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Conserved domains on  [gi|25777734|ref|NP_003739|]
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delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial isoform a precursor [Homo sapiens]

Protein Classification

L-glutamate gamma-semialdehyde dehydrogenase( domain architecture ID 10162973)

L-glutamate gamma-semialdehyde dehydrogenase catalyzes the second step in L-proline degradation, oxidizing L-glutamate 5-semialdehyde to form L-glutamate in an NAD(+)-dependent fashion

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ALDH_F4-17_P5CDH cd07123
Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Delta(1) ...
32-553 0e+00

Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.


:

Pssm-ID: 143441 [Multi-domain]  Cd Length: 522  Bit Score: 1036.00  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  32 VANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALA 111
Cdd:cd07123   1 PVNEPVLSYAPGSPERAKLQEALAELKSLTVEIPLVIGGKEVRTGNTGKQVMPHDHAHVLATYHYADAALVEKAIEAALE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 112 ARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPS 191
Cdd:cd07123  81 ARKEWARMPFEDRAAIFLKAADLLSGKYRYELNAATMLGQGKNVWQAEIDAACELIDFLRFNVKYAEELYAQQPLSSPAG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 192 T-NSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFG 270
Cdd:cd07123 161 VwNRLEYRPLEGFVYAVSPFNFTAIGGNLAGAPALMGNVVLWKPSDTAVLSNYLVYKILEEAGLPPGVINFVPGDGPVVG 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 271 DTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSA 350
Cdd:cd07123 241 DTVLASPHLAGLHFTGSTPTFKSLWKQIGENLDRYRTYPRIVGETGGKNFHLVHPSADVDSLVTATVRGAFEYQGQKCSA 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 351 CSRLYVPHSLWPQIKGRLLEEHSRIKVGDPaEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVE 430
Cdd:cd07123 321 ASRAYVPESLWPEVKERLLEELKEIKMGDP-DDFSNFMGAVIDEKAFDRIKGYIDHAKSDPEAEIIAGGKCDDSVGYFVE 399
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 431 PCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKS 510
Cdd:cd07123 400 PTVIETTDPKHKLMTEEIFGPVLTVYVYPDSDFEETLELVDTTSPYALTGAIFAQDRKAIREATDALRNAAGNFYINDKP 479
                       490       500       510       520
                ....*....|....*....|....*....|....*....|...
gi 25777734 511 TGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKP 553
Cdd:cd07123 480 TGAVVGQQPFGGARASGTNDKAGSPLNLLRWVSPRTIKETFVP 522
 
Name Accession Description Interval E-value
ALDH_F4-17_P5CDH cd07123
Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Delta(1) ...
32-553 0e+00

Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.


Pssm-ID: 143441 [Multi-domain]  Cd Length: 522  Bit Score: 1036.00  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  32 VANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALA 111
Cdd:cd07123   1 PVNEPVLSYAPGSPERAKLQEALAELKSLTVEIPLVIGGKEVRTGNTGKQVMPHDHAHVLATYHYADAALVEKAIEAALE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 112 ARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPS 191
Cdd:cd07123  81 ARKEWARMPFEDRAAIFLKAADLLSGKYRYELNAATMLGQGKNVWQAEIDAACELIDFLRFNVKYAEELYAQQPLSSPAG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 192 T-NSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFG 270
Cdd:cd07123 161 VwNRLEYRPLEGFVYAVSPFNFTAIGGNLAGAPALMGNVVLWKPSDTAVLSNYLVYKILEEAGLPPGVINFVPGDGPVVG 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 271 DTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSA 350
Cdd:cd07123 241 DTVLASPHLAGLHFTGSTPTFKSLWKQIGENLDRYRTYPRIVGETGGKNFHLVHPSADVDSLVTATVRGAFEYQGQKCSA 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 351 CSRLYVPHSLWPQIKGRLLEEHSRIKVGDPaEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVE 430
Cdd:cd07123 321 ASRAYVPESLWPEVKERLLEELKEIKMGDP-DDFSNFMGAVIDEKAFDRIKGYIDHAKSDPEAEIIAGGKCDDSVGYFVE 399
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 431 PCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKS 510
Cdd:cd07123 400 PTVIETTDPKHKLMTEEIFGPVLTVYVYPDSDFEETLELVDTTSPYALTGAIFAQDRKAIREATDALRNAAGNFYINDKP 479
                       490       500       510       520
                ....*....|....*....|....*....|....*....|...
gi 25777734 511 TGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKP 553
Cdd:cd07123 480 TGAVVGQQPFGGARASGTNDKAGSPLNLLRWVSPRTIKETFVP 522
D1pyr5carbox1 TIGR01236
delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; This model represents one of two ...
33-563 0e+00

delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; This model represents one of two related branches of delta-1-pyrroline-5-carboxylate dehydrogenase. The two branches are not as closely related to each other as some aldehyde dehydrogenases are to this branch, and separate models are built for this reason. The enzyme is the second of two in the degradation of proline to glutamate. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273517  Cd Length: 532  Bit Score: 998.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734    33 ANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGDEEVWTSDV-QYQVSPFNHGHKVAKFCYADKSLLNKAIEAALA 111
Cdd:TIGR01236   1 ANEPVLPFRPGSPERDLLRKSLKELKSSSLEIPLVIGGEEVYDSNErIPQVNPHNHQAVLAKATNATEEDAMKAVEAALD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   112 ARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPS 191
Cdd:TIGR01236  81 AKKDWSNLPFYDRAAIFLKAADLLSGPYRYEILAATMLGQSKTVYQAEIDAVAELIDFFRFNVKYARELYAQQPISAPGE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   192 TNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGD 271
Cdd:TIGR01236 161 WNRTEYRPLEGFVYAISPFNFTAIAGNLAGAPALMGNTVVWKPSQTAALSNYLLMRILEEAGLPPGVINFVPGDGVQVSD 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   272 TVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSAC 351
Cdd:TIGR01236 241 QVLADPDLAGIHFTGSTNTFKHLWKKVAQNLDRYHNFPRIVGETGGKDFHLVHPSADISHAVLGTIRGAFEYQGQKCSAA 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   352 SRLYVPHSLWPQIKGRLLEEHSRIKVGDPaEDFGTFFSAVIDAKSFARIKKWLEHARSSPS-LTILAGGKCDDSVGYFVE 430
Cdd:TIGR01236 321 SRLYVPHSKWPEFKSDLLAELQSVKVGDP-DDFRGFMGAVIDEQSFDKIVKYIEDAKKDPEaLTILYGGKYDDSQGYFVE 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   431 PCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKS 510
Cdd:TIGR01236 400 PTVVESKDPDHPLMSEEIFGPVLTVYVYPDDKYKEILDLVDSTSQYGLTGAVFAKDRKAILEADKKLRFAAGNFYINDKC 479
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 25777734   511 TGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWSYAYMQ 563
Cdd:TIGR01236 480 TGAVVGQQPFGGARMSGTNDKAGGPNNLLRWTSPRSIKETFVPLTDWSYPYMY 532
AdhE COG1012
Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase [Lipid transport and ...
64-551 1.06e-138

Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase [Lipid transport and metabolism]; Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase is part of the Pathway/BioSystem: Proline degradation


Pssm-ID: 440636 [Multi-domain]  Cd Length: 479  Bit Score: 410.67  E-value: 1.06e-138
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  64 IPCVVGDEEVWTSDVQYQ--VSPFNhGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRA 141
Cdd:COG1012   6 YPLFIGGEWVAAASGETFdvINPAT-GEVLARVPAATAEDVDAAVAAARAAFPAWAATPPAERAAILLRAADLLE--ERR 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 142 EILAKTMV-GQGKTVIQAEIDAAaELIDFFRFNAKYAVELEGQQ-PISVPPSTNSTVYRGLeGFVAAISPFNFTAIGGNL 219
Cdd:COG1012  83 EELAALLTlETGKPLAEARGEVD-RAADFLRYYAGEARRLYGETiPSDAPGTRAYVRREPL-GVVGAITPWNFPLALAAW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 220 AGAPAL-MGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQV 298
Cdd:COG1012 161 KLAPALaAGNTVVLKPAEQTPLSALLLAELLEEAGLPAGVLNVVTGDGSEVGAALVAHPDVDKISFTGSTAVGRRIAAAA 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 299 AQNLdrfhtfPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVG 378
Cdd:COG1012 241 AENL------KRVTLELGGKNPAIVLDDADLDAAVEAAVRGAFGNAGQRCTAASRLLVHESIYDEFVERLVAAAKALKVG 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 379 DPAeDFGTFFSAVIDAKSFARIKKWLEHARSSpSLTILAGGKC-DDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYV 457
Cdd:COG1012 315 DPL-DPGTDMGPLISEAQLERVLAYIEDAVAE-GAELLTGGRRpDGEGGYFVEPTVLADVTPDMRIAREEIFGPVLSVIP 392
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 458 YPDdkYKETLQLVDStTSYGLTGAVFSQDKDVVQEATKVLRnaAGNFYINDKSTGSiVGQQPFGGARASGTNDKpGGPHY 537
Cdd:COG1012 393 FDD--EEEAIALAND-TEYGLAASVFTRDLARARRVARRLE--AGMVWINDGTTGA-VPQAPFGGVKQSGIGRE-GGREG 465
                       490
                ....*....|....
gi 25777734 538 ILRWTSPQVIKETH 551
Cdd:COG1012 466 LEEYTETKTVTIRL 479
Aldedh pfam00171
Aldehyde dehydrogenase family; This family of dehydrogenases act on aldehyde substrates. ...
82-547 5.44e-125

Aldehyde dehydrogenase family; This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.


Pssm-ID: 425500 [Multi-domain]  Cd Length: 459  Bit Score: 374.95  E-value: 5.44e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734    82 VSPFNhGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMV-GQGKTVIQAEI 160
Cdd:pfam00171  12 INPAT-GEVIATVPAATAEDVDAAIAAARAAFPAWRKTPAAERAAILRKAADLLE--ERKDELAELETlENGKPLAEARG 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   161 DAAaELIDFFRFNAKYAVELEGQqPISVPPSTNSTVYRGLEGFVAAISPFNFTAiggNLAG---APALM-GNVVLWKPSD 236
Cdd:pfam00171  89 EVD-RAIDVLRYYAGLARRLDGE-TLPSDPGRLAYTRREPLGVVGAITPWNFPL---LLPAwkiAPALAaGNTVVLKPSE 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   237 TAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLdrfhtfPRLAGECG 316
Cdd:pfam00171 164 LTPLTALLLAELFEEAGLPAGVLNVVTGSGAEVGEALVEHPDVRKVSFTGSTAVGRHIAEAAAQNL------KRVTLELG 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   317 GKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPaEDFGTFFSAVIDAKS 396
Cdd:pfam00171 238 GKNPLIVLEDADLDAAVEAAVFGAFGNAGQVCTATSRLLVHESIYDEFVEKLVEAAKKLKVGDP-LDPDTDMGPLISKAQ 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   397 FARIKKWLEHARSSpSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDSTTsY 476
Cdd:pfam00171 317 LERVLKYVEDAKEE-GAKLLTGGEAGLDNGYFVEPTVLANVTPDMRIAQEEIFGPVLSVIRFKDE--EEAIEIANDTE-Y 392
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 25777734   477 GLTGAVFSQDKDVVQEATKVLRnaAGNFYINDKSTGSIVGqQPFGGARASGTNDKpGGPHYILRWTSPQVI 547
Cdd:pfam00171 393 GLAAGVFTSDLERALRVARRLE--AGMVWINDYTTGDADG-LPFGGFKQSGFGRE-GGPYGLEEYTEVKTV 459
PRK03137 PRK03137
1-pyrroline-5-carboxylate dehydrogenase; Provisional
34-550 3.16e-117

1-pyrroline-5-carboxylate dehydrogenase; Provisional


Pssm-ID: 179543  Cd Length: 514  Bit Score: 356.94  E-value: 3.16e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   34 NEPVLAFTQgsPE-RDALQKALKDLKGRM-EAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALA 111
Cdd:PRK03137   7 HEPFTDFSV--EEnVEAFEEALKKVEKELgQDYPLIIGGERITTEDKIVSINPANKSEVVGRVSKATKELAEKAMQAALE 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  112 ARKEWDLKPIADRAQIFLKAADMLSgPRRAEILAkTMVGQ-GKTVIQAEIDAAaELIDFFRFNAKYAVEL-EGQQPISVP 189
Cdd:PRK03137  85 AFETWKKWSPEDRARILLRAAAIIR-RRKHEFSA-WLVKEaGKPWAEADADTA-EAIDFLEYYARQMLKLaDGKPVESRP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  190 PSTNSTVYRGLeGFVAAISPFNF-TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPL 268
Cdd:PRK03137 162 GEHNRYFYIPL-GVGVVISPWNFpFAIMAGMTLAAIVAGNTVLLKPASDTPVIAAKFVEVLEEAGLPAGVVNFVPGSGSE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  269 FGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKC 348
Cdd:PRK03137 241 VGDYLVDHPKTRFITFTGSREVGLRIYERAAKVQPGQIWLKRVIAEMGGKDAIVVDEDADLDLAAESIVASAFGFSGQKC 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  349 SACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfgTFFSAVIDAKSFARIKKWLEHARSSPSLtiLAGGKCDDSVGYF 428
Cdd:PRK03137 321 SACSRAIVHEDVYDEVLEKVVELTKELTVGNPEDN--AYMGPVINQASFDKIMSYIEIGKEEGRL--VLGGEGDDSKGYF 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  429 VEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDdkYKETLQLVDStTSYGLTGAVFSQDKDVVQEATKVLRnaAGNFYIND 508
Cdd:PRK03137 397 IQPTIFADVDPKARIMQEEIFGPVVAFIKAKD--FDHALEIANN-TEYGLTGAVISNNREHLEKARREFH--VGNLYFNR 471
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|..
gi 25777734  509 KSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKET 550
Cdd:PRK03137 472 GCTGAIVGYHPFGGFNMSGTDSKAGGPDYLLLFLQAKTVSEM 513
 
Name Accession Description Interval E-value
ALDH_F4-17_P5CDH cd07123
Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Delta(1) ...
32-553 0e+00

Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.


Pssm-ID: 143441 [Multi-domain]  Cd Length: 522  Bit Score: 1036.00  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  32 VANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALA 111
Cdd:cd07123   1 PVNEPVLSYAPGSPERAKLQEALAELKSLTVEIPLVIGGKEVRTGNTGKQVMPHDHAHVLATYHYADAALVEKAIEAALE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 112 ARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPS 191
Cdd:cd07123  81 ARKEWARMPFEDRAAIFLKAADLLSGKYRYELNAATMLGQGKNVWQAEIDAACELIDFLRFNVKYAEELYAQQPLSSPAG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 192 T-NSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFG 270
Cdd:cd07123 161 VwNRLEYRPLEGFVYAVSPFNFTAIGGNLAGAPALMGNVVLWKPSDTAVLSNYLVYKILEEAGLPPGVINFVPGDGPVVG 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 271 DTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSA 350
Cdd:cd07123 241 DTVLASPHLAGLHFTGSTPTFKSLWKQIGENLDRYRTYPRIVGETGGKNFHLVHPSADVDSLVTATVRGAFEYQGQKCSA 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 351 CSRLYVPHSLWPQIKGRLLEEHSRIKVGDPaEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVE 430
Cdd:cd07123 321 ASRAYVPESLWPEVKERLLEELKEIKMGDP-DDFSNFMGAVIDEKAFDRIKGYIDHAKSDPEAEIIAGGKCDDSVGYFVE 399
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 431 PCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKS 510
Cdd:cd07123 400 PTVIETTDPKHKLMTEEIFGPVLTVYVYPDSDFEETLELVDTTSPYALTGAIFAQDRKAIREATDALRNAAGNFYINDKP 479
                       490       500       510       520
                ....*....|....*....|....*....|....*....|...
gi 25777734 511 TGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKP 553
Cdd:cd07123 480 TGAVVGQQPFGGARASGTNDKAGSPLNLLRWVSPRTIKETFVP 522
D1pyr5carbox1 TIGR01236
delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; This model represents one of two ...
33-563 0e+00

delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; This model represents one of two related branches of delta-1-pyrroline-5-carboxylate dehydrogenase. The two branches are not as closely related to each other as some aldehyde dehydrogenases are to this branch, and separate models are built for this reason. The enzyme is the second of two in the degradation of proline to glutamate. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273517  Cd Length: 532  Bit Score: 998.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734    33 ANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGDEEVWTSDV-QYQVSPFNHGHKVAKFCYADKSLLNKAIEAALA 111
Cdd:TIGR01236   1 ANEPVLPFRPGSPERDLLRKSLKELKSSSLEIPLVIGGEEVYDSNErIPQVNPHNHQAVLAKATNATEEDAMKAVEAALD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   112 ARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPS 191
Cdd:TIGR01236  81 AKKDWSNLPFYDRAAIFLKAADLLSGPYRYEILAATMLGQSKTVYQAEIDAVAELIDFFRFNVKYARELYAQQPISAPGE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   192 TNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGD 271
Cdd:TIGR01236 161 WNRTEYRPLEGFVYAISPFNFTAIAGNLAGAPALMGNTVVWKPSQTAALSNYLLMRILEEAGLPPGVINFVPGDGVQVSD 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   272 TVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSAC 351
Cdd:TIGR01236 241 QVLADPDLAGIHFTGSTNTFKHLWKKVAQNLDRYHNFPRIVGETGGKDFHLVHPSADISHAVLGTIRGAFEYQGQKCSAA 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   352 SRLYVPHSLWPQIKGRLLEEHSRIKVGDPaEDFGTFFSAVIDAKSFARIKKWLEHARSSPS-LTILAGGKCDDSVGYFVE 430
Cdd:TIGR01236 321 SRLYVPHSKWPEFKSDLLAELQSVKVGDP-DDFRGFMGAVIDEQSFDKIVKYIEDAKKDPEaLTILYGGKYDDSQGYFVE 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   431 PCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKS 510
Cdd:TIGR01236 400 PTVVESKDPDHPLMSEEIFGPVLTVYVYPDDKYKEILDLVDSTSQYGLTGAVFAKDRKAILEADKKLRFAAGNFYINDKC 479
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 25777734   511 TGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWSYAYMQ 563
Cdd:TIGR01236 480 TGAVVGQQPFGGARMSGTNDKAGGPNNLLRWTSPRSIKETFVPLTDWSYPYMY 532
ALDH_P5CDH cd07083
ALDH subfamily NAD+-dependent delta(1)-pyrroline-5-carboxylate dehydrogenase-like; ALDH ...
47-551 0e+00

ALDH subfamily NAD+-dependent delta(1)-pyrroline-5-carboxylate dehydrogenase-like; ALDH subfamily of the NAD+-dependent, delta(1)-pyrroline-5-carboxylate dehydrogenases (P5CDH, EC=1.5.1.12). The proline catabolic enzymes, proline dehydrogenase and P5CDH catalyze the two-step oxidation of proline to glutamate. P5CDH catalyzes the oxidation of glutamate semialdehyde, utilizing NAD+ as the electron acceptor. In some bacteria, the two enzymes are fused into the bifunctional flavoenzyme, proline utilization A (PutA). These enzymes play important roles in cellular redox control, superoxide generation, and apoptosis. In certain prokaryotes such as Escherichia coli, PutA is also a transcriptional repressor of the proline utilization genes. Monofunctional enzyme sequences such as those seen in the Bacillus RocA P5CDH are also present in this subfamily as well as the human ALDH4A1 P5CDH and the Drosophila Aldh17 P5CDH.


Pssm-ID: 143402 [Multi-domain]  Cd Length: 500  Bit Score: 826.06  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  47 RDALQKALKDLKG-RMEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRA 125
Cdd:cd07083   1 RRAMREALRRVKEeFGRAYPLVIGGEWVDTKERMVSVSPFAPSEVVGTTAKADKAEAEAALEAAWAAFKTWKDWPQEDRA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 126 QIFLKAADMLSGPRRAEILAKTMVGqGKTVIQaEIDAAAELIDFFRFNAKYAVELEGQQPI--SVPPSTNSTVYRGLeGF 203
Cdd:cd07083  81 RLLLKAADLLRRRRRELIATLTYEV-GKNWVE-AIDDVAEAIDFIRYYARAALRLRYPAVEvvPYPGEDNESFYVGL-GA 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 204 VAAISPFNFT-AIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGI 282
Cdd:cd07083 158 GVVISPWNFPvAIFTGMIVAPVAVGNTVIAKPAEDAVVVGYKVFEIFHEAGFPPGVVQFLPGVGEEVGAYLTEHERIRGI 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 283 NFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWP 362
Cdd:cd07083 238 NFTGSLETGKKIYEAAARLAPGQTWFKRLYVETGGKNAIIVDETADFELVVEGVVVSAFGFQGQKCSAASRLILTQGAYE 317
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 363 QIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEHARSspSLTILAGGKCDDSVGYFVEPCIVESKDPQEP 442
Cdd:cd07083 318 PVLERLLKRAERLSVGPPEEN-GTDLGPVIDAEQEAKVLSYIEHGKN--EGQLVLGGKRLEGEGYFVAPTVVEEVPPKAR 394
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 443 IMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQdKDVVQEATKVLrnAAGNFYINDKSTGSIVGQQPFGG 522
Cdd:cd07083 395 IAQEEIFGPVLSVIRYKDDDFAEALEVANSTPYGLTGGVYSRK-REHLEEARREF--HVGNLYINRKITGALVGVQPFGG 471
                       490       500
                ....*....|....*....|....*....
gi 25777734 523 ARASGTNDKPGGPHYILRWTSPQVIKETH 551
Cdd:cd07083 472 FKLSGTNAKTGGPHYLRRFLEMKAVAERF 500
ALDH cd07078
NAD(P)+ dependent aldehyde dehydrogenase family; The aldehyde dehydrogenase family (ALDH) of ...
103-547 1.28e-141

NAD(P)+ dependent aldehyde dehydrogenase family; The aldehyde dehydrogenase family (ALDH) of NAD(P)+ dependent enzymes, in general, oxidize a wide range of endogenous and exogenous aliphatic and aromatic aldehydes to their corresponding carboxylic acids and play an important role in detoxification. Besides aldehyde detoxification, many ALDH isozymes possess multiple additional catalytic and non-catalytic functions such as participating in metabolic pathways, or as binding proteins, or as osmoregulants, to mention a few. The enzyme has three domains, a NAD(P)+ cofactor-binding domain, a catalytic domain, and a bridging domain; and the active enzyme is generally either homodimeric or homotetrameric. The catalytic mechanism is proposed to involve cofactor binding, resulting in a conformational change and activation of an invariant catalytic cysteine nucleophile. The cysteine and aldehyde substrate form an oxyanion thiohemiacetal intermediate resulting in hydride transfer to the cofactor and formation of a thioacylenzyme intermediate. Hydrolysis of the thioacylenzyme and release of the carboxylic acid product occurs, and in most cases, the reduced cofactor dissociates from the enzyme. The evolutionary phylogenetic tree of ALDHs appears to have an initial bifurcation between what has been characterized as the classical aldehyde dehydrogenases, the ALDH family (ALDH) and extended family members or aldehyde dehydrogenase-like (ALDH-like) proteins. The ALDH proteins are represented by enzymes which share a number of highly conserved residues necessary for catalysis and cofactor binding and they include such proteins as retinal dehydrogenase, 10-formyltetrahydrofolate dehydrogenase, non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase, delta(1)-pyrroline-5-carboxylate dehydrogenases, alpha-ketoglutaric semialdehyde dehydrogenase, alpha-aminoadipic semialdehyde dehydrogenase, coniferyl aldehyde dehydrogenase and succinate-semialdehyde dehydrogenase. Included in this larger group are all human, Arabidopsis, Tortula, fungal, protozoan, and Drosophila ALDHs identified in families ALDH1 through ALDH22 with the exception of families ALDH18, ALDH19, and ALDH20 which are present in the ALDH-like group.


Pssm-ID: 143397 [Multi-domain]  Cd Length: 432  Bit Score: 416.22  E-value: 1.28e-141
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 103 NKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGqGKTVIQAEIDAAaELIDFFRFNAKYAVELEG 182
Cdd:cd07078   1 DAAVAAARAAFKAWAALPPAERAAILRKLADLLEERREELAALETLET-GKPIEEALGEVA-RAADTFRYYAGLARRLHG 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 183 QQ-PISVPPSTNSTVYRGLeGFVAAISPFNFT-AIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQ 260
Cdd:cd07078  79 EViPSPDPGELAIVRREPL-GVVGAITPWNFPlLLAAWKLAPALAAGNTVVLKPSELTPLTALLLAELLAEAGLPPGVLN 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 261 FVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLdrfhtfPRLAGECGGKNFHFVHRSADVESVVSGTLRSA 340
Cdd:cd07078 158 VVTGDGDEVGAALASHPRVDKISFTGSTAVGKAIMRAAAENL------KRVTLELGGKSPLIVFDDADLDAAVKGAVFGA 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 341 FEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAeDFGTFFSAVIDAKSFARIKKWLEHARSSPSlTILAGGK 420
Cdd:cd07078 232 FGNAGQVCTAASRLLVHESIYDEFVERLVERVKALKVGNPL-DPDTDMGPLISAAQLDRVLAYIEDAKAEGA-KLLCGGK 309
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 421 CDDS-VGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDSTTsYGLTGAVFSQDKDVVQEATKVLRn 499
Cdd:cd07078 310 RLEGgKGYFVPPTVLTDVDPDMPIAQEEIFGPVLPVIPFKDE--EEAIELANDTE-YGLAAGVFTRDLERALRVAERLE- 385
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*...
gi 25777734 500 aAGNFYINDKSTGsIVGQQPFGGARASGTNdKPGGPHYILRWTSPQVI 547
Cdd:cd07078 386 -AGTVWINDYSVG-AEPSAPFGGVKQSGIG-REGGPYGLEEYTEPKTV 430
AdhE COG1012
Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase [Lipid transport and ...
64-551 1.06e-138

Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase [Lipid transport and metabolism]; Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase is part of the Pathway/BioSystem: Proline degradation


Pssm-ID: 440636 [Multi-domain]  Cd Length: 479  Bit Score: 410.67  E-value: 1.06e-138
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  64 IPCVVGDEEVWTSDVQYQ--VSPFNhGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRA 141
Cdd:COG1012   6 YPLFIGGEWVAAASGETFdvINPAT-GEVLARVPAATAEDVDAAVAAARAAFPAWAATPPAERAAILLRAADLLE--ERR 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 142 EILAKTMV-GQGKTVIQAEIDAAaELIDFFRFNAKYAVELEGQQ-PISVPPSTNSTVYRGLeGFVAAISPFNFTAIGGNL 219
Cdd:COG1012  83 EELAALLTlETGKPLAEARGEVD-RAADFLRYYAGEARRLYGETiPSDAPGTRAYVRREPL-GVVGAITPWNFPLALAAW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 220 AGAPAL-MGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQV 298
Cdd:COG1012 161 KLAPALaAGNTVVLKPAEQTPLSALLLAELLEEAGLPAGVLNVVTGDGSEVGAALVAHPDVDKISFTGSTAVGRRIAAAA 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 299 AQNLdrfhtfPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVG 378
Cdd:COG1012 241 AENL------KRVTLELGGKNPAIVLDDADLDAAVEAAVRGAFGNAGQRCTAASRLLVHESIYDEFVERLVAAAKALKVG 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 379 DPAeDFGTFFSAVIDAKSFARIKKWLEHARSSpSLTILAGGKC-DDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYV 457
Cdd:COG1012 315 DPL-DPGTDMGPLISEAQLERVLAYIEDAVAE-GAELLTGGRRpDGEGGYFVEPTVLADVTPDMRIAREEIFGPVLSVIP 392
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 458 YPDdkYKETLQLVDStTSYGLTGAVFSQDKDVVQEATKVLRnaAGNFYINDKSTGSiVGQQPFGGARASGTNDKpGGPHY 537
Cdd:COG1012 393 FDD--EEEAIALAND-TEYGLAASVFTRDLARARRVARRLE--AGMVWINDGTTGA-VPQAPFGGVKQSGIGRE-GGREG 465
                       490
                ....*....|....
gi 25777734 538 ILRWTSPQVIKETH 551
Cdd:COG1012 466 LEEYTETKTVTIRL 479
ALDH_PutA-P5CDH-RocA cd07124
Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Delta(1)-pyrroline-5-carboxylate ...
34-549 7.35e-135

Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), RocA: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. The proline catabolic enzymes, proline dehydrogenase and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), catalyze the two-step oxidation of proline to glutamate; P5CDH catalyzes the oxidation of glutamate semialdehyde, utilizing NAD+ as the electron acceptor. In some bacteria, the two enzymes are fused into the bifunctional flavoenzyme, proline utilization A (PutA). In this CD, monofunctional enzyme sequences such as seen in the Bacillus subtilis RocA P5CDH are also present. These enzymes play important roles in cellular redox control, superoxide generation, and apoptosis.


