVNLTFIYLQHNQLKEdaVSASLKGLKSLEYLDLSFNQMSKLPAGLP--TSLLTLYLDNNKISNIPDEyFKR 227
Cdd:COG4886  127 DLPeELANLTNLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGN 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 228 FTGLQYLRLSHNELADsgVPGNSFNISSLLELDLSYNKLKSIPTVNE--NLENYYLEVNELEKFDVKSFCKilgplsysK 305
Cdd:COG4886  204 LTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPELGNltNLEELDLSNNQLTDLPPLANLT--------N 273

                        250
                 ....*....|....*.
gi 160333372 306 IKHLRLDGNPLTQSSL 321
Cdd:COG4886  274 LKTLDLSNNQLTDLKL 289
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-318 1.85e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 1.85e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372  68 IKYLYLRNNQIDHIDEkAFENVTDLQWLILDHNLLENSkikGKVFSKLKQLKKLHINYNNLT---ESVGPLPKsLQDLQL 144
Cdd:COG4886  115 LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL---PEPLGNLTNLKSLDLSNNQLTdlpEELGNLTN-LKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 145 TNNKISKLG-SFDGLVNLTFIYLQHNQLKEdaVSASLKGLKSLEYLDLSFNQMSKLPA-GLPTSLLTLYLDNNKISNIPD 222
Cdd:COG4886  190 SNNQITDLPePLGNLTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPElGNLTNLEELDLSNNQLTDLPP 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 223 EyfKRFTGLQYLRLSHNELADSGVPGNSFNISSLLELDLSYNKLKSIPTVNENLENYYLEVNELEKFDVKSFCKILGPLS 302
Cdd:COG4886  268 L--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345

                        250
                 ....*....|....*.
gi 160333372 303 YSKIKHLRLDGNPLTQ 318
Cdd:COG4886  346 LLALLTLLLLLNLLSL 361
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-290 3.35e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 3.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372  66 PGIKYLYLRNNQIDHIDEkAFENVTDLQWLILDHNLLENSkikGKVFSKLKQLKKLHINYNNLT---ESVGPLpKSLQDL 142
Cdd:COG4886  159 TNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTdlpEPLANL-TNLETL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 143 QLTNNKISKLGSFDGLVNLTFIYLQHNQLKEdavSASLKGLKSLEYLDLSFNQMSKLP-AGLPTSLLTLYLDNNKISNIP 221
Cdd:COG4886  234 DLSNNQLTDLPELGNLTNLEELDLSNNQLTD---LPPLANLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNL 310

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 160333372 222 DEYFKRFTGLQYLRLSHNELADSGVPGNSFNISSLLELDLSYNKLKSIPTVNENLENYYLEVNELEKFD 290
Cdd:COG4886  311 LELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATL 379
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
35-321 1.43e-14

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 74.81  E-value: 1.43e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372  35 PNCAPecncphSYPTAMYCDDLKLKSVPMVPPGIKYLYLRNNQIDHIDekafenvtdlqwlILDHNLLENSkIKGKVFSK 114
Cdd:PRK15387 217 PDCLP------AHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLP-------------VLPPGLLELS-IFSNPLTH 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 115 LKQLK----KLHINYNNLTeSVGPLPKSLQDLQLTNNKISKLGSFDGlvNLTFIYLQHNQLkedavsASLKGLKS-LEYL 189
Cdd:PRK15387 277 LPALPsglcKLWIFGNQLT-SLPVLPPGLQELSVSDNQLASLPALPS--ELCKLWAYNNQL------TSLPTLPSgLQEL 347

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 190 DLSFNQMSKLPAgLPTSLLTLYLDNNKISNIPdeyfKRFTGLQYLRLSHNELADSGV-PgnsfniSSLLELDLSYNKLKS 268
Cdd:PRK15387 348 SVSDNQLASLPT-LPSELYKLWAYNNRLTSLP----ALPSGLKELIVSGNRLTSLPVlP------SELKELMVSGNRLTS 416

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 160333372 269 IPTVNENLENYYLEVNELEKFDvKSFckilgpLSYSKIKHLRLDGNPLTQSSL 321
Cdd:PRK15387 417 LPMLPSGLLSLSVYRNQLTRLP-ESL------IHLSSETTVNLEGNPLSERTL 462
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
44-242 4.09e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 73.19  E-value: 4.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372  44 PHSYP---TAMYCDDLKLKSVPM-VPPGIKYLYLRNNQI--------DHIDEKAFE--NVTDL--------QWLILDHNl 101
Cdd:PRK15370 194 PACIPeqiTTLILDNNELKSLPEnLQGNIKTLYANSNQLtsipatlpDTIQEMELSinRITELperlpsalQSLDLFHN- 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 102 lensKIKGKVFSKLKQLKKLHINYNNLTESVGPLPKSLQDLQLTNNKISKLGSFDGLvNLTFIYLQHNQLKedAVSASLK 181
Cdd:PRK15370 273 ----KISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPP-GLKTLEAGENALT--SLPASLP 345

