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Conserved domains on  [gi|6679863|ref|NP_032070|]
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frataxin, mitochondrial precursor [Mus musculus]

Protein Classification

frataxin( domain architecture ID 10022430)

frataxin is a mitochondrial protein that promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways

CATH:  3.30.920.10
Gene Ontology:  GO:0008199|GO:0008198|GO:0016226|GO:0051537|GO:0004322
SCOP:  4001566
TCDB:  9.B.21

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 91-189 2.51e-54

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


:

Pssm-ID: 132463  Cd Length: 97  Bit Score: 168.18  E-value: 2.51e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679863     91 AYERLAEETLDSLAEFFEDLADKpYTLEDYDVSFGDGVLTIKLGGdLGTYVINKQTPNKQIWLSSPSSGPKRYDWTGKNW 170
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGES-RPDLDFDVEYSSGVLTLELPS-VGTYVINKQPPNKQIWLSSPVSGPKRYDYVNGEW 78

                          90
                  ....*....|....*....
gi 6679863    171 VYSHDGVSLHELLARELTK 189
Cdd:TIGR03422  79 IYLRDGSSLTELLEEELSK 97
 
Name Accession Description Interval E-value
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 91-189 2.51e-54

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


Pssm-ID: 132463  Cd Length: 97  Bit Score: 168.18  E-value: 2.51e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679863     91 AYERLAEETLDSLAEFFEDLADKpYTLEDYDVSFGDGVLTIKLGGdLGTYVINKQTPNKQIWLSSPSSGPKRYDWTGKNW 170
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGES-RPDLDFDVEYSSGVLTLELPS-VGTYVINKQPPNKQIWLSSPVSGPKRYDYVNGEW 78

                          90
                  ....*....|....*....
gi 6679863    171 VYSHDGVSLHELLARELTK 189
Cdd:TIGR03422  79 IYLRDGSSLTELLEEELSK 97
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 87-195 1.85e-52

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 163.85  E-value: 1.85e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679863     87 LDETAYERLAEETLDSLAEFFEDLADKPytlEDYDVSFGDGVLTIKLGgDLGTYVINKQTPNKQIWLSSPSSGPKRYDWT 166
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDEG---SDADVEYSGGVLTLEFD-NGGTYVINKQPPNRQIWLSSPISGPFHFDYD 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 6679863    167 GKN-WVYSHDGVSLHELLARELTKALNTKL 195
Cdd:pfam01491  77 DAGqWIYTRDGEELFELLSRELSEQLGEPV 106
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 87-197 4.46e-46

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 147.80  E-value: 4.46e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679863   87 LDETAYERLAEETLDSLAEFFEDLADKpytlEDYDVSFGDGVLTIKLGgDLGTYVINKQTPNKQIWLSSPSsGPKRYDWT 166
Cdd:cd00503   1 MNESEFHRLADDLLLKIEDTLEEQDDD----ADIDVETQGGVLTLTFG-NGSTIVINRQEPLRQIWLASKV-GGYHFDYK 74

                        90       100       110
                ....*....|....*....|....*....|.
gi 6679863  167 GKNWVYSHDGVSLHELLARELTKALNTKLDL 197
Cdd:cd00503  75 NGKWICTRSGEELWELLEEECSAQSGEDVEF 105
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 87-199 2.60e-21

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 84.46  E-value: 2.60e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679863   87 LDETAYERLAEETLDSLAEFFEDLADkpytlEDYDVSFGDGVLTIKLGGDlGTYVINKQTPNKQIWLSSPsSGPKRYDWT 166
Cdd:COG1965   1 MTESEFHQLADALLEAIEEALDRDDD-----ADIDCERSGGVLTLEFDNG-SKIIINRQEPLRQIWLAAK-SGGFHFDYD 73

                        90       100       110
                ....*....|....*....|....*....|...
gi 6679863  167 GKNWVYSHDGVSLHELLARELTKALNTKLDLSS 199
Cdd:COG1965  74 DGKWIDTRSGEELFALLSRALSEQAGEPVTLAA 106
cyaY PRK00446
frataxin-like protein; Provisional
 87-198 1.37e-14

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 66.83  E-value: 1.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679863    87 LDETAYERLAEETLDSLAEFFEDLADKpytleDYDVSFGDGVLTIKLGGdlGT-YVINKQTPNKQIWLSSPSSGpKRYDW 165
Cdd:PRK00446   1 MNDSEFHQLADALWQAIEEQLDDDGDA-----DIDCERNGGVLTLTFEN--GSkIIINRQEPLHELWLAAKSGG-FHFDY 72

                         90       100       110
                 ....*....|....*....|....*....|...
gi 6679863   166 TGKNWVYSHDGVSLHELLARELTKALNTKLDLS 198
Cdd:PRK00446  73 KDGEWICDRSGEEFWALLEEAATQQAGEPVSFR 105
 
Name Accession Description Interval E-value
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 91-189 2.51e-54