Pssm-ID: 143442  Cd Length: 512  Bit Score: 401.99  E-value: 7.35e-135
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  34 NEPVLAFTQGSpERDALQKALKDLKGRMEA-IPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAA 112
Cdd:cd07124   3 NEPFTDFADEE-NRAAFRAALARVREELGReYPLVIGGKEVRTEEKIESRNPADPSEVLGTVQKATKEEAEAAVQAARAA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 113 RKEWDLKPIADRAQIFLKAADMLSgPRRAEiLAKTMVGQ-GKTVIQAEIDAAaELIDFFRFNAKYAVELEGQQPISVPPS 191
Cdd:cd07124  82 FPTWRRTPPEERARLLLRAAALLR-RRRFE-LAAWMVLEvGKNWAEADADVA-EAIDFLEYYAREMLRLRGFPVEMVPGE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 192 TNSTVYRGLeGFVAAISPFNF-TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFG 270
Cdd:cd07124 159 DNRYVYRPL-GVGAVISPWNFpLAILAGMTTAALVTGNTVVLKPAEDTPVIAAKLVEILEEAGLPPGVVNFLPGPGEEVG 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 271 DTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSA 350
Cdd:cd07124 238 DYLVEHPDVRFIAFTGSREVGLRIYERAAKVQPGQKWLKRVIAEMGGKNAIIVDEDADLDEAAEGIVRSAFGFQGQKCSA 317
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 351 CSRLYVPHSLWPQIKGRLLEEHSRIKVGDPaEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLtiLAGGKCDDSV--GYF 428
Cdd:cd07124 318 CSRVIVHESVYDEFLERLVERTKALKVGDP-EDPEVYMGPVIDKGARDRIRRYIEIGKSEGRL--LLGGEVLELAaeGYF 394
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 429 VEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDdkYKETLQLVDStTSYGLTGAVFSQDKDVVQEATKVLRnaAGNFYIND 508
Cdd:cd07124 395 VQPTIFADVPPDHRLAQEEIFGPVLAVIKAKD--FDEALEIAND-TEYGLTGGVFSRSPEHLERARREFE--VGNLYANR 469
                       490       500       510       520
                ....*....|....*....|....*....|....*....|.
gi 25777734 509 KSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKE 549
Cdd:cd07124 470 KITGALVGRQPFGGFKMSGTGSKAGGPDYLLQFMQPKTVTE 510
Aldedh pfam00171
Aldehyde dehydrogenase family; This family of dehydrogenases act on aldehyde substrates. ...
82-547 5.44e-125

Aldehyde dehydrogenase family; This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.


Pssm-ID: 425500 [Multi-domain]  Cd Length: 459  Bit Score: 374.95  E-value: 5.44e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734    82 VSPFNhGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMV-GQGKTVIQAEI 160
Cdd:pfam00171  12 INPAT-GEVIATVPAATAEDVDAAIAAARAAFPAWRKTPAAERAAILRKAADLLE--ERKDELAELETlENGKPLAEARG 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   161 DAAaELIDFFRFNAKYAVELEGQqPISVPPSTNSTVYRGLEGFVAAISPFNFTAiggNLAG---APALM-GNVVLWKPSD 236
Cdd:pfam00171  89 EVD-RAIDVLRYYAGLARRLDGE-TLPSDPGRLAYTRREPLGVVGAITPWNFPL---LLPAwkiAPALAaGNTVVLKPSE 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   237 TAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLdrfhtfPRLAGECG 316
Cdd:pfam00171 164 LTPLTALLLAELFEEAGLPAGVLNVVTGSGAEVGEALVEHPDVRKVSFTGSTAVGRHIAEAAAQNL------KRVTLELG 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   317 GKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPaEDFGTFFSAVIDAKS 396
Cdd:pfam00171 238 GKNPLIVLEDADLDAAVEAAVFGAFGNAGQVCTATSRLLVHESIYDEFVEKLVEAAKKLKVGDP-LDPDTDMGPLISKAQ 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   397 FARIKKWLEHARSSpSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDSTTsY 476
Cdd:pfam00171 317 LERVLKYVEDAKEE-GAKLLTGGEAGLDNGYFVEPTVLANVTPDMRIAQEEIFGPVLSVIRFKDE--EEAIEIANDTE-Y 392
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 25777734   477 GLTGAVFSQDKDVVQEATKVLRnaAGNFYINDKSTGSIVGqQPFGGARASGTNDKpGGPHYILRWTSPQVI 547
Cdd:pfam00171 393 GLAAGVFTSDLERALRVARRLE--AGMVWINDYTTGDADG-LPFGGFKQSGFGRE-GGPYGLEEYTEVKTV 459
PRK03137 PRK03137
1-pyrroline-5-carboxylate dehydrogenase; Provisional
34-550 3.16e-117

1-pyrroline-5-carboxylate dehydrogenase; Provisional


Pssm-ID: 179543  Cd Length: 514  Bit Score: 356.94  E-value: 3.16e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   34 NEPVLAFTQgsPE-RDALQKALKDLKGRM-EAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALA 111
Cdd:PRK03137   7 HEPFTDFSV--EEnVEAFEEALKKVEKELgQDYPLIIGGERITTEDKIVSINPANKSEVVGRVSKATKELAEKAMQAALE 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  112 ARKEWDLKPIADRAQIFLKAADMLSgPRRAEILAkTMVGQ-GKTVIQAEIDAAaELIDFFRFNAKYAVEL-EGQQPISVP 189
Cdd:PRK03137  85 AFETWKKWSPEDRARILLRAAAIIR-RRKHEFSA-WLVKEaGKPWAEADADTA-EAIDFLEYYARQMLKLaDGKPVESRP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  190 PSTNSTVYRGLeGFVAAISPFNF-TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPL 268
Cdd:PRK03137 162 GEHNRYFYIPL-GVGVVISPWNFpFAIMAGMTLAAIVAGNTVLLKPASDTPVIAAKFVEVLEEAGLPAGVVNFVPGSGSE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  269 FGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKC 348
Cdd:PRK03137 241 VGDYLVDHPKTRFITFTGSREVGLRIYERAAKVQPGQIWLKRVIAEMGGKDAIVVDEDADLDLAAESIVASAFGFSGQKC 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  349 SACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfgTFFSAVIDAKSFARIKKWLEHARSSPSLtiLAGGKCDDSVGYF 428
Cdd:PRK03137 321 SACSRAIVHEDVYDEVLEKVVELTKELTVGNPEDN--AYMGPVINQASFDKIMSYIEIGKEEGRL--VLGGEGDDSKGYF 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  429 VEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDdkYKETLQLVDStTSYGLTGAVFSQDKDVVQEATKVLRnaAGNFYIND 508
Cdd:PRK03137 397 IQPTIFADVDPKARIMQEEIFGPVVAFIKAKD--FDHALEIANN-TEYGLTGAVISNNREHLEKARREFH--VGNLYFNR 471
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|..
gi 25777734  509 KSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKET 550
Cdd:PRK03137 472 GCTGAIVGYHPFGGFNMSGTDSKAGGPDYLLLFLQAKTVSEM 513
ALDH-SF cd06534
NAD(P)+-dependent aldehyde dehydrogenase superfamily; The aldehyde dehydrogenase superfamily ...
107-547 3.89e-104

NAD(P)+-dependent aldehyde dehydrogenase superfamily; The aldehyde dehydrogenase superfamily (ALDH-SF) of NAD(P)+-dependent enzymes, in general, oxidize a wide range of endogenous and exogenous aliphatic and aromatic aldehydes to their corresponding carboxylic acids and play an important role in detoxification. Besides aldehyde detoxification, many ALDH isozymes possess multiple additional catalytic and non-catalytic functions such as participating in metabolic pathways, or as binding proteins, or osmoregulants, to mention a few. The enzyme has three domains, a NAD(P)+ cofactor-binding domain, a catalytic domain, and a bridging domain; and the active enzyme is generally either homodimeric or homotetrameric. The catalytic mechanism is proposed to involve cofactor binding, resulting in a conformational change and activation of an invariant catalytic cysteine nucleophile. The cysteine and aldehyde substrate form an oxyanion thiohemiacetal intermediate resulting in hydride transfer to the cofactor and formation of a thioacylenzyme intermediate. Hydrolysis of the thioacylenzyme and release of the carboxylic acid product occurs, and in most cases, the reduced cofactor dissociates from the enzyme. The evolutionary phylogenetic tree of ALDHs appears to have an initial bifurcation between what has been characterized as the classical aldehyde dehydrogenases, the ALDH family (ALDH) and extended family members or aldehyde dehydrogenase-like (ALDH-L) proteins. The ALDH proteins are represented by enzymes which share a number of highly conserved residues necessary for catalysis and cofactor binding and they include such proteins as retinal dehydrogenase, 10-formyltetrahydrofolate dehydrogenase, non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase, delta(1)-pyrroline-5-carboxylate dehydrogenases, alpha-ketoglutaric semialdehyde dehydrogenase, alpha-aminoadipic semialdehyde dehydrogenase, coniferyl aldehyde dehydrogenase and succinate-semialdehyde dehydrogenase. Included in this larger group are all human, Arabidopsis, Tortula, fungal, protozoan, and Drosophila ALDHs identified in families ALDH1 through ALDH22 with the exception of families ALDH18, ALDH19, and ALDH20 which are present in the ALDH-like group. The ALDH-like group is represented by such proteins as gamma-glutamyl phosphate reductase, LuxC-like acyl-CoA reductase, and coenzyme A acylating aldehyde dehydrogenase. All of these proteins have a conserved cysteine that aligns with the catalytic cysteine of the ALDH group.


Pssm-ID: 143395 [Multi-domain]  Cd Length: 367  Bit Score: 318.02  E-value: 3.89e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 107 EAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGqGKTvIQAEIDAAAELIDFFRFNAKYAVELEGQQPI 186
Cdd:cd06534   1 AAARAAFKAWAALPPAERAAILRKIADLLEERREELAALETLET-GKP-IEEALGEVARAIDTFRYAAGLADKLGGPELP 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 187 SVPPSTNSTVYRGLEGFVAAISPFNF-TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPAD 265
Cdd:cd06534  79 SPDPGGEAYVRREPLGVVGVITPWNFpLLLAAWKLAPALAAGNTVVLKPSELTPLTALALAELLQEAGLPPGVVNVVPGG 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 266 GPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLdrfhtfPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGG 345
Cdd:cd06534 159 GDEVGAALLSHPRVDKISFTGSTAVGKAIMKAAAENL------KPVTLELGGKSPVIVDEDADLDAAVEGAVFGAFFNAG 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 346 QKCSACSRLYVPHSLWPQIKGRLLeehsrikvgdpaedfgtffsavidaksfarikkwleharsspsltilaggkcddsv 425
Cdd:cd06534 233 QICTAASRLLVHESIYDEFVEKLV-------------------------------------------------------- 256
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 426 gyfvepCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDSTTsYGLTGAVFSQDKDVVQEATKVLRnaAGNFY 505
Cdd:cd06534 257 ------TVLVDVDPDMPIAQEEIFGPVLPVIRFKDE--EEAIALANDTE-YGLTAGVFTRDLNRALRVAERLR--AGTVY 325
                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 25777734 506 INDKSTGSiVGQQPFGGARASGTNDKpGGPHYILRWTSPQVI 547
Cdd:cd06534 326 INDSSIGV-GPEAPFGGVKNSGIGRE-GGPYGLEEYTRTKTV 365
D1pyr5carbox2 TIGR01237
delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; This enzyme is the second of ...
34-549 4.40e-103

delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; This enzyme is the second of two in the degradation of proline to glutamate. This model represents one of several related branches of delta-1-pyrroline-5-carboxylate dehydrogenase. Members of this branch may be associated with proline dehydrogenase (the other enzyme of the pathway from proline to glutamate) but have not been demonstrated experimentally. The branches are not as closely related to each other as some distinct aldehyde dehydrogenases are to some; separate models were built to let each model describe a set of equivalogs. [Energy metabolism, Amino acids and amines]


Pssm-ID: 200087 [Multi-domain]  Cd Length: 511  Bit Score: 320.27  E-value: 4.40e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734    34 NEPVLAFTQgSPERDALQKALKDLKGRM-EAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAA 112
Cdd:TIGR01237   3 HEPFTDFAD-EENRQAFFKALATVKEQLgKTYPLVINGERVETENKIVSINPCDKSEVVGTVSKASQEHAEHALQAAAKA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   113 RKEWDLKPIADRAQIFLKAADMLSgPRRAEILAKTMVGQGKTVIQAEIDAAaELIDFFRFNAKYAVELEGQQPI-SVPPS 191
Cdd:TIGR01237  82 FEAWKKTDPEERAAILFKAAAIVR-RRRHEFSALLVKEVGKPWNEADAEVA-EAIDFMEYYARQMIELAKGKPVnSREGE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   192 TNSTVYRGLeGFVAAISPFNFT-AIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFG 270
Cdd:TIGR01237 160 TNQYVYTPT-GVTVVISPWNFPfAIMVGMTVAPIVTGNCVVLKPAEAAPVIAAKFVEILEEAGLPKGVVQFVPGSGSEVG 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   271 DTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSA 350
Cdd:TIGR01237 239 DYLVDHPKTSLITFTGSREVGTRIFERAAKVQPGQKHLKRVIAEMGGKDTVIVDEDADIELAAQSAFTSAFGFAGQKCSA 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   351 CSRLYVPHSLWPQIKGRLLEEHSRIKVGDPaEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTIlaGGKCDDSVGYFVE 430
Cdd:TIGR01237 319 GSRAVVHEKVYDEVVERFVEITESLKVGPP-DSADVYVGPVIDQKSFNKIMEYIEIGKAEGRLVS--GGCGDDSKGYFIG 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   431 PCIVESKDPQEPIMKEEIFGPVLSVYVYPDdkYKETLQLVDSTtSYGLTGAVFSQDKDVVQEATKVLRnaAGNFYINDKS 510
Cdd:TIGR01237 396 PTIFADVDRKARLAQEEIFGPVVAFIRASD--FDEALEIANNT-EYGLTGGVISNNRDHINRAKAEFE--VGNLYFNRNI 470
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 25777734   511 TGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKE 549
Cdd:TIGR01237 471 TGAIVGYQPFGGFKMSGTDSKAGGPDYLALFMQAKTVTE 509
ALDH_PutA-P5CDH cd07125
Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; The proline catabolic enzymes of the ...
62-540 2.46e-96

Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; The proline catabolic enzymes of the aldehyde dehydrogenase (ALDH) protein superfamily, proline dehydrogenase and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH, (EC=1.5.1.12 )), catalyze the two-step oxidation of proline to glutamate; P5CDH catalyzes the oxidation of glutamate semialdehyde, utilizing NAD+ as the electron acceptor. In some bacteria, the two enzymes are fused into the bifunctional flavoenzyme, proline utilization A (PutA) These enzymes play important roles in cellular redox control, superoxide generation, and apoptosis. In certain prokaryotes such as Escherichia coli, PutA is also a transcriptional repressor of the proline utilization genes.


Pssm-ID: 143443 [Multi-domain]  Cd Length: 518  Bit Score: 302.96  E-value: 2.46e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  62 EAIPCVVGDEEVWTsDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGpRRA 141
Cdd:cd07125  32 EAIPIINGEETETG-EGAPVIDPADHERTIGEVSLADAEDVDAALAIAAAAFAGWSATPVEERAEILEKAADLLEA-NRG 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 142 EILAKTMVGQGKTVIQAeIDAAAELIDFFRFNAKYAVELEGQQPISVPPS-TNSTVYRGLeGFVAAISPFNF---TAIGG 217
Cdd:cd07125 110 ELIALAAAEAGKTLADA-DAEVREAIDFCRYYAAQARELFSDPELPGPTGeLNGLELHGR-GVFVCISPWNFplaIFTGQ 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 218 NLAgapALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWK 296
Cdd:cd07125 188 IAA---ALAaGNTVIAKPAEQTPLIAARAVELLHEAGVPRDVLQLVPGDGEEIGEALVAHPRIDGVIFTGSTETAKLINR 264
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 297 QVAQnldRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWP----QIKGRLLEeh 372
Cdd:cd07125 265 ALAE---RDGPILPLIAETGGKNAMIVDSTALPEQAVKDVVQSAFGSAGQRCSALRLLYLQEEIAErfieMLKGAMAS-- 339
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 373 srIKVGDPAeDFGTFFSAVIDAKSFARIKKWLEHARSSPSLtiLAGGKCDDSVGYFVEPCIVESKDPQEpiMKEEIFGPV 452
Cdd:cd07125 340 --LKVGDPW-DLSTDVGPLIDKPAGKLLRAHTELMRGEAWL--IAPAPLDDGNGYFVAPGIIEIVGIFD--LTTEVFGPI 412
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 453 LSVYVYPDDKYKETLQLVDStTSYGLTGAVFSQDKDvvqEATKVLRNA-AGNFYINDKSTGSIVGQQPFGGARASGTNDK 531
Cdd:cd07125 413 LHVIRFKAEDLDEAIEDINA-TGYGLTLGIHSRDER---EIEYWRERVeAGNLYINRNITGAIVGRQPFGGWGLSGTGPK 488

                ....*....
gi 25777734 532 PGGPHYILR 540
Cdd:cd07125 489 AGGPNYLLR 497
PRK11904 PRK11904
bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA;
44-547 6.21e-79

bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA;


Pssm-ID: 237017 [Multi-domain]  Cd Length: 1038  Bit Score: 268.22  E-value: 6.21e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734    44 SPERDALQKALKDLKGRMEAIPCVVGDeevwTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIAD 123
Cdd:PRK11904  533 RSELEPLAAAIAAFLEKQWQAGPIING----EGEARPVVSPADRRRVVGEVAFADAEQVEQALAAARAAFPAWSRTPVEE 608
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   124 RAQIFLKAADMLSGpRRAEILAKTMVGQGKTVIQAeIDAAAELIDFFRFnakYAVELEGQ--QPISVPPSTNSTVYRGLE 201
Cdd:PRK11904  609 RAAILERAADLLEA-NRAELIALCVREAGKTLQDA-IAEVREAVDFCRY---YAAQARRLfgAPEKLPGPTGESNELRLH 683
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   202 G---FVAaISPFNFT-AIggnLAG--APALM-GNVVLWKPSD-TAMLASYAVyRILREAGLPPNIIQFVPADGPLFGDTV 273
Cdd:PRK11904  684 GrgvFVC-ISPWNFPlAI---FLGqvAAALAaGNTVIAKPAEqTPLIAAEAV-KLLHEAGIPKDVLQLLPGDGATVGAAL 758
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   274 TSSEHLCGINFTGSVptfkhlwkQVAQNLDRfhtfpRLAG----------ECGGKNFHFVHRSADVESVVSGTLRSAFEY 343
Cdd:PRK11904  759 TADPRIAGVAFTGST--------ETARIINR-----TLAArdgpivpliaETGGQNAMIVDSTALPEQVVDDVVTSAFRS 825
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   344 GGQKCSACSRLYVPHSLWPQ----IKGRLLEehsrIKVGDPAeDFGTFFSAVIDAKSFARIKKWLEHARSSPslTILAGG 419
Cdd:PRK11904  826 AGQRCSALRVLFVQEDIADRviemLKGAMAE----LKVGDPR-LLSTDVGPVIDAEAKANLDAHIERMKREA--RLLAQL 898
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   420 KCDDS--VGYFVEPCIVESKDPQEpiMKEEIFGPVLSVYVYpddKYKETLQLVDS--TTSYGLTGAVFSQDKDVVQEATK 495
Cdd:PRK11904  899 PLPAGteNGHFVAPTAFEIDSISQ--LEREVFGPILHVIRY---KASDLDKVIDAinATGYGLTLGIHSRIEETADRIAD 973
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 25777734   496 VLRnaAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVI 547
Cdd:PRK11904  974 RVR--VGNVYVNRNQIGAVVGVQPFGGQGLSGTGPKAGGPHYLLRFATEKTV 1023
PutA2 COG4230
Delta 1-pyrroline-5-carboxylate dehydrogenase [Amino acid transport and metabolism];
46-547 2.90e-78

Delta 1-pyrroline-5-carboxylate dehydrogenase [Amino acid transport and metabolism];


Pssm-ID: 443374 [Multi-domain]  Cd Length: 1156  Bit Score: 267.57  E-value: 2.90e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   46 ERDALQKALKDLKGRM-EAIPCVVGDEEvwTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADR 124
Cdd:COG4230  540 VLAALSAALAAAAEKQwQAAPLIAGEAA--SGEARPVRNPADHSDVVGTVVEATAADVEAALAAAQAAFPAWSATPVEER 617
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  125 AQIFLKAADMLSGpRRAEILAKTMVGQGKTvIQaeiDAAAEL---IDFFRFnakYAVELEGQQpisvppsTNSTVYRGLe 201
Cdd:COG4230  618 AAILERAADLLEA-HRAELMALLVREAGKT-LP---DAIAEVreaVDFCRY---YAAQARRLF-------AAPTVLRGR- 681
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  202 GFVAAISPFNFTaiggnLAG-----APALM-GNVVLWKPSD-TAMLASYAVyRILREAGLPPNIIQFVPADGPLFGDTVT 274
Cdd:COG4230  682 GVFVCISPWNFP-----LAIftgqvAAALAaGNTVLAKPAEqTPLIAARAV-RLLHEAGVPADVLQLLPGDGETVGAALV 755
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  275 SSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFprLAgECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRL 354
Cdd:COG4230  756 ADPRIAGVAFTGSTETARLINRTLAARDGPIVPL--IA-ETGGQNAMIVDSSALPEQVVDDVLASAFDSAGQRCSALRVL 832
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  355 YVPHSLWPQ----IKGRLLEehsrIKVGDPAE---DFGtffsAVIDAKSFARIKKWLEHARSSPslTILAGGKCDDSV-- 425
Cdd:COG4230  833 CVQEDIADRvlemLKGAMAE----LRVGDPADlstDVG----PVIDAEARANLEAHIERMRAEG--RLVHQLPLPEECan 902
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  426 GYFVEPCIVESKDPQEpiMKEEIFGPVLSVYVYpddKYKETLQLVDS--TTSYGLTGAVFSQDKDVVQEATKVLRnaAGN 503
Cdd:COG4230  903 GTFVAPTLIEIDSISD--LEREVFGPVLHVVRY---KADELDKVIDAinATGYGLTLGVHSRIDETIDRVAARAR--VGN 975
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....
gi 25777734  504 FYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVI 547
Cdd:COG4230  976 VYVNRNIIGAVVGVQPFGGEGLSGTGPKAGGPHYLLRFATERTV 1019
ALDH_KGSADH-YcbD cd07097
Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; ...
77-536 5.34e-73

Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Kinetic studies of the Bacillus subtilis ALDH-like ycbD protein, which is involved in d-glucarate/d-galactarate utilization, reveal that it is a NADP+-dependent, alpha-ketoglutaric semialdehyde dehydrogenase (KGSADH). KGSADHs (EC 1.2.1.26) catalyze the NAD(P)+-dependent conversion of KGSA to alpha-ketoglutarate. Interestingly, the NADP+-dependent, tetrameric, 2,5-dioxopentanoate dehydrogenase (EC=1.2.1.26), an enzyme involved in the catabolic pathway for D-arabinose in Sulfolobus solfataricus, also clusters in this group. This CD shows a distant phylogenetic relationship to the Azospirillum brasilense KGSADH-II (-III) group.


Pssm-ID: 143415 [Multi-domain]  Cd Length: 473  Bit Score: 240.61  E-value: 5.34e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  77 DVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMV-GQGKTV 155
Cdd:cd07097  14 DGEENRNPSDTSDVVGKYARASAEDADAAIAAAAAAFPAWRRTSPEARADILDKAGDELE--ARKEELARLLTrEEGKTL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 156 IQA--EIDAAaelIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNF-TAIGGNLAgAPALM-GNVVL 231
Cdd:cd07097  92 PEArgEVTRA---GQIFRYYAGEALRLSGETLPSTRPGVEVETTREPLGVVGLITPWNFpIAIPAWKI-APALAyGNTVV 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 232 WKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTfprl 311
Cdd:cd07097 168 FKPAELTPASAWALVEILEEAGLPAGVFNLVMGSGSEVGQALVEHPDVDAVSFTGSTAVGRRIAAAAAARGARVQL---- 243
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 312 agECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAV 391
Cdd:cd07097 244 --EMGGKNPLVVLDDADLDLAVECAVQGAFFSTGQRCTASSRLIVTEGIHDRFVEALVERTKALKVGDALDE-GVDIGPV 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 392 IDAKSFARIKKWLEHARSSPSlTILAGG---KCDDSvGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDdkYKETLQ 468
Cdd:cd07097 321 VSERQLEKDLRYIEIARSEGA-KLVYGGerlKRPDE-GYYLAPALFAGVTNDMRIAREEIFGPVAAVIRVRD--YDEALA 396
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 469 LVDStTSYGLTGAVFSQDkdvVQEATKVLRNA-AGNFYINDKSTGsiVGQQ-PFGGARASGTNDKPGGPH 536
Cdd:cd07097 397 IAND-TEFGLSAGIVTTS---LKHATHFKRRVeAGVVMVNLPTAG--VDYHvPFGGRKGSSYGPREQGEA 460
PRK11905 PRK11905
bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed
33-544 6.00e-71

bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed


Pssm-ID: 237018 [Multi-domain]  Cd Length: 1208  Bit Score: 247.09  E-value: 6.00e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734    33 ANEPVLAftqgsperdALQKALKDLKG-RMEAIPCVVGDEevwTSDVQYQV-SPFNHGHKVAKFCYADKSLLNKAIEAAL 110
Cdd:PRK11905  533 SDEATLA---------ALDEALNAFAAkTWHAAPLLAGGD---VDGGTRPVlNPADHDDVVGTVTEASAEDVERALAAAQ 600
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   111 AARKEWDLKPIADRAQIFLKAADMLSGpRRAEILAKTMVGQGKTVIqaeiDAAAEL---IDFFRFNAKYAVELEGQQPIs 187
Cdd:PRK11905  601 AAFPEWSATPAAERAAILERAADLMEA-HMPELFALAVREAGKTLA----NAIAEVreaVDFLRYYAAQARRLLNGPGH- 674
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   188 vppstnstvyRGLeGFVAAISPFNFT-AI-GGNLAGAPAlMGNVVLWKPSD-TAMLASYAVyRILREAGLPPNIIQFVPA 264
Cdd:PRK11905  675 ----------KPL-GPVVCISPWNFPlAIfTGQIAAALV-AGNTVLAKPAEqTPLIAARAV-RLLHEAGVPKDALQLLPG 741
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   265 DGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRfhtFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYG 344
Cdd:PRK11905  742 DGRTVGAALVADPRIAGVMFTGSTEVARLIQRTLAKRSGP---PVPLIAETGGQNAMIVDSSALPEQVVADVIASAFDSA 818
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   345 GQKCSACSRLYVPHSLWPQI----KGRLLEehsrIKVGDPAE---DFGtffsAVIDAKSFARIKKWLEHARSSPSL--TI 415
Cdd:PRK11905  819 GQRCSALRVLCLQEDVADRVltmlKGAMDE----LRIGDPWRlstDVG----PVIDAEAQANIEAHIEAMRAAGRLvhQL 890
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   416 LAGGKCDDsvGYFVEPCIVESKDPQEpiMKEEIFGPVLSVYVYpddKYKETLQLVDS--TTSYGLTGAVFSQDKDVVQEA 493
Cdd:PRK11905  891 PLPAETEK--GTFVAPTLIEIDSISD--LEREVFGPVLHVVRF---KADELDRVIDDinATGYGLTFGLHSRIDETIAHV 963
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 25777734   494 TKvlRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSP 544
Cdd:PRK11905  964 TS--RIRAGNIYVNRNIIGAVVGVQPFGGEGLSGTGPKAGGPLYLGRLVRE 1012
ALDH_y4uC cd07149
Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; ...
83-528 1.78e-68

Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Uncharacterized aldehyde dehydrogenase (ORF name y4uC) with sequence similarity to the moss Tortula ruralis aldehyde dehydrogenase ALDH21A1 (RNP123) believed to play an important role in the detoxification of aldehydes generated in response to desiccation- and salinity-stress, and similar sequences are included in this CD.


