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Conserved domains on  [gi|255683406|ref|NP_031989|]
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histone-lysine N-methyltransferase MECOM isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
414-438 2.16e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.16e-05
                          10        20
                  ....*....|....*....|....*
gi 255683406  414 NLTRHLRTHTGEQPYRCKYCDRSFS 438
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
PHA00733 super family cl26169
hypothetical protein
 333-452 7.83e-05

hypothetical protein


The actual alignment was detected with superfamily member PHA00733:

Pssm-ID: 177301  Cd Length: 128  Bit Score: 42.94  E-value: 7.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683406 333 EKYLRPSPGFLFHPQMsaienmaEKLESFSALKPEASELLQSVPSMFSFRapPNTLPEN------LLRKGKERYTCRYCG 406
Cdd:PHA00733  10 KKYLSNHKGIFIHVTL-------EELKRYHSLTPEQKRLIRAVVKTLIYN--PQLLDESsylyklLTSKAVSPYVCPLCL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 255683406 407 KIFPRSANLTRHLRThtGEQPYRCKYCDRSFSISSNLQRHVRNIHN 452
Cdd:PHA00733  81 MPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHVCKKHN 124
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
101-558 4.11e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 4.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683406 101 REYKCDQCPKAFNWKSNLIRHQMSHDSGKHYEC--ENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGlkqH 178
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS---S 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683406 179 KHIHSSVKPFISFSQSMYPFPDrdlrslplkmepqspsevkklQKGSSESPFDLTTKRKDEKPLtsgpsKPSGTPATSQD 258
Cdd:COG5048  109 SLSSSSSNSNDNNLLSSHSLPP---------------------SSRDPQLPDLLSISNLRNNPL-----PGNNSSSVNTP 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683406 259 QPLDLSMGSRGRASGTKLTEPRKNHVFGEKkgSNMDTRPSSDGSLQHARPTPFFmdpiYRVEKRKLTDPLEALKEKYLRP 338
Cdd:COG5048  163 QSNSLHPPLPANSLSKDPSSNLSLLISSNV--STSIPSSSENSPLSSSYSIPSS----SSDQNLENSSSSLPLTTNSQLS 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683406 339 SPGFLFHPQMSAI--ENMAEKLESFSALKPEAsellqsvpsmFSFRAPPNTLPENLLRKGKERYTCRYCGKIFPRSANLT 416
Cdd:COG5048  237 PKSLLSQSPSSLSssDSSSSASESPRSSLPTA----------SSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLT 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683406 417 RHLRT--HTGE--QPYRCKY--CDRSFSISSNLQRHVRNIHNKeKPFKCHLCDRCFgqqtnldrhlKKHENGNMSGTATS 490
Cdd:COG5048  307 RHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI-SPAKEKLLNSSS----------KFSPLLNNEPPQSL 375

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255683406 491 SPHSELEsagaILDDKEDAYFTEIRNFigNSNHGSQSPRNMEERMNGSHFKDKKALATSQNSDLLDDE 558
Cdd:COG5048  376 QQYKDLK----NDKKSETLSNSCIRNF--KRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPH 437
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 77-123 6.38e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 6.38e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 255683406  77 CKECDRVFPDlqslEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQM 123
Cdd:cd20908    4 CYYCDREFDD----EKILIQHQKAKHFKCHICHKKLYTAGGLAVHCL 46
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
414-438 2.16e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.16e-05
                          10        20
                  ....*....|....*....|....*
gi 255683406  414 NLTRHLRTHTGEQPYRCKYCDRSFS 438
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
PHA00733 PHA00733
hypothetical protein
 333-452 7.83e-05