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


Pssm-ID: 132463  Cd Length: 97  Bit Score: 168.18  E-value: 2.51e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679863     91 AYERLAEETLDSLAEFFEDLADKpYTLEDYDVSFGDGVLTIKLGGdLGTYVINKQTPNKQIWLSSPSSGPKRYDWTGKNW 170
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGES-RPDLDFDVEYSSGVLTLELPS-VGTYVINKQPPNKQIWLSSPVSGPKRYDYVNGEW 78

                          90
                  ....*....|....*....
gi 6679863    171 VYSHDGVSLHELLARELTK 189
Cdd:TIGR03422  79 IYLRDGSSLTELLEEELSK 97
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 87-195 1.85e-52

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 163.85  E-value: 1.85e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679863     87 LDETAYERLAEETLDSLAEFFEDLADKPytlEDYDVSFGDGVLTIKLGgDLGTYVINKQTPNKQIWLSSPSSGPKRYDWT 166
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDEG---SDADVEYSGGVLTLEFD-NGGTYVINKQPPNRQIWLSSPISGPFHFDYD 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 6679863    167 GKN-WVYSHDGVSLHELLARELTKALNTKL 195
Cdd:pfam01491  77 DAGqWIYTRDGEELFELLSRELSEQLGEPV 106
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 87-197 4.46e-46

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 147.80  E-value: 4.46e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679863   87 LDETAYERLAEETLDSLAEFFEDLADKpytlEDYDVSFGDGVLTIKLGgDLGTYVINKQTPNKQIWLSSPSsGPKRYDWT 166
Cdd:cd00503   1 MNESEFHRLADDLLLKIEDTLEEQDDD----ADIDVETQGGVLTLTFG-NGSTIVINRQEPLRQIWLASKV-GGYHFDYK 74

                        90       100       110
                ....*....|....*....|....*....|.
gi 6679863  167 GKNWVYSHDGVSLHELLARELTKALNTKLDL 197
Cdd:cd00503  75 NGKWICTRSGEELWELLEEECSAQSGEDVEF 105
FeS_CyaY TIGR03421
iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) ...
 88-197 2.17e-34

iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274572  Cd Length: 102  Bit Score: 117.70  E-value: 2.17e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679863     88 DETAYERLAEETLDSLAEFFEDlADKpytleDYDVSFGDGVLTIKLGgDLGTYVINKQTPNKQIWLSSPSsGPKRYDWTG 167
Cdd:TIGR03421   1 NESEFHQLAEALLDAIEEAIDD-GDA-----DIDCERQGGVLTLTFE-NGSQIIINKQEPLHQIWLAAKS-GGFHFDYDG 72

                          90       100       110
                  ....*....|....*....|....*....|
gi 6679863    168 KNWVYSHDGVSLHELLARELTKALNTKLDL 197
Cdd:TIGR03421  73 GAWIDTRDGEELWALLARACSEQAGEPVVF 102
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 87-199 2.60e-21

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 84.46  E-value: 2.60e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679863   87 LDETAYERLAEETLDSLAEFFEDLADkpytlEDYDVSFGDGVLTIKLGGDlGTYVINKQTPNKQIWLSSPsSGPKRYDWT 166
Cdd:COG1965   1 MTESEFHQLADALLEAIEEALDRDDD-----ADIDCERSGGVLTLEFDNG-SKIIINRQEPLRQIWLAAK-SGGFHFDYD 73

                        90       100       110
                ....*....|....*....|....*....|...
gi 6679863  167 GKNWVYSHDGVSLHELLARELTKALNTKLDLSS 199
Cdd:COG1965  74 DGKWIDTRSGEELFALLSRALSEQAGEPVTLAA 106
cyaY PRK00446
frataxin-like protein; Provisional
 87-198 1.37e-14

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 66.83  E-value: 1.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679863    87 LDETAYERLAEETLDSLAEFFEDLADKpytleDYDVSFGDGVLTIKLGGdlGT-YVINKQTPNKQIWLSSPSSGpKRYDW 165
Cdd:PRK00446   1 MNDSEFHQLADALWQAIEEQLDDDGDA-----DIDCERNGGVLTLTFEN--GSkIIINRQEPLHELWLAAKSGG-FHFDY 72

                         90       100       110
                 ....*....|....*....|....*....|...
gi 6679863   166 TGKNWVYSHDGVSLHELLARELTKALNTKLDLS 198
Cdd:PRK00446  73 KDGEWICDRSGEEFWALLEEAATQQAGEPVSFR 105
cyaY PRK01379
iron donor protein CyaY;
87-187 2.29e-11

iron donor protein CyaY;


Pssm-ID: 134546  Cd Length: 103  Bit Score: 58.41  E-value: 2.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679863    87 LDETAYERLAEETLDSLAEFFEDlADKPYTLeDYDVSfGDgvlTIKLGGDLGTYVINKQTPNKQIWLSSPSSGPKRYDWT 166
Cdd:PRK01379   1 MNNSEFSKIAETTIAYIADKIEE-QDKEASI-DVDLQ-GD---ILNLDTDKGIYVINKQSAAKEIWLSSPVSGPYHFFYE 74

                         90       100
                 ....*....|....*....|.
gi 6679863   167 GKNWvYSHDGVSLHELLAREL 187
Cdd:PRK01379  75 QGKW-KNRAGLELMAILTEEL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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