Pssm-ID: 143467 [Multi-domain]  Cd Length: 453  Bit Score: 228.25  E-value: 1.78e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  83 SPFnHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVGQ-GKTVIQA--E 159
Cdd:cd07149   5 SPY-DGEVIGRVPVASEEDVEKAIAAAKEGAKEMKSLPAYERAEILERAAQLLE--ERREEFARTIALEaGKPIKDArkE 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 160 IDAAaelIDFFRFNAKYAVELEGQQ-PISVPPSTNSTV---YRGLEGFVAAISPFNFTAiggNLAG---APALM-GNVVL 231
Cdd:cd07149  82 VDRA---IETLRLSAEEAKRLAGETiPFDASPGGEGRIgftIREPIGVVAAITPFNFPL---NLVAhkvGPAIAaGNAVV 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 232 WKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAqnldrfhtFPRL 311
Cdd:cd07149 156 LKPASQTPLSALKLAELLLEAGLPKGALNVVTGSGETVGDALVTDPRVRMISFTGSPAVGEAIARKAG--------LKKV 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 312 AGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAV 391
Cdd:cd07149 228 TLELGSNAAVIVDADADLEKAVERCVSGAFANAGQVCISVQRIFVHEDIYDEFLERFVAATKKLVVGDPLDE-DTDVGPM 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 392 IDAKSFARIKKWLEHARSSPSlTILAGGKCDdsvGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYpdDKYKETLQLVD 471
Cdd:cd07149 307 ISEAEAERIEEWVEEAVEGGA-RLLTGGKRD---GAILEPTVLTDVPPDMKVVCEEVFAPVVSLNPF--DTLDEAIAMAN 380
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 25777734 472 StTSYGLTGAVFSQDKDVVQEATKVLRnaAGNFYINDKSTGSiVGQQPFGGARASGT 528
Cdd:cd07149 381 D-SPYGLQAGVFTNDLQKALKAARELE--VGGVMINDSSTFR-VDHMPYGGVKESGT 433
ALDH_BenzADH-like cd07104
ALDH subfamily: NAD(P)+-dependent benzaldehyde dehydrogenase II, vanillin dehydrogenase, ...
102-543 4.21e-67

ALDH subfamily: NAD(P)+-dependent benzaldehyde dehydrogenase II, vanillin dehydrogenase, p-hydroxybenzaldehyde dehydrogenase and related proteins; ALDH subfamily which includes the NAD(P)+-dependent, benzaldehyde dehydrogenase II (XylC, BenzADH, EC=1.2.1.28) involved in the oxidation of benzyl alcohol to benzoate; p-hydroxybenzaldehyde dehydrogenase (PchA, HBenzADH) which catalyzes the oxidation of p-hydroxybenzaldehyde to p-hydroxybenzoic acid; vanillin dehydrogenase (Vdh, VaniDH) involved in the metabolism of ferulic acid as seen in Pseudomonas putida KT2440; and other related sequences.


Pssm-ID: 143422 [Multi-domain]  Cd Length: 431  Bit Score: 223.95  E-value: 4.21e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 102 LNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVGQ-GKTVIQAEIDAAAElIDFFRFNAKYAVEL 180
Cdd:cd07104   2 VDRAYAAAAAAQKAWAATPPQERAAILRKAAEILE--ERRDEIADWLIREsGSTRPKAAFEVGAA-IAILREAAGLPRRP 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 181 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPAL-MGNVVLWKPS-DTAMLASYAVYRILREAGLPPNI 258
Cdd:cd07104  79 EGEILPSDVPGKESMVRRVPLGVVGVISPFNFPLILAMRSVAPALaLGNAVVLKPDsRTPVTGGLLIAEIFEEAGLPKGV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 259 IQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRfhtfprLAGECGGKNFHFVHRSADVESVVSGTLR 338
Cdd:cd07104 159 LNVVPGGGSEIGDALVEHPRVRMISFTGSTAVGRHIGELAGRHLKK------VALELGGNNPLIVLDDADLDLAVSAAAF 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 339 SAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEHARSSpSLTILAG 418
Cdd:cd07104 233 GAFLHQGQICMAAGRILVHESVYDEFVEKLVAKAKALPVGDPRDP-DTVIGPLINERQVDRVHAIVEDAVAA-GARLLTG 310
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 419 GKCDdsvGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGLTGAVFSQDkdvVQEATKVLR 498
Cdd:cd07104 311 GTYE---GLFYQPTVLSDVTPDMPIFREEIFGPVAPVIPFDDD--EEAVELAND-TEYGLSAAVFTRD---LERAMAFAE 381
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 25777734 499 NA-AGNFYINDKST--GSIVgqqPFGGARASGTnDKPGGPHYI-----LRWTS 543
Cdd:cd07104 382 RLeTGMVHINDQTVndEPHV---PFGGVKASGG-GRFGGPASLeefteWQWIT 430
ALDH_LactADH_F420-Bios cd07145
Methanocaldococcus jannaschii NAD+-dependent lactaldehyde dehydrogenase-like; NAD+-dependent, ...
105-528 1.54e-66

Methanocaldococcus jannaschii NAD+-dependent lactaldehyde dehydrogenase-like; NAD+-dependent, lactaldehyde dehydrogenase (EC=1.2.1.22) involved the biosynthesis of coenzyme F(420) in Methanocaldococcus jannaschii through the oxidation of lactaldehyde to lactate and generation of NAPH, and similar sequences are included in this CD.


Pssm-ID: 143463 [Multi-domain]  Cd Length: 456  Bit Score: 222.99  E-value: 1.54e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 105 AIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVGQ-GKTVIQA--EIDAAAELidfFRFNAKYAVELE 181
Cdd:cd07145  26 AIEVAEKAKDVMSNLPAYKRYKILMKVAELIE--RRKEELAKLLTIEvGKPIKQSrvEVERTIRL---FKLAAEEAKVLR 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 182 GQqpisVPPSTNstvYRGLE-----------GFVAAISPFNFTAiggNLAG---APAL-MGNVVLWKPSDTAMLASYAVY 246
Cdd:cd07145 101 GE----TIPVDA---YEYNErriaftvrepiGVVGAITPFNFPA---NLFAhkiAPAIaVGNSVVVKPSSNTPLTAIELA 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 247 RILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQnldrfhTFPRLAGECGGKNFHFVHRS 326
Cdd:cd07145 171 KILEEAGLPPGVINVVTGYGSEVGDEIVTNPKVNMISFTGSTAVGLLIASKAGG------TGKKVALELGGSDPMIVLKD 244
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 327 ADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEH 406
Cdd:cd07145 245 ADLERAVSIAVRGRFENAGQVCNAVKRILVEEEVYDKFLKLLVEKVKKLKVGDPLDE-STDLGPLISPEAVERMENLVND 323
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 407 ARSSPSlTILAGGKCDDsvGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGLTGAVFSQD 486
Cdd:cd07145 324 AVEKGG-KILYGGKRDE--GSFFPPTVLENDTPDMIVMKEEVFGPVLPIAKVKDD--EEAVEIANS-TEYGLQASVFTND 397
                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 25777734 487 kdvVQEATKVLRN-AAGNFYINDKSTGSIvGQQPFGGARASGT 528
Cdd:cd07145 398 ---INRALKVARElEAGGVVINDSTRFRW-DNLPFGGFKKSGI 436
D1pyr5carbox3 TIGR01238
delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain); This model represents ...
25-545 6.51e-66

delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain); This model represents one of several related branches of delta-1-pyrroline-5-carboxylate dehydrogenase. Members of this branch are the C-terminal domain of the PutA bifunctional proline dehydrogenase / delta-1-pyrroline-5-carboxylate dehydrogenase. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273518 [Multi-domain]  Cd Length: 500  Bit Score: 222.86  E-value: 6.51e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734    25 KHTSSLKVANEPVLAFTQGSPERDALQKalkdlkgrMEAIPcVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNK 104
Cdd:TIGR01238   8 KNSLGIDLDNESELKPLEAQIHAWADKT--------WQAAP-IIGHSYKADGEAQPVTNPADRRDIVGQVFHANLAHVQA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   105 AIEAALAARKEWDLKPIADRAQIFLKAADMLSgPRRAEILAKTMVGQGKTVIQAeIDAAAELIDFFRFNAKYAVELEGQQ 184
Cdd:TIGR01238  79 AIDSAQQAFPTWNATPAKERAAKLDRLADLLE-LHMPELMALCVREAGKTIHNA-IAEVREAVDFCRYYAKQVRDVLGEF 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   185 piSVPPstnstvyrglEGFVAAISPFNFT-AI-GGNLAGAPAlMGNVVLWKPSD-TAMLASYAVyRILREAGLPPNIIQF 261
Cdd:TIGR01238 157 --SVES----------RGVFVCISPWNFPlAIfTGQISAALA-AGNTVIAKPAEqTSLIAYRAV-ELMQEAGFPAGTIQL 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDrfHTFPRLAgECGGKNFHFVHRSADVESVVSGTLRSAF 341
Cdd:TIGR01238 223 LPGRGADVGAALTSDPRIAGVAFTGSTEVAQLINQTLAQRED--APVPLIA-ETGGQNAMIVDSTALPEQVVRDVLRSAF 299
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   342 EYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEdFGTFFSAVIDAKSFARIKKWLEH----ARSSPSLTILA 417
Cdd:TIGR01238 300 DSAGQRCSALRVLCVQEDVADRVLTMIQGAMQELKVGVPHL-LTTDVGPVIDAEAKQNLLAHIEHmsqtQKKIAQLTLDD 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   418 GGKCDDsvGYFVEPCIVESKDPQEpiMKEEIFGPVLSVYVYpddKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATK 495
Cdd:TIGR01238 379 SRACQH--GTFVAPTLFELDDIAE--LSEEVFGPVLHVVRY---KARELDQIVDqiNQTGYGLTMGVHSRIETTYRWIEK 451
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 25777734   496 VLRnaAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQ 545
Cdd:TIGR01238 452 HAR--VGNCYVNRNQVGAVVGVQPFGGQGLSGTGPKAGGPHYLYRLTQVQ 499
ALDH_LactADH-AldA cd07088
Escherichia coli lactaldehyde dehydrogenase AldA-like; Lactaldehyde dehydrogenase from ...
88-507 1.35e-65

Escherichia coli lactaldehyde dehydrogenase AldA-like; Lactaldehyde dehydrogenase from Escherichia coli (AldA, LactADH, EC=1.2.1.22), an NAD(+)-dependent enzyme involved in the metabolism of L-fucose and L-rhamnose, and other similar sequences are present in this CD.


Pssm-ID: 143407 [Multi-domain]  Cd Length: 468  Bit Score: 220.98  E-value: 1.35e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  88 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVG-QGKTVIQA--EIDAAA 164
Cdd:cd07088  23 GEVVATVPAATAEDADRAVDAAEAAQKAWERLPAIERAAYLRKLADLIR--ENADELAKLIVEeQGKTLSLArvEVEFTA 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 165 eliDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIggnLAG---APALM-GNVVLWKPSDTAML 240
Cdd:cd07088 101 ---DYIDYMAEWARRIEGEIIPSDRPNENIFIFKVPIGVVAGILPWNFPFF---LIArklAPALVtGNTIVIKPSEETPL 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 241 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLdrfhTFPRLagECGGKNF 320
Cdd:cd07088 175 NALEFAELVDEAGLPAGVLNIVTGRGSVVGDALVAHPKVGMISLTGSTEAGQKIMEAAAENI----TKVSL--ELGGKAP 248
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 321 HFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARI 400
Cdd:cd07088 249 AIVMKDADLDLAVKAIVDSRIINCGQVCTCAERVYVHEDIYDEFMEKLVEKMKAVKVGDPFDA-ATDMGPLVNEAALDKV 327
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 401 KKWLEHARSSPSlTILAGGKCDDS-VGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYpdDKYKETLQLVDStTSYGLT 479
Cdd:cd07088 328 EEMVERAVEAGA-TLLTGGKRPEGeKGYFYEPTVLTNVRQDMEIVQEEIFGPVLPVVKF--SSLDEAIELAND-SEYGLT 403
                       410       420
                ....*....|....*....|....*...
gi 25777734 480 GAVFSQDKDVVQEATKVLRnaAGNFYIN 507
Cdd:cd07088 404 SYIYTENLNTAMRATNELE--FGETYIN 429
ALDH_AldA-AAD23400 cd07106
Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Putative ...
97-547 7.14e-65

Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Putative aldehyde dehydrogenase, AldA, from Streptomyces aureofaciens (locus AAD23400) and other similar sequences are present in this CD.


Pssm-ID: 143424 [Multi-domain]  Cd Length: 446  Bit Score: 218.55  E-value: 7.14e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  97 ADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLS--GPRRAEILAKTmvgQGKTVIQA--EIDAAAeliDFFRF 172
Cdd:cd07106  16 ASEAQLDQAVAAAKAAFPGWSATPLEERRAALLAIADAIEanAEELARLLTLE---QGKPLAEAqfEVGGAV---AWLRY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 173 NAKYAVELEGQQpiSVPPSTNSTVYRGLeGFVAAISPFNFTAIggnLAG---APALM-GNVVLWKPSDTAMLASYAVYRI 248
Cdd:cd07106  90 TASLDLPDEVIE--DDDTRRVELRRKPL-GVVAAIVPWNFPLL---LAAwkiAPALLaGNTVVLKPSPFTPLCTLKLGEL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 249 LREAgLPPNIIQFVPADGPLfGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRfhtfprLAGECGGKNFHFVHRSAD 328
Cdd:cd07106 164 AQEV-LPPGVLNVVSGGDEL-GPALTSHPDIRKISFTGSTATGKKVMASAAKTLKR------VTLELGGNDAAIVLPDVD 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 329 VESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEHAR 408
Cdd:cd07106 236 IDAVAPKLFWGAFINSGQVCAAIKRLYVHESIYDEFCEALVALAKAAVVGDGLDP-GTTLGPVQNKMQYDKVKELVEDAK 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 409 SSpSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGLTGAVFSQDkd 488
Cdd:cd07106 315 AK-GAKVLAGGEPLDGPGYFIPPTIVDDPPEGSRIVDEEQFGPVLPVLKYSDE--DEVIARAND-SEYGLGASVWSSD-- 388
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25777734 489 vVQEATKV-LRNAAGNFYINdkSTGSIVGQQPFGGARASGTndkpG---GPHYILRWTSPQVI 547
Cdd:cd07106 389 -LERAEAVaRRLEAGTVWIN--THGALDPDAPFGGHKQSGI----GvefGIEGLKEYTQTQVI 444
ALDH_VaniDH_like cd07150
Pseudomonas putida vanillin dehydrogenase-like; Vanillin dehydrogenase (Vdh, VaniDH) involved ...
103-543 3.95e-64

Pseudomonas putida vanillin dehydrogenase-like; Vanillin dehydrogenase (Vdh, VaniDH) involved in the metabolism of ferulic acid and other related sequences are included in this CD. The E. coli vanillin dehydrogenase (LigV) preferred NAD+ to NADP+ and exhibited a broad substrate preference, including vanillin, benzaldehyde, protocatechualdehyde, m-anisaldehyde, and p-hydroxybenzaldehyde.


Pssm-ID: 143468 [Multi-domain]  Cd Length: 451  Bit Score: 216.43  E-value: 3.95e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 103 NKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEG 182
Cdd:cd07150  24 ERAIAAAYDAFPAWAATTPSERERILLKAAEIME--RRADDLIDLLIDEGGSTYGKAWFETTFTPELLRAAAGECRRVRG 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 183 QQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPAL-MGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
Cdd:cd07150 102 ETLPSDSPGTVSMSVRRPLGVVAGITPFNYPLILATKKVAFALaAGNTVVLKPSEETPVIGLKIAEIMEEAGLPKGVFNV 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAqnldrfHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAF 341
Cdd:cd07150 182 VTGGGAEVGDELVDDPRVRMVTFTGSTAVGREIAEKAG------RHLKKITLELGGKNPLIVLADADLDYAVRAAAFGAF 255
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 342 EYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAeDFGTFFSAVIDAKSFARIKKWLEHARSSPSlTILAGGKC 421
Cdd:cd07150 256 MHQGQICMSASRIIVEEPVYDEFVKKFVARASKLKVGDPR-DPDTVIGPLISPRQVERIKRQVEDAVAKGA-KLLTGGKY 333
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 422 DdsvGYFVEPCIVESKDPQEPIMKEEIFGPVLSvyVYPDDKYKETLQLVDStTSYGLTGAVFSQDkdvVQEATKVLRNA- 500
Cdd:cd07150 334 D---GNFYQPTVLTDVTPDMRIFREETFGPVTS--VIPAKDAEEALELAND-TEYGLSAAILTND---LQRAFKLAERLe 404
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*...
gi 25777734 501 AGNFYINDkSTGSIVGQQPFGGARASGTNdKPGGPHYI-----LRWTS 543
Cdd:cd07150 405 SGMVHIND-PTILDEAHVPFGGVKASGFG-REGGEWSMeefteLKWIT 450
ALDH_F5_SSADH_GabD cd07103
Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; ...
88-527 8.11e-64

Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Succinate-semialdehyde dehydrogenase, mitochondrial (SSADH, GabD, EC=1.2.1.24) catalyzes the NAD+-dependent oxidation of succinate semialdehyde (SSA) to succinate. This group includes the human aldehyde dehydrogenase family 5 member A1 (ALDH5A1) which is a mitochondrial homotetramer that converts SSA to succinate in the last step of 4-aminobutyric acid (GABA) catabolism. This CD also includes the Arabidopsis SSADH gene product ALDH5F1. Mutations in this gene result in the accumulation of H2O2, suggesting a role in plant defense against the environmental stress of elevated reactive oxygen species.


Pssm-ID: 143421 [Multi-domain]  Cd Length: 451  Bit Score: 215.76  E-value: 8.11e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  88 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMV-GQGKTVIQA--EIDAAA 164
Cdd:cd07103   7 GEVIGEVPDAGAADADAAIDAAAAAFKTWRKTTARERAAILRRWADLIR--ERAEDLARLLTlEQGKPLAEArgEVDYAA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 165 eliDFFRFNAKYAVELEGQqpiSVPPSTNST---VYRGLEGFVAAISPFNFTAigGNLA--GAPAL-MGNVVLWKPSDTA 238
Cdd:cd07103  85 ---SFLEWFAEEARRIYGR---TIPSPAPGKrilVIKQPVGVVAAITPWNFPA--AMITrkIAPALaAGCTVVLKPAEET 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 239 MLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDrfhtfpRLAGECGGk 318
Cdd:cd07103 157 PLSALALAELAEEAGLPAGVLNVVTGSPAEIGEALCASPRVRKISFTGSTAVGKLLMAQAADTVK------RVSLELGG- 229
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 319 NFHF-VHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSF 397
Cdd:cd07103 230 NAPFiVFDDADLDKAVDGAIASKFRNAGQTCVCANRIYVHESIYDEFVEKLVERVKKLKVGNGLDE-GTDMGPLINERAV 308
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 398 ARIKKWLEHARSSPSlTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYG 477
Cdd:cd07103 309 EKVEALVEDAVAKGA-KVLTGGKRLGLGGYFYEPTVLTDVTDDMLIMNEETFGPVAPIIPFDTE--DEVIARAND-TPYG 384
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|.
gi 25777734 478 LTGAVFSQDKDVVQEATKVLRnaAGNFYINdksTGSIVG-QQPFGGARASG 527
Cdd:cd07103 385 LAAYVFTRDLARAWRVAEALE--AGMVGIN---TGLISDaEAPFGGVKESG 430
ALDH_F7_AASADH-like cd07086
NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase and related proteins; ALDH ...
67-527 1.19e-63

NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase and related proteins; ALDH subfamily which includes the NAD+-dependent, alpha-aminoadipic semialdehyde dehydrogenase (AASADH, EC=1.2.1.31), also known as Antiquitin-1, ALDH7A1, ALDH7B or delta-1-piperideine-6-carboxylate dehydrogenase (P6CDH), and other similar sequences, such as the uncharacterized aldehyde dehydrogenase of Candidatus kuenenia AldH (locus CAJ73105).


Pssm-ID: 143405 [Multi-domain]  Cd Length: 478  Bit Score: 215.89  E-value: 1.19e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  67 VVGDEEVWTSdvqyqVSPFNhGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAK 146
Cdd:cd07086   8 VGSGGETFTS-----RNPAN-GEPIARVFPASPEDVEAAVAAAREAFKEWRKVPAPRRGEIVRQIGEALR--KKKEALGR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 147 TM---VGQGKTVIQAEIDaaaELIDFfrfnAKYAVELEGQQPISVPPSTNS-----TVYRGLeGFVAAISPFNF-TAIGG 217
Cdd:cd07086  80 LVsleMGKILPEGLGEVQ---EMIDI----CDYAVGLSRMLYGLTIPSERPghrlmEQWNPL-GVVGVITAFNFpVAVPG 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 218 -NLAgaPALM-GNVVLWKPSDTAMLASYAVYRILREA----GLPPNIIQFVPADGPlFGDTVTSSEHLCGINFTGSVPTf 291
Cdd:cd07086 152 wNAA--IALVcGNTVVWKPSETTPLTAIAVTKILAEVleknGLPPGVVNLVTGGGD-GGELLVHDPRVPLVSFTGSTEV- 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 292 khlWKQVAQNLDRfhTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEE 371
Cdd:cd07086 228 ---GRRVGETVAR--RFGRVLLELGGNNAIIVMDDADLDLAVRAVLFAAVGTAGQRCTTTRRLIVHESVYDEFLERLVKA 302
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 372 HSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEHARSSpSLTILAGGKC--DDSVGYFVEPCIVESKDPQEPIMKEEIF 449
Cdd:cd07086 303 YKQVRIGDPLDE-GTLVGPLINQAAVEKYLNAIEIAKSQ-GGTVLTGGKRidGGEPGNYVEPTIVTGVTDDARIVQEETF 380
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 450 GPVLsvYVYPDDKYKETLQLVDStTSYGLTGAVFSQDkdvVQEATKVLRNA---AGNFYINDKSTGSIVGqQPFGGARAS 526
Cdd:cd07086 381 APIL--YVIKFDSLEEAIAINND-VPQGLSSSIFTED---LREAFRWLGPKgsdCGIVNVNIPTSGAEIG-GAFGGEKET 453

                .
gi 25777734 527 G 527
Cdd:cd07086 454 G 454
ALDH_AldH-CAJ73105 cd07131
Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; ...
91-542 1.69e-63

Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Uncharacterized aldehyde dehydrogenase of Candidatus kuenenia AldH (locus CAJ73105) and similar sequences with similarity to alpha-aminoadipic semialdehyde dehydrogenase (AASADH, human ALDH7A1, EC=1.2.1.31), Arabidopsis ALDH7B4, and Streptomyces clavuligerus delta-1-piperideine-6-carboxylate dehydrogenase (P6CDH) are included in this CD.


Pssm-ID: 143449 [Multi-domain]  Cd Length: 478  Bit Score: 215.67  E-value: 1.69e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  91 VAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVGQ-GKTVIQAEIDAAaELIDF 169
Cdd:cd07131  28 VGTFPLSTASDVDAAVEAAREAFPEWRKVPAPRRAEYLFRAAELLK--KRKEELARLVTREmGKPLAEGRGDVQ-EAIDM 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 170 FRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNF-TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRI 248
Cdd:cd07131 105 AQYAAGEGRRLFGETVPSELPNKDAMTRRQPIGVVALITPWNFpVAIPSWKIFPALVCGNTVVFKPAEDTPACALKLVEL 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 249 LREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQnldrfhTFPRLAGECGGKNFHFVHRSAD 328
Cdd:cd07131 185 FAEAGLPPGVVNVVHGRGEEVGEALVEHPDVDVVSFTGSTEVGERIGETCAR------PNKRVALEMGGKNPIIVMDDAD 258
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 329 VESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEHAR 408
Cdd:cd07131 259 LDLALEGALWSAFGTTGQRCTATSRLIVHESVYDEFLKRFVERAKRLRVGDGLDE-ETDMGPLINEAQLEKVLNYNEIGK 337
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 409 SSpSLTILAGG----KCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSvyVYPDDKYKETLQLVDStTSYGLTGAVFS 484
Cdd:cd07131 338 EE-GATLLLGGerltGGGYEKGYFVEPTVFTDVTPDMRIAQEEIFGPVVA--LIEVSSLEEAIEIAND-TEYGLSSAIYT 413
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 25777734 485 QDkdvVQEATKVLRNA-AGNFYINDKSTGSIVgQQPFGGARASGTNDKPGGPHYILRWT 542
Cdd:cd07131 414 ED---VNKAFRARRDLeAGITYVNAPTIGAEV-HLPFGGVKKSGNGHREAGTTALDAFT 468
ALDH_F8_HMSADH cd07093
Human aldehyde dehydrogenase family 8 member A1-like; In humans, the aldehyde dehydrogenase ...
82-528 7.86e-63

Human aldehyde dehydrogenase family 8 member A1-like; In humans, the aldehyde dehydrogenase family 8 member A1 (ALDH8A1) protein functions to convert 9-cis-retinal to 9-cis-retinoic acid and has a preference for NAD+. Also included in this CD is the 2-hydroxymuconic semialdehyde dehydrogenase (HMSADH) which catalyzes the conversion of 2-hydroxymuconic semialdehyde to 4-oxalocrotonate, a step in the meta cleavage pathway of aromatic hydrocarbons in bacteria. Such HMSADHs seen here are: XylG of the TOL plasmid pWW0 of Pseudomonas putida, TomC of Burkholderia cepacia G4, and AphC of Comamonas testosterone.


