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Conserved domains on  [gi|83779014|ref|NP_005877|]
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katanin p80 WD40 repeat-containing subunit B1 [Homo sapiens]

Protein Classification

WD repeat KATNB1 family protein( domain architecture ID 10078096)

WD repeat KATNB1 family protein similar to Mus musculus katanin p80 WD40 repeat-containing subunit B1 (KATNB1) that participates in a complex which severs microtubules in an ATP-dependent manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-257 1.88e-77

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 248.79  E-value: 1.88e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   7 TKTAWKLQEIVAHASNVSSLVLGkASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGS 86
Cdd:cd00200  38 LETGELLRTLKGHTGPVRDVAAS-ADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  87 IRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAA 166
Cdd:cd00200 117 IKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSS 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 167 DDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCL 246
Cdd:cd00200 197 SDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRL 276

                       250
                ....*....|..
gi 83779014 247 YSGCQD-SLRVY 257
Cdd:cd00200 277 ASGSADgTIRIW 288
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 493-651 8.91e-66

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


:

Pssm-ID: 464044  Cd Length: 160  Bit Score: 213.24  E-value: 8.91e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   493 KGHDTMCVVLTSRHKNLDTVRAVWTMGDIKTSVDSAVAINDLSVVVDLLNIVNQKASLWKLDLCTTVLPQIEKLLQSKYE 572
Cdd:pfam13925   1 KDHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQDPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   573 SYVQTGCTSLKLILQRFLPLITDMLAAPP-SVGVDISREERLHKCRLCYKQLKSISGLVKSKSGLSGRHGSTFRELHLLM 651
Cdd:pfam13925  81 RYIIVGLDFLRLILKNFGPVIKSALSAPPsSVGVDLSREERLEKCNECFKELQKIRQILKKLARRSGKLGELARELNLLL 160
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
386-494 2.56e-05

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14951:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 618  Bit Score: 47.40  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  386 FQPKNSISRTPPRRSEPfPAPPEDDAATAKEAAKPSPAMDVQFPVPNLEVLPRPPVVASTPAPKAEPAIIPATRNEPIGL 465
Cdd:PRK14951 364 FKPAAAAEAAAPAEKKT-PARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAP 442

                         90       100
                 ....*....|....*....|....*....
gi 83779014  466 KASDFLPAVKIPQQAELVDEDAMSQIRKG 494
Cdd:PRK14951 443 AAVALAPAPPAQAAPETVAIPVRVAPEPA 471
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-257 1.88e-77

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 248.79  E-value: 1.88e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   7 TKTAWKLQEIVAHASNVSSLVLGkASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGS 86
Cdd:cd00200  38 LETGELLRTLKGHTGPVRDVAAS-ADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  87 IRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAA 166
Cdd:cd00200 117 IKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSS 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 167 DDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCL 246
Cdd:cd00200 197 SDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRL 276

                       250
                ....*....|..
gi 83779014 247 YSGCQD-SLRVY 257
Cdd:cd00200 277 ASGSADgTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
7-262 5.95e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 248.67  E-value: 5.95e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   7 TKTAWKLQEIVAHASNVSSLVLGkASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGS 86
Cdd:COG2319 149 LATGKLLRTLTGHSGAVTSVAFS-PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT 227

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  87 IRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAA 166
Cdd:COG2319 228 VRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 167 DDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCL 246
Cdd:COG2319 308 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387

                       250
                ....*....|....*..
gi 83779014 247 YSGCQD-SLRVygWEPE 262
Cdd:COG2319 388 ASGSADgTVRL--WDLA 402
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 493-651 8.91e-66

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


Pssm-ID: 464044  Cd Length: 160  Bit Score: 213.24  E-value: 8.91e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   493 KGHDTMCVVLTSRHKNLDTVRAVWTMGDIKTSVDSAVAINDLSVVVDLLNIVNQKASLWKLDLCTTVLPQIEKLLQSKYE 572
Cdd:pfam13925   1 KDHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQDPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   573 SYVQTGCTSLKLILQRFLPLITDMLAAPP-SVGVDISREERLHKCRLCYKQLKSISGLVKSKSGLSGRHGSTFRELHLLM 651
Cdd:pfam13925  81 RYIIVGLDFLRLILKNFGPVIKSALSAPPsSVGVDLSREERLEKCNECFKELQKIRQILKKLARRSGKLGELARELNLLL 160
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 17-240 1.67e-14