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 160333372 182 glKSLEYLDLSFNQMSKLPAGLPTSLLTLYLDNNKISNIPDEYfkrFTGLQYLRLSHNELA 242
Cdd:PRK15370 346 --PELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENL---PAALQIMQASRNNLV 401
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 49-200 1.75e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.66  E-value: 1.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372  49 TAMYCDDLKLKSVPM--VPPGIKYLYLRNNQIDHIDekAFENVTDLQWLILDHNLLEnsKIKGkvFSKLKQLKKLHINYN 126
Cdd:cd21340    5 THLYLNDKNITKIDNlsLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIE--KIEN--LENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 127 ------------NLTE-------------------SVGPLPKSLQDLQLTNNKISKLGSFDGLVNLTFIYLQHNQLKE-D 174
Cdd:cd21340   79 risvveglenltNLEElhienqrlppgekltfdprSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDlE 158

                        170       180
                 ....*....|....*....|....*.
gi 160333372 175 AVSASLKGLKSLEYLDLSFNQMSKLP 200
Cdd:cd21340  159 ELLDLLSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 115-318 1.48e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.96  E-value: 1.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 115 LKQLKKLHINYNNLTE-SVGPLPKSLQDLQLTNNKISKLGSFDGLVNLTFIYLQHNQLKEdavsasLKGLKSLEYLDlsf 193
Cdd:cd21340    1 LKRITHLYLNDKNITKiDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEK------IENLENLVNLK--- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 194 nqmsklpaglptsllTLYLDNNKISNIpdEYFKRFTGLQYLRLSHNELAdsgvPGNSF--------NIS-SLLELDLSYN 264
Cdd:cd21340   72 ---------------KLYLGGNRISVV--EGLENLTNLEELHIENQRLP----PGEKLtfdprslaALSnSLRVLNISGN 130

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 160333372 265 KLKSI-PTVN-ENLENYYLEVNELEkfDVKSFCKILGPLSYskIKHLRLDGNPLTQ 318
Cdd:cd21340  131 NIDSLePLAPlRNLEQLDASNNQIS--DLEELLDLLSSWPS--LRELDLTGNPVCK 182
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-286 3.39e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 3.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372  66 PGIKYLYLRNNQIDHIDEkAFENVTDLQWLILDHNLLENskiKGKVFSKLKQLKKLHINYNNLTE--SVGPLPKsLQDLQ 143
Cdd:COG4886  182 TNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD---LPEPLANLTNLETLDLSNNQLTDlpELGNLTN-LEELD 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 144 LTNNKISKLGSFDGLVNLTFIYLQHNQLKEDAVS--ASLKGLKSLEYLDLSFNQMSKLPAGLPTSLLTLYLDNNKISNIP 221
Cdd:COG4886  257 LSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKelELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 160333372 222 DEYFKRFTGLQYLRLSHNELADSGVPGNSFNISSLLELDLSYNKLKSIPTVNENLENYYLEVNEL 286
Cdd:COG4886  337 LTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 56-266 1.94e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 61.73  E-value: 1.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372  56 LKLKSVPMVPPGIKYLYLRNNQID------HIDEKAFENvTDLQWLILDHNLLENSKIK--GKVFSKLKQLKKLHINYNN 127
Cdd:COG5238  141 INLIQVLKDPLGGNAVHLLGLAARlgllaaISMAKALQN-NSVETVYLGCNQIGDEGIEelAEALTQNTTVTTLWLKRNP 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 128 LTES-------VGPLPKSLQDLQLTNNKISKLGS---FDGLVN---LTFIYLQHNQLKED---AVSASLKGLKSLEYLDL 191
Cdd:COG5238  220 IGDEgaeilaeALKGNKSLTTLDLSNNQIGDEGVialAEALKNnttVETLYLSGNQIGAEgaiALAKALQGNTTLTSLDL 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 192 SFNQMS-----KLPAGLPTS--LLTLYLDNNKISN---IP-DEYFKRFTGLQYLRLSHNELADSGVPG--NSF-NISSLL 257
Cdd:COG5238  300 SVNRIGdegaiALAEGLQGNktLHTLNLAYNGIGAqgaIAlAKALQENTTLHSLDLSDNQIGDEGAIAlaKYLeGNTTLR 379