Pssm-ID: 143412 [Multi-domain]  Cd Length: 455  Bit Score: 213.20  E-value: 7.86e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  82 VSPFNhGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGpRRAEILAKTMVGQGKTVIQA--- 158
Cdd:cd07093   2 FNPAT-GEVLAKVPEGGAAEVDAAVAAAKEAFPGWSRMSPAERARILHKVADLIEA-RADELALLESLDTGKPITLArtr 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 159 EIDAAAElidFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLeGFVAAISPFNFTAIggnLAG---APAL-MGNVVLWKP 234
Cdd:cd07093  80 DIPRAAA---NFRFFADYILQLDGESYPQDGGALNYVLRQPV-GVAGLITPWNLPLM---LLTwkiAPALaFGNTVVLKP 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 235 SDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTfprlagE 314
Cdd:cd07093 153 SEWTPLTAWLLAELANEAGLPPGVVNVVHGFGPEAGAALVAHPDVDLISFTGETATGRTIMRAAAPNLKPVSL------E 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 315 CGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPaEDFGTFFSAVIDA 394
Cdd:cd07093 227 LGGKNPNIVFADADLDRAVDAAVRSSFSNNGEVCLAGSRILVQRSIYDEFLERFVERAKALKVGDP-LDPDTEVGPLISK 305
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 395 KSFARIKKWLEHARSSPSlTILAGGKCDDSV----GYFVEPCIVESKDPQEPIMKEEIFGPVLSvyVYPDDKYKETLQLV 470
Cdd:cd07093 306 EHLEKVLGYVELARAEGA-TILTGGGRPELPdlegGYFVEPTVITGLDNDSRVAQEEIFGPVVT--VIPFDDEEEAIELA 382
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25777734 471 DSTTsYGLTGAVFSQDKDVVQEATKVLRnaAGNFYIN-----DKSTgsivgqqPFGGARASGT 528
Cdd:cd07093 383 NDTP-YGLAAYVWTRDLGRAHRVARRLE--AGTVWVNcwlvrDLRT-------PFGGVKASGI 435
ALDH_BADH-GbsA cd07119
Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Included in this CD is ...
82-527 2.54e-62

Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Included in this CD is the NAD+-dependent, betaine aldehyde dehydrogenase (BADH, GbsA, EC=1.2.1.8) of Bacillus subtilis involved in the synthesis of the osmoprotectant glycine betaine from choline or glycine betaine aldehyde.


Pssm-ID: 143437  Cd Length: 482  Bit Score: 212.56  E-value: 2.54e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  82 VSPFNhGHKVAKFCYADKSLLNKAIEAALAA--RKEWDLKPIADRAQIFLKAADMLSgpRRAEILAK-TMVGQGKTVIQA 158
Cdd:cd07119  18 INPAN-GEVIATVPEGTAEDAKRAIAAARRAfdSGEWPHLPAQERAALLFRIADKIR--EDAEELARlETLNTGKTLRES 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 159 EIDAAaELIDFFRFNAKYAVELEGQQpISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDT 237
Cdd:cd07119  95 EIDID-DVANCFRYYAGLATKETGEV-YDVPPHVISRTVREPVGVCGLITPWNYPLLQAAWKLAPALAaGNTVVIKPSEV 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 238 AMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNldrfhtFPRLAGECGG 317
Cdd:cd07119 173 TPLTTIALFELIEEAGLPAGVVNLVTGSGATVGAELAESPDVDLVSFTGGTATGRSIMRAAAGN------VKKVALELGG 246
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 318 KNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPaEDFGTFFSAVIDAKSF 397
Cdd:cd07119 247 KNPNIVFADADFETAVDQALNGVFFNAGQVCSAGSRLLVEESIHDKFVAALAERAKKIKLGNG-LDADTEMGPLVSAEHR 325
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 398 ARIKKWLEHARSSPSlTILAGGK------CDDsvGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVD 471
Cdd:cd07119 326 EKVLSYIQLGKEEGA-RLVCGGKrptgdeLAK--GYFVEPTIFDDVDRTMRIVQEEIFGPVLTVERFDTE--EEAIRLAN 400
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 25777734 472 STTsYGLTGAVFSQDKDVVQEATKVLRnaAGNFYINDksTGSIVGQQPFGGARASG 527
Cdd:cd07119 401 DTP-YGLAGAVWTKDIARANRVARRLR--AGTVWIND--YHPYFAEAPWGGYKQSG 451
ALDH_HBenzADH cd07151
NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; NADP+-dependent, ...
74-527 1.12e-61

NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; NADP+-dependent, p-hydroxybenzaldehyde dehydrogenase (PchA, HBenzADH) which catalyzes oxidation of p-hydroxybenzaldehyde to p-hydroxybenzoic acid and other related sequences are included in this CD.


Pssm-ID: 143469 [Multi-domain]  Cd Length: 465  Bit Score: 210.62  E-value: 1.12e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  74 WTSDVQyqvSPFNhGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgPRRAEILAKTMVGQGK 153
Cdd:cd07151  10 RTIDVL---NPYT-GETLAEIPAASKEDVDEAYRAAAAAQKEWAATLPQERAEILEKAAQILE-ERRDEIVEWLIRESGS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 154 TVIQAEIDAAAElIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAiggNLAG---APAL-MGNV 229
Cdd:cd07151  85 TRIKANIEWGAA-MAITREAATFPLRMEGRILPSDVPGKENRVYREPLGVVGVISPWNFPL---HLSMrsvAPALaLGNA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 230 VLWKP-SDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDrfhtf 308
Cdd:cd07151 161 VVLKPaSDTPITGGLLLAKIFEEAGLPKGVLNVVVGAGSEIGDAFVEHPVPRLISFTGSTPVGRHIGELAGRHLK----- 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 309 pRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFF 388
Cdd:cd07151 236 -KVALELGGNNPFVVLEDADIDAAVNAAVFGKFLHQGQICMAINRIIVHEDVYDEFVEKFVERVKALPYGDPSDP-DTVV 313
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 389 SAVIDAKSFARIKKWLEHARSSpSLTILAGGKCDDSVgyfVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQ 468
Cdd:cd07151 314 GPLINESQVDGLLDKIEQAVEE-GATLLVGGEAEGNV---LEPTVLSDVTNDMEIAREEIFGPVAPIIKADDE--EEALE 387
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25777734 469 LVDStTSYGLTGAVFSQDkdvVQEATKV-LRNAAGNFYINDKStgsiVGQQP---FGGARASG 527
Cdd:cd07151 388 LAND-TEYGLSGAVFTSD---LERGVQFaRRIDAGMTHINDQP----VNDEPhvpFGGEKNSG 442
ALDH_F21_LactADH-like cd07094
ALDH subfamily: NAD+-dependent, lactaldehyde dehydrogenase, ALDH family 21 A1, and related ...
82-527 1.13e-61

ALDH subfamily: NAD+-dependent, lactaldehyde dehydrogenase, ALDH family 21 A1, and related proteins; ALDH subfamily which includes Tortula ruralis aldehyde dehydrogenase ALDH21A1 (RNP123), and NAD+-dependent, lactaldehyde dehydrogenase (EC=1.2.1.22) and like sequences.


Pssm-ID: 143413 [Multi-domain]  Cd Length: 453  Bit Score: 209.98  E-value: 1.13e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  82 VSPFNhGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVGQ-GKTVIQA-- 158
Cdd:cd07094   4 HNPYD-GEVIGKVPADDRADAEEALATARAGAENRRALPPHERMAILERAADLLK--KRAEEFAKIIACEgGKPIKDArv 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 159 EIDAAaelIDFFRFNAKYAVELEGQQpISVPPSTNSTVYRGLE-----GFVAAISPFNFTAiggNLAG---APAL-MGNV 229
Cdd:cd07094  81 EVDRA---IDTLRLAAEEAERIRGEE-IPLDATQGSDNRLAWTirepvGVVLAITPFNFPL---NLVAhklAPAIaTGCP 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 230 VLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAqnldrfhtFP 309
Cdd:cd07094 154 VVLKPASKTPLSALELAKILVEAGVPEGVLQVVTGEREVLGDAFAADERVAMLSFTGSAAVGEALRANAG--------GK 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 310 RLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFS 389
Cdd:cd07094 226 RIALELGGNAPVIVDRDADLDAAIEALAKGGFYHAGQVCISVQRIYVHEELYDEFIEAFVAAVKKLKVGDPLDE-DTDVG 304
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 390 AVIDAKSFARIKKWLEHARSSPSlTILAGGKCDDSVgyfVEPCIVESKDPQEPIMKEEIFGPVLSVYVYpdDKYKETLQL 469
Cdd:cd07094 305 PLISEEAAERVERWVEEAVEAGA-RLLCGGERDGAL---FKPTVLEDVPRDTKLSTEETFGPVVPIIRY--DDFEEAIRI 378
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 25777734 470 VDStTSYGLTGAVFSQDKDVVQEATKVLRnaAGNFYINDkSTGSIVGQQPFGGARASG 527
Cdd:cd07094 379 ANS-TDYGLQAGIFTRDLNVAFKAAEKLE--VGGVMVND-SSAFRTDWMPFGGVKESG 432
ALDH_F9_TMBADH cd07090
NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; NAD+-dependent, ...
88-527 3.50e-61

NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; NAD+-dependent, 4-trimethylaminobutyraldehyde dehydrogenase (TMABADH, EC=1.2.1.47), also known as aldehyde dehydrogenase family 9 member A1 (ALDH9A1) in humans, is a cytosolic tetramer which catalyzes the oxidation of gamma-aminobutyraldehyde involved in 4-aminobutyric acid (GABA) biosynthesis and also oxidizes betaine aldehyde (gamma-trimethylaminobutyraldehyde) which is involved in carnitine biosynthesis.


Pssm-ID: 143409 [Multi-domain]  Cd Length: 457  Bit Score: 209.08  E-value: 3.50e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  88 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgPRRAEILAKTMVGQGKTV--IQAEIDAAAE 165
Cdd:cd07090   7 GEVLATVHCAGAEDVDLAVKSAKAAQKEWSATSGMERGRILRKAADLLR-ERNDEIARLETIDNGKPIeeARVDIDSSAD 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 166 LIDFFrfnAKYAVELEGQQpisVPPSTNSTVYRGLE--GFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLAS 242
Cdd:cd07090  86 CLEYY---AGLAPTLSGEH---VPLPGGSFAYTRREplGVCAGIGAWNYPIQIASWKSAPALAcGNAMVYKPSPFTPLTA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 243 YAVYRILREAGLPPNIIQFVPADGPLfGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRfhtfprLAGECGGKNFHF 322
Cdd:cd07090 160 LLLAEILTEAGLPDGVFNVVQGGGET-GQLLCEHPDVAKVSFTGSVPTGKKVMSAAAKGIKH------VTLELGGKSPLI 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 323 VHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAeDFGTFFSAVIDAKSFARIKK 402
Cdd:cd07090 233 IFDDADLENAVNGAMMANFLSQGQVCSNGTRVFVQRSIKDEFTERLVERTKKIRIGDPL-DEDTQMGALISEEHLEKVLG 311
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 403 WLEHARSSPSlTILAGG-------KCDDsvGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYpdDKYKETLQLVDSTTs 475
Cdd:cd07090 312 YIESAKQEGA-KVLCGGervvpedGLEN--GFYVSPCVLTDCTDDMTIVREEIFGPVMSILPF--DTEEEVIRRANDTT- 385
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 25777734 476 YGLTGAVFSQDkdvVQEATKVLRN-AAGNFYINDKSTGSIvgQQPFGGARASG 527
Cdd:cd07090 386 YGLAAGVFTRD---LQRAHRVIAQlQAGTCWINTYNISPV--EVPFGGYKQSG 433
ALDH_HMSADH_HapE cd07115
Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; 4-hydroxymuconic ...
88-527 4.92e-61

Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; 4-hydroxymuconic semialdehyde dehydrogenase (HapE, EC=1.2.1.61) of Pseudomonas fluorescens ACB involved in 4-hydroxyacetophenone degradation, and putative hydroxycaproate semialdehyde dehydrogenase (ChnE) of Brachymonas petroleovorans involved in cyclohexane metabolism, and other similar sequences, are present in this CD.


Pssm-ID: 143433 [Multi-domain]  Cd Length: 453  Bit Score: 208.45  E-value: 4.92e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  88 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGpRRAEILAKTMVGQGKTVIQAEIDAAAELI 167
Cdd:cd07115   7 GELIARVAQASAEDVDAAVAAARAAFEAWSAMDPAERGRILWRLAELILA-NADELARLESLDTGKPIRAARRLDVPRAA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 168 DFFRFNAKYAVELEGQQ-PISvPPSTNSTVyRGLEGFVAAISPFNFTAIGGNLAGAPAL-MGNVVLWKPSDTAMLASYAV 245
Cdd:cd07115  86 DTFRYYAGWADKIEGEViPVR-GPFLNYTV-REPVGVVGAIVPWNFPLMFAAWKVAPALaAGNTVVLKPAELTPLSALRI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 246 YRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRfhtfprLAGECGGKNFHFVHR 325
Cdd:cd07115 164 AELMAEAGFPAGVLNVVTGFGEVAGAALVEHPDVDKITFTGSTAVGRKIMQGAAGNLKR------VSLELGGKSANIVFA 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 326 SADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAeDFGTFFSAVIDAKSFARIKKWLE 405
Cdd:cd07115 238 DADLDAAVRAAATGIFYNQGQMCTAGSRLLVHESIYDEFLERFTSLARSLRPGDPL-DPKTQMGPLVSQAQFDRVLDYVD 316
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 406 HARSSPSlTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDSTTsYGLTGAVFSQ 485
Cdd:cd07115 317 VGREEGA-RLLTGGKRPGARGFFVEPTIFAAVPPEMRIAQEEIFGPVVSVMRFRDE--EEALRIANGTE-YGLAAGVWTR 392
                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 25777734 486 DKDVVQEATKVLRnaAGNFYINdkSTGSIVGQQPFGGARASG 527
Cdd:cd07115 393 DLGRAHRVAAALK--AGTVWIN--TYNRFDPGSPFGGYKQSG 430
ALDH_DhaS cd07114
Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Uncharacterized ...
87-527 1.23e-60

Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Uncharacterized aldehyde dehydrogenase from Candidatus pelagibacter (DhaS) and other related sequences are present in this CD.


Pssm-ID: 143432 [Multi-domain]  Cd Length: 457  Bit Score: 207.40  E-value: 1.23e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  87 HGHKVAKFCYADKSLLNKAIEAALAA--RKEW-DLKPIAdRAQIFLKAADMLSgpRRAEILAKTMVGQ-GKTViqAEIDA 162
Cdd:cd07114   6 TGEPWARVPEASAADVDRAVAAARAAfeGGAWrKLTPTE-RGKLLRRLADLIE--ANAEELAELETRDnGKLI--RETRA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 163 -AAELIDFFRFNAKYAVELEGQ-QPISVPPSTNSTVYRGLeGFVAAISPFN----FTAiggnLAGAPAL-MGNVVLWKPS 235
Cdd:cd07114  81 qVRYLAEWYRYYAGLADKIEGAvIPVDKGDYLNFTRREPL-GVVAAITPWNspllLLA----KKLAPALaAGNTVVLKPS 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 236 DTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNldrfhtFPRLAGEC 315
Cdd:cd07114 156 EHTPASTLELAKLAEEAGFPPGVVNVVTGFGPETGEALVEHPLVAKIAFTGGTETGRHIARAAAEN------LAPVTLEL 229
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 316 GGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAK 395
Cdd:cd07114 230 GGKSPNIVFDDADLDAAVNGVVAGIFAAAGQTCVAGSRLLVQRSIYDEFVERLVARARAIRVGDPLDP-ETQMGPLATER 308
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 396 SFARIKKWLEHARSSPSlTILAGGK----CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVD 471
Cdd:cd07114 309 QLEKVERYVARAREEGA-RVLTGGErpsgADLGAGYFFEPTILADVTNDMRIAQEEVFGPVLSVIPFDDE--EEAIALAN 385
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 25777734 472 StTSYGLTGAVFSQDKDVVQEATKVLRnaAGNFYINDKSTGSIVgqQPFGGARASG 527
Cdd:cd07114 386 D-SEYGLAAGIWTRDLARAHRVARAIE--AGTVWVNTYRALSPS--SPFGGFKDSG 436
ALDH_SSADH2_GabD2 cd07101
Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Succinate-semialdehyde ...
83-549 6.99e-59

Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Succinate-semialdehyde dehydrogenase 2 (SSADH2) and similar proteins are in this CD. SSADH1 (GabD1, EC=1.2.1.16) catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. SSADH activity in Mycobacterium tuberculosis is encoded by both gabD1 (Rv0234c) and gabD2 (Rv1731), however ,the Vmax of GabD1 was shown to be much higher than that of GabD2, and GabD2 (SSADH2) is likely to serve physiologically as a dehydrogenase for a different aldehyde(s).


Pssm-ID: 143419 [Multi-domain]  Cd Length: 454  Bit Score: 202.54  E-value: 6.99e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  83 SPFNhGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgPRRAEILAKTMVGQGKTVIQA--EI 160
Cdd:cd07101   2 APFT-GEPLGELPQSTPADVEAAFARARAAQRAWAARPFAERAAVFLRFHDLVL-ERRDELLDLIQLETGKARRHAfeEV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 161 DAAAELIDFFRFNAKYAVELEGQQPiSVPPSTNSTVYRGLEGFVAAISPFNF---TAIGGNLagaPALM-GNVVLWKPSD 236
Cdd:cd07101  80 LDVAIVARYYARRAERLLKPRRRRG-AIPVLTRTTVNRRPKGVVGVISPWNYpltLAVSDAI---PALLaGNAVVLKPDS 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 237 TAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTssEHLCGINFTGSVPTFKHLWKQVAQNLDRFhtfprlAGECG 316
Cdd:cd07101 156 QTALTALWAVELLIEAGLPRDLWQVVTGPGSEVGGAIV--DNADYVMFTGSTATGRVVAERAGRRLIGC------SLELG 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 317 GKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGdPAEDFGTFFSAVIDAKS 396
Cdd:cd07101 228 GKNPMIVLEDADLDKAAAGAVRACFSNAGQLCVSIERIYVHESVYDEFVRRFVARTRALRLG-AALDYGPDMGSLISQAQ 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 397 FARIKKWLEHARSSPSlTILAGGKCDDSVG-YFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTS 475
Cdd:cd07101 307 LDRVTAHVDDAVAKGA-TVLAGGRARPDLGpYFYEPTVLTGVTEDMELFAEETFGPVVSIYRVADD--DEAIELAND-TD 382
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25777734 476 YGLTGAVFSQDKDVVQEATKVLRnaAGNFYIND---KSTGSIvgQQPFGGARASGTNDKpGGPHYILRWTSPQVIKE 549
Cdd:cd07101 383 YGLNASVWTRDGARGRRIAARLR--AGTVNVNEgyaAAWASI--DAPMGGMKDSGLGRR-HGAEGLLKYTETQTVAV 454
ALDH_CddD-AldA-like cd07089
Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; The 6-oxolauric ...
97-527 1.45e-58

Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; The 6-oxolauric acid dehydrogenase (CddD) from Rhodococcus ruber SC1 which converts 6-oxolauric acid to dodecanedioic acid; and the aldehyde dehydrogenase (locus SSP0762) from Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 and also, the Mycobacterium tuberculosis H37Rv ALDH AldA (locus Rv0768) sequence; and other similar sequences, are included in this CD.


Pssm-ID: 143408 [Multi-domain]  Cd Length: 459  Bit Score: 202.09  E-value: 1.45e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  97 ADKSLLNKAIEAALAARKEWDLK-PIADRAQIFLKAADMLSgpRRAEILAKTMVGQ-GKTVIQAEIDAAAELIDFFRFNA 174
Cdd:cd07089  16 AGAADVDAAIAAARRAFDTGDWStDAEERARCLRQLHEALE--ARKEELRALLVAEvGAPVMTARAMQVDGPIGHLRYFA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 175 KYAVELEGQQPISVPPS----TNSTVYRGLEGFVAAISPFNFtAIGGNLAG-APAL-MGNVVLWKPSDTAMLASYAVYRI 248
Cdd:cd07089  94 DLADSFPWEFDLPVPALrggpGRRVVRREPVGVVAAITPWNF-PFFLNLAKlAPALaAGNTVVLKPAPDTPLSALLLGEI 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 249 LREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTfprlagECGGKNFHFVHRSAD 328
Cdd:cd07089 173 IAETDLPAGVVNVVTGSDNAVGEALTTDPRVDMVSFTGSTAVGRRIMAQAAATLKRVLL------ELGGKSANIVLDDAD 246
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 329 VESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAeDFGTFFSAVIDAKSFARIKKWLEHAR 408
Cdd:cd07089 247 LAAAAPAAVGVCMHNAGQGCALTTRLLVPRSRYDEVVEALAAAFEALPVGDPA-DPGTVMGPLISAAQRDRVEGYIARGR 325
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 409 SSPSlTILAGGKCDDS--VGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGLTGAVFSQD 486
Cdd:cd07089 326 DEGA-RLVTGGGRPAGldKGFYVEPTLFADVDNDMRIAQEEIFGPVLVVIPYDDD--DEAVRIAND-SDYGLSGGVWSAD 401
                       410       420       430       440
                ....*....|....*....|....*....|....*....|.
gi 25777734 487 KDVVQEATKVLRnaAGNFYINDKSTGSIVGqqPFGGARASG 527
Cdd:cd07089 402 VDRAYRVARRIR--TGSVGINGGGGYGPDA--PFGGYKQSG 438
ALDH_PADH_NahF cd07113
Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; NAD+-dependent, ...
88-545 1.54e-58

Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; NAD+-dependent, homodimeric, phenylacetaldehyde dehydrogenase (PADH, EC=1.2.1.39) PadA of Escherichia coli involved in the catabolism of 2-phenylethylamine, and other related sequences, are present in this CD. Also included is the Pseudomonas fluorescens ST StyD PADH involved in styrene catabolism, the Sphingomonas sp. LB126 FldD protein involved in fluorene degradation, and the Novosphingobium aromaticivorans NahF salicylaldehyde dehydrogenase involved in the NAD+-dependent conversion of salicylaldehyde to salicylate.


Pssm-ID: 143431  Cd Length: 477  Bit Score: 202.29  E-value: 1.54e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  88 GHKVAKFCYADKSLLNKAIEAALAA-RKEWDLKPIADRAQIFLKAADMLSGpRRAEILAKTMVGQGKTVIQAEIDAAAEL 166
Cdd:cd07113  25 EQVIASVASATEADVDAAVASAWRAfVSAWAKTTPAERGRILLRLADLIEQ-HGEELAQLETLCSGKSIHLSRAFEVGQS 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 167 IDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE-----GFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAML 240
Cdd:cd07113 104 ANFLRYFAGWATKINGETLAPSIPSMQGERYTAFTrrepvGVVAGIVPWNFSVMIAVWKIGAALAtGCTIVIKPSEFTPL 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 241 ASYAVYRILREAGLPPNIIQFVPADGPLfGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTfprlagECGGKNF 320
Cdd:cd07113 184 TLLRVAELAKEAGIPDGVLNVVNGKGAV-GAQLISHPDVAKVSFTGSVATGKKIGRQAASDLTRVTL------ELGGKNA 256
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 321 HFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARI 400
Cdd:cd07113 257 AAFLKDADIDWVVEGLLTAGFLHQGQVCAAPERFYVHRSKFDELVTKLKQALSSFQVGSPMDE-SVMFGPLANQPHFDKV 335
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 401 KKWLEHARSSPSlTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGLTG 480
Cdd:cd07113 336 CSYLDDARAEGD-EIVRGGEALAGEGYFVQPTLVLARSADSRLMREETFGPVVSFVPYEDE--EELIQLIND-TPFGLTA 411
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25777734 481 AVFSQDkdvvqeATKVLRNA----AGNFYIN-----DKSTgsivgqqPFGGARASGTNdKPGGPHYILRWTSPQ 545
Cdd:cd07113 412 SVWTNN------LSKALRYIprieAGTVWVNmhtflDPAV-------PFGGMKQSGIG-REFGSAFIDDYTELK 471
ALDH_MGR_2402 cd07108
Magnetospirillum NAD(P)+-dependent aldehyde dehydrogenase MSR-1-like; NAD(P)+-dependent ...
82-527 2.48e-58

Magnetospirillum NAD(P)+-dependent aldehyde dehydrogenase MSR-1-like; NAD(P)+-dependent aldehyde dehydrogenase of Magnetospirillum gryphiswaldense MSR-1 (MGR_2402) , and other similar sequences, are present in this CD.


Pssm-ID: 143426  Cd Length: 457  Bit Score: 201.44  E-value: 2.48e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  82 VSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGprRAEILAKTMVGQ-GKTV-IQAE 159
Cdd:cd07108   1 VINPATGQVIGEVPRSRAADVDRAVAAAKAAFPEWAATPARERGKLLARIADALEA--RSEELARLLALEtGNALrTQAR 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 160 IDAAAeLIDFFRFNAKYAVELEGQqpiSVPPSTNSTVYRGLE--GFVAAISPFNFTAIGGNLAGAPAL-MGNVVLWKPSD 236
Cdd:cd07108  79 PEAAV-LADLFRYFGGLAGELKGE---TLPFGPDVLTYTVREplGVVGAILPWNAPLMLAALKIAPALvAGNTVVLKAAE 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 237 TAMLASYAVYRILREAgLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAqnldrfhtfPRLAG--- 313
Cdd:cd07108 155 DAPLAVLLLAEILAQV-LPAGVLNVITGYGEECGAALVDHPDVDKVTFTGSTEVGKIIYRAAA---------DRLIPvsl 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 314 ECGGKNFHFVHRSADVESVVSGTLRSA-FEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDP---AEDFGtffs 389
Cdd:cd07108 225 ELGGKSPMIVFPDADLDDAVDGAIAGMrFTRQGQSCTAGSRLFVHEDIYDAFLEKLVAKLSKLKIGDPldeATDIG---- 300
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 390 AVIDAKSFARIKKWLEHARSSPSLTILAGGK----CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDdkYKE 465
Cdd:cd07108 301 AIISEKQFAKVCGYIDLGLSTSGATVLRGGPlpgeGPLADGFFVQPTIFSGVDNEWRLAREEIFGPVLCAIPWKD--EDE 378
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25777734 466 TLQLVDSTTsYGLTGAVFSQDKDVVQEATKVLRnaAGNFYINDKstgsiVGQQP---FGGARASG 527
Cdd:cd07108 379 VIAMANDSH-YGLAAYVWTRDLGRALRAAHALE--AGWVQVNQG-----GGQQPgqsYGGFKQSG 435
ALDH_PhdK-like cd07107
Nocardioides 2-carboxybenzaldehyde dehydrogenase, PhdK-like; Nocardioides sp. strain ...
105-528 5.12e-58

Nocardioides 2-carboxybenzaldehyde dehydrogenase, PhdK-like; Nocardioides sp. strain KP72-carboxybenzaldehyde dehydrogenase (PhdK), an enzyme involved in phenanthrene degradation, and other similar sequences, are present in this CD.