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 77.05  E-value: 1.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   17 VAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPE-ELIVAGSQSGSIRVWDLEAA 95
Cdd:PLN00181 529 LASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQG 608

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   96 KILRTLMGhKANICSLDF-HPYGEFVASGSQDTNIKLWDIRR-KGCVFRYRGHSQAVRCLRFSpDGKWLASAADDHTVKL 173
Cdd:PLN00181 609 VSIGTIKT-KANICCVQFpSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKL 686

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 83779014  174 WDLTAG------KMMSEFPGHTGPVNVVEFHPNEYLLASGSsdrtirfwdlEKFQVVSCIEGEPGPVRSVLFN 240
Cdd:PLN00181 687 WDLSMSisgineTPLHSFMGHTNVKNFVGLSVSDGYIATGS----------ETNEVFVYHKAFPMPVLSYKFK 749
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 139-175 1.25e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 59.63  E-value: 1.25e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 83779014    139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWD 175
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
139-175 1.38e-11

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 59.28  E-value: 1.38e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 83779014   139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWD 175
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 386-494 2.56e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 47.40  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  386 FQPKNSISRTPPRRSEPfPAPPEDDAATAKEAAKPSPAMDVQFPVPNLEVLPRPPVVASTPAPKAEPAIIPATRNEPIGL 465
Cdd:PRK14951 364 FKPAAAAEAAAPAEKKT-PARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAP 442

                         90       100
                 ....*....|....*....|....*....
gi 83779014  466 KASDFLPAVKIPQQAELVDEDAMSQIRKG 494
Cdd:PRK14951 443 AAVALAPAPPAQAAPETVAIPVRVAPEPA 471
ZipA COG3115
Cell division protein ZipA, interacts with FtsZ [Cell cycle control, cell division, chromosome ...
 367-487 2.67e-03

Cell division protein ZipA, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442349 [Multi-domain]  Cd Length: 298  Bit Score: 40.45  E-value: 2.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 367 RDERESRAEIQNAEDYNEIFQPKNSISRTPPRRSEPFPAPPEDDAATAKEAAKPSPAMDVQFPVPNLEVLPRPPVvASTP 446
Cdd:COG3115  31 RSSFRDKPSKRDVLLDDDGIGEVRVVAAEAPERVEPEASFDAEDEVREPDQEEVDPLLDDEADIEAAPAEPVRWA-GTAA 109

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 83779014 447 APKAEPAIIPATRNEPIGLKASDFLPAVKIPQQAELVDEDA 487
Cdd:COG3115 110 AVEPAPEQEAYEEAGPAGESAEQEDAPAEEPEAEAPAEEAL 150
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-257 1.88e-77

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 248.79  E-value: 1.88e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   7 TKTAWKLQEIVAHASNVSSLVLGkASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGS 86
Cdd:cd00200  38 LETGELLRTLKGHTGPVRDVAAS-ADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  87 IRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAA 166
Cdd:cd00200 117 IKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSS 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 167 DDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCL 246
Cdd:cd00200 197 SDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRL 276

                       250
                ....*....|..
gi 83779014 247 YSGCQD-SLRVY 257
Cdd:cd00200 277 ASGSADgTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
7-262 5.95e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 248.67  E-value: 5.95e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   7 TKTAWKLQEIVAHASNVSSLVLGkASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGS 86
Cdd:COG2319 149 LATGKLLRTLTGHSGAVTSVAFS-PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT 227

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  87 IRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAA 166
Cdd:COG2319 228 VRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 167 DDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCL 246
Cdd:COG2319 308 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387

                       250
                ....*....|....*..
gi 83779014 247 YSGCQD-SLRVygWEPE 262
Cdd:COG2319 388 ASGSADgTVRL--WDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
7-283 6.54e-75

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 245.98  E-value: 6.54e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   7 TKTAWKLQEIVAHASNVSSLVLGkASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGS 86
Cdd:COG2319 107 LATGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  87 IRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAA 166
Cdd:COG2319 186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 167 DDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCL 246
Cdd:COG2319 266 ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL 345

