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Conserved domains on  [gi|111378397|ref|NP_032182|]
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phosphatidylinositol-glycan-specific phospholipase D precursor [Mus musculus]

Protein Classification

integrin alpha( domain architecture ID 10467975)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zn_dep_PLPC pfam00882
Zinc dependent phospholipase C;
28-220 5.65e-20

Zinc dependent phospholipase C;


:

Pssm-ID: 425927  Cd Length: 173  Bit Score: 88.16  E-value: 5.65e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111378397   28 THVEIGHRALEFLRLQDGRinyKELILEHQDAYQAGTVFPDAFYpsICKRGKYHDVSERTHWT---PFLNASIHYIREny 104
Cdd:pfam00882   1 THLTIASHALAVLPLLKKA---RKLLKLNKAALLLGSVAPDIPY--LFGFLPYSYLTHTHHWWetgDFILLLIKALRK-- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111378397  105 plpWEKDTEKLVAFLFGITSHMVADVSWHSLGieqgflRTMGAIDFYNSYSDAHSAGDFGGDVLSQFEfnfnylsRRWYV 184
Cdd:pfam00882  74 ---RKKGNLKLAAFLLGVLSHYLADVFTHSYG------VPLAGNGTFSGSLLQHVSYELGLDFLLLNY-------YRLEK 137

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 111378397  185 PVRDLLRIYDNLYGRKVITKDVLVDCTYLQFLEMHG 220
Cdd:pfam00882 138 EVDLLLLSVGDKDSNEALDELIKETLAAYLKEAFSG 173
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 446-502 8.09e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.07  E-value: 8.09e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 111378397   446 PSGRFGSALA-VLDFNQDGLPDLAVGAPSVGSGQLTynGSVYVYYGSQQG-RLSSSPNV 502
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGET--GAVYVYFGSSGGgNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 377-434 1.23e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 54.69  E-value: 1.23e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 111378397   377 PYARLGWVMTSA-DLNQDGHGDLVVGAPGYSHPGRfqIGRVYIIYGNDLGLPPIDLDLD 434
Cdd:smart00191   1 PGSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 514-547 1.48e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


:

Pssm-ID: 460357  Cd Length: 36  Bit Score: 36.72  E-value: 1.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 111378397  514 GWTLLATDADGDGRHDLVISSPFAPGGGKQRGIV 547
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPGEGGAGAGAVYV 35
 
Name Accession Description Interval E-value
Zn_dep_PLPC pfam00882
Zinc dependent phospholipase C;
28-220 5.65e-20

Zinc dependent phospholipase C;


Pssm-ID: 425927  Cd Length: 173  Bit Score: 88.16  E-value: 5.65e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111378397   28 THVEIGHRALEFLRLQDGRinyKELILEHQDAYQAGTVFPDAFYpsICKRGKYHDVSERTHWT---PFLNASIHYIREny 104
Cdd:pfam00882   1 THLTIASHALAVLPLLKKA---RKLLKLNKAALLLGSVAPDIPY--LFGFLPYSYLTHTHHWWetgDFILLLIKALRK-- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111378397  105 plpWEKDTEKLVAFLFGITSHMVADVSWHSLGieqgflRTMGAIDFYNSYSDAHSAGDFGGDVLSQFEfnfnylsRRWYV 184
Cdd:pfam00882  74 ---RKKGNLKLAAFLLGVLSHYLADVFTHSYG------VPLAGNGTFSGSLLQHVSYELGLDFLLLNY-------YRLEK 137