Pssm-ID: 143425 [Multi-domain]  Cd Length: 456  Bit Score: 200.29  E-value: 5.12e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 105 AIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVGQGKTVIQA---EIDAAAELIDFFrfnAKYAVELE 181
Cdd:cd07107  24 AVAAARAAFPEWRATTPLERARMLRELATRLR--EHAEELALIDALDCGNPVSAmlgDVMVAAALLDYF---AGLVTELK 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 182 GQqpiSVPPSTNSTVYRGLE--GFVAAISPFN----FTAigGNLAgAPALMGNVVLWKPSDTAMLASYAVYRILREAgLP 255
Cdd:cd07107  99 GE---TIPVGGRNLHYTLREpyGVVARIVAFNhplmFAA--AKIA-APLAAGNTVVVKPPEQAPLSALRLAELAREV-LP 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 256 PNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQnldrfhTFPRLAGECGGKNFHFVHRSADVESVVSG 335
Cdd:cd07107 172 PGVFNILPGDGATAGAALVRHPDVKRIALIGSVPTGRAIMRAAAE------GIKHVTLELGGKNALIVFPDADPEAAADA 245
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 336 TLRSA-FEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEHARSSPSLT 414
Cdd:cd07107 246 AVAGMnFTWCGQSCGSTSRLFVHESIYDEVLARVVERVAAIKVGDPTDP-ATTMGPLVSRQQYDRVMHYIDSAKREGARL 324
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 415 ILAGGKCDDSV---GYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGLTGAVFSQDkdvVQ 491
Cdd:cd07107 325 VTGGGRPEGPAlegGFYVEPTVFADVTPGMRIAREEIFGPVLSVLRWRDE--AEMVAQANG-VEYGLTAAIWTND---IS 398
                       410       420       430       440
                ....*....|....*....|....*....|....*....|.
gi 25777734 492 EATKVLRNA-AGNFYINDKST---GSivgqqPFGGARASGT 528
Cdd:cd07107 399 QAHRTARRVeAGYVWINGSSRhflGA-----PFGGVKNSGI 434
ALDH_SNDH cd07118
Gluconobacter oxydans L-sorbosone dehydrogenase-like; Included in this CD is the L-sorbosone ...
82-527 1.10e-57

Gluconobacter oxydans L-sorbosone dehydrogenase-like; Included in this CD is the L-sorbosone dehydrogenase (SNDH) from Gluconobacter oxydans UV10. In G. oxydans, D-sorbitol is converted to 2-keto-L-gulonate (a precursor of L-ascorbic acid) in sequential oxidation steps catalyzed by a FAD-dependent, L-sorbose dehydrogenase and an NAD(P)+-dependent, L-sorbosone dehydrogenase.


Pssm-ID: 143436 [Multi-domain]  Cd Length: 454  Bit Score: 199.49  E-value: 1.10e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  82 VSPfNHGHKVAKFCYADKSLLNKAIEAALAA--RKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVGQ-GKTVIQA 158
Cdd:cd07118   2 RSP-AHGVVVARYAEGTVEDVDAAVAAARKAfdKGPWPRMSGAERAAVLLKVADLIR--ARRERLALIETLEsGKPISQA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 159 --EIDAAAELidfFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTA--IGGNLAGAPAlMGNVVLWKP 234
Cdd:cd07118  79 rgEIEGAADL---WRYAASLARTLHGDSYNNLGDDMLGLVLREPIGVVGIITPWNFPFliLSQKLPFALA-AGCTVVVKP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 235 SD-----TAMLAsyavyRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRfhtfp 309
Cdd:cd07118 155 SEftsgtTLMLA-----ELLIEAGLPAGVVNIVTGYGATVGQAMTEHPDVDMVSFTGSTRVGKAIAAAAARNLKK----- 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 310 rLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFS 389
Cdd:cd07118 225 -VSLELGGKNPQIVFADADLDAAADAVVFGVYFNAGECCNSGSRLLVHESIADAFVAAVVARSRKVRVGDPLDP-ETKVG 302
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 390 AVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYpdDKYKETLQL 469
Cdd:cd07118 303 AIINEAQLAKITDYVDAGRAEGATLLLGGERLASAAGLFYQPTIFTDVTPDMAIAREEIFGPVLSVLTF--DTVDEAIAL 380
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 25777734 470 VDStTSYGLTGAVFSQDKDVVQEATKVLRnaAGNFYINDKSTGSIvgQQPFGGARASG 527
Cdd:cd07118 381 AND-TVYGLSAGVWSKDIDTALTVARRIR--AGTVWVNTFLDGSP--ELPFGGFKQSG 433
gabD2 PRK09407
succinic semialdehyde dehydrogenase; Reviewed
104-555 2.78e-57

succinic semialdehyde dehydrogenase; Reviewed


Pssm-ID: 236501 [Multi-domain]  Cd Length: 524  Bit Score: 200.10  E-value: 2.78e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  104 KAIEAALAARKEWDLKPIADRAQIFLKAADMLSGpRRAEILaktmvgqgkTVIQAEI-----DAAAELIDFF---RFNAK 175
Cdd:PRK09407  58 AAFARARAAQRAWAATPVRERAAVLLRFHDLVLE-NREELL---------DLVQLETgkarrHAFEEVLDVAltaRYYAR 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  176 YAVELEGQQPIS--VPPSTNSTVYRGLEGFVAAISPFNF---TAIGGNLagaPALM-GNVVLWKP-SDTAMLASYAVyRI 248
Cdd:PRK09407 128 RAPKLLAPRRRAgaLPVLTKTTELRQPKGVVGVISPWNYpltLAVSDAI---PALLaGNAVVLKPdSQTPLTALAAV-EL 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  249 LREAGLPPNIIQFVPADGPLFGDTVT-SSEHLCginFTGSVPTFKHLWKQVAQNLDRFhtfprlAGECGGKNFHFVHRSA 327
Cdd:PRK09407 204 LYEAGLPRDLWQVVTGPGPVVGTALVdNADYLM---FTGSTATGRVLAEQAGRRLIGF------SLELGGKNPMIVLDDA 274
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  328 DVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGdPAEDFGTFFSAVIDAKSFARIKKWLEHA 407
Cdd:PRK09407 275 DLDKAAAGAVRACFSNAGQLCISIERIYVHESIYDEFVRAFVAAVRAMRLG-AGYDYSADMGSLISEAQLETVSAHVDDA 353
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  408 RSSPSlTILAGGKCDDSVG-YFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDSTTsYGLTGAVFSQD 486
Cdd:PRK09407 354 VAKGA-TVLAGGKARPDLGpLFYEPTVLTGVTPDMELAREETFGPVVSVYPVADV--DEAVERANDTP-YGLNASVWTGD 429
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25777734  487 KDVVQEATKVLRnaAGNFYINDKST---GSIvgQQPFGGARASGTNDKpGGPHYILRWTSPQVIKETHK-PLG 555
Cdd:PRK09407 430 TARGRAIAARIR--AGTVNVNEGYAaawGSV--DAPMGGMKDSGLGRR-HGAEGLLKYTESQTIATQRVlPLA 497
ALDH_F21_RNP123 cd07147
Aldehyde dehydrogenase family 21A1-like; Aldehyde dehydrogenase ALDH21A1 (gene name RNP123) ...
82-527 6.06e-57

Aldehyde dehydrogenase family 21A1-like; Aldehyde dehydrogenase ALDH21A1 (gene name RNP123) was first described in the moss Tortula ruralis and is believed to play an important role in the detoxification of aldehydes generated in response to desiccation- and salinity-stress, and ALDH21A1 expression represents a unique stress tolerance mechanism. So far, of plants, only the bryophyte sequence has been observed, but similar protein sequences from bacteria and archaea are also present in this CD.


Pssm-ID: 143465 [Multi-domain]  Cd Length: 452  Bit Score: 197.47  E-value: 6.06e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  82 VSPFNhGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVGQ-GKTVIQAEI 160
Cdd:cd07147   4 TNPYT-GEVVARVALAGPDDIEEAIAAAVKAFRPMRALPAHRRAAILLHCVARLE--ERFEELAETIVLEaGKPIKDARG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 161 DAAaELIDFFRFNAKYAVELEGQ-QPISVPPSTNStvYRGL-----EGFVAAISPFNFTAiggNLAG---APAL-MGNVV 230
Cdd:cd07147  81 EVA-RAIDTFRIAAEEATRIYGEvLPLDISARGEG--RQGLvrrfpIGPVSAITPFNFPL---NLVAhkvAPAIaAGCPF 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 231 LWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLfGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNldrfhtfpR 310
Cdd:cd07147 155 VLKPASRTPLSALILGEVLAETGLPKGAFSVLPCSRDD-ADLLVTDERIKLLSFTGSPAVGWDLKARAGKK--------K 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 311 LAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSA 390
Cdd:cd07147 226 VVLELGGNAAVIVDSDADLDFAAQRIIFGAFYQAGQSCISVQRVLVHRSVYDEFKSRLVARVKALKTGDPKDD-ATDVGP 304
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 391 VIDAKSFARIKKWLEHARSSPSlTILAGGKCDDSVgyfVEPCIVESKDPQEPIMKEEIFGPVLSVYVYpdDKYKETLQLV 470
Cdd:cd07147 305 MISESEAERVEGWVNEAVDAGA-KLLTGGKRDGAL---LEPTILEDVPPDMEVNCEEVFGPVVTVEPY--DDFDEALAAV 378
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 25777734 471 DStTSYGLTGAVFSQDKDVVQEATKVLRnaAGNFYINDKSTGSiVGQQPFGGARASG 527
Cdd:cd07147 379 ND-SKFGLQAGVFTRDLEKALRAWDELE--VGGVVINDVPTFR-VDHMPYGGVKDSG 431
ALDH_AAS00426 cd07109
Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; ...
88-527 1.20e-55

Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Uncharacterized aldehyde dehydrogenase of Saccharopolyspora spinosa (AAS00426) and other similar sequences, are present in this CD.


Pssm-ID: 143427 [Multi-domain]  Cd Length: 454  Bit Score: 193.99  E-value: 1.20e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  88 GHKVAKFCYADKSLLNKAIEAALAA--RKEWDLKPiADRAQIFLKAADMLSgpRRAEILAKTM-VGQGKTVIQAEIDAAA 164
Cdd:cd07109   7 GEVFARIARGGAADVDRAVQAARRAfeSGWLRLSP-AERGRLLLRIARLIR--EHADELARLEsLDTGKPLTQARADVEA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 165 eLIDFFRFNAKYAVELEGQqpiSVPPSTNSTVYRGLE--GFVAAISPFNFTA-IGGNLAgAPAL-MGNVVLWKPSDTAML 240
Cdd:cd07109  84 -AARYFEYYGGAADKLHGE---TIPLGPGYFVYTVREphGVTGHIIPWNYPLqITGRSV-APALaAGNAVVVKPAEDAPL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 241 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNldrfhtFPRLAGECGGKNF 320
Cdd:cd07109 159 TALRLAELAEEAGLPAGALNVVTGLGAEAGAALVAHPGVDHISFTGSVETGIAVMRAAAEN------VVPVTLELGGKSP 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 321 HFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGtfFSAVIDAKSFARI 400
Cdd:cd07109 233 QIVFADADLEAALPVVVNAIIQNAGQTCSAGSRLLVHRSIYDEVLERLVERFRALRVGPGLEDPD--LGPLISAKQLDRV 310
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 401 KKWLEHARSSpSLTILAGG---KCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYG 477
Cdd:cd07109 311 EGFVARARAR-GARIVAGGriaEGAPAGGYFVAPTLLDDVPPDSRLAQEEIFGPVLAVMPFDDE--AEAIALANG-TDYG 386
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|
gi 25777734 478 LTGAVFSQDKDVVQEATKVLRnaAGNFYINDKSTGSIVgQQPFGGARASG 527
Cdd:cd07109 387 LVAGVWTRDGDRALRVARRLR--AGQVFVNNYGAGGGI-ELPFGGVKKSG 433
ALDH_F1-2_Ald2-like cd07091
ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD ...
88-527 2.30e-55

ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; ALDH subfamily which includes the NAD+-dependent retinal dehydrogenase 1 (RALDH 1, ALDH1, EC=1.2.1.36), also known as aldehyde dehydrogenase family 1 member A1 (ALDH1A1), in humans, a homotetrameric, cytosolic enzyme that catalyzes the oxidation of retinaldehyde to retinoic acid. Human ALDH1B1 and ALDH2 are also in this cluster; both are mitochrondrial homotetramers which play important roles in acetaldehyde oxidation; ALDH1B1 in response to UV light exposure and ALDH2 during ethanol metabolism. 10-formyltetrahydrofolate dehydrogenase (FTHFDH, EC=1.5.1.6), also known as aldehyde dehydrogenase family 1 member L1 (ALDH1L1), in humans, a multi-domain homotetramer with an N-terminal formyl transferase domain and a C-terminal ALDH domain. FTHFDH catalyzes an NADP+-dependent dehydrogenase reaction resulting in the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2. Also included in this subfamily is the Arabidosis aldehyde dehydrogenase family 2 members B4 and B7 (EC=1.2.1.3), which are mitochondrial, homotetramers that oxidize acetaldehyde and glycolaldehyde, as well as, the Arabidosis cytosolic, homotetramer ALDH2C4 (EC=1.2.1.3), an enzyme involved in the oxidation of sinapalehyde and coniferaldehyde. Also included is the AldA aldehyde dehydrogenase of Aspergillus nidulans (locus AN0554), the aldehyde dehydrogenase 2 (YMR170c, ALD5, EC=1.2.1.5) of Saccharomyces cerevisiae, and other similar sequences.


Pssm-ID: 143410  Cd Length: 476  Bit Score: 193.96  E-value: 2.30e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  88 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPI--ADRAQIFLKAADMLSgpRRAEILAK--TMVGqGKTV-IQAEIDA 162
Cdd:cd07091  29 EEVICQVAEADEEDVDAAVKAARAAFETGWWRKMdpRERGRLLNKLADLIE--RDRDELAAleSLDN-GKPLeESAKGDV 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 163 AaELIDFFRFNAKYAVELEGQqpiSVPPSTNSTVYRGLE--GFVAAISPFNFTAIGGNLAGAPAL-MGNVVLWKPSDTAM 239
Cdd:cd07091 106 A-LSIKCLRYYAGWADKIQGK---TIPIDGNFLAYTRREpiGVCGQIIPWNFPLLMLAWKLAPALaAGNTVVLKPAEQTP 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 240 LASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ-NLDRFhTFprlagECGGK 318
Cdd:cd07091 182 LSALYLAELIKEAGFPPGVVNIVPGFGPTAGAAISSHMDVDKIAFTGSTAVGRTIMEAAAKsNLKKV-TL-----ELGGK 255
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 319 NFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFA 398
Cdd:cd07091 256 SPNIVFDDADLDKAVEWAAFGIFFNQGQCCCAGSRIFVQESIYDEFVEKFKARAEKRVVGDPFDP-DTFQGPQVSKAQFD 334
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 399 RIKKWLEHARSSpSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYvypddKYKETLQLVD--STTSY 476
Cdd:cd07091 335 KILSYIESGKKE-GATLLTGGERHGSKGYFIQPTVFTDVKDDMKIAKEEIFGPVVTIL-----KFKTEDEVIEraNDTEY 408
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|..
gi 25777734 477 GLTGAVFSQDKDVVQEATKVLRnaAGNFYINdksTGSIVGQQ-PFGGARASG 527
Cdd:cd07091 409 GLAAGVFTKDINKALRVSRALK--AGTVWVN---TYNVFDAAvPFGGFKQSG 455
putA PRK11809
trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate ...
105-540 6.09e-55

trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed


Pssm-ID: 236989 [Multi-domain]  Cd Length: 1318  Bit Score: 200.59  E-value: 6.09e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   105 AIEAALAARKEWDLKPIADRAQIFLKAADMLSGprRAEILAKTMVGQ-GKTVIQAeIDAAAELIDFFRFnakYAVELEGQ 183
Cdd:PRK11809  687 ALESAVNAAPIWFATPPAERAAILERAADLMEA--QMQTLMGLLVREaGKTFSNA-IAEVREAVDFLRY---YAGQVRDD 760
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   184 qpisvppSTNSTvYRGLeGFVAAISPFNFT-AI-GGNLAGAPAlMGNVVLWKPSD-TAMLASYAVyRILREAGLPPNIIQ 260
Cdd:PRK11809  761 -------FDNDT-HRPL-GPVVCISPWNFPlAIfTGQVAAALA-AGNSVLAKPAEqTPLIAAQAV-RILLEAGVPAGVVQ 829
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   261 FVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLD-RFHTFPRLAgECGGKNFHFVHRSADVESVVSGTLRS 339
Cdd:PRK11809  830 LLPGRGETVGAALVADARVRGVMFTGSTEVARLLQRNLAGRLDpQGRPIPLIA-ETGGQNAMIVDSSALTEQVVADVLAS 908
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   340 AFEYGGQKCSACSRLYVP-----HSLwPQIKGRLLEehsrIKVGDPaEDFGTFFSAVIDAKSFARIKKWLEHARSS--PS 412
Cdd:PRK11809  909 AFDSAGQRCSALRVLCLQddvadRTL-KMLRGAMAE----CRMGNP-DRLSTDIGPVIDAEAKANIERHIQAMRAKgrPV 982
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   413 LTILAGGKCDDSVGYFVEPCIVESKDPQEpiMKEEIFGPVLSVYVYpddKYKETLQLVDS--TTSYGLTGAVFSQDKDVV 490
Cdd:PRK11809  983 FQAARENSEDWQSGTFVPPTLIELDSFDE--LKREVFGPVLHVVRY---NRNQLDELIEQinASGYGLTLGVHTRIDETI 1057
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 25777734   491 QEATKvlRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 540
Cdd:PRK11809 1058 AQVTG--SAHVGNLYVNRNMVGAVVGVQPFGGEGLSGTGPKAGGPLYLYR 1105
ALDH_SGSD_AstD cd07095
N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; N-succinylglutamate ...
105-534 1.27e-53

N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; N-succinylglutamate 5-semialdehyde dehydrogenase or succinylglutamic semialdehyde dehydrogenase (SGSD, E. coli AstD, EC=1.2.1.71) involved in L-arginine degradation via the arginine succinyltransferase (AST) pathway and catalyzes the NAD+-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.


Pssm-ID: 143414 [Multi-domain]  Cd Length: 431  Bit Score: 187.86  E-value: 1.27e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 105 AIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTM---VGQGKTVIQAEIDAAAELIDFfrfNAKYAVELE 181
Cdd:cd07095   5 AVAAARAAFPGWAALSLEERAAILRRFAELLK--ANKEELARLIsreTGKPLWEAQTEVAAMAGKIDI---SIKAYHERT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 182 GQQPISVPPSTNSTVYRGLeGFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQ 260
Cdd:cd07095  80 GERATPMAQGRAVLRHRPH-GVMAVFGPFNFPGHLPNGHIVPALLaGNTVVFKPSELTPAVAELMVELWEEAGLPPGVLN 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 261 FVPADGPLfGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFhtfprLAGECGGKNFHFVHRSADVESVVSGTLRSA 340
Cdd:cd07095 159 LVQGGRET-GEALAAHEGIDGLLFTGSAATGLLLHRQFAGRPGKI-----LALEMGGNNPLVVWDVADIDAAAYLIVQSA 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 341 FEYGGQKCSACSRLYVPHSLWPQ-IKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGG 419
Cdd:cd07095 233 FLTAGQRCTCARRLIVPDGAVGDaFLERLVEAAKRLRIGAPDAE-PPFMGPLIIAAAAARYLLAQQDLLALGGEPLLAME 311
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 420 KCDDSvGYFVEPCIVESKDPQEPiMKEEIFGPVLSVYVYpdDKYKETLQLVDStTSYGLTGAVFSQDKDVVQEATKVLRn 499
Cdd:cd07095 312 RLVAG-TAFLSPGIIDVTDAADV-PDEEIFGPLLQVYRY--DDFDEAIALANA-TRFGLSAGLLSDDEALFERFLARIR- 385
                       410       420       430
                ....*....|....*....|....*....|....*
gi 25777734 500 aAGNFYINDKSTGSiVGQQPFGGARASGtNDKPGG 534
Cdd:cd07095 386 -AGIVNWNRPTTGA-SSTAPFGGVGLSG-NHRPSA 417
ALDH_GABALDH-PuuC cd07112
Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase ...
103-527 2.10e-53

Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; NADP+-dependent, gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase (GABALDH) PuuC of Escherichia coli which catalyzes the conversion of putrescine to 4-aminobutanoate and other similar sequences are present in this CD.


Pssm-ID: 143430 [Multi-domain]  Cd Length: 462  Bit Score: 188.19  E-value: 2.10e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 103 NKAIEAALAA--RKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKT-MVGQGKTVIQAEIDAAAELIDFFRFNAKYAVE 179
Cdd:cd07112  27 DRAVAAARRAfeSGVWSRLSPAERKAVLLRLADLIE--AHRDELALLeTLDMGKPISDALAVDVPSAANTFRWYAEAIDK 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 180 LEGQQPiSVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPAL-MGNVVLWKPSDTAMLASYAVYRILREAGLPPNI 258
Cdd:cd07112 105 VYGEVA-PTGPDALALITREPLGVVGAVVPWNFPLLMAAWKIAPALaAGNSVVLKPAEQSPLTALRLAELALEAGLPAGV 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 259 IQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ-NLDRFHTfprlagECGGKNFHFV-HRSADVESVVSGT 336
Cdd:cd07112 184 LNVVPGFGHTAGEALGLHMDVDALAFTGSTEVGRRFLEYSGQsNLKRVWL------ECGGKSPNIVfADAPDLDAAAEAA 257
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 337 LRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAeDFGTFFSAVIDAKSFARIKKWLEHARSSpSLTIL 416
Cdd:cd07112 258 AAGIFWNQGEVCSAGSRLLVHESIKDEFLEKVVAAAREWKPGDPL-DPATRMGALVSEAHFDKVLGYIESGKAE-GARLV 335
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 417 AGGKCD--DSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVdSTTSYGLTGAVFSQDKDVVQEAT 494
Cdd:cd07112 336 AGGKRVltETGGFFVEPTVFDGVTPDMRIAREEIFGPVLSVITFDSE--EEAVALA-NDSVYGLAASVWTSDLSRAHRVA 412
                       410       420       430
                ....*....|....*....|....*....|...
gi 25777734 495 KVLRnaAGNFYINDKSTGSIvgQQPFGGARASG 527
Cdd:cd07112 413 RRLR--AGTVWVNCFDEGDI--TTPFGGFKQSG 441
ALDH_PsfA-ACA09737 cd07120
Pseudomonas putida aldehyde dehydrogenase PsfA (ACA09737)-like; Included in this CD is the ...
95-527 2.48e-52

Pseudomonas putida aldehyde dehydrogenase PsfA (ACA09737)-like; Included in this CD is the aldehyde dehydrogenase (PsfA, locus ACA09737) of Pseudomonas putida involved in furoic acid metabolism. Transcription of psfA was induced in response to 2-furoic acid, furfuryl alcohol, and furfural.


Pssm-ID: 143438 [Multi-domain]  Cd Length: 455  Bit Score: 185.24  E-value: 2.48e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  95 CYAD--KSLLNKAIEAALAARKE--WDLKPiADRAQIFLKAADMLSgpRRAEILAKTMV-GQGKTVIQA--EIDAAaelI 167
Cdd:cd07120  12 TYADggVAEAEAAIAAARRAFDEtdWAHDP-RLRARVLLELADAFE--ANAERLARLLAlENGKILGEArfEISGA---I 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 168 DFFRFNAKYAVELEGQQpISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKP-SDTAMLASyAV 245
Cdd:cd07120  86 SELRYYAGLARTEAGRM-IEPEPGSFSLVLREPMGVAGIIVPWNSPVVLLVRSLAPALAaGCTVVVKPaGQTAQINA-AI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 246 YRILREA-GLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFhtfprlAGECGGKNFHFVH 324
Cdd:cd07120 164 IRILAEIpSLPAGVVNLFTESGSEGAAHLVASPDVDVISFTGSTATGRAIMAAAAPTLKRL------GLELGGKTPCIVF 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 325 RSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVG---DPAEDFGtffsAVIDAKSFARIK 401
Cdd:cd07120 238 DDADLDAALPKLERALTIFAGQFCMAGSRVLVQRSIADEVRDRLAARLAAVKVGpglDPASDMG----PLIDRANVDRVD 313
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 402 KWLEHARSSPSLTILAGGKCDD--SVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGLT 479
Cdd:cd07120 314 RMVERAIAAGAEVVLRGGPVTEglAKGAFLRPTLLEVDDPDADIVQEEIFGPVLTLETFDDE--AEAVALAND-TDYGLA 390
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*....
gi 25777734 480 GAVFSQDkdvVQEATKVLRN-AAGNFYINDKstGSIVGQQPFGGARASG 527
Cdd:cd07120 391 ASVWTRD---LARAMRVARAiRAGTVWINDW--NKLFAEAEEGGYRQSG 434
ALDH_BenzADH cd07152
NAD-dependent benzaldehyde dehydrogenase II-like; NAD-dependent, benzaldehyde dehydrogenase II ...
96-535 7.34e-52

NAD-dependent benzaldehyde dehydrogenase II-like; NAD-dependent, benzaldehyde dehydrogenase II (XylC, BenzADH, EC=1.2.1.28) is involved in the oxidation of benzyl alcohol to benzoate. In Acinetobacter calcoaceticus, this process is carried out by the chromosomally encoded, benzyl alcohol dehydrogenase (xylB) and benzaldehyde dehydrogenase II (xylC) enzymes; whereas in Pseudomonas putida they are encoded by TOL plasmids.


Pssm-ID: 143470 [Multi-domain]  Cd Length: 443  Bit Score: 183.65  E-value: 7.34e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  96 YADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVGQGKTVI---QAEIDAAAElidFFRF 172
Cdd:cd07152   9 VADAADVDRAAARAAAAQRAWAATPPRERAAVLRRAADLLE--EHADEIADWIVRESGSIRpkaGFEVGAAIG---ELHE 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 173 NAKYAVELEGQQPISVPPSTNSTVYRGLeGFVAAISPFNFTAIGGNLAGAPAL-MGNVVLWKPS-DTAMLASYAVYRILR 250
Cdd:cd07152  84 AAGLPTQPQGEILPSAPGRLSLARRVPL-GVVGVISPFNFPLILAMRSVAPALaLGNAVVLKPDpRTPVSGGVVIARLFE 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 251 EAGLPPNIIQFVPAdGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTfprlagECGGKNFHFVHRSADVE 330
Cdd:cd07152 163 EAGLPAGVLHVLPG-GADAGEALVEDPNVAMISFTGSTAVGRKVGEAAGRHLKKVSL------ELGGKNALIVLDDADLD 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 331 SVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEHARSS 410
Cdd:cd07152 236 LAASNGAWGAFLHQGQICMAAGRHLVHESVADAYTAKLAAKAKHLPVGDPATG-QVALGPLINARQLDRVHAIVDDSVAA 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 411 PSlTILAGGKCDdsvGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGLTGAVFSQDKDVV 490
Cdd:cd07152 315 GA-RLEAGGTYD---GLFYRPTVLSGVKPGMPAFDEEIFGPVAPVTVFDSD--EEAVALAND-TEYGLSAGIISRDVGRA 387
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*
gi 25777734 491 QEATKVLRnaAGNFYINDKSTGSIVgQQPFGGARASGTNDKPGGP 535
Cdd:cd07152 388 MALADRLR--TGMLHINDQTVNDEP-HNPFGGMGASGNGSRFGGP 429
ALDH_CddD_SSP0762 cd07138
Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; The 6-oxolauric acid dehydrogenase ...
103-527 7.50e-52

Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; The 6-oxolauric acid dehydrogenase (CddD) from Rhodococcus ruber SC1 which converts 6-oxolauric acid to dodecanedioic acid, and the aldehyde dehydrogenase (locus SSP0762) from Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 and other similar sequences, are included in this CD.