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 83779014 247 YSGCQD-SLRVYGWEPERCFDVVLVNWGKVADLAICND 283
Cdd:COG2319 346 ASGSDDgTVRLWDLATGELLRTLTGHTGAVTSVAFSPD 383
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-264 2.49e-72

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 235.31  E-value: 2.49e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  13 LQEIVAHASNVSSLVLGkASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
Cdd:cd00200   2 RRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVK 172
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 173 LWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                       250
                ....*....|...
gi 83779014 253 -SLRVYGWEPERC 264
Cdd:cd00200 241 gTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
19-283 4.78e-71

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 235.96  E-value: 4.78e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  19 HASNVSSLVLgKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKIL 98
Cdd:COG2319  77 HTAAVLSVAF-SPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  99 RTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTA 178
Cdd:COG2319 156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 179 GKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVY 257
Cdd:COG2319 236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDgTVRLW 315

                       250       260
                ....*....|....*....|....*.
gi 83779014 258 GWEPERCFDVVLVNWGKVADLAICND 283
Cdd:COG2319 316 DLATGKLLRTLTGHTGAVRSVAFSPD 341
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 493-651 8.91e-66

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


Pssm-ID: 464044  Cd Length: 160  Bit Score: 213.24  E-value: 8.91e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   493 KGHDTMCVVLTSRHKNLDTVRAVWTMGDIKTSVDSAVAINDLSVVVDLLNIVNQKASLWKLDLCTTVLPQIEKLLQSKYE 572
Cdd:pfam13925   1 KDHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQDPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   573 SYVQTGCTSLKLILQRFLPLITDMLAAPP-SVGVDISREERLHKCRLCYKQLKSISGLVKSKSGLSGRHGSTFRELHLLM 651
Cdd:pfam13925  81 RYIIVGLDFLRLILKNFGPVIKSALSAPPsSVGVDLSREERLEKCNECFKELQKIRQILKKLARRSGKLGELARELNLLL 160
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-217 1.67e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 214.51  E-value: 1.67e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  12 KLQEIVAHASNVSSLVLgKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91
Cdd:cd00200  85 CVRTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  92 LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTV 171
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTI 243

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 83779014 172 KLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
Cdd:cd00200 244 RVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
9-283 1.22e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 215.93  E-value: 1.22e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   9 TAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDcRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIR 88
Cdd:COG2319  25 LGALLLLLLGLAAAVASLAASPDGARLAAGAGDL-TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  89 VWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADD 168
Cdd:COG2319 104 LWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDD 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 169 HTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYS 248
Cdd:COG2319 184 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 83779014 249 GCQD-SLRVYGWEPERCFDVVLVNWGKVADLAICND 283
Cdd:COG2319 264 GSADgTVRLWDLATGELLRTLTGHSGGVNSVAFSPD 299
WD40 COG2319
WD40 repeat [General function prediction only];
31-291 1.52e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 186.27  E-value: 1.52e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  31 ASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICS 110
Cdd:COG2319   4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 111 LDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTG 190
Cdd:COG2319  84 VAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 191 PVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERCfdvvl 269
Cdd:COG2319 164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADgTVRLWDLATGKL----- 238

                       250       260
                ....*....|....*....|..
gi 83779014 270 vnwgkVADLAICNDQLIGVAFS 291
Cdd:COG2319 239 -----LRTLTGHSGSVRSVAFS 255
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-303 7.91e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.14  E-value: 7.91e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL 218
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 219 EKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERCfdvvlvnwgkVADLAICNDQLIGVAFSQSN--V 295
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDkTIKVWDVETGKC----------LTTLRGHTDWVNSVAFSPDGtfV 150


                ....*...
gi 83779014 296 SSYVVDLT 303
Cdd:cd00200 151 ASSSQDGT 158
WD40 COG2319
WD40 repeat [General function prediction only];
112-280 5.51e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.59  E-value: 5.51e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 112 DFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGP 191
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 192 VNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERCFDVVLV 270
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADgTVRLWDLATGKLLRTLTG 160

                       170
                ....*....|
gi 83779014 271 NWGKVADLAI 280
Cdd:COG2319 161 HSGAVTSVAF 170
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 17-240 1.67e-14

