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Conserved domains on  [gi|31560722|ref|NP_031699|]
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homeobox protein CDX-2 [Mus musculus]

Protein Classification

Caudal_act and homeodomain domain-containing protein( domain architecture ID 11152543)

Caudal_act and homeodomain domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Caudal_act pfam04731
Caudal like protein activation region; This family consists of the amino termini of proteins ...
 13-178 5.84e-30

Caudal like protein activation region; This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (pfam00046).


:

Pssm-ID: 461413 [Multi-domain]  Cd Length: 136  Bit Score: 110.61  E-value: 5.84e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31560722    13 MYPSSVRHSGgLNLAPQNFVSPPQYPDYGGYHvaaaaaATANLDSAQSPGPSWPTAYGAPlREDWNgyAPGGAAAANAVA 92
Cdd:pfam04731   1 MYPGSVRHPG-LNLPAQNFVAPPQYSDYMGYH------HVPGMDPHGQSLGAWGSPYGPP-REDWN--AYGPGPSSTVGT 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31560722    93 HGLNGGSPaAAMGYsSPAEYhahhhphhhPHHPAASPSCASGLLQTLNlgppgpaatAAAEQLSPSGQRRNLCEWMRKPA 172
Cdd:pfam04731  71 APMNDASP-GQIAY-SPPDY---------SSLHPPGPSSGLSLPPPLN---------SSLEQLSPSRQRRSPYEWMRKTV 130


                  ....*.
gi 31560722   173 QQSLGS 178
Cdd:pfam04731 131 QVTSKG 136
Homeodomain pfam00046
Homeodomain;
187-242 2.60e-26

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 98.34  E-value: 2.60e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 31560722   187 KYRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWFQNRRAKERK 242
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
Caudal_act pfam04731
Caudal like protein activation region; This family consists of the amino termini of proteins ...
 13-178 5.84e-30

Caudal like protein activation region; This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (pfam00046).


Pssm-ID: 461413 [Multi-domain]  Cd Length: 136  Bit Score: 110.61  E-value: 5.84e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31560722    13 MYPSSVRHSGgLNLAPQNFVSPPQYPDYGGYHvaaaaaATANLDSAQSPGPSWPTAYGAPlREDWNgyAPGGAAAANAVA 92
Cdd:pfam04731   1 MYPGSVRHPG-LNLPAQNFVAPPQYSDYMGYH------HVPGMDPHGQSLGAWGSPYGPP-REDWN--AYGPGPSSTVGT 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31560722    93 HGLNGGSPaAAMGYsSPAEYhahhhphhhPHHPAASPSCASGLLQTLNlgppgpaatAAAEQLSPSGQRRNLCEWMRKPA 172
Cdd:pfam04731  71 APMNDASP-GQIAY-SPPDY---------SSLHPPGPSSGLSLPPPLN---------SSLEQLSPSRQRRSPYEWMRKTV 130


                  ....*.
gi 31560722   173 QQSLGS 178
Cdd:pfam04731 131 QVTSKG 136
Homeodomain pfam00046
Homeodomain;
187-242 2.60e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 98.34  E-value: 2.60e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 31560722   187 KYRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWFQNRRAKERK 242
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 187-241 4.34e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 90.00  E-value: 4.34e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 31560722    187 KYRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWFQNRRAKER 241
Cdd:smart00389   3 RKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 187-244 1.56e-22

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 88.45  E-value: 1.56e-22
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31560722 187 KYRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWFQNRRAKERKIK 244
Cdd:cd00086   2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
177-246 1.76e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 58.60  E-value: 1.76e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31560722 177 GSQVKTRTKDKYRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWFQNRRAKERKIKKK 246
Cdd:COG5576  43 RKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSG 112
 
Name Accession Description Interval E-value
Caudal_act pfam04731
Caudal like protein activation region; This family consists of the amino termini of proteins ...
 13-178 5.84e-30

Caudal like protein activation region; This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (pfam00046).


Pssm-ID: 461413 [Multi-domain]  Cd Length: 136  Bit Score: 110.61  E-value: 5.84e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31560722    13 MYPSSVRHSGgLNLAPQNFVSPPQYPDYGGYHvaaaaaATANLDSAQSPGPSWPTAYGAPlREDWNgyAPGGAAAANAVA 92
Cdd:pfam04731   1 MYPGSVRHPG-LNLPAQNFVAPPQYSDYMGYH------HVPGMDPHGQSLGAWGSPYGPP-REDWN--AYGPGPSSTVGT 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31560722    93 HGLNGGSPaAAMGYsSPAEYhahhhphhhPHHPAASPSCASGLLQTLNlgppgpaatAAAEQLSPSGQRRNLCEWMRKPA 172
Cdd:pfam04731  71 APMNDASP-GQIAY-SPPDY---------SSLHPPGPSSGLSLPPPLN---------SSLEQLSPSRQRRSPYEWMRKTV 130


                  ....*.
gi 31560722   173 QQSLGS 178
Cdd:pfam04731 131 QVTSKG 136
Homeodomain pfam00046
Homeodomain;
187-242 2.60e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 98.34  E-value: 2.60e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 31560722   187 KYRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWFQNRRAKERK 242
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 187-241 4.34e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 90.00  E-value: 4.34e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 31560722    187 KYRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWFQNRRAKER 241
Cdd:smart00389   3 RKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 187-244 1.56e-22

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 88.45  E-value: 1.56e-22
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31560722 187 KYRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWFQNRRAKERKIK 244
Cdd:cd00086   2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
177-246 1.76e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 58.60  E-value: 1.76e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31560722 177 GSQVKTRTKDKYRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWFQNRRAKERKIKKK 246
Cdd:COG5576  43 RKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSG 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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