Pssm-ID: 143456 [Multi-domain]  Cd Length: 466  Bit Score: 184.24  E-value: 7.50e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 103 NKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTM---VGQGKTV---IQAE-----IDAAAELIDFFR 171
Cdd:cd07138  39 DRAVAAARRAFPAWSATSVEERAALLERIAEAYE--ARADELAQAItleMGAPITLaraAQVGlgighLRAAADALKDFE 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 172 FnakyaVELEGqqpisvppstNSTVYRGLEGFVAAISPFNFTA--IGGNLAgaPALM-GNVVLWKPSDTAMLASYAVYRI 248
Cdd:cd07138 117 F-----EERRG----------NSLVVREPIGVCGLITPWNWPLnqIVLKVA--PALAaGCTVVLKPSEVAPLSAIILAEI 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 249 LREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTfkhlWKQVAQNLDRfhTFPRLAGECGGKNFHFVHRSAD 328
Cdd:cd07138 180 LDEAGLPAGVFNLVNGDGPVVGEALSAHPDVDMVSFTGSTRA----GKRVAEAAAD--TVKRVALELGGKSANIILDDAD 253
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 329 VESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWL---- 404
Cdd:cd07138 254 LEKAVPRGVAACFANSGQSCNAPTRMLVPRSRYAEAEEIAAAAAEAYVVGDPRDP-ATTLGPLASAAQFDRVQGYIqkgi 332
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 405 -EHARsspsltILAGG--KCDD-SVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGLTG 480
Cdd:cd07138 333 eEGAR------LVAGGpgRPEGlERGYFVKPTVFADVTPDMTIAREEIFGPVLSIIPYDDE--DEAIAIAND-TPYGLAG 403
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*..
gi 25777734 481 AVFSQDKDVVQEATKVLRnaAGNFYINDkstGSIVGQQPFGGARASG 527
Cdd:cd07138 404 YVWSADPERARAVARRLR--AGQVHING---AAFNPGAPFGGYKQSG 445
ALDH_F11_NP-GAPDH cd07082
NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family ...
103-527 1.97e-51

NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase (NP-GAPDH, EC=1.2.1.9) catalyzes the irreversible oxidation of glyceraldehyde 3-phosphate to 3-phosphoglycerate generating NADPH for biosynthetic reactions. This CD also includes the Arabidopsis thaliana osmotic-stress-inducible ALDH family 11, ALDH11A3 and similar sequences. In autotrophic eukaryotes, NP-GAPDH generates NADPH for biosynthetic processes from photosynthetic glyceraldehyde-3-phosphate exported from the chloroplast and catalyzes one of the classic glycolytic bypass reactions unique to plants.


Pssm-ID: 143401 [Multi-domain]  Cd Length: 473  Bit Score: 183.16  E-value: 1.97e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 103 NKAIEAALAA-RKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTM---VGQGKTVIQAEIDAAAELIDFFRFNAKyav 178
Cdd:cd07082  41 LEAAETAYDAgRGWWPTMPLEERIDCLHKFADLLK--ENKEEVANLLmweIGKTLKDALKEVDRTIDYIRDTIEELK--- 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 179 ELEGQ--QPISVPPSTNS--TVYRGLEGFVAAISPFNFTAiggNLAG---APAL-MGNVVLWKPSDTAMLASYAVYRILR 250
Cdd:cd07082 116 RLDGDslPGDWFPGTKGKiaQVRREPLGVVLAIGPFNYPL---NLTVsklIPALiMGNTVVFKPATQGVLLGIPLAEAFH 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 251 EAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQvaqnldrfHTFPRLAGECGGKNFHFVHRSADVE 330
Cdd:cd07082 193 DAGFPKGVVNVVTGRGREIGDPLVTHGRIDVISFTGSTEVGNRLKKQ--------HPMKRLVLELGGKDPAIVLPDADLE 264
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 331 SVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEHARSS 410
Cdd:cd07082 265 LAAKEIVKGALSYSGQRCTAIKRVLVHESVADELVELLKEEVAKLKVGMPWDN-GVDITPLIDPKSADFVEGLIDDAVAK 343
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 411 PSlTILAGGKCDdsVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGLTGAVFSQDKDVV 490
Cdd:cd07082 344 GA-TVLNGGGRE--GGNLIYPTLLDPVTPDMRLAWEEPFGPVLPIIRVNDI--EEAIELANK-SNYGLQASIFTKDINKA 417
                       410       420       430
                ....*....|....*....|....*....|....*..
gi 25777734 491 QEATKVLRnaAGNFYINDKSTGSIvGQQPFGGARASG 527
Cdd:cd07082 418 RKLADALE--VGTVNINSKCQRGP-DHFPFLGRKDSG 451
ALDH_ABALDH-YdcW cd07092
Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; NAD ...
88-528 3.65e-51

Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; NAD+-dependent, tetrameric, gamma-aminobutyraldehyde dehydrogenase (ABALDH), YdcW of Escherichia coli K12, catalyzes the oxidation of gamma-aminobutyraldehyde to gamma-aminobutyric acid. ABALDH can also oxidize n-alkyl medium-chain aldehydes, but with a lower catalytic efficiency.


Pssm-ID: 143411 [Multi-domain]  Cd Length: 450  Bit Score: 181.76  E-value: 3.65e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  88 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVGQ-GKTVIQAEIDAAAEL 166
Cdd:cd07092   7 GEEIATVPDASAADVDAAVAAAHAAFPSWRRTTPAERSKALLKLADAIE--ENAEELAALESRNtGKPLHLVRDDELPGA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 167 IDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPAL-MGNVVLWKPSDTAMLASYAV 245
Cdd:cd07092  85 VDNFRFFAGAARTLEGPAAGEYLPGHTSMIRREPIGVVAQIAPWNYPLMMAAWKIAPALaAGNTVVLKPSETTPLTTLLL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 246 YRILREaGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTfprlagECGGKNFHFVHR 325
Cdd:cd07092 165 AELAAE-VLPPGVVNVVCGGGASAGDALVAHPRVRMVSLTGSVRTGKKVARAAADTLKRVHL------ELGGKAPVIVFD 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 326 SADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLE 405
Cdd:cd07092 238 DADLDAAVAGIATAGYYNAGQDCTAACRVYVHESVYDEFVAALVEAVSAIRVGDPDDE-DTEMGPLNSAAQRERVAGFVE 316
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 406 HARSspSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGLTGAVFSQ 485
Cdd:cd07092 317 RAPA--HARVLTGGRRAEGPGYFYEPTVVAGVAQDDEIVQEEIFGPVVTVQPFDDE--DEAIELAND-VEYGLASSVWTR 391
                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 25777734 486 DKDVVQEATKVLRnaAGNFYINDKstGSIVGQQPFGGARASGT 528
Cdd:cd07092 392 DVGRAMRLSARLD--FGTVWVNTH--IPLAAEMPHGGFKQSGY 430
ALDH_AldA_AN0554 cd07143
Aspergillus nidulans aldehyde dehydrogenase, AldA (AN0554)-like; NAD(P)+-dependent aldehyde ...
82-527 1.14e-50

Aspergillus nidulans aldehyde dehydrogenase, AldA (AN0554)-like; NAD(P)+-dependent aldehyde dehydrogenase (AldA) of Aspergillus nidulans (locus AN0554), and other similar sequences, are present in this CD.


Pssm-ID: 143461  Cd Length: 481  Bit Score: 181.19  E-value: 1.14e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  82 VSPFNhGHKVAKFCYADKSLLNKAIEAALAA-RKEWDLK-PIADRAQIFLKAADMLSgpRRAEILAKT-MVGQGKTVIQA 158
Cdd:cd07143  27 YNPST-GKLITKIAEATEADVDIAVEVAHAAfETDWGLKvSGSKRGRCLSKLADLME--RNLDYLASIeALDNGKTFGTA 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 159 EIDAAAELIDFFRFNAKYAVELEGQQpISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDT 237
Cdd:cd07143 104 KRVDVQASADTFRYYGGWADKIHGQV-IETDIKKLTYTRHEPIGVCGQIIPWNFPLLMCAWKIAPALAaGNTIVLKPSEL 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 238 AMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNldrfhTFPRLAGECGG 317
Cdd:cd07143 183 TPLSALYMTKLIPEAGFPPGVINVVSGYGRTCGNAISSHMDIDKVAFTGSTLVGRKVMEAAAKS-----NLKKVTLELGG 257
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 318 KNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSF 397
Cdd:cd07143 258 KSPNIVFDDADLESAVVWTAYGIFFNHGQVCCAGSRIYVQEGIYDKFVKRFKEKAKKLKVGDPFAE-DTFQGPQVSQIQY 336
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 398 ARIKKWLEHARSSPSlTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDSTTsYG 477
Cdd:cd07143 337 ERIMSYIESGKAEGA-TVETGGKRHGNEGYFIEPTIFTDVTEDMKIVKEEIFGPVVAVIKFKTE--EEAIKRANDST-YG 412
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|..
gi 25777734 478 LTGAVFSQDkdvVQEATKVlRNA--AGNFYINDKSTgsIVGQQPFGGARASG 527
Cdd:cd07143 413 LAAAVFTNN---INNAIRV-ANAlkAGTVWVNCYNL--LHHQVPFGGYKQSG 458
ALDH_F10_BADH cd07110
Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Present in ...
97-527 2.46e-50

Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Present in this CD are the Arabidopsis betaine aldehyde dehydrogenase (BADH) 1 (chloroplast) and 2 (mitochondria), also known as, aldehyde dehydrogenase family 10 member A8 and aldehyde dehydrogenase family 10 member A9, respectively, and are putative dehydration- and salt-inducible BADHs (EC 1.2.1.8) that catalyze the oxidation of betaine aldehyde to the compatible solute glycine betaine.


Pssm-ID: 143428 [Multi-domain]  Cd Length: 456  Bit Score: 179.85  E-value: 2.46e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  97 ADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGpRRAEILAKTMVGQGKTVIQAEIDAAaELIDFFRFNAKY 176
Cdd:cd07110  16 ATAEDVDAAVRAARRAFPRWKKTTGAERAKYLRAIAEGVRE-RREELAELEARDNGKPLDEAAWDVD-DVAGCFEYYADL 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 177 AVELEGQQPISVP---PSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREA 252
Cdd:cd07110  94 AEQLDAKAERAVPlpsEDFKARVRREPVGVVGLITPWNFPLLMAAWKVAPALAaGCTVVLKPSELTSLTELELAEIAAEA 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 253 GLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRfhtfprLAGECGGKNFHFVHRSADVESV 332
Cdd:cd07110 174 GLPPGVLNVVTGTGDEAGAPLAAHPGIDKISFTGSTATGSQVMQAAAQDIKP------VSLELGGKSPIIVFDDADLEKA 247
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 333 VSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEHARSSpS 412
Cdd:cd07110 248 VEWAMFGCFWNNGQICSATSRLLVHESIADAFLERLATAAEAIRVGDPLEE-GVRLGPLVSQAQYEKVLSFIARGKEE-G 325
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 413 LTILAGGKCDDSV--GYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGLTGAVFSQDKDVV 490
Cdd:cd07110 326 ARLLCGGRRPAHLekGYFIAPTVFADVPTDSRIWREEIFGPVLCVRSFATE--DEAIALAND-SEYGLAAAVISRDAERC 402
                       410       420       430
                ....*....|....*....|....*....|....*..
gi 25777734 491 QEATKVLRnaAGNFYINdkSTGSIVGQQPFGGARASG 527
Cdd:cd07110 403 DRVAEALE--AGIVWIN--CSQPCFPQAPWGGYKRSG 435
ALDH_DDALDH cd07099
Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; The 4,4 ...
88-547 8.11e-50

Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; The 4,4'-diapolycopene-dialdehyde dehydrogenase (DDALDH) involved in C30 carotenoid synthesis in Methylomonas sp. strain 16a and other similar sequences are present in this CD. DDALDH converts 4,4'-diapolycopene-dialdehyde into 4,4'-diapolycopene-diacid.


Pssm-ID: 143417 [Multi-domain]  Cd Length: 453  Bit Score: 178.18  E-value: 8.11e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  88 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGpRRAEILAKTMVGQGKTVIQA--EIDAAAE 165
Cdd:cd07099   6 GEVLGEVPVTDPAEVAAAVARARAAQRAWAALGVEGRAQRLLRWKRALAD-HADELAELLHAETGKPRADAglEVLLALE 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 166 LIDFFrfnAKYAVELEGQQPISVPPSTN---STVYRGLEGFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLA 241
Cdd:cd07099  85 AIDWA---ARNAPRVLAPRKVPTGLLMPnkkATVEYRPYGVVGVISPWNYPLLTPMGDIIPALAaGNAVVLKPSEVTPLV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 242 SYAVYRILREAGLPPNIIQFVPADGPlfgdtvtSSEHLCG-----INFTGSVPTFKHLWKQVAQNLdrfhtFPRLAgECG 316
Cdd:cd07099 162 GELLAEAWAAAGPPQGVLQVVTGDGA-------TGAALIDagvdkVAFTGSVATGRKVMAAAAERL-----IPVVL-ELG 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 317 GKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTfFSAVIDAKS 396
Cdd:cd07099 229 GKDPMIVLADADLERAAAAAVWGAMVNAGQTCISVERVYVHESVYDEFVARLVAKARALRPGADDIGDAD-IGPMTTARQ 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 397 FARIKKWLEHARSSPSlTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDSTTsY 476
Cdd:cd07099 308 LDIVRRHVDDAVAKGA-KALTGGARSNGGGPFYEPTVLTDVPHDMDVMREETFGPVLPVMPVADE--DEAIALANDSR-Y 383
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 25777734 477 GLTGAVFSQDKDVVQEATKVLRnaAGNFYINDKSTGSIVGQQPFGGARASGTNDKpGGPHYILRWTSPQVI 547
Cdd:cd07099 384 GLSASVFSRDLARAEAIARRLE--AGAVSINDVLLTAGIPALPFGGVKDSGGGRR-HGAEGLREFCRPKAI 451
PRK13473 PRK13473
aminobutyraldehyde dehydrogenase;
88-527 1.40e-49

aminobutyraldehyde dehydrogenase;


Pssm-ID: 237391  Cd Length: 475  Bit Score: 178.18  E-value: 1.40e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   88 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVGQ-GK---TVIQAEIDAA 163
Cdd:PRK13473  27 GEVLAEIAEASAAQVDAAVAAADAAFPEWSQTTPKERAEALLKLADAIE--ENADEFARLESLNcGKplhLALNDEIPAI 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  164 aelIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLAS 242
Cdd:PRK13473 105 ---VDVFRFFAGAARCLEGKAAGEYLEGHTSMIRRDPVGVVASIAPWNYPLMMAAWKLAPALAaGNTVVLKPSEITPLTA 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  243 YAVYRILREAgLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTfprlagECGGKNFHF 322
Cdd:PRK13473 182 LKLAELAADI-LPPGVLNVVTGRGATVGDALVGHPKVRMVSLTGSIATGKHVLSAAADSVKRTHL------ELGGKAPVI 254
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  323 VHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPaEDFGTFFSAVIDAKSFARIKK 402
Cdd:PRK13473 255 VFDDADLDAVVEGIRTFGYYNAGQDCTAACRIYAQRGIYDDLVAKLAAAVATLKVGDP-DDEDTELGPLISAAHRDRVAG 333
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  403 WLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDsTTSYGLTGAV 482
Cdd:PRK13473 334 FVERAKALGHIRVVTGGEAPDGKGYYYEPTLLAGARQDDEIVQREVFGPVVSVTPFDDE--DQAVRWAN-DSDYGLASSV 410
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 25777734  483 FSQDKDVVQEATKVLRnaAGNFYINDKstGSIVGQQPFGGARASG 527
Cdd:PRK13473 411 WTRDVGRAHRVSARLQ--YGCTWVNTH--FMLVSEMPHGGQKQSG 451
PLN02467 PLN02467
betaine aldehyde dehydrogenase
105-527 5.42e-49

betaine aldehyde dehydrogenase


Pssm-ID: 215260 [Multi-domain]  Cd Length: 503  Bit Score: 177.23  E-value: 5.42e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  105 AIEAALAA-----RKEWDLKPIADRAQiFLKA-ADMLSgpRRAEILAKT-MVGQGKTVIQAE--IDAAAELIDFFrfnAK 175
Cdd:PLN02467  50 AVEAARKAfkrnkGKDWARTTGAVRAK-YLRAiAAKIT--ERKSELAKLeTLDCGKPLDEAAwdMDDVAGCFEYY---AD 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  176 YAVELEGQQ--PISVPPST-NSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILRE 251
Cdd:PLN02467 124 LAEALDAKQkaPVSLPMETfKGYVLKEPLGVVGLITPWNYPLLMATWKVAPALAaGCTAVLKPSELASVTCLELADICRE 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  252 AGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDrfhtfPrLAGECGGKNFHFVHRSADVES 331
Cdd:PLN02467 204 VGLPPGVLNVVTGLGTEAGAPLASHPGVDKIAFTGSTATGRKIMTAAAQMVK-----P-VSLELGGKSPIIVFDDVDLDK 277
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  332 VVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEHARSSp 411
Cdd:PLN02467 278 AVEWAMFGCFWTNGQICSATSRLLVHERIASEFLEKLVKWAKNIKISDPLEE-GCRLGPVVSEGQYEKVLKFISTAKSE- 355
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  412 SLTILAGGKCDD--SVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDSTTsYGLTGAVFSQDKDV 489
Cdd:PLN02467 356 GATILCGGKRPEhlKKGFFIEPTIITDVTTSMQIWREEVFGPVLCVKTFSTE--DEAIELANDSH-YGLAGAVISNDLER 432
                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 25777734  490 VQEATKVLRnaAGNFYINdkSTGSIVGQQPFGGARASG 527
Cdd:PLN02467 433 CERVSEAFQ--AGIVWIN--CSQPCFCQAPWGGIKRSG 466
ALDH_ALD2-YMR170C cd07144
Saccharomyces cerevisiae aldehyde dehydrogenase 2 (YMR170c)-like; NAD(P)+-dependent ...
88-527 2.42e-48

Saccharomyces cerevisiae aldehyde dehydrogenase 2 (YMR170c)-like; NAD(P)+-dependent Saccharomyces cerevisiae aldehyde dehydrogenase 2 (YMR170c, ALD5, EC=1.2.1.5) and other similar sequences, are present in this CD.


Pssm-ID: 143462  Cd Length: 484  Bit Score: 174.90  E-value: 2.42e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  88 GHKVAKFCYADKSLLNKAIEAALAARKEWDLK-PIADRAQIFLKAADMLSgpRRAEILA--KTMvGQGKTVIQAEIDAAA 164
Cdd:cd07144  33 GEVIASVYAAGEEDVDKAVKAARKAFESWWSKvTGEERGELLDKLADLVE--KNRDLLAaiEAL-DSGKPYHSNALGDLD 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 165 ELIDFFRFNAKYAVELEGQqpiSVPPSTNSTVYRGLE--GFVAAISPFNFTAiggNLAG---APALM-GNVVLWKPSDTA 238
Cdd:cd07144 110 EIIAVIRYYAGWADKIQGK---TIPTSPNKLAYTLHEpyGVCGQIIPWNYPL---AMAAwklAPALAaGNTVVIKPAENT 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 239 MLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDrfhtfpRLAGECGGK 318
Cdd:cd07144 184 PLSLLYFANLVKEAGFPPGVVNIIPGYGAVAGSALAEHPDVDKIAFTGSTATGRLVMKAAAQNLK------AVTLECGGK 257
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 319 NFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEE-HSRIKVGDPAEDfGTFFSAVIDAKSF 397
Cdd:cd07144 258 SPALVFEDADLDQAVKWAAAGIMYNSGQNCTATSRIYVQESIYDKFVEKFVEHvKQNYKVGSPFDD-DTVVGPQVSKTQY 336
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 398 ARIKKWLEHARSSPSLTILAGGK--CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDdkYKETLQLVDSTTs 475
Cdd:cd07144 337 DRVLSYIEKGKKEGAKLVYGGEKapEGLGKGYFIPPTIFTDVPQDMRIVKEEIFGPVVVISKFKT--YEEAIKKANDTT- 413
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 25777734 476 YGLTGAVFSQDkdvVQEATKVLRN-AAGNFYINDKSTGSIvgQQPFGGARASG 527
Cdd:cd07144 414 YGLAAAVFTKD---IRRAHRVARElEAGMVWINSSNDSDV--GVPFGGFKMSG 461
ALDH_SaliADH cd07105
Salicylaldehyde dehydrogenase, DoxF-like; Salicylaldehyde dehydrogenase (DoxF, SaliADH, EC=1.2. ...
103-527 3.41e-48

Salicylaldehyde dehydrogenase, DoxF-like; Salicylaldehyde dehydrogenase (DoxF, SaliADH, EC=1.2.1.65) involved in the upper naphthalene catabolic pathway of Pseudomonas strain C18 and other similar sequences are present in this CD.


Pssm-ID: 143423 [Multi-domain]  Cd Length: 432  Bit Score: 173.15  E-value: 3.41e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 103 NKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGpRRAEILAKTMVGQGKTVIQAEIDAAAeLIDFFRFNAKYAVELEG 182
Cdd:cd07105   3 DQAVEAAAAAFPAWSKTPPSERRDILLKAADLLES-RRDEFIEAMMEETGATAAWAGFNVDL-AAGMLREAASLITQIIG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 183 QQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
Cdd:cd07105  81 GSIPSDKPGTLAMVVKEPVGVVLGIAPWNAPVILGTRAIAYPLAaGNTVVLKASELSPRTHWLIGRVFHEAGLPKGVLNV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 262 V---PADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDrfhtfPRLAgECGGKNFHFVHRSADVESVVSGTLR 338
Cdd:cd07105 161 VthsPEDAPEVVEALIAHPAVRKVNFTGSTRVGRIIAETAAKHLK-----PVLL-ELGGKAPAIVLEDADLDAAANAALF 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 339 SAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEdfgtffSAVIDAKSFARIKKWLEHARSSPSlTILAG 418
Cdd:cd07105 235 GAFLNSGQICMSTERIIVHESIADEFVEKLKAAAEKLFAGPVVL------GSLVSAAAADRVKELVDDALSKGA-KLVVG 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 419 GKCDDSV-GYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGLTGAVFSQDkdvvqeATKVL 497
Cdd:cd07105 308 GLADESPsGTSMPPTILDNVTPDMDIYSEESFGPVVSIIRVKDE--EEAVRIAND-SEYGLSAAVFTRD------LARAL 378
                       410       420       430
                ....*....|....*....|....*....|....*..
gi 25777734 498 RNA----AGNFYINdkstGSIVG---QQPFGGARASG 527
Cdd:cd07105 379 AVAkrieSGAVHIN----GMTVHdepTLPHGGVKSSG 411
ALDH_EDX86601 cd07102
Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); ...
82-507 4.40e-48

Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (locus EDX86601) and other similar sequences, are present in this CD.


Pssm-ID: 143420 [Multi-domain]  Cd Length: 452  Bit Score: 173.59  E-value: 4.40e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  82 VSPFNhGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVGQ-GKTVIQA-- 158
Cdd:cd07102   1 ISPID-GSVIAERPLASLEAVRAALERARAAQKGWRAVPLEERKAIVTRAVELLA--ANTDEIAEELTWQmGRPIAQAgg 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 159 EIDAAAELIDFFRFNAKYAVelegqQPISVPPSTNST---VYRGLeGFVAAISPFN---FTAIGgnlAGAPALM-GNVVL 231
Cdd:cd07102  78 EIRGMLERARYMISIAEEAL-----ADIRVPEKDGFEryiRREPL-GVVLIIAPWNypyLTAVN---AVIPALLaGNAVI 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 232 WKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLfGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNldrfhtFPRL 311
Cdd:cd07102 149 LKHSPQTPLCGERFAAAFAEAGLPEGVFQVLHLSHET-SAALIADPRIDHVSFTGSVAGGRAIQRAAAGR------FIKV 221
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 312 AGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAV 391
Cdd:cd07102 222 GLELGGKDPAYVRPDADLDAAAESLVDGAFFNSGQSCCSIERIYVHESIYDAFVEAFVAVVKGYKLGDPLDP-STTLGPV 300
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 392 IDAKSFARIKKWLEHARSSPSlTILAGGK---CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQ 468
Cdd:cd07102 301 VSARAADFVRAQIADAIAKGA-RALIDGAlfpEDKAGGAYLAPTVLTNVDHSMRVMREETFGPVVGIMKVKSD--AEAIA 377
                       410       420       430       440
                ....*....|....*....|....*....|....*....|.
gi 25777734 469 LV-DSTtsYGLTGAVFSQDKDVVQE-ATKVlrnAAGNFYIN 507
Cdd:cd07102 378 LMnDSE--YGLTASVWTKDIARAEAlGEQL---ETGTVFMN 413
ALDH_SSADH1_GabD1 cd07100
Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Succinate-semialdehyde ...
102-527 3.46e-45

Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Succinate-semialdehyde dehydrogenase 1 (SSADH1, GabD1, EC=1.2.1.16) catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde (SSA) to succinate. SSADH activity in Mycobacterium tuberculosis (Mtb) is encoded by both gabD1 (Rv0234c) and gabD2 (Rv1731). The Mtb GabD1 SSADH1 reportedly is an enzyme of the gamma-aminobutyrate shunt, which forms a functional link between two TCA half-cycles by converting alpha-ketoglutarate to succinate.


