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Conserved domains on  [gi|6680393|ref|NP_032376|]
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interleukin-11 isoform 1 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL11 pfam07400
Interleukin 11; This family contains interleukin 11 (approximately 200 residues long). This is ...
 32-199 1.52e-59

Interleukin 11; This family contains interleukin 11 (approximately 200 residues long). This is a secreted protein that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of interleukin 11. Family members seem to be restricted to mammals.


:

Pssm-ID: 462155  Cd Length: 167  Bit Score: 183.76  E-value: 1.52e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680393     32 SSDPRADLDSAVLLTRSLLADTRQLAAQMRDKFPADGDHSLDSLPTLAMSAGTLGSLQLPGVLTRLRVDLMSYLRHVQWL 111
Cdd:pfam07400   1 HRRPKAELDSLVNQTRSLLKDTKQLLADHELKFPTDGEHRLDSLPALAMSASDLSALQVKSTLSQLHTDLKSFLRHFEWL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680393    112 RRAGGPSLKTLEPELGALQARLERLLRRLQLLMSRLALPQaAPDQPVIPLGPPASAWGSIRAAHAILGGLHLTLDWAVRG 191
Cdd:pfam07400  81 RKAGGNSKHSLEPKLGGLISHIKRLLNSLQLLMNRLGAPR-PPVPSPPLPPIPATAWEVIQASHEILGGLHLFCDWAVRV 159


                  ....*...
gi 6680393    192 LLLLKTRL 199
Cdd:pfam07400 160 LLLLKRKL 167
 
Name Accession Description Interval E-value
IL11 pfam07400
Interleukin 11; This family contains interleukin 11 (approximately 200 residues long). This is ...
 32-199 1.52e-59

Interleukin 11; This family contains interleukin 11 (approximately 200 residues long). This is a secreted protein that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of interleukin 11. Family members seem to be restricted to mammals.


Pssm-ID: 462155  Cd Length: 167  Bit Score: 183.76  E-value: 1.52e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680393     32 SSDPRADLDSAVLLTRSLLADTRQLAAQMRDKFPADGDHSLDSLPTLAMSAGTLGSLQLPGVLTRLRVDLMSYLRHVQWL 111
Cdd:pfam07400   1 HRRPKAELDSLVNQTRSLLKDTKQLLADHELKFPTDGEHRLDSLPALAMSASDLSALQVKSTLSQLHTDLKSFLRHFEWL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680393    112 RRAGGPSLKTLEPELGALQARLERLLRRLQLLMSRLALPQaAPDQPVIPLGPPASAWGSIRAAHAILGGLHLTLDWAVRG 191
Cdd:pfam07400  81 RKAGGNSKHSLEPKLGGLISHIKRLLNSLQLLMNRLGAPR-PPVPSPPLPPIPATAWEVIQASHEILGGLHLFCDWAVRV 159


                  ....*...
gi 6680393    192 LLLLKTRL 199
Cdd:pfam07400 160 LLLLKRKL 167
 
Name Accession Description Interval E-value
IL11 pfam07400
Interleukin 11; This family contains interleukin 11 (approximately 200 residues long). This is ...
 32-199 1.52e-59

Interleukin 11; This family contains interleukin 11 (approximately 200 residues long). This is a secreted protein that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of interleukin 11. Family members seem to be restricted to mammals.


Pssm-ID: 462155  Cd Length: 167  Bit Score: 183.76  E-value: 1.52e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680393     32 SSDPRADLDSAVLLTRSLLADTRQLAAQMRDKFPADGDHSLDSLPTLAMSAGTLGSLQLPGVLTRLRVDLMSYLRHVQWL 111
Cdd:pfam07400   1 HRRPKAELDSLVNQTRSLLKDTKQLLADHELKFPTDGEHRLDSLPALAMSASDLSALQVKSTLSQLHTDLKSFLRHFEWL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680393    112 RRAGGPSLKTLEPELGALQARLERLLRRLQLLMSRLALPQaAPDQPVIPLGPPASAWGSIRAAHAILGGLHLTLDWAVRG 191
Cdd:pfam07400  81 RKAGGNSKHSLEPKLGGLISHIKRLLNSLQLLMNRLGAPR-PPVPSPPLPPIPATAWEVIQASHEILGGLHLFCDWAVRV 159


                  ....*...
gi 6680393    192 LLLLKTRL 199
Cdd:pfam07400 160 LLLLKRKL 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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