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 77.05  E-value: 1.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   17 VAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPE-ELIVAGSQSGSIRVWDLEAA 95
Cdd:PLN00181 529 LASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQG 608

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   96 KILRTLMGhKANICSLDF-HPYGEFVASGSQDTNIKLWDIRR-KGCVFRYRGHSQAVRCLRFSpDGKWLASAADDHTVKL 173
Cdd:PLN00181 609 VSIGTIKT-KANICCVQFpSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKL 686

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 83779014  174 WDLTAG------KMMSEFPGHTGPVNVVEFHPNEYLLASGSsdrtirfwdlEKFQVVSCIEGEPGPVRSVLFN 240
Cdd:PLN00181 687 WDLSMSisgineTPLHSFMGHTNVKNFVGLSVSDGYIATGS----------ETNEVFVYHKAFPMPVLSYKFK 749
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 139-175 1.25e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 59.63  E-value: 1.25e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 83779014    139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWD 175
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
139-175 1.38e-11

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 59.28  E-value: 1.38e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 83779014   139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWD 175
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-217 3.97e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.40  E-value: 3.97e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 83779014    179 GKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-133 1.79e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 1.79e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 83779014     96 KILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWD 133
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
96-133 2.21e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 2.21e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 83779014    96 KILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWD 133
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
179-217 3.09e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 3.09e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 83779014   179 GKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 56-219 8.03e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 55.34  E-value: 8.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   56 IMSLTGHTSPVESVRLNtP--EELIVAGSQSGSIRVWDL----EAAKILR----TLMGHKANICSLDFHPYGEFVASGSQ 125
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFN-PcfSEILASGSEDLTIRVWEIphndESVKEIKdpqcILKGHKKKISIIDWNPMNYYIMCSSG 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  126 -DTNIKLWDIRRKGCVFRYRgHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF------H 198
Cdd:PTZ00420 146 fDSFVNIWDIENEKRAFQIN-MPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDGGKNTKNIwidglgG 224

                        170       180
                 ....*....|....*....|....
gi 83779014  199 PNEYLLASGSSD---RTIRFWDLE 219
Cdd:PTZ00420 225 DDNYILSTGFSKnnmREMKLWDLK 248
PTZ00421 PTZ00421
coronin; Provisional
 101-232 1.97e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.13  E-value: 1.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  101 LMGHKANICSLDFHPYGE---FVASgsQDTNIKLWDIRRKGC-------VFRYRGHSQAVRCLRFSPDGK-WLASAADDH 169
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPFDPqklFTAS--EDGTIMGWGIPEEGLtqnisdpIVHLQGHTKKVGIVSFHPSAMnVLASAGADM 148

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 83779014  170 TVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPG 232
Cdd:PTZ00421 149 VVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHAS 211
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 52-91 6.27e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 6.27e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 83779014     52 KPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 129-251 7.51e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 52.26  E-value: 7.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  129 IKLWDIRRKGCVFRYRGHSQAVRCLRFSP-DGKWLASAADDHTVKLWDLTAG-KMMSE-------FPGHTGPVNVVEFHP 199
Cdd:PTZ00420  56 IRLENQMRKPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNdESVKEikdpqciLKGHKKKISIIDWNP 135

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 83779014  200 -NEYLLASGSSDRTIRFWDLEK----FQVVSciegePGPVRSVLFNPDGCCLYSGCQ 251
Cdd:PTZ00420 136 mNYYIMCSSGFDSFVNIWDIENekraFQINM-----PKKLSSLKWNIKGNLLSGTCV 187
WD40 pfam00400
WD domain, G-beta repeat;
54-91 2.28e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 2.28e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 83779014    54 NCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 120-257 4.27e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.09  E-value: 4.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  120 VASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSP-DGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGpVNVVEFh 198
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQF- 625

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 83779014  199 PNEY--LLASGSSDRTIRFWDLEKFQVVSC-IEGEPGPVRSVLFNPDGCCLYSGCQDSLRVY 257
Cdd:PLN00181 626 PSESgrSLAFGSADHKVYYYDLRNPKLPLCtMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLW 687
PTZ00421 PTZ00421
coronin; Provisional
 153-293 7.29e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.12  E-value: 7.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  153 LRFSP-DGKWLASAADDHTVKLWDLTAGKMMS-------EFPGHTGPVNVVEFHPNEY-LLASGSSDRTIRFWDLEKFQV 223
Cdd:PTZ00421  81 VAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQnisdpivHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKA 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  224 VSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYgwEPERCFDVVLVN-----------WGKVADLAICndqlIGVAFS 291
Cdd:PTZ00421 161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDkKLNII--DPRDGTIVSSVEahasaksqrclWAKRKDLIIT----LGCSKS 234