Pssm-ID: 143418 [Multi-domain]  Cd Length: 429  Bit Score: 164.94  E-value: 3.46e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 102 LNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVGQ-GKTVIQA--EIDAAAELIDFFrfnAKYAV 178
Cdd:cd07100   1 IEAALDRAHAAFLAWRKTSFAERAALLRKLADLLR--ERKDELARLITLEmGKPIAEAraEVEKCAWICRYY---AENAE 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 179 ELEGQQPISVPPSTNSTVYRGLeGFVAAISPFNFT-------AiggnlagAPALM-GNVVLWKPSDTAMLASYAVYRILR 250
Cdd:cd07100  76 AFLADEPIETDAGKAYVRYEPL-GVVLGIMPWNFPfwqvfrfA-------APNLMaGNTVLLKHASNVPGCALAIEELFR 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 251 EAGLPPNIIQFVPADGPLFgDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFhtfprlAGECGGKNFHFVHRSADVE 330
Cdd:cd07100 148 EAGFPEGVFQNLLIDSDQV-EAIIADPRVRGVTLTGSERAGRAVAAEAGKNLKKS------VLELGGSDPFIVLDDADLD 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 331 SVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFS--AVIDAKSfaRIKKWLEHAR 408
Cdd:cd07100 221 KAVKTAVKGRLQNAGQSCIAAKRFIVHEDVYDEFLEKFVEAMAALKVGDPMDE-DTDLGplARKDLRD--ELHEQVEEAV 297
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 409 SSpSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGLTGAVFSQDKD 488
Cdd:cd07100 298 AA-GATLLLGGKRPDGPGAFYPPTVLTDVTPGMPAYDEELFGPVAAVIKVKDE--EEAIALAND-SPFGLGGSVFTTDLE 373
                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 25777734 489 vvqEATKVLRN-AAGNFYIND--KSTGSIvgqqPFGGARASG 527
Cdd:cd07100 374 ---RAERVARRlEAGMVFINGmvKSDPRL----PFGGVKRSG 408
PLN02278 PLN02278
succinic semialdehyde dehydrogenase
103-538 1.41e-44

succinic semialdehyde dehydrogenase


Pssm-ID: 215157 [Multi-domain]  Cd Length: 498  Bit Score: 164.86  E-value: 1.41e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  103 NKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVG-QGKTVIQA--EIDAAAELIDFFrfnAKYAVE 179
Cdd:PLN02278  65 NDAIASAHDAFPSWSKLTASERSKILRRWYDLII--ANKEDLAQLMTLeQGKPLKEAigEVAYGASFLEYF---AEEAKR 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  180 LEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTaiggnLA-----GAPALM-GNVVLWKPSDTAMLASYAVYRILREAG 253
Cdd:PLN02278 140 VYGDIIPSPFPDRRLLVLKQPVGVVGAITPWNFP-----LAmitrkVGPALAaGCTVVVKPSELTPLTALAAAELALQAG 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  254 LPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQnldrfhTFPRLAGECGGKNFHFVHRSADVESVV 333
Cdd:PLN02278 215 IPPGVLNVVMGDAPEIGDALLASPKVRKITFTGSTAVGKKLMAGAAA------TVKRVSLELGGNAPFIVFDDADLDVAV 288
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  334 SGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEHARSSPSl 413
Cdd:PLN02278 289 KGALASKFRNSGQTCVCANRILVQEGIYDKFAEAFSKAVQKLVVGDGFEE-GVTQGPLINEAAVQKVESHVQDAVSKGA- 366
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  414 TILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDSTTsYGLTGAVFSQDkdvVQEA 493
Cdd:PLN02278 367 KVLLGGKRHSLGGTFYEPTVLGDVTEDMLIFREEVFGPVAPLTRFKTE--EEAIAIANDTE-AGLAAYIFTRD---LQRA 440
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 25777734  494 TKVlrNAAGNFYINDKSTGSIVGQQ-PFGGARASGTNdKPGGPHYI 538
Cdd:PLN02278 441 WRV--SEALEYGIVGVNEGLISTEVaPFGGVKQSGLG-REGSKYGI 483
PRK13252 PRK13252
betaine aldehyde dehydrogenase; Provisional
97-527 2.19e-44

betaine aldehyde dehydrogenase; Provisional


Pssm-ID: 183918  Cd Length: 488  Bit Score: 164.28  E-value: 2.19e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   97 ADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMV-GQGKTvIQ----AEIDAAAELIDFFr 171
Cdd:PRK13252  41 ATPADVEAAVASAKQGQKIWAAMTAMERSRILRRAVDILR--ERNDELAALETlDTGKP-IQetsvVDIVTGADVLEYY- 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  172 fnAKYAVELEGQQpisVPPSTNSTVYRGLE--GFVAAISPFNFTAIGGNLAGAPAL-MGNVVLWKPSDTAMLASYAVYRI 248
Cdd:PRK13252 117 --AGLAPALEGEQ---IPLRGGSFVYTRREplGVCAGIGAWNYPIQIACWKSAPALaAGNAMIFKPSEVTPLTALKLAEI 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  249 LREAGLPPNIIQFVPADGPLfGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRfhtfprLAGECGGKNFHFVHRSAD 328
Cdd:PRK13252 192 YTEAGLPDGVFNVVQGDGRV-GAWLTEHPDIAKVSFTGGVPTGKKVMAAAAASLKE------VTMELGGKSPLIVFDDAD 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  329 VESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPaEDFGTFFSAVIDAKSFARIKKWLEHAR 408
Cdd:PRK13252 265 LDRAADIAMLANFYSSGQVCTNGTRVFVQKSIKAAFEARLLERVERIRIGDP-MDPATNFGPLVSFAHRDKVLGYIEKGK 343
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  409 SSPSlTILAGGKC----DDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDSTTsYGLTGAVFS 484
Cdd:PRK13252 344 AEGA-RLLCGGERltegGFANGAFVAPTVFTDCTDDMTIVREEIFGPVMSVLTFDDE--DEVIARANDTE-YGLAAGVFT 419
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 25777734  485 QDkdvVQEATKVL-RNAAGNFYINdkSTGSIVGQQPFGGARASG 527
Cdd:PRK13252 420 AD---LSRAHRVIhQLEAGICWIN--TWGESPAEMPVGGYKQSG 458
ALDH_PhpJ cd07146
Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Putative ...
102-533 3.17e-44

Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Putative phosphonoformaldehyde dehydrogenase (PhpJ), an aldehyde dehydrogenase homolog reportedly involved in the biosynthesis of phosphinothricin tripeptides in Streptomyces viridochromogenes DSM 40736, and similar sequences are included in this CD.


Pssm-ID: 143464 [Multi-domain]  Cd Length: 451  Bit Score: 162.91  E-value: 3.17e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 102 LNKAIEAALAARKEwdLKPiADRAQIFLKAADMLSgpRRAEILAKTMVGQ-GKTVIQA--EIDAAaelIDFFRFNAKYAV 178
Cdd:cd07146  23 LREALALAASYRST--LTR-YQRSAILNKAAALLE--ARREEFARLITLEsGLCLKDTryEVGRA---ADVLRFAAAEAL 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 179 ELEGQQpISVPPSTNSTVYRGLE-----GFVAAISPFNFTAiggNLAG---APALM-GNVVLWKPSDTAMLASYAVYRIL 249
Cdd:cd07146  95 RDDGES-FSCDLTANGKARKIFTlreplGVVLAITPFNHPL---NQVAhkiAPAIAaNNRIVLKPSEKTPLSAIYLADLL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 250 REAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAqnldrfhtFPRLAGECGGKNFHFVHRSADV 329
Cdd:cd07146 171 YEAGLPPDMLSVVTGEPGEIGDELITHPDVDLVTFTGGVAVGKAIAATAG--------YKRQLLELGGNDPLIVMDDADL 242
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 330 ESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEHARS 409
Cdd:cd07146 243 ERAATLAVAGSYANSGQRCTAVKRILVHESVADEFVDLLVEKSAALVVGDPMDP-ATDMGTVIDEEAAIQIENRVEEAIA 321
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 410 SPSLTILAGGKcddsVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGLTGAVFSQDKDV 489
Cdd:cd07146 322 QGARVLLGNQR----QGALYAPTVLDHVPPDAELVTEETFGPVAPVIRVKDL--DEAIAISNS-TAYGLSSGVCTNDLDT 394
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 25777734 490 VQEATKVLRNAAGNfyINDkSTGSIVGQQPFGGARASGTNDKPG 533
Cdd:cd07146 395 IKRLVERLDVGTVN--VNE-VPGFRSELSPFGGVKDSGLGGKEG 435
ALDH_AldA-Rv0768 cd07139
Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; The Mycobacterium tuberculosis ...
104-527 3.94e-44

Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; The Mycobacterium tuberculosis NAD+-dependent, aldehyde dehydrogenase PDB structure, 3B4W, and the Mycobacterium tuberculosis H37Rv aldehyde dehydrogenase AldA (locus Rv0768) sequence, as well as the Rhodococcus rhodochrous ALDH involved in haloalkane catabolism, and other similar sequences, are included in this CD.


Pssm-ID: 143457 [Multi-domain]  Cd Length: 471  Bit Score: 163.13  E-value: 3.94e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 104 KAIEAALAA--RKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVGQ-GKTVIQAEIDAAAELIDFFRFNAKYAVEL 180
Cdd:cd07139  40 AAVAAARRAfdNGPWPRLSPAERAAVLRRLADALE--ARADELARLWTAEnGMPISWSRRAQGPGPAALLRYYAALARDF 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 181 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNII 259
Cdd:cd07139 118 PFEERRPGSGGGHVLVRREPVGVVAAIVPWNAPLFLAALKIAPALAaGCTVVLKPSPETPLDAYLLAEAAEEAGLPPGVV 197
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 260 QFVPADgplfgdtVTSSEHLCG------INFTGSVPTFKHLWKQVAQNLDRFHTfprlagECGGKNFHFVHRSADVESVV 333
Cdd:cd07139 198 NVVPAD-------REVGEYLVRhpgvdkVSFTGSTAAGRRIAAVCGERLARVTL------ELGGKSAAIVLDDADLDAAV 264
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 334 SGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEHARSSPSL 413
Cdd:cd07139 265 PGLVPASLMNNGQVCVALTRILVPRSRYDEVVEALAAAVAALKVGDPLDP-ATQIGPLASARQRERVEGYIAKGRAEGAR 343
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 414 TILAGGKCDD-SVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGLTGAVFSQDkdvVQE 492
Cdd:cd07139 344 LVTGGGRPAGlDRGWFVEPTLFADVDNDMRIAQEEIFGPVLSVIPYDDE--DDAVRIAND-SDYGLSGSVWTAD---VER 417
                       410       420       430
                ....*....|....*....|....*....|....*.
gi 25777734 493 ATKVLRNA-AGNFYINDKSTGSivgQQPFGGARASG 527
Cdd:cd07139 418 GLAVARRIrTGTVGVNGFRLDF---GAPFGGFKQSG 450
PRK10090 PRK10090
aldehyde dehydrogenase A; Provisional
140-527 1.19e-43

aldehyde dehydrogenase A; Provisional


Pssm-ID: 182233 [Multi-domain]  Cd Length: 409  Bit Score: 160.29  E-value: 1.19e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  140 RAEILAKTMVG-QGKTVIQAEIDAAAElIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFT--AIG 216
Cdd:PRK10090  11 RASEISALIVEeGGKIQQLAEVEVAFT-ADYIDYMAEWARRYEGEIIQSDRPGENILLFKRALGVTTGILPWNFPffLIA 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  217 GNLAgaPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLW 295
Cdd:PRK10090  90 RKMA--PALLtGNTIVIKPSEFTPNNAIAFAKIVDEIGLPKGVFNLVLGRGETVGQELAGNPKVAMVSMTGSVSAGEKIM 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  296 KQVAQNLdrfhtfPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRI 375
Cdd:PRK10090 168 AAAAKNI------TKVCLELGGKAPAIVMDDADLDLAVKAIVDSRVINSGQVCNCAERVYVQKGIYDQFVNRLGEAMQAV 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  376 KVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSlTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSV 455
Cdd:PRK10090 242 QFGNPAERNDIAMGPLINAAALERVEQKVARAVEEGA-RVALGGKAVEGKGYYYPPTLLLDVRQEMSIMHEETFGPVLPV 320
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25777734  456 YVYpdDKYKETLQLVDStTSYGLTGAVFSQDKDVVQEATKVLRnaAGNFYINDKSTGSIvgqQPF-GGARASG 527
Cdd:PRK10090 321 VAF--DTLEEAIAMAND-SDYGLTSSIYTQNLNVAMKAIKGLK--FGETYINRENFEAM---QGFhAGWRKSG 385
ALDH_F7_AASADH cd07130
NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; ...
82-486 2.08e-43

NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Alpha-aminoadipic semialdehyde dehydrogenase (AASADH, EC=1.2.1.31), also known as ALDH7A1, Antiquitin-1, ALDH7B, or delta-1-piperideine-6-carboxylate dehydrogenase (P6CDH), is a NAD+-dependent ALDH. Human ALDH7A1 is involved in the pipecolic acid pathway of lysine catabolism, catalyzing the oxidation of alpha-aminoadipic semialdehyde to alpha-aminoadipate. Arabidopsis thaliana ALDH7B4 appears to be an osmotic-stress-inducible ALDH gene encoding a turgor-responsive or stress-inducible ALDH. The Streptomyces clavuligerus P6CDH appears to be involved in cephamycin biosynthesis, catalyzing the second stage of the two-step conversion of lysine to alpha-aminoadipic acid. The ALDH7A1 enzyme and others in this group have been observed as tetramers, yet the bacterial P6CDH enzyme has been reported as a monomer.


Pssm-ID: 143448  Cd Length: 474  Bit Score: 161.22  E-value: 2.08e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  82 VSPFNhGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPiadraqiflkaadmlsGPRRAEIL---------AKTMVGQ- 151
Cdd:cd07130  17 ISPAN-GEPIARVRQATPEDYESTIKAAQEAFKEWRDVP----------------APKRGEIVrqigdalrkKKEALGKl 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 152 -----GKTVIQA--EIDaaaELIDFfrfnAKYAVELEGQQPISVPPSTNSTvYRGLE-----GFVAAISPFNF-TAIGG- 217
Cdd:cd07130  80 vslemGKILPEGlgEVQ---EMIDI----CDFAVGLSRQLYGLTIPSERPG-HRMMEqwnplGVVGVITAFNFpVAVWGw 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 218 NLAGApALMGNVVLWKPSDTAMLASYAVYRI----LREAGLPPNIIQFVPADGPLfGDTVTSSEHLCGINFTGSVptfkH 293
Cdd:cd07130 152 NAAIA-LVCGNVVVWKPSPTTPLTAIAVTKIvarvLEKNGLPGAIASLVCGGADV-GEALVKDPRVPLVSFTGST----A 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 294 LWKQVAQNLDRfhTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 373
Cdd:cd07130 226 VGRQVGQAVAA--RFGRSLLELGGNNAIIVMEDADLDLAVRAVLFAAVGTAGQRCTTTRRLIVHESIYDEVLERLKKAYK 303
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 374 RIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEHARSSPSlTILAGGKCDDSVGYFVEPCIVESKdPQEPIMKEEIFGPVL 453
Cdd:cd07130 304 QVRIGDPLDD-GTLVGPLHTKAAVDNYLAAIEEAKSQGG-TVLFGGKVIDGPGNYVEPTIVEGL-SDAPIVKEETFAPIL 380
                       410       420       430
                ....*....|....*....|....*....|...
gi 25777734 454 svYVYPDDKYKETLQLVDStTSYGLTGAVFSQD 486
Cdd:cd07130 381 --YVLKFDTLEEAIAWNNE-VPQGLSSSIFTTD 410
ALDH_StaphAldA1 cd07117
Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; ...
84-527 3.29e-43

Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Uncharacterized aldehyde dehydrogenase from Staphylococcus aureus (AldA1, locus SACOL0154) and other similar sequences are present in this CD.


Pssm-ID: 143435  Cd Length: 475  Bit Score: 160.70  E-value: 3.29e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  84 PFNhGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAK--TMvGQGKTVIQ---A 158
Cdd:cd07117  23 PAN-GETLSEITDATDADVDRAVKAAQEAFKTWRKTTVAERANILNKIADIID--ENKELLAMveTL-DNGKPIREtraV 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 159 EIDAAAeliDFFRFNAKyAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDT 237
Cdd:cd07117  99 DIPLAA---DHFRYFAG-VIRAEEGSANMIDEDTLSIVLREPIGVVGQIIPWNFPFLMAAWKLAPALAaGNTVVIKPSST 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 238 AMLASYAVYRILREAgLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLdrfhtFPRLAgECGG 317
Cdd:cd07117 175 TSLSLLELAKIIQDV-LPKGVVNIVTGKGSKSGEYLLNHPGLDKLAFTGSTEVGRDVAIAAAKKL-----IPATL-ELGG 247
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 318 KNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSF 397
Cdd:cd07117 248 KSANIIFDDANWDKALEGAQLGILFNQGQVCCAGSRIFVQEGIYDEFVAKLKEKFENVKVGNPLDP-DTQMGAQVNKDQL 326
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 398 ARIKKWLEHARSSPSlTILAGGK----CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDSt 473
Cdd:cd07117 327 DKILSYVDIAKEEGA-KILTGGHrlteNGLDKGFFIEPTLIVNVTNDMRVAQEEIFGPVATVIKFKTE--DEVIDMAND- 402
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*
gi 25777734 474 TSYGLTGAVFSQDkdvVQEATKVLRNA-AGNFYINdkSTGSIVGQQPFGGARASG 527
Cdd:cd07117 403 SEYGLGGGVFTKD---INRALRVARAVeTGRVWVN--TYNQIPAGAPFGGYKKSG 452
ALDH_F1AB_F2_RALDH1 cd07141
NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like; NAD+-dependent ...
82-528 4.61e-43

NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like; NAD+-dependent retinal dehydrogenase 1 (RALDH 1, ALDH1, EC=1.2.1.36) also known as aldehyde dehydrogenase family 1 member A1 (ALDH1A1) in humans, is a homotetrameric, cytosolic enzyme that catalyzes the oxidation of retinaldehyde to retinoic acid. Human ALDH1B1 and ALDH2 are also in this cluster; both are mitochrondrial homotetramers which play important roles in acetaldehyde oxidation; ALDH1B1 in response to UV light exposure and ALDH2 during ethanol metabolism.


Pssm-ID: 143459  Cd Length: 481  Bit Score: 160.21  E-value: 4.61e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  82 VSPFNhGHKVAKFCYADKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSgpRRAEILA--KTMVGqGKTVI 156
Cdd:cd07141  27 INPAT-GEKICEVQEGDKADVDKAVKAARAAFKlgsPWRTMDASERGRLLNKLADLIE--RDRAYLAslETLDN-GKPFS 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 157 QAEIDAAAELIDFFRFNAKYAVELEGQqpiSVPPSTNSTVYRGLE--GFVAAISPFNFTAIGGNLAGAPAL-MGNVVLWK 233
Cdd:cd07141 103 KSYLVDLPGAIKVLRYYAGWADKIHGK---TIPMDGDFFTYTRHEpvGVCGQIIPWNFPLLMAAWKLAPALaCGNTVVLK 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 234 PSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTfKHLWKQVA--QNLDrfhtfpRL 311
Cdd:cd07141 180 PAEQTPLTALYLASLIKEAGFPPGVVNVVPGYGPTAGAAISSHPDIDKVAFTGSTEV-GKLIQQAAgkSNLK------RV 252
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 312 AGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAV 391
Cdd:cd07141 253 TLELGGKSPNIVFADADLDYAVEQAHEALFFNMGQCCCAGSRTFVQESIYDEFVKRSVERAKKRVVGNPFDP-KTEQGPQ 331
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 392 IDAKSFARIKKWLEHARSSPSlTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYvypddKYKETLQLVD 471
Cdd:cd07141 332 IDEEQFKKILELIESGKKEGA-KLECGGKRHGDKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQIF-----KFKTIDEVIE 405
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 25777734 472 --STTSYGLTGAVFSQDKDVVQEATKVLRnaAGNFYINDKSTGSIvgQQPFGGARASGT 528
Cdd:cd07141 406 raNNTTYGLAAAVFTKDIDKAITFSNALR--AGTVWVNCYNVVSP--QAPFGGYKMSGN 460
ALDH_F2BC cd07142
Arabidosis aldehyde dehydrogenase family 2 B4, B7, C4-like; Included in this CD is the ...
88-533 1.36e-42

Arabidosis aldehyde dehydrogenase family 2 B4, B7, C4-like; Included in this CD is the Arabidosis aldehyde dehydrogenase family 2 members B4 and B7 (EC=1.2.1.3), which are mitochondrial homotetramers that oxidize acetaldehyde and glycolaldehyde, but not L-lactaldehyde. Also in this group, is the Arabidosis cytosolic, homotetramer ALDH2C4 (EC=1.2.1.3), an enzyme involved in the oxidation of sinapalehyde and coniferaldehyde.


Pssm-ID: 143460  Cd Length: 476  Bit Score: 158.81  E-value: 1.36e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  88 GHKVAKFCYADKSLLNKAIEAALAARKE--WDLKPIADRAQIFLKAADMLSgPRRAEILAKTMVGQGKTVIQAEIDAAAE 165
Cdd:cd07142  29 GEVIAHVAEGDAEDVDRAVKAARKAFDEgpWPRMTGYERSRILLRFADLLE-KHADELAALETWDNGKPYEQARYAEVPL 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 166 LIDFFRFNAKYAVELEGqqpISVPPSTNSTVYRGLE--GFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLAS 242
Cdd:cd07142 108 AARLFRYYAGWADKIHG---MTLPADGPHHVYTLHEpiGVVGQIIPWNFPLLMFAWKVGPALAcGNTIVLKPAEQTPLSA 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 243 YAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ-NLDrfhtfpRLAGECGGKNFH 321
Cdd:cd07142 185 LLAAKLAAEAGLPDGVLNIVTGFGPTAGAAIASHMDVDKVAFTGSTEVGKIIMQLAAKsNLK------PVTLELGGKSPF 258
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPaedfgtFFSAV-----IDAKS 396
Cdd:cd07142 259 IVCEDADVDKAVELAHFALFFNQGQCCCAGSRTFVHESIYDEFVEKAKARALKRVVGDP------FRKGVeqgpqVDKEQ 332
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 397 FARIKKWLEHARSSPSlTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDdkYKETLQLVDStTSY 476
Cdd:cd07142 333 FEKILSYIEHGKEEGA-TLITGGDRIGSKGYYIQPTIFSDVKDDMKIARDEIFGPVQSILKFKT--VDEVIKRANN-SKY 408
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 25777734 477 GLTGAVFSQDKDVVQEATKVLRnaAGNFYIN--DKSTGSIvgqqPFGGARASGTNDKPG 533
Cdd:cd07142 409 GLAAGVFSKNIDTANTLSRALK--AGTVWVNcyDVFDASI----PFGGYKMSGIGREKG 461
ALDH_ACDHII_AcoD-like cd07559
Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus ...
82-527 3.72e-42

Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Included in this CD is the NAD+-dependent, acetaldehyde dehydrogenase II (AcDHII, AcoD, EC=1.2.1.3) from Ralstonia (Alcaligenes) eutrophus H16 involved in the catabolism of acetoin and ethanol, and similar proteins, such as, the dimeric dihydrolipoamide dehydrogenase of the acetoin dehydrogenase enzyme system of Klebsiella pneumonia. Also included are sequences similar to the NAD+-dependent chloroacetaldehyde dehydrogenases (AldA and AldB) of Xanthobacter autotrophicus GJ10 which are involved in the degradation of 1,2-dichloroethane, as well as, the uncharacterized aldehyde dehydrogenase from Staphylococcus aureus (AldA1, locus SACOL0154) and other similar sequences.


Pssm-ID: 143471 [Multi-domain]  Cd Length: 480  Bit Score: 157.89  E-value: 3.72e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  82 VSPFNhGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAK--TMvGQGKTV---I 156
Cdd:cd07559  21 YNPVN-GKVLCEIPRSTAEDVDLAVDAAHEAFKTWGKTSVAERANILNKIADRIE--ENLELLAVaeTL-DNGKPIretL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 157 QAEIDAAaelIDFFRFNAKYAVELEGQqpIS-VPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKP 234
Cdd:cd07559  97 AADIPLA---IDHFRYFAGVIRAQEGS--LSeIDEDTLSYHFHEPLGVVGQIIPWNFPLLMAAWKLAPALAaGNTVVLKP 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 235 SDTAMLASYAVYRILREAgLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLdrfhtFPrLAGE 314
Cdd:cd07559 172 ASQTPLSILVLMELIGDL-LPKGVVNVVTGFGSEAGKPLASHPRIAKLAFTGSTTVGRLIMQYAAENL-----IP-VTLE 244
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 315 CGGK--NFHFvhrsADVES--------VVSGTLRSAFEYGgQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDf 384
Cdd:cd07559 245 LGGKspNIFF----DDAMDadddfddkAEEGQLGFAFNQG-EVCTCPSRALVQESIYDEFIERAVERFEAIKVGNPLDP- 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 385 GTFFSAVIDAKSFARIKKWLEHARSSPSlTILAGGK----CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPD 460
Cdd:cd07559 319 ETMMGAQVSKDQLEKILSYVDIGKEEGA-EVLTGGErltlGGLDKGYFYEPTLIKGGNNDMRIFQEEIFGPVLAVITFKD 397
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 25777734 461 DkyKETLQLVDStTSYGLTGAVFSQDkdvVQEATKVLRN-AAGNFYINdkSTGSIVGQQPFGGARASG 527
Cdd:cd07559 398 E--EEAIAIAND-TEYGLGGGVWTRD---INRALRVARGiQTGRVWVN--CYHQYPAHAPFGGYKKSG 457
ALDH_F6_MMSDH cd07085
Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Methylmalonate ...
87-526 4.79e-42

Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Methylmalonate semialdehyde dehydrogenase (MMSDH, EC=1.2.1.27) [acylating] from Bacillus subtilis is involved in valine metabolism and catalyses the NAD+- and CoA-dependent oxidation of methylmalonate semialdehyde into propionyl-CoA. Mitochondrial human MMSDH ALDH6A1 and Arabidopsis MMSDH ALDH6B2 are also present in this CD.


Pssm-ID: 143404 [Multi-domain]  Cd Length: 478  Bit Score: 157.29  E-value: 4.79e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  87 HGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMV-GQGKTVIQA--EIDAA 163
Cdd:cd07085  25 TGEVIARVPLATAEEVDAAVAAAKAAFPAWSATPVLKRQQVMFKFRQLLE--ENLDELARLITlEHGKTLADArgDVLRG 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 164 AELIDFfrfNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIggnlagAPALM-------GNVVLWKPSD 236
Cdd:cd07085 103 LEVVEF---ACSIPHLLKGEYLENVARGIDTYSYRQPLGVVAGITPFNFPAM------IPLWMfpmaiacGNTFVLKPSE 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 237 TAMLASYAVYRILREAGLPPNIIQFVPADGplfgDTVtssEHLC------GINFTGSVPTFKHLWKQVAQNLDRFHTFpr 310
Cdd:cd07085 174 RVPGAAMRLAELLQEAGLPDGVLNVVHGGK----EAV---NALLdhpdikAVSFVGSTPVGEYIYERAAANGKRVQAL-- 244
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 311 lageCGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGdPAEDFGTFFSA 390
Cdd:cd07085 245 ----GGAKNHAVVMPDADLEQTANALVGAAFGAAGQRCMALSVAVAVGDEADEWIPKLVERAKKLKVG-AGDDPGADMGP 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 391 VIDAKSFARIKKWLEHArsspsltILAGGKC-----DDSV-----GYFVEPCIVESKDPQEPIMKEEIFGPVLSVyVYPD 460
Cdd:cd07085 320 VISPAAKERIEGLIESG-------VEEGAKLvldgrGVKVpgyenGNFVGPTILDNVTPDMKIYKEEIFGPVLSI-VRVD 391
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25777734 461 DkYKETLQLVDStTSYGLTGAVFSQDKDVvqeATKVLRNA-AGNFYINdkstgsI-----VGQQPFGGARAS 526
Cdd:cd07085 392 T-LDEAIAIINA-NPYGNGAAIFTRSGAA---ARKFQREVdAGMVGIN------VpipvpLAFFSFGGWKGS 452
ALDH_F16 cd07111
Aldehyde dehydrogenase family 16A1-like; Uncharacterized aldehyde dehydrogenase family 16 ...
88-536 3.23e-41

Aldehyde dehydrogenase family 16A1-like; Uncharacterized aldehyde dehydrogenase family 16 member A1 (ALDH16A1) and other related sequences are present in this CD. The active site cysteine and glutamate residues are not conserved in the human ALDH16A1 protein sequence.