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 42.94  E-value: 7.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683406 333 EKYLRPSPGFLFHPQMsaienmaEKLESFSALKPEASELLQSVPSMFSFRapPNTLPEN------LLRKGKERYTCRYCG 406
Cdd:PHA00733  10 KKYLSNHKGIFIHVTL-------EELKRYHSLTPEQKRLIRAVVKTLIYN--PQLLDESsylyklLTSKAVSPYVCPLCL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 255683406 407 KIFPRSANLTRHLRThtGEQPYRCKYCDRSFSISSNLQRHVRNIHN 452
Cdd:PHA00733  81 MPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHVCKKHN 124
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 400-422 8.92e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.98  E-value: 8.92e-05
                          10        20
                  ....*....|....*....|...
gi 255683406  400 YTCRYCGKIFPRSANLTRHLRTH 422
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
101-558 4.11e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 4.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683406 101 REYKCDQCPKAFNWKSNLIRHQMSHDSGKHYEC--ENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGlkqH 178
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS---S 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683406 179 KHIHSSVKPFISFSQSMYPFPDrdlrslplkmepqspsevkklQKGSSESPFDLTTKRKDEKPLtsgpsKPSGTPATSQD 258
Cdd:COG5048  109 SLSSSSSNSNDNNLLSSHSLPP---------------------SSRDPQLPDLLSISNLRNNPL-----PGNNSSSVNTP 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683406 259 QPLDLSMGSRGRASGTKLTEPRKNHVFGEKkgSNMDTRPSSDGSLQHARPTPFFmdpiYRVEKRKLTDPLEALKEKYLRP 338
Cdd:COG5048  163 QSNSLHPPLPANSLSKDPSSNLSLLISSNV--STSIPSSSENSPLSSSYSIPSS----SSDQNLENSSSSLPLTTNSQLS 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683406 339 SPGFLFHPQMSAI--ENMAEKLESFSALKPEAsellqsvpsmFSFRAPPNTLPENLLRKGKERYTCRYCGKIFPRSANLT 416
Cdd:COG5048  237 PKSLLSQSPSSLSssDSSSSASESPRSSLPTA----------SSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLT 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683406 417 RHLRT--HTGE--QPYRCKY--CDRSFSISSNLQRHVRNIHNKeKPFKCHLCDRCFgqqtnldrhlKKHENGNMSGTATS 490
Cdd:COG5048  307 RHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI-SPAKEKLLNSSS----------KFSPLLNNEPPQSL 375

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255683406 491 SPHSELEsagaILDDKEDAYFTEIRNFigNSNHGSQSPRNMEERMNGSHFKDKKALATSQNSDLLDDE 558
Cdd:COG5048  376 QQYKDLK----NDKKSETLSNSCIRNF--KRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPH 437
zf-H2C2_2 pfam13465
Zinc-finger double domain;
89-113 4.64e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.64e-04
                          10        20
                  ....*....|....*....|....*
gi 255683406   89 SLEKHMLSHTEEREYKCDQCPKAFN 113
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 77-123 6.38e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 6.38e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 255683406  77 CKECDRVFPDlqslEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQM 123
Cdd:cd20908    4 CYYCDREFDD----EKILIQHQKAKHFKCHICHKKLYTAGGLAVHCL 46
InsA COG3677
Transposase InsA [Mobilome: prophages, transposons];
394-439 2.28e-03

Transposase InsA [Mobilome: prophages, transposons];


Pssm-ID: 442893 [Multi-domain]  Cd Length: 241  Bit Score: 40.24  E-value: 2.28e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 255683406 394 RKGKERYTCRYCGkifprSANLTRHLRTHTGEQPYRCKYCDRSFSI 439
Cdd:COG3677   11 IRWPNGPVCPHCG-----STRIVKNGKTRNGRQRYRCKDCGRTFTV 51
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 430-464 3.87e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 3.87e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 255683406 430 CKYCDRSFSISSNLQrhvrnIHNKEKPFKCHLCDR 464
Cdd:cd20908    4 CYYCDREFDDEKILI-----QHQKAKHFKCHICHK 33
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 136-178 6.97e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 6.97e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 255683406 136 CAKVFTDPSNLQRHIRSQHVgarahACPECGKTFATSSGLKQH 178
Cdd:cd20908    7 CDREFDDEKILIQHQKAKHF-----KCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
414-438 2.16e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.16e-05
                          10        20
                  ....*....|....*....|....*
gi 255683406  414 NLTRHLRTHTGEQPYRCKYCDRSFS 438
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
PHA00733 PHA00733
hypothetical protein
 333-452 7.83e-05

