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Conserved domains on  [gi|6680431|ref|NP_032396|]
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interleukin-5 receptor subunit alpha precursor [Mus musculus]

Protein Classification

IL6Ra-bind and FN3 domain-containing protein( domain architecture ID 10557933)

IL6Ra-bind and FN3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 128-233 1.34e-30

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


:

Pssm-ID: 401252  Cd Length: 96  Bit Score: 112.89  E-value: 1.34e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680431    128 NLTCTTHTVVSshthlrpyqvsLRCTWLVGKDAPEDTQYFLYYRFGVL--TEKCQEYSRDAlNRNTACWFPRTFINSKGF 205
Cdd:pfam09240   1 DLTCFIHNPSN-----------LSCEWKPGPNAPPDTNYVLYVRKSPLgpVLQCQYYIRDD-GTRIGCQFDDLEGLSSSF 68

                          90       100
                  ....*....|....*....|....*...
gi 6680431    206 EQLAVHINGSSKRAAIKPFDQLFSPLAI 233
Cdd:pfam09240  69 HQVYICVNGSSSAGPIRSSDQTFQLQNI 96
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 237-328 5.95e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 35.94  E-value: 5.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680431  237 NPPRNVTV-EIESNSLYIQWEKPLSAFPDHcFNYELKIYNTKNG---HIQKEKLIANKFisKIDDV---STYSIQVRAav 309
Cdd:cd00063   2 SPPTNLRVtDVTSTSVTLSWTPPEDDGGPI-TGYVVEYREKGSGdwkEVEVTPGSETSY--TLTGLkpgTEYEFRVRA-- 76

                        90
                ....*....|....*....
gi 6680431  310 sspcRMPGRWGEWSQPIYV 328
Cdd:cd00063  77 ----VNGGGESPPSESVTV 91
 
Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 128-233 1.34e-30

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 112.89  E-value: 1.34e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680431    128 NLTCTTHTVVSshthlrpyqvsLRCTWLVGKDAPEDTQYFLYYRFGVL--TEKCQEYSRDAlNRNTACWFPRTFINSKGF 205
Cdd:pfam09240   1 DLTCFIHNPSN-----------LSCEWKPGPNAPPDTNYVLYVRKSPLgpVLQCQYYIRDD-GTRIGCQFDDLEGLSSSF 68

                          90       100
                  ....*....|....*....|....*...
gi 6680431    206 EQLAVHINGSSKRAAIKPFDQLFSPLAI 233
Cdd:pfam09240  69 HQVYICVNGSSSAGPIRSSDQTFQLQNI 96
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 237-328 5.95e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 35.94  E-value: 5.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680431  237 NPPRNVTV-EIESNSLYIQWEKPLSAFPDHcFNYELKIYNTKNG---HIQKEKLIANKFisKIDDV---STYSIQVRAav 309
Cdd:cd00063   2 SPPTNLRVtDVTSTSVTLSWTPPEDDGGPI-TGYVVEYREKGSGdwkEVEVTPGSETSY--TLTGLkpgTEYEFRVRA-- 76

                        90
                ....*....|....*....
gi 6680431  310 sspcRMPGRWGEWSQPIYV 328
Cdd:cd00063  77 ----VNGGGESPPSESVTV 91
 
Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 128-233 1.34e-30

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 112.89  E-value: 1.34e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680431    128 NLTCTTHTVVSshthlrpyqvsLRCTWLVGKDAPEDTQYFLYYRFGVL--TEKCQEYSRDAlNRNTACWFPRTFINSKGF 205
Cdd:pfam09240   1 DLTCFIHNPSN-----------LSCEWKPGPNAPPDTNYVLYVRKSPLgpVLQCQYYIRDD-GTRIGCQFDDLEGLSSSF 68

                          90       100
                  ....*....|....*....|....*...
gi 6680431    206 EQLAVHINGSSKRAAIKPFDQLFSPLAI 233
Cdd:pfam09240  69 HQVYICVNGSSSAGPIRSSDQTFQLQNI 96
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 237-328 5.95e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 35.94  E-value: 5.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680431  237 NPPRNVTV-EIESNSLYIQWEKPLSAFPDHcFNYELKIYNTKNG---HIQKEKLIANKFisKIDDV---STYSIQVRAav 309
Cdd:cd00063   2 SPPTNLRVtDVTSTSVTLSWTPPEDDGGPI-TGYVVEYREKGSGdwkEVEVTPGSETSY--TLTGLkpgTEYEFRVRA-- 76

                        90
                ....*....|....*....
gi 6680431  310 sspcRMPGRWGEWSQPIYV 328
Cdd:cd00063  77 ----VNGGGESPPSESVTV 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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