                 ..
gi 83779014  292 QS 293
Cdd:PTZ00421 235 QQ 236
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 386-494 2.56e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 47.40  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  386 FQPKNSISRTPPRRSEPfPAPPEDDAATAKEAAKPSPAMDVQFPVPNLEVLPRPPVVASTPAPKAEPAIIPATRNEPIGL 465
Cdd:PRK14951 364 FKPAAAAEAAAPAEKKT-PARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAP 442

                         90       100
                 ....*....|....*....|....*....
gi 83779014  466 KASDFLPAVKIPQQAELVDEDAMSQIRKG 494
Cdd:PRK14951 443 AAVALAPAPPAQAAPETVAIPVRVAPEPA 471
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
77-253 2.64e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 46.23  E-value: 2.64e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  77 LIVAGSQSGSIRVWDLEAAKILRTLmghkanicSLDFHPYGefvasgsqdtniklwdirrkgcvfryrghsqavrcLRFS 156
Cdd:COG3391  82 LYVANSGSGRVSVIDLATGKVVATI--------PVGGGPRG-----------------------------------LAVD 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 157 PDGKWL-ASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVeFHP-NEYLLASGSSDRTIRF----WDLEKFQVVSCIEGE 230
Cdd:COG3391 119 PDGGRLyVADSGNGRVSVIDTATGKVVATIPVGAGPHGIA-VDPdGKRLYVANSGSNTVSVivsvIDTATGKVVATIPVG 197

                       170       180
                ....*....|....*....|...
gi 83779014 231 PGPVrSVLFNPDGCCLYSGCQDS 253
Cdd:COG3391 198 GGPV-GVAVSPDGRRLYVANRGS 219
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
157-301 2.69e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 46.23  E-value: 2.69e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 157 PDGKWL-ASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVeFHP-NEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPv 234
Cdd:COG3391  77 ADGRRLyVANSGSGRVSVIDLATGKVVATIPVGGGPRGLA-VDPdGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGP- 154

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 83779014 235 RSVLFNPDGCCLYSGCQDSLRVYgwepercfdVVLV-----NWGKVADLAIcNDQLIGVAFSQSNVSSYVVD 301
Cdd:COG3391 155 HGIAVDPDGKRLYVANSGSNTVS---------VIVSvidtaTGKVVATIPV-GGGPVGVAVSPDGRRLYVAN 216
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 145-197 6.31e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.88  E-value: 6.31e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 83779014   145 GHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
Cdd:pfam12894  36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGW 88
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 17-225 8.11e-04

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 42.21  E-value: 8.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  17 VAHASNVSSlVLGKASGRLLATggddcrvnlWSINKPNCIMSLTGHTspvesVRLNTPEELIVAGSQSGSIRVW----DL 92
Cdd:cd22857  49 VARKNGTVE-VLDPENGDLLAS---------FSDSEPATKLSEEDHF-----VGLHLFSGTLLTCTSKGSLRSTklpdDS 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK-GCVFR-------YRGHSQAV--RCLRF-SPDG-- 159
Cdd:cd22857 114 TASSSPTAWVCLGGNLLCMRVDPNENYFAFGGKEVELNVWDLEEKpGKIWRaknvpndSLGLRVPVwvTDLTFlSKDDhr 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 160 ---------------------------------KWLASAADDHTV-------KLW--DLTAGKMMSEFPGHTG-PVNVVE 196
Cdd:cd22857 194 kivtgtgyhqvrlydtraqrrpvvsvdfgetpiKAVAEDPDGHTVyvgdtsgDLAsiDLRTGKLLGCFKGKCGgSIRSIA 273