                 ....*....
gi 160333372 258 ELDLSYNKL 266
Cdd:COG5238  380 ELNLGKNNI 388
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 102-271 7.08e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.17  E-value: 7.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 102 LENSKIKGKV---FSKLKQLKKLHINYNNLTESVGPLP---KSLQDLQLTNNKIS-KLGSFDGLVNLTFIYLQHNQLKEd 174
Cdd:PLN00113 411 LQDNSFSGELpseFTKLPLVYFLDISNNNLQGRINSRKwdmPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSG- 489

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 175 AVSASLKGLKSLEYLDLSFNQMS-KLPAGLPT--SLLTLYLDNNKIS-NIPDEyFKRFTGLQYLRLSHNELADSgVPGNS 250
Cdd:PLN00113 490 AVPRKLGSLSELMQLKLSENKLSgEIPDELSSckKLVSLDLSHNQLSgQIPAS-FSEMPVLSQLDLSQNQLSGE-IPKNL 567

                        170       180
                 ....*....|....*....|..
gi 160333372 251 FNISSLLELDLSYNKLK-SIPT 271
Cdd:PLN00113 568 GNVESLVQVNISHNHLHgSLPS 589
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 92-278 7.74e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.17  E-value: 7.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372  92 LQWLILDHNLLeNSKIKGKVFSKLKQLKKLHINYNNLTesvGPLPKS----LQDLQLTNNKIS-----KLGSFDglvNLT 162
Cdd:PLN00113  95 IQTINLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNNFT---GSIPRGsipnLETLDLSNNMLSgeipnDIGSFS---SLK 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 163 FIYLQHNQLKeDAVSASLKGLKSLEYLDLSFNQM---------------------SKLPAGLPTSLLTL----YLD---N 214
Cdd:PLN00113 168 VLDLGGNVLV-GKIPNSLTNLTSLEFLTLASNQLvgqiprelgqmkslkwiylgyNNLSGEIPYEIGGLtslnHLDlvyN 246

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 160333372 215 NKISNIPDEyFKRFTGLQYLRLSHNELADSgVPGNSFNISSLLELDLSYNKLK-SIPTVNENLEN 278
Cdd:PLN00113 247 NLTGPIPSS-LGNLKNLQYLFLYQNKLSGP-IPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQN 309
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 66-267 4.62e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.90  E-value: 4.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372  66 PGIKYLYLRNNQIDHIDEKAFENVT---DLQWLILDHNLLENSKIKgkvfsklkqlkklhinynNLTESVGPLPKSLQDL 142
Cdd:cd00116   81 CGLQELDLSDNALGPDGCGVLESLLrssSLQELKLNNNGLGDRGLR------------------LLAKGLKDLPPALEKL 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 143 QLTNNKISKLGSFDGLVNLTFIYLQH------NQLKEDAVSASLKGLKS---LEYLDLSFNQ-----MSKLPAGLPT--S 206
Cdd:cd00116  143 VLGRNRLEGASCEALAKALRANRDLKelnlanNGIGDAGIRALAEGLKAncnLEVLDLNNNGltdegASALAETLASlkS 222

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 160333372 207 LLTLYLDNNKISNIP-----DEYFKRFTGLQYLRLSHNELADSGVPGNS---FNISSLLELDLSYNKLK 267
Cdd:cd00116  223 LEVLNLGDNNLTDAGaaalaSALLSPNISLLTLSLSCNDITDDGAKDLAevlAEKESLLELDLRGNKFG 291
LRR_8 pfam13855
Leucine rich repeat;
66-128 5.17e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 5.17e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 160333372   66 PGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLenSKIKGKVFSKLKQLKKLHINYNNL 128
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
205-266 7.36e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 7.36e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 160333372  205 TSLLTLYLDNNKISNIPDEYFKRFTGLQYLRLSHNELadSGVPGNSF-NISSLLELDLSYNKL 266
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFsGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
37-71 2.35e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 46.54  E-value: 2.35e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 160333372    37 CAPECNCPHsypTAMYCDDLKLKSVPMVPPGIKYL 71
Cdd:smart00013   2 CPAPCNCSG---TAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 37-66 3.00e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 46.08  E-value: 3.00e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 160333372   37 CAPECNCPHsypTAMYCDDLKLKSVPMVPP 66
Cdd:pfam01462   2 CPVPCHCSA---TVVNCSDRGLTAVPRDLP 28
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
44-205 6.58e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 6.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372  44 PHSYPTAMYCDDL---KLKSVP-MVPPGIKYLYLRNNQIDHIDEKAFENVTDLqwlildhNLLENSkikgkvFSKLKQ-- 117
Cdd:PRK15370 257 PERLPSALQSLDLfhnKISCLPeNLPEELRYLSVYDNSIRTLPAHLPSGITHL-------NVQSNS------LTALPEtl 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 118 ---LKKLHINYNNLTESVGPLPKSLQDLQLTNNKISKLGsfDGLV-NLTFIYLQHN---QLKEDAVSAslkglksLEYLD 190
Cdd:PRK15370 324 ppgLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLP--ETLPpTITTLDVSRNaltNLPENLPAA-------LQIMQ 394