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 42.94  E-value: 7.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683406 333 EKYLRPSPGFLFHPQMsaienmaEKLESFSALKPEASELLQSVPSMFSFRapPNTLPEN------LLRKGKERYTCRYCG 406
Cdd:PHA00733  10 KKYLSNHKGIFIHVTL-------EELKRYHSLTPEQKRLIRAVVKTLIYN--PQLLDESsylyklLTSKAVSPYVCPLCL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 255683406 407 KIFPRSANLTRHLRThtGEQPYRCKYCDRSFSISSNLQRHVRNIHN 452
Cdd:PHA00733  81 MPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHVCKKHN 124
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 400-422 8.92e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.98  E-value: 8.92e-05
                          10        20
                  ....*....|....*....|...
gi 255683406  400 YTCRYCGKIFPRSANLTRHLRTH 422
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
101-558 4.11e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 4.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683406 101 REYKCDQCPKAFNWKSNLIRHQMSHDSGKHYEC--ENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGlkqH 178
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS---S 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683406 179 KHIHSSVKPFISFSQSMYPFPDrdlrslplkmepqspsevkklQKGSSESPFDLTTKRKDEKPLtsgpsKPSGTPATSQD 258
Cdd:COG5048  109 SLSSSSSNSNDNNLLSSHSLPP---------------------SSRDPQLPDLLSISNLRNNPL-----PGNNSSSVNTP 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683406 259 QPLDLSMGSRGRASGTKLTEPRKNHVFGEKkgSNMDTRPSSDGSLQHARPTPFFmdpiYRVEKRKLTDPLEALKEKYLRP 338
Cdd:COG5048  163 QSNSLHPPLPANSLSKDPSSNLSLLISSNV--STSIPSSSENSPLSSSYSIPSS----SSDQNLENSSSSLPLTTNSQLS 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683406 339 SPGFLFHPQMSAI--ENMAEKLESFSALKPEAsellqsvpsmFSFRAPPNTLPENLLRKGKERYTCRYCGKIFPRSANLT 416
Cdd:COG5048  237 PKSLLSQSPSSLSssDSSSSASESPRSSLPTA----------SSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLT 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255683406 417 RHLRT--HTGE--QPYRCKY--CDRSFSISSNLQRHVRNIHNKeKPFKCHLCDRCFgqqtnldrhlKKHENGNMSGTATS 490
Cdd:COG5048  307 RHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI-SPAKEKLLNSSS----------KFSPLLNNEPPQSL 375

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255683406 491 SPHSELEsagaILDDKEDAYFTEIRNFigNSNHGSQSPRNMEERMNGSHFKDKKALATSQNSDLLDDE 558
Cdd:COG5048  376 QQYKDLK----NDKKSETLSNSCIRNF--KRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPH 437
zf-H2C2_2 pfam13465
Zinc-finger double domain;
89-113 4.64e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.64e-04
                          10        20
                  ....*....|....*....|....*
gi 255683406   89 SLEKHMLSHTEEREYKCDQCPKAFN 113
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 77-123 6.38e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 6.38e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 255683406  77 CKECDRVFPDlqslEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQM 123
Cdd:cd20908    4 CYYCDREFDD----EKILIQHQKAKHFKCHICHKKLYTAGGLAVHCL 46
InsA COG3677
Transposase InsA [Mobilome: prophages, transposons];
394-439 2.28e-03

Transposase InsA [Mobilome: prophages, transposons];


Pssm-ID: 442893 [Multi-domain]  Cd Length: 241  Bit Score: 40.24  E-value: 2.28e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 255683406 394 RKGKERYTCRYCGkifprSANLTRHLRTHTGEQPYRCKYCDRSFSI 439
Cdd:COG3677   11 IRWPNGPVCPHCG-----STRIVKNGKTRNGRQRYRCKDCGRTFTV 51
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 457-479 2.65e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.65e-03
                          10        20
                  ....*....|....*....|...
gi 255683406  457 FKCHLCDRCFGQQTNLDRHLKKH 479
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 430-464 3.87e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 3.87e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 255683406 430 CKYCDRSFSISSNLQrhvrnIHNKEKPFKCHLCDR 464
Cdd:cd20908    4 CYYCDREFDDEKILI-----QHQKAKHFKCHICHK 33
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 136-178 6.97e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 6.97e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 255683406 136 CAKVFTDPSNLQRHIRSQHVgarahACPECGKTFATSSGLKQH 178
Cdd:cd20908    7 CDREFDDEKILIQHQKAKHF-----KCHICHKKLYTAGGLAVH 44
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 131-152 7.29e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.29e-03
                          10        20
                  ....*....|....*....|..
gi 255683406  131 YECENCAKVFTDPSNLQRHIRS 152
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRT 22
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 428-448 7.73e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.73e-03
                          10        20
                  ....*....|....*....|.
gi 255683406  428 YRCKYCDRSFSISSNLQRHVR 448
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLR 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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