                       250       260
                ....*....|....*....|....*....
gi 83779014 197 FHPNEYLLASGSSDRTIRFWDLEKFQVVS 225
Cdd:cd22857 274 RHPELPLIASCGLDRYLRIWDTETRQLLS 302
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 220-257 9.17e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 9.17e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 83779014    220 KFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVY 257
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDgTIKLW 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 388-480 9.93e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 9.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   388 PKNSISRTPPRRSEPFPAPPEDDAAT--------AKEAAKPSPAMDVQFPVPNLEVLP-------RPPVVAS--TPAPKA 450
Cdd:PHA03247 2694 SLTSLADPPPPPPTPEPAPHALVSATplppgpaaARQASPALPAAPAPPAVPAGPATPggparpaRPPTTAGppAPAPPA 2773

                          90       100       110
                  ....*....|....*....|....*....|.
gi 83779014   451 EPAIIPATR-NEPIGLKASDFLPAVKIPQQA 480
Cdd:PHA03247 2774 APAAGPPRRlTRPAVASLSESRESLPSPWDP 2804
ZipA COG3115
Cell division protein ZipA, interacts with FtsZ [Cell cycle control, cell division, chromosome ...
 367-487 2.67e-03

Cell division protein ZipA, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442349 [Multi-domain]  Cd Length: 298  Bit Score: 40.45  E-value: 2.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014 367 RDERESRAEIQNAEDYNEIFQPKNSISRTPPRRSEPFPAPPEDDAATAKEAAKPSPAMDVQFPVPNLEVLPRPPVvASTP 446
Cdd:COG3115  31 RSSFRDKPSKRDVLLDDDGIGEVRVVAAEAPERVEPEASFDAEDEVREPDQEEVDPLLDDEADIEAAPAEPVRWA-GTAA 109

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 83779014 447 APKAEPAIIPATRNEPIGLKASDFLPAVKIPQQAELVDEDA 487
Cdd:COG3115 110 AVEPAPEQEAYEEAGPAGESAEQEDAPAEEPEAEAPAEEAL 150
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 71-134 2.95e-03

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 40.31  E-value: 2.95e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 83779014  71 LNTPEELIVAGSQSGSIRVWDLEAAKI----LRTLMGHKANICSLDFHPYGEFV-ASGSQDTNIKLWDI 134
Cdd:cd22850  95 LLRSLGLLTCATKSGLLHIIDLEDSKKdsleVKAPLTLPGFLSAFRVNPTDEGVfAYGGKENDLKLWDL 163
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
386-480 3.11e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 3.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  386 FQPKNSISRTPPRRSEPFPAPPEDDAATAKEAAKPSPAMDVQFPVPNLEVLPRPPVVAS-----TPAPKAEPAIIPATRN 460
Cdd:PRK12323 363 FRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAaparrSPAPEALAAARQASAR 442

                         90       100
                 ....*....|....*....|.
gi 83779014  461 EPIGLKASDFLP-AVKIPQQA 480
Cdd:PRK12323 443 GPGGAPAPAPAPaAAPAAAAR 463
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 304-473 3.77e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 3.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   304 RVTRTGTVARDPVQDHRPLAQPLPNPSAPLRRIYERPSTTCSKPQRvkqnsESERRSPSSEDDRDERESRAEIQNAEdyn 383
Cdd:PHA03307   50 LAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTL-----APASPAREGSPTPPGPSSPDPPPPTP--- 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014   384 eifQPKNSISRTPPRRSEPF--------------PAPPEDDAATAKEAAKPSPAMDVQFPVPNLE---VLPRPPVVASTP 446
Cdd:PHA03307  122 ---PPASPPPSPAPDLSEMLrpvgspgpppaaspPAAGASPAAVASDAASSRQAALPLSSPEETArapSSPPAEPPPSTP 198

                         170       180
                  ....*....|....*....|....*..
gi 83779014   447 APKAEPAiiPATRNEPIGLKASDFLPA 473
Cdd:PHA03307  199 PAAASPR--PPRRSSPISASASSPAPA 223
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
395-462 6.06e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.83  E-value: 6.06e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83779014  395 TPPRRSEPFPAPPEDDAATAKEAAKPSPAMDVQFPVPNleVLPRPPVVASTPAPKAEPA--IIPATRNEP 462
Cdd:PRK07003 425 APPAAPAPPATADRGDDAADGDAPVPAKANARASADSR--CDERDAQPPADSGSASAPAsdAPPDAAFEP 492
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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