                        170
                 ....*....|....*
gi 160333372 191 LSFNQMSKLPAGLPT 205
Cdd:PRK15370 395 ASRNNLVRLPESLPH 409
LRR_8 pfam13855
Leucine rich repeat;
117-171 1.62e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 1.62e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 160333372  117 QLKKLHINYNNLTeSVGPL----PKSLQDLQLTNNKISKL--GSFDGLVNLTFIYLQHNQL 171
Cdd:pfam13855   2 NLRSLDLSNNRLT-SLDDGafkgLSNLKVLDLSNNLLTTLspGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 71-222 4.84e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.86  E-value: 4.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372  71 LYLRNNQIDhiDE------KAFENVTDLQWLILDHNLLENSKIKG--KVFSKLKQLKKLHINYNNLT-ESVGPLPKSLQ- 140
Cdd:COG5238  241 LDLSNNQIG--DEgvialaEALKNNTTVETLYLSGNQIGAEGAIAlaKALQGNTTLTSLDLSVNRIGdEGAIALAEGLQg 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 141 -----DLQLTNNKISKLG------SFDGLVNLTFIYLQHNQLKEDAVSA---SLKGLKSLEYLDLSFNQMSK-----LPA 201
Cdd:COG5238  319 nktlhTLNLAYNGIGAQGaialakALQENTTLHSLDLSDNQIGDEGAIAlakYLEGNTTLRELNLGKNNIGKqgaeaLID 398

                        170       180
                 ....*....|....*....|..
gi 160333372 202 GL-PTSLLTLYLDNNKISNIPD 222
Cdd:COG5238  399 ALqTNRLHTLILDGNLIGAEAQ 420
LRR_8 pfam13855
Leucine rich repeat;
138-196 8.36e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 8.36e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 160333372  138 SLQDLQLTNNKISKL--GSFDGLVNLTFIYLQHNQLKEDAvSASLKGLKSLEYLDLSFNQM 196
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 68-266 4.08e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 4.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372  68 IKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLeNSKIKGKVfSKLKQLKKLHINYNNLTEsvgPLPKSLQDLQltnn 147
Cdd:PLN00113 190 LEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL-SGEIPYEI-GGLTSLNHLDLVYNNLTG---PIPSSLGNLK---- 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 148 kisklgsfdglvNLTFIYLQHNQLKeDAVSASLKGLKSLEYLDLSFNQMS----KLPAGLpTSLLTLYLDNNKISNIPDE 223
Cdd:PLN00113 261 ------------NLQYLFLYQNKLS-GPIPPSIFSLQKLISLDLSDNSLSgeipELVIQL-QNLEILHLFSNNFTGKIPV 326

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 160333372 224 YFKRFTGLQYLRLSHNELAdSGVPGNSFNISSLLELDLSYNKL 266
Cdd:PLN00113 327 ALTSLPRLQVLQLWSNKFS-GEIPKNLGKHNNLTVLDLSTNNL 368
LRR_8 pfam13855
Leucine rich repeat;
160-217 1.86e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 1.86e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 160333372  160 NLTFIYLQHNQLKEDAVSAsLKGLKSLEYLDLSFNQMSKLP----AGLPtSLLTLYLDNNKI 217
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGA-FKGLSNLKVLDLSNNLLTTLSpgafSGLP-SLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 166-317 4.15e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 4.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 166 LQHNQLKEDAVSASLKGL---KSLEYLDLSFNQMSKLPAGL---------PTSLLTLYLDNNKISniPD-----EYFKRF 228
Cdd:cd00116   30 LEGNTLGEEAAKALASALrpqPSLKELCLSLNETGRIPRGLqsllqgltkGCGLQELDLSDNALG--PDgcgvlESLLRS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160333372 229 TGLQYLRLSHNELADSGVP----GNSFNISSLLELDLSYNKLKSIPT--------VNENLENYYLEVNELEKFDVKSFCK 296
Cdd:cd00116  108 SSLQELKLNNNGLGDRGLRllakGLKDLPPALEKLVLGRNRLEGASCealakalrANRDLKELNLANNGIGDAGIRALAE 187

                        170       180
                 ....*....|....*....|.
gi 160333372 297 ILgpLSYSKIKHLRLDGNPLT 317
Cdd:cd00116  188 GL--KANCNLEVLDLNNNGLT 206
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 137-174 5.53e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 5.53e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 160333372  137 KSLQDLQLTNNKISKLGSFDGLVNLTFIYLQHNQLKED 174
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNKITD 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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