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Conserved domains on  [gi|181337117|ref|NP_032119|]
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transcription factor GATA-5 [Mus musculus]

Protein Classification

GATA-type transcription factor( domain architecture ID 12062858)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
Gene Ontology:  GO:0003700|GO:0006357|GO:0006355|GO:0008270|GO:0043565|GO:0000981
PubMed:  31574210
SCOP:  4003617

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 1-181 2.40e-51

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


:

Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 169.92  E-value: 2.40e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181337117    1 MYQSLALAQSPGQGTY-ADSGAFLHSSGTgSPVFVAPTRMPSM---LPYLPSCEPGSQAPALAAHSSWTQAvAADSSAFG 76
Cdd:pfam05349   1 MYQSLALAANHGQAAYdHDSGGFLHSAAS-SPVYVPTTRVPSMlptLPYLQGCGSSQQSHPVSSHSGWAQA-GAESSSYN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181337117   77 SGSPHPpaahppgATTFPFAHSPPGSGsggsAGVRDGgAFQGALL----AREQYpTPLGRPMGASYPTTYPAYMSSDVAP 152
Cdd:pfam05349  79 PGSPHP-------SPRFSYSHSPPGSN----GTSRDA-AYQSPLLisagGREQY-GALGRPLGGSYPSPYPAYVSPEMAP 145

                         170       180
                  ....*....|....*....|....*....
gi 181337117  153 SWTSGAFDSSILHGLQARPGGLPGRRTSF 181
Cdd:pfam05349 146 SWTAGPFDSSVLHSLQGRGAPLPGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 250-300 5.52e-21

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 85.50  E-value: 5.52e-21
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 181337117 250 CSNCHTATTTLWRRN-SEGEPVCNACGLYMKLHGVPRPLAMKKES-IQTRKRK 300
Cdd:cd00202    2 CSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 195-239 1.20e-16

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 73.56  E-value: 1.20e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 181337117 195 ECVNCGALSTPLWRRDG-TGHYLCNACGLYHKMNGVNRPLVRPQKR 239
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKD 46
 
Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 1-181 2.40e-51

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 169.92  E-value: 2.40e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181337117    1 MYQSLALAQSPGQGTY-ADSGAFLHSSGTgSPVFVAPTRMPSM---LPYLPSCEPGSQAPALAAHSSWTQAvAADSSAFG 76
Cdd:pfam05349   1 MYQSLALAANHGQAAYdHDSGGFLHSAAS-SPVYVPTTRVPSMlptLPYLQGCGSSQQSHPVSSHSGWAQA-GAESSSYN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181337117   77 SGSPHPpaahppgATTFPFAHSPPGSGsggsAGVRDGgAFQGALL----AREQYpTPLGRPMGASYPTTYPAYMSSDVAP 152
Cdd:pfam05349  79 PGSPHP-------SPRFSYSHSPPGSN----GTSRDA-AYQSPLLisagGREQY-GALGRPLGGSYPSPYPAYVSPEMAP 145

                         170       180
                  ....*....|....*....|....*....
gi 181337117  153 SWTSGAFDSSILHGLQARPGGLPGRRTSF 181
Cdd:pfam05349 146 SWTAGPFDSSVLHSLQGRGAPLPGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 250-300 5.52e-21

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 85.50  E-value: 5.52e-21
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 181337117 250 CSNCHTATTTLWRRN-SEGEPVCNACGLYMKLHGVPRPLAMKKES-IQTRKRK 300
Cdd:cd00202    2 CSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
245-294 8.73e-18

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 76.69  E-value: 8.73e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 181337117   245 RSGLCCSNCHTATTTLWRRNSEGE-PVCNACGLYMKLHGVP-RPLAMKKESI 294
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 195-239 1.20e-16

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 73.56  E-value: 1.20e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 181337117 195 ECVNCGALSTPLWRRDG-TGHYLCNACGLYHKMNGVNRPLVRPQKR 239
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKD 46
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
191-236 5.44e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 68.60  E-value: 5.44e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 181337117   191 GEGRECVNCGALSTPLWRRDGTGH-YLCNACGLYHKMNGV-NRPLVRP 236
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLK 48
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 250-284 3.86e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.11  E-value: 3.86e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 181337117  250 CSNCHTATTTLWRRNSEGEP-VCNACGLYMKLHGVP 284
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 196-230 1.94e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 61.18  E-value: 1.94e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 181337117  196 CVNCGALSTPLWRRDGTGHY-LCNACGLYHKMNGVN 230
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
198-342 6.46e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 57.57  E-value: 6.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181337117 198 NCGALSTPLWRR-DGTGHYLCNACGLYHKMNGVNRPLVRpqKRLSSSRRSGLCCSNCHTATTTlwrRNSEGEPVCNACGL 276
Cdd:COG5641  303 LTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPLLP--KPDPNSKRSNATCMNCSSTPTN---KILSPPTTSNSPGA 377