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 111378397  185 PVRDLLRIYDNLYGRKVITKDVLVDCTYLQFLEMHG 220
Cdd:pfam00882 138 EVDLLLLSVGDKDSNEALDELIKETLAAYLKEAFSG 173
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 446-502 8.09e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.07  E-value: 8.09e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 111378397   446 PSGRFGSALA-VLDFNQDGLPDLAVGAPSVGSGQLTynGSVYVYYGSQQG-RLSSSPNV 502
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGET--GAVYVYFGSSGGgNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 377-434 1.23e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 54.69  E-value: 1.23e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 111378397   377 PYARLGWVMTSA-DLNQDGHGDLVVGAPGYSHPGRfqIGRVYIIYGNDLGLPPIDLDLD 434
Cdd:smart00191   1 PGSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 450-488 3.24e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 52.90  E-value: 3.24e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 111378397  450 FGSALAVLDFNQDGLPDLAVGAPSVGSgqlTYNGSVYVY 488
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAPGEGG---AGAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 382-419 3.81e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 44.04  E-value: 3.81e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 111378397  382 GWVMTSADLNQDGHGDLVVGAPGYSHPGRfqiGRVYII 419
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPGEGGAGA---GAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 514-547 1.48e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 36.72  E-value: 1.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 111378397  514 GWTLLATDADGDGRHDLVISSPFAPGGGKQRGIV 547
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPGEGGAGAGAVYV 35
 
Name Accession Description Interval E-value
Zn_dep_PLPC pfam00882
Zinc dependent phospholipase C;
28-220 5.65e-20

Zinc dependent phospholipase C;


Pssm-ID: 425927  Cd Length: 173  Bit Score: 88.16  E-value: 5.65e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111378397   28 THVEIGHRALEFLRLQDGRinyKELILEHQDAYQAGTVFPDAFYpsICKRGKYHDVSERTHWT---PFLNASIHYIREny 104
Cdd:pfam00882   1 THLTIASHALAVLPLLKKA---RKLLKLNKAALLLGSVAPDIPY--LFGFLPYSYLTHTHHWWetgDFILLLIKALRK-- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111378397  105 plpWEKDTEKLVAFLFGITSHMVADVSWHSLGieqgflRTMGAIDFYNSYSDAHSAGDFGGDVLSQFEfnfnylsRRWYV 184
Cdd:pfam00882  74 ---RKKGNLKLAAFLLGVLSHYLADVFTHSYG------VPLAGNGTFSGSLLQHVSYELGLDFLLLNY-------YRLEK 137

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 111378397  185 PVRDLLRIYDNLYGRKVITKDVLVDCTYLQFLEMHG 220
Cdd:pfam00882 138 EVDLLLLSVGDKDSNEALDELIKETLAAYLKEAFSG 173
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 446-502 8.09e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.07  E-value: 8.09e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 111378397   446 PSGRFGSALA-VLDFNQDGLPDLAVGAPSVGSGQLTynGSVYVYYGSQQG-RLSSSPNV 502
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGET--GAVYVYFGSSGGgNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 377-434 1.23e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 54.69  E-value: 1.23e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 111378397   377 PYARLGWVMTSA-DLNQDGHGDLVVGAPGYSHPGRfqIGRVYIIYGNDLGLPPIDLDLD 434
Cdd:smart00191   1 PGSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 450-488 3.24e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 52.90  E-value: 3.24e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 111378397  450 FGSALAVLDFNQDGLPDLAVGAPSVGSgqlTYNGSVYVY 488
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAPGEGG---AGAGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 458-532 5.00e-07

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 47.22  E-value: 5.00e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 111378397  458 DFNQDGLPDLAVgapsvgsgqlTYNGSVYVYYGSQQGRLSSSPNVTISCKDTycnlGWTLLATDADGDGRHDLVI 532
Cdd:pfam13517   1 DLDGDGKLDLVV----------ANDGGLRLYLNNGDGTFTFITSVSLGGGGG----GLSVAVGDLDGDGRLDLLV 61
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 382-419 3.81e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 44.04  E-value: 3.81e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 111378397  382 GWVMTSADLNQDGHGDLVVGAPGYSHPGRfqiGRVYII 419
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPGEGGAGA---GAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 389-469 1.27e-04

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 40.67  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111378397  389 DLNQDGHGDLVVGAPGYShpgrfqigRVYIIYGNDLGLPPIDLDLdkeahgilegfqPSGRFGSALAVLDFNQDGLPDLA 468
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGL--------RLYLNNGDGTFTFITSVSL------------GGGGGGLSVAVGDLDGDGRLDLL 60


                  .
gi 111378397  469 V 469
Cdd:pfam13517  61 V 61
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 514-547 1.48e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 36.72  E-value: 1.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 111378397  514 GWTLLATDADGDGRHDLVISSPFAPGGGKQRGIV 547
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPGEGGAGAGAVYV 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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