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 181337117 277 YMKLHGVPRPLAMKKESIqtrKRKPKNPAKIKGSSGSTANTTAS--SPTLLNSESSATTLKAESSLAS 342
Cdd:COG5641  378 QVKLPNQTRSTGATKKKI---TRRRMNSGKIPALSSSMKNPVPKefSPLIPQSTESETPSQSKSSLTS 442
 
Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 1-181 2.40e-51

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 169.92  E-value: 2.40e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181337117    1 MYQSLALAQSPGQGTY-ADSGAFLHSSGTgSPVFVAPTRMPSM---LPYLPSCEPGSQAPALAAHSSWTQAvAADSSAFG 76
Cdd:pfam05349   1 MYQSLALAANHGQAAYdHDSGGFLHSAAS-SPVYVPTTRVPSMlptLPYLQGCGSSQQSHPVSSHSGWAQA-GAESSSYN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181337117   77 SGSPHPpaahppgATTFPFAHSPPGSGsggsAGVRDGgAFQGALL----AREQYpTPLGRPMGASYPTTYPAYMSSDVAP 152
Cdd:pfam05349  79 PGSPHP-------SPRFSYSHSPPGSN----GTSRDA-AYQSPLLisagGREQY-GALGRPLGGSYPSPYPAYVSPEMAP 145

                         170       180
                  ....*....|....*....|....*....
gi 181337117  153 SWTSGAFDSSILHGLQARPGGLPGRRTSF 181
Cdd:pfam05349 146 SWTAGPFDSSVLHSLQGRGAPLPGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 250-300 5.52e-21

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 85.50  E-value: 5.52e-21
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 181337117 250 CSNCHTATTTLWRRN-SEGEPVCNACGLYMKLHGVPRPLAMKKES-IQTRKRK 300
Cdd:cd00202    2 CSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
245-294 8.73e-18

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 76.69  E-value: 8.73e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 181337117   245 RSGLCCSNCHTATTTLWRRNSEGE-PVCNACGLYMKLHGVP-RPLAMKKESI 294
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 195-239 1.20e-16

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 73.56  E-value: 1.20e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 181337117 195 ECVNCGALSTPLWRRDG-TGHYLCNACGLYHKMNGVNRPLVRPQKR 239
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKD 46
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
191-236 5.44e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 68.60  E-value: 5.44e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 181337117   191 GEGRECVNCGALSTPLWRRDGTGH-YLCNACGLYHKMNGV-NRPLVRP 236
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLK 48
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 250-284 3.86e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.11  E-value: 3.86e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 181337117  250 CSNCHTATTTLWRRNSEGEP-VCNACGLYMKLHGVP 284
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 196-230 1.94e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 61.18  E-value: 1.94e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 181337117  196 CVNCGALSTPLWRRDGTGHY-LCNACGLYHKMNGVN 230
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
198-342 6.46e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 57.57  E-value: 6.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181337117 198 NCGALSTPLWRR-DGTGHYLCNACGLYHKMNGVNRPLVRpqKRLSSSRRSGLCCSNCHTATTTlwrRNSEGEPVCNACGL 276
Cdd:COG5641  303 LTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPLLP--KPDPNSKRSNATCMNCSSTPTN---KILSPPTTSNSPGA 377

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 181337117 277 YMKLHGVPRPLAMKKESIqtrKRKPKNPAKIKGSSGSTANTTAS--SPTLLNSESSATTLKAESSLAS 342
Cdd:COG5641  378 QVKLPNQTRSTGATKKKI---TRRRMNSGKIPALSSSMKNPVPKefSPLIPQSTESETPSQSKSSLTS 442
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
188-318 9.62e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 57.19  E-value: 9.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181337117 188 EFPGEGRECVNCGALSTPLWRRD-----GTGHYLCNACGLYHKMNGVNRPLVRPQKRLSSSRRSGLCCSNC-HTATTTLW 261
Cdd:COG5641  153 DNSNQPHVCSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNdSNGENANT 232

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 181337117 262 RRNSEGEPVCNACGLYMKLHGvpRPLAMKKESIQTRKRKPKNPA--KIKGSSGSTANTT 318
Cdd:COG5641  233 ESIGNSSASKLTKSWEERPQG--RQLLSDAGSLSPRSNNPKSPLleGLMGSTSLQPVST 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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