Pssm-ID: 143429 [Multi-domain]  Cd Length: 480  Bit Score: 155.25  E-value: 3.23e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  88 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGqGKTVIQ---AEIDAAA 164
Cdd:cd07111  47 GEVLASVLQAEEEDVDAAVAAARTAFESWSALPGHVRARHLYRIARHIQKHQRLFAVLESLDN-GKPIREsrdCDIPLVA 125
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 165 ELidfFRFNAKYA----VELEGQQPIsvppstnstvyrgleGFVAAISPFNFTAIGGNLAGAPAL-MGNVVLWKPSDTAM 239
Cdd:cd07111 126 RH---FYHHAGWAqlldTELAGWKPV---------------GVVGQIVPWNFPLLMLAWKICPALaMGNTVVLKPAEYTP 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 240 LASYAVYRILREAGLPPNIIQFVPADGPlFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQnldrfhTFPRLAGECGGKN 319
Cdd:cd07111 188 LTALLFAEICAEAGLPPGVLNIVTGNGS-FGSALANHPGVDKVAFTGSTEVGRALRRATAG------TGKKLSLELGGKS 260
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 320 FHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDP---AEDFGtffsAVIDAKS 396
Cdd:cd07111 261 PFIVFDDADLDSAVEGIVDAIWFNQGQVCCAGSRLLVQESVAEELIRKLKERMSHLRVGDPldkAIDMG----AIVDPAQ 336
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 397 FARIKKWLEHARSSPSLTILAGGKCDDSvGYFVEPCIVESKDPQEPIMKEEIFGPVLSvyVYPDDKYKETLQLVDStTSY 476
Cdd:cd07111 337 LKRIRELVEEGRAEGADVFQPGADLPSK-GPFYPPTLFTNVPPASRIAQEEIFGPVLV--VLTFRTAKEAVALANN-TPY 412
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 477 GLTGAVFSQDKDVVQEATKVLRnaAGNFYINdkSTGSIVGQQPFGGARASGTNdKPGGPH 536
Cdd:cd07111 413 GLAASVWSENLSLALEVALSLK--AGVVWIN--GHNLFDAAAGFGGYRESGFG-REGGKE 467
ALDH_F15-22 cd07098
Aldehyde dehydrogenase family 15A1 and 22A1-like; Aldehyde dehydrogenase family members ...
104-535 9.17e-40

Aldehyde dehydrogenase family 15A1 and 22A1-like; Aldehyde dehydrogenase family members ALDH15A1 (Saccharomyces cerevisiae YHR039C) and ALDH22A1 (Arabidopsis thaliana, EC=1.2.1.3), and similar sequences, are in this CD. Significant improvement of stress tolerance in tobacco plants was observed by overexpressing the ALDH22A1 gene from maize (Zea mays) and was accompanied by a reduction of malondialdehyde derived from cellular lipid peroxidation.


Pssm-ID: 143416 [Multi-domain]  Cd Length: 465  Bit Score: 150.91  E-value: 9.17e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 104 KAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAK-TMVGQGKTVIQA---EIDAAAELIDFFRFNAKYAVe 179
Cdd:cd07098  22 EAIAAARAAQREWAKTSFAERRKVLRSLLKYIL--ENQEEICRvACRDTGKTMVDAslgEILVTCEKIRWTLKHGEKAL- 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 180 legqQPISVPPSTNsTVYRGLE------GFVAAISPFNF---TAIGGNLAgapALM-GNVVLWKPSDTAMLASYAVYRIL 249
Cdd:cd07098  99 ----RPESRPGGLL-MFYKRARveyeplGVVGAIVSWNYpfhNLLGPIIA---ALFaGNAIVVKVSEQVAWSSGFFLSII 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 250 REA----GLPPNIIQFVPADGPLfGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDrfhtfPRLAgECGGKNFHFVHR 325
Cdd:cd07098 171 REClaacGHDPDLVQLVTCLPET-AEALTSHPVIDHITFIGSPPVGKKVMAAAAESLT-----PVVL-ELGGKDPAIVLD 243
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 326 SADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAE---DFGtffsAVIDAKSFARIKK 402
Cdd:cd07098 244 DADLDQIASIIMRGTFQSSGQNCIGIERVIVHEKIYDKLLEILTDRVQALRQGPPLDgdvDVG----AMISPARFDRLEE 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 403 WLEHARSSPSlTILAGGK----CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGL 478
Cdd:cd07098 320 LVADAVEKGA-RLLAGGKryphPEYPQGHYFPPTLLVDVTPDMKIAQEEVFGPVMVVMKASDD--EEAVEIANS-TEYGL 395
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 25777734 479 TGAVFSQDKDVVQEATKVLRnaAGNFYINDKSTGSIVGQQPFGGARASGTnDKPGGP 535
Cdd:cd07098 396 GASVFGKDIKRARRIASQLE--TGMVAINDFGVNYYVQQLPFGGVKGSGF-GRFAGE 449
astD PRK09457
succinylglutamic semialdehyde dehydrogenase; Reviewed
97-532 1.31e-37

succinylglutamic semialdehyde dehydrogenase; Reviewed


Pssm-ID: 181873  Cd Length: 487  Bit Score: 145.10  E-value: 1.31e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   97 ADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAkTMVGQ--GKTVIQAEIDAAAELidffrfnA 174
Cdd:PRK09457  34 ATAAQVDAAVRAARAAFPAWARLSFEERQAIVERFAALLE--ENKEELA-EVIARetGKPLWEAATEVTAMI-------N 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  175 KYAV------ELEGQQPISVPPSTNSTVYRGLeGFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYR 247
Cdd:PRK09457 104 KIAIsiqayhERTGEKRSEMADGAAVLRHRPH-GVVAVFGPYNFPGHLPNGHIVPALLaGNTVVFKPSELTPWVAELTVK 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  248 ILREAGLPPNIIQFVPAdGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFhtfprLAGECGGKNFHFVHRSA 327
Cdd:PRK09457 183 LWQQAGLPAGVLNLVQG-GRETGKALAAHPDIDGLLFTGSANTGYLLHRQFAGQPEKI-----LALEMGGNNPLVIDEVA 256
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  328 DVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQ-IKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEH 406
Cdd:PRK09457 257 DIDAAVHLIIQSAFISAGQRCTCARRLLVPQGAQGDaFLARLVAVAKRLTVGRWDAEPQPFMGAVISEQAAQGLVAAQAQ 336
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  407 ARSSPSLTILAGGKCDDSVGyFVEPCIVESKDPQEPImKEEIFGPVLSVYVYPDdkYKETLQLVDStTSYGLTGAVFSQD 486
Cdd:PRK09457 337 LLALGGKSLLEMTQLQAGTG-LLTPGIIDVTGVAELP-DEEYFGPLLQVVRYDD--FDEAIRLANN-TRFGLSAGLLSDD 411
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 25777734  487 KDVVQEATKVLRnaAGNFYINDKSTGSiVGQQPFGGARASGtNDKP 532
Cdd:PRK09457 412 REDYDQFLLEIR--AGIVNWNKPLTGA-SSAAPFGGVGASG-NHRP 453
ALDH_RL0313 cd07148
Uncharacterized ALDH ( RL0313) with similarity to Tortula ruralis aldehyde dehydrogenase ...
82-529 5.04e-37

Uncharacterized ALDH ( RL0313) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Uncharacterized aldehyde dehydrogenase (locus RL0313) with sequence similarity to the moss Tortula ruralis aldehyde dehydrogenase ALDH21A1 (RNP123) believed to play an important role in the detoxification of aldehydes generated in response to desiccation- and salinity-stress, and similar sequences are included in this CD.


Pssm-ID: 143466 [Multi-domain]  Cd Length: 455  Bit Score: 142.94  E-value: 5.04e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  82 VSPFNHGHkVAKFCYADKSLLNKAIEAALAA---RKEWdlKPIADRAQIFLKAADMLSGprRAEILAKTMVGQG-KTVIQ 157
Cdd:cd07148   4 VNPFDLKP-IGEVPTVDWAAIDKALDTAHALfldRNNW--LPAHERIAILERLADLMEE--RADELALLIAREGgKPLVD 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 158 A--EIDAAaelIDFFRFNAKYAVELEGQQ-PISV-PPSTNSTVYRGLE--GFVAAISPFNFTAiggNLA---GAPAL-MG 227
Cdd:cd07148  79 AkvEVTRA---IDGVELAADELGQLGGREiPMGLtPASAGRIAFTTREpiGVVVAISAFNHPL---NLIvhqVAPAIaAG 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 228 NVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEhLCGINFTGSVPTFKHLWKQVAQNldrfht 307
Cdd:cd07148 153 CPVIVKPALATPLSCLAFVDLLHEAGLPEGWCQAVPCENAVAEKLVTDPR-VAFFSFIGSARVGWMLRSKLAPG------ 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 308 fPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAeDFGTF 387
Cdd:cd07148 226 -TRCALEHGGAAPVIVDRSADLDAMIPPLVKGGFYHAGQVCVSVQRVFVPAEIADDFAQRLAAAAEKLVVGDPT-DPDTE 303
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 388 FSAVIDAKSFARIKKWLEHARSSPSlTILAGGKCDDSVGYfvEPCIVESKDPQEPIMKEEIFGPVLSVYVYpdDKYKETL 467
Cdd:cd07148 304 VGPLIRPREVDRVEEWVNEAVAAGA-RLLCGGKRLSDTTY--APTVLLDPPRDAKVSTQEIFGPVVCVYSY--DDLDEAI 378
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25777734 468 QLVDStTSYGLTGAVFSQDKDVVQEATKVLrnAAGNFYINDKsTGSIVGQQPFGGARASGTN 529
Cdd:cd07148 379 AQANS-LPVAFQAAVFTKDLDVALKAVRRL--DATAVMVNDH-TAFRVDWMPFAGRRQSGYG 436
PLN02466 PLN02466
aldehyde dehydrogenase family 2 member
88-533 2.07e-36

aldehyde dehydrogenase family 2 member


Pssm-ID: 215259 [Multi-domain]  Cd Length: 538  Bit Score: 142.64  E-value: 2.07e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   88 GHKVAKFCYADKSLLNKAIEAALAARKE--WDLKPIADRAQIFLKAADMLSgPRRAEILAKTMVGQGKTVIQAeidAAAE 165
Cdd:PLN02466  83 GEVIAHVAEGDAEDVNRAVAAARKAFDEgpWPKMTAYERSRILLRFADLLE-KHNDELAALETWDNGKPYEQS---AKAE 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  166 L---IDFFRFNAKYAVELEGqqpISVPPSTNSTVYRGLE--GFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAM 239
Cdd:PLN02466 159 LpmfARLFRYYAGWADKIHG---LTVPADGPHHVQTLHEpiGVAGQIIPWNFPLLMFAWKVGPALAcGNTIVLKTAEQTP 235
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  240 LASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFprlagECGGKN 319
Cdd:PLN02466 236 LSALYAAKLLHEAGLPPGVLNVVSGFGPTAGAALASHMDVDKLAFTGSTDTGKIVLELAAKSNLKPVTL-----ELGGKS 310
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  320 FHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQI----KGRLLeehsRIKVGDPaedfgtFFSAV---- 391
Cdd:PLN02466 311 PFIVCEDADVDKAVELAHFALFFNQGQCCCAGSRTFVHERVYDEFvekaKARAL----KRVVGDP------FKKGVeqgp 380
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  392 -IDAKSFARIKKWLEHARSSPSlTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYvypddKYKETLQLV 470
Cdd:PLN02466 381 qIDSEQFEKILRYIKSGVESGA-TLECGGDRFGSKGYYIQPTVFSNVQDDMLIAQDEIFGPVQSIL-----KFKDLDEVI 454
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25777734  471 D--STTSYGLTGAVFSQDKDVVQEATKVLRnaAGNFYIN--DKSTGSIvgqqPFGGARASGTNDKPG 533
Cdd:PLN02466 455 RraNNTRYGLAAGVFTQNLDTANTLSRALR--VGTVWVNcfDVFDAAI----PFGGYKMSGIGREKG 515
PLN02766 PLN02766
coniferyl-aldehyde dehydrogenase
88-527 3.89e-36

coniferyl-aldehyde dehydrogenase


Pssm-ID: 215410 [Multi-domain]  Cd Length: 501  Bit Score: 141.11  E-value: 3.89e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   88 GHKVAKFCYADKSLLNKAIEAALAA--RKEWDLKPIADRAQIFLKAADMLSgpRRAEILAK-------TMVGQGKTViqa 158
Cdd:PLN02766  46 GEVIARIAEGDKEDVDLAVKAAREAfdHGPWPRMSGFERGRIMMKFADLIE--EHIEELAAldtidagKLFALGKAV--- 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  159 EIDAAAELidfFRFNAKYAVELEGQQpISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDT 237
Cdd:PLN02766 121 DIPAAAGL---LRYYAGAADKIHGET-LKMSRQLQGYTLKEPIGVVGHIIPWNFPSTMFFMKVAPALAaGCTMVVKPAEQ 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  238 AMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ-NLDRfhtfprLAGECG 316
Cdd:PLN02766 197 TPLSALFYAHLAKLAGVPDGVINVVTGFGPTAGAAIASHMDVDKVSFTGSTEVGRKIMQAAATsNLKQ------VSLELG 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  317 GKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAeDFGTFFSAVIDAKS 396
Cdd:PLN02766 271 GKSPLLIFDDADVDMAVDLALLGIFYNKGEICVASSRVYVQEGIYDEFVKKLVEKAKDWVVGDPF-DPRARQGPQVDKQQ 349
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  397 FARIKKWLEHARSSPSlTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYvypddKYK---ETLQLVDSt 473
Cdd:PLN02766 350 FEKILSYIEHGKREGA-TLLTGGKPCGDKGYYIEPTIFTDVTEDMKIAQDEIFGPVMSLM-----KFKtveEAIKKANN- 422
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 25777734  474 TSYGLTGAVFSQDKDVVQEATKVLRnaAGNFYIN-----DKSTgsivgqqPFGGARASG 527
Cdd:PLN02766 423 TKYGLAAGIVTKDLDVANTVSRSIR--AGTIWVNcyfafDPDC-------PFGGYKMSG 472
gabD PRK11241
NADP-dependent succinate-semialdehyde dehydrogenase I;
104-527 1.17e-35

NADP-dependent succinate-semialdehyde dehydrogenase I;


Pssm-ID: 183050 [Multi-domain]  Cd Length: 482  Bit Score: 139.66  E-value: 1.17e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  104 KAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTM-VGQGKTVIQA--EIDAAAELIDFFRFNAK--YAV 178
Cdd:PRK11241  52 AAIDAANRALPAWRALTAKERANILRRWFNLMM--EHQDDLARLMtLEQGKPLAEAkgEISYAASFIEWFAEEGKriYGD 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  179 ELEGQQPisvppSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPN 257
Cdd:PRK11241 130 TIPGHQA-----DKRLIVIKQPIGVTAAITPWNFPAAMITRKAGPALAaGCTMVLKPASQTPFSALALAELAIRAGIPAG 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  258 IIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRfhtfprLAGECGGKNFHFVHRSADVESVVSGTL 337
Cdd:PRK11241 205 VFNVVTGSAGAVGGELTSNPLVRKLSFTGSTEIGRQLMEQCAKDIKK------VSLELGGNAPFIVFDDADLDKAVEGAL 278
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  338 RSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEHARSSPSlTILA 417
Cdd:PRK11241 279 ASKFRNAGQTCVCANRLYVQDGVYDRFAEKLQQAVSKLHIGDGLEK-GVTIGPLIDEKAVAKVEEHIADALEKGA-RVVC 356
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  418 GGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGLTGAVFSQDkdvvqeATKVL 497
Cdd:PRK11241 357 GGKAHELGGNFFQPTILVDVPANAKVAKEETFGPLAPLFRFKDE--ADVIAQAND-TEFGLAAYFYARD------LSRVF 427
                        410       420       430
                 ....*....|....*....|....*....|..
gi 25777734  498 RNA-AGNFYINDKSTGSIVGQ-QPFGGARASG 527
Cdd:PRK11241 428 RVGeALEYGIVGINTGIISNEvAPFGGIKASG 459
ALDH_F1L_FTFDH cd07140
10-formyltetrahydrofolate dehydrogenase, ALDH family 1L; 10-formyltetrahydrofolate ...
88-527 1.82e-34

10-formyltetrahydrofolate dehydrogenase, ALDH family 1L; 10-formyltetrahydrofolate dehydrogenase (FTHFDH, EC=1.5.1.6), also known as aldehyde dehydrogenase family 1 member L1 (ALDH1L1) in humans, is a multi-domain homotetramer with an N-terminal formyl transferase domain and a C-terminal ALDH domain. FTHFDH catalyzes an NADP+-dependent dehydrogenase reaction resulting in the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2. The ALDH domain is also capable of the oxidation of short chain aldehydes to their corresponding acids.


Pssm-ID: 143458 [Multi-domain]  Cd Length: 486  Bit Score: 136.09  E-value: 1.82e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  88 GHKVAKFCYADKSLLNKAIEAALAA--RKEWDLKPIADRAQIFLKAADMLSgpRRAEILA---------------KTMVG 150
Cdd:cd07140  31 GSVICKVSLATVEDVDRAVAAAKEAfeNGEWGKMNARDRGRLMYRLADLME--EHQEELAtiesldsgavytlalKTHVG 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 151 QGktviqaeidaaaelIDFFRFNAKYAVELEGQQ-PIS-VPPSTNSTVYRGLE-GFVAAISPFNFTAIGGNLAGAPALM- 226
Cdd:cd07140 109 MS--------------IQTFRYFAGWCDKIQGKTiPINqARPNRNLTLTKREPiGVCGIVIPWNYPLMMLAWKMAACLAa 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 227 GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVA-QNLDRf 305
Cdd:cd07140 175 GNTVVLKPAQVTPLTALKFAELTVKAGFPKGVINILPGSGSLVGQRLSDHPDVRKLGFTGSTPIGKHIMKSCAvSNLKK- 253
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 306 htfprLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDP---AE 382
Cdd:cd07140 254 -----VSLELGGKSPLIIFADCDMDKAVRMGMSSVFFNKGENCIAAGRLFVEESIHDEFVRRVVEEVKKMKIGDPldrST 328
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 383 DFGTffsavidAKSFARIKKWLEHARSS--PSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPD 460
Cdd:cd07140 329 DHGP-------QNHKAHLDKLVEYCERGvkEGATLVYGGKQVDRPGFFFEPTVFTDVEDHMFIAKEESFGPIMIISKFDD 401
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 25777734 461 DKYKETLQLVDsTTSYGLTGAVFSQDkdvvqeATKVLRNA----AGNFYINDKSTGSIVGqqPFGGARASG 527
Cdd:cd07140 402 GDVDGVLQRAN-DTEYGLASGVFTKD------INKALYVSdkleAGTVFVNTYNKTDVAA--PFGGFKQSG 463
ALDH_KGSADH-like cd07084
ALDH subfamily: NAD(P)+-dependent alpha-ketoglutaric semialdehyde dehydrogenases and plant ...
102-547 1.46e-31

ALDH subfamily: NAD(P)+-dependent alpha-ketoglutaric semialdehyde dehydrogenases and plant delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH family 12-like; ALDH subfamily which includes the NAD(P)+-dependent, alpha-ketoglutaric semialdehyde dehydrogenases (KGSADH, EC 1.2.1.26); plant delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH, EC=1.5.1.12 ), ALDH family 12; the N-terminal domain of the MaoC (monoamine oxidase C) dehydratase regulatory protein; and orthologs of MaoC, PaaZ and PaaN, which are putative ring-opening enzymes of the aerobic phenylacetic acid catabolic pathway.


Pssm-ID: 143403 [Multi-domain]  Cd Length: 442  Bit Score: 126.97  E-value: 1.46e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 102 LNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSgPRRAEILAKTMVGQGKTVIQAEiDAAAeliDFFRFNAKYAVELE 181
Cdd:cd07084   1 PERALLAADISTKAARRLALPKRADFLARIIQRLA-AKSYDIAAGAVLVTGKGWMFAE-NICG---DQVQLRARAFVIYS 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 182 GQQP------ISVPPSTNSTVYRGLEGFVAAISPFNF--TAIGGNLAGAPAlMGNVVLWKPSDTAMLASYAVYRILREAG 253
Cdd:cd07084  76 YRIPhepgnhLGQGLKQQSHGYRWPYGPVLVIGAFNFplWIPLLQLAGALA-MGNPVIVKPHTAVSIVMQIMVRLLHYAG 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 254 -LPPNIIQFVPADGPLfGDTVTSSEHLCGINFTGSVptfkhlwkQVAQNLDRFHTFPRLAGECGGKNFHFVHRSAD-VES 331
Cdd:cd07084 155 lLPPEDVTLINGDGKT-MQALLLHPNPKMVLFTGSS--------RVAEKLALDAKQARIYLELAGFNWKVLGPDAQaVDY 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 332 VVSGTLRSAFEYGGQKCSACSRLYVPH--SLWPQIKgRLLEEHSRIKVGDpaedfgTFFSAVIDAKSFARIkkwlEHARS 409
Cdd:cd07084 226 VAWQCVQDMTACSGQKCTAQSMLFVPEnwSKTPLVE-KLKALLARRKLED------LLLGPVQTFTTLAMI----AHMEN 294
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 410 SPSLTILAGGK--CDDSVGYFVEPCI-------VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYgLTG 480
Cdd:cd07084 295 LLGSVLLFSGKelKNHSIPSIYGACVasalfvpIDEILKTYELVTEEIFGPFAIVVEYKKDQLALVLELLERMHGS-LTA 373
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25777734 481 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVI 547
Cdd:cd07084 374 AIYSNDPIFLQELIGNLWVAGRTYAILRGRTGVAPNQNHGGGPAADPRGAGIGGPEAIKLVWRCHAE 440
PRK09847 PRK09847
gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional
102-547 5.35e-31

gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional


Pssm-ID: 182108 [Multi-domain]  Cd Length: 494  Bit Score: 126.16  E-value: 5.35e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  102 LNKAIEAALAA--RKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMvGQGKTV---IQAEIDAAAELIdffRFNAKY 176
Cdd:PRK09847  59 IDRAVSAARGVfeRGDWSLSSPAKRKAVLNKLADLMEAHAEELALLETL-DTGKPIrhsLRDDIPGAARAI---RWYAEA 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  177 AVELEGQqpisVPPSTN---STVYRGLEGFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREA 252
Cdd:PRK09847 135 IDKVYGE----VATTSShelAMIVREPVGVIAAIVPWNFPLLLTCWKLGPALAaGNSVILKPSEKSPLSAIRLAGLAKEA 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  253 GLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNldrfhTFPRLAGECGGKNFHFVHRSA-DVES 331
Cdd:PRK09847 211 GLPDGVLNVVTGFGHEAGQALSRHNDIDAIAFTGSTRTGKQLLKDAGDS-----NMKRVWLEAGGKSANIVFADCpDLQQ 285
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  332 VVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAeDFGTFFSAVIDAKSFARIKKWLEHARSSP 411
Cdd:PRK09847 286 AASATAAGIFYNQGQVCIAGTRLLLEESIADEFLALLKQQAQNWQPGHPL-DPATTMGTLIDCAHADSVHSFIREGESKG 364
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  412 SLtiLAGGKCDDSVGYfVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDkyKETLQLVDStTSYGLTGAVFSQDKDVVQ 491
Cdd:PRK09847 365 QL--LLDGRNAGLAAA-IGPTIFVDVDPNASLSREEIFGPVLVVTRFTSE--EQALQLAND-SQYGLGAAVWTRDLSRAH 438
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 25777734  492 EATKVLRnaAGNFYINDKSTGSIVgqQPFGGARASGtNDKPGGPHYILRWTSPQVI 547
Cdd:PRK09847 439 RMSRRLK--AGSVFVNNYNDGDMT--VPFGGYKQSG-NGRDKSLHALEKFTELKTI 489
gabD1 PRK09406
succinic semialdehyde dehydrogenase; Reviewed
88-527 1.45e-30

succinic semialdehyde dehydrogenase; Reviewed


Pssm-ID: 181826 [Multi-domain]  Cd Length: 457  Bit Score: 124.46  E-value: 1.45e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   88 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAeiLAKTMVGQ-GKTVIQAEIDAAaEL 166
Cdd:PRK09406  11 GETVKTFTALTDDEVDAAIARAHARFRDYRTTTFAQRARWANAAADLLEAEADQ--VAALMTLEmGKTLASAKAEAL-KC 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  167 IDFFRFNAKYAVELEGQQPISVPPSTNS---TVYRGLeGFVAAISPFNFTAIGGNLAGAPALM-GNVVLWK-PSDTAMLA 241
Cdd:PRK09406  88 AKGFRYYAEHAEALLADEPADAAAVGASrayVRYQPL-GVVLAVMPWNFPLWQVVRFAAPALMaGNVGLLKhASNVPQTA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  242 SYaVYRILREAGLPPNIIQ--FVPADGPlfgDTVTSSEHLCGINFTGSVPTfkhlWKQVAQnldrfhtfprLAG------ 313
Cdd:PRK09406 167 LY-LADLFRRAGFPDGCFQtlLVGSGAV---EAILRDPRVAAATLTGSEPA----GRAVAA----------IAGdeikkt 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  314 --ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAV 391
Cdd:PRK09406 229 vlELGGSDPFIVMPSADLDRAAETAVTARVQNNGQSCIAAKRFIVHADVYDAFAEKFVARMAALRVGDPTDP-DTDVGPL 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  392 IDAKSFARIKKWLEHARSSPSlTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDdkYKETLQLVD 471
Cdd:PRK09406 308 ATEQGRDEVEKQVDDAVAAGA-TILCGGKRPDGPGWFYPPTVITDITPDMRLYTEEVFGPVASLYRVAD--IDEAIEIAN 384
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 25777734  472 STTsYGLTGAVFSQDkdvVQEATKVLRN-AAGNFYINDKSTGSivGQQPFGGARASG 527
Cdd:PRK09406 385 ATT-FGLGSNAWTRD---EAEQERFIDDlEAGQVFINGMTVSY--PELPFGGVKRSG 435
PLN02315 PLN02315
aldehyde dehydrogenase family 7 member
104-533 2.94e-30

aldehyde dehydrogenase family 7 member


Pssm-ID: 177949  Cd Length: 508  Bit Score: 124.18  E-value: 2.94e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  104 KAIEAALAARKEWDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVGQGKTVIQAEIDAAAELIDFfrfnAKYAVELEGQ 183
Cdd:PLN02315  60 EGLRACEEAAKIWMQVPAPKRGEIVRQIGDALR--AKLDYLGRLVSLEMGKILAEGIGEVQEIIDM----CDFAVGLSRQ 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  184 QPISVPPSTNST-----VYRGLeGFVAAISPFNF-TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRI----LREAG 253
Cdd:PLN02315 134 LNGSIIPSERPNhmmmeVWNPL-GIVGVITAFNFpCAVLGWNACIALVCGNCVVWKGAPTTPLITIAMTKLvaevLEKNN 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  254 LPPNIIQFVpADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNldrfhtFPRLAGECGGKNFHFVHRSADVESVV 333
Cdd:PLN02315 213 LPGAIFTSF-CGGAEIGEAIAKDTRIPLVSFTGSSKVGLMVQQTVNAR------FGKCLLELSGNNAIIVMDDADIQLAV 285
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  334 SGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEHARSSPSl 413
Cdd:PLN02315 286 RSVLFAAVGTAGQRCTTCRRLLLHESIYDDVLEQLLTVYKQVKIGDPLEK-GTLLGPLHTPESKKNFEKGIEIIKSQGG- 363
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  414 TILAGGKCDDSVGYFVEPCIVESKdPQEPIMKEEIFGPVLsvYVYPDDKYKETLQLVDSTTSyGLTGAVFSQDKDVVQEA 493
Cdd:PLN02315 364 KILTGGSAIESEGNFVQPTIVEIS-PDADVVKEELFGPVL--YVMKFKTLEEAIEINNSVPQ-GLSSSIFTRNPETIFKW 439
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 25777734  494 TKVLRNAAGNFYINDKSTGSIVGQQpFGGARASGTNDKPG 533
Cdd:PLN02315 440 IGPLGSDCGIVNVNIPTNGAEIGGA-FGGEKATGGGREAG 478
ALDH_F3-13-14_CALDH-like cd07087
ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other ...
154-527 3.54e-27

ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; ALDH subfamily which includes NAD(P)+-dependent, aldehyde dehydrogenase, family 3 member A1 and B1 (ALDH3A1, ALDH3B1, EC=1.2.1.5) and fatty aldehyde dehydrogenase, family 3 member A2 (ALDH3A2, EC=1.2.1.3), and also plant ALDH family members ALDH3F1, ALDH3H1, and ALDH3I1, fungal ALDH14 (YMR110C) and the protozoan family 13 member (ALDH13), as well as coniferyl aldehyde dehydrogenases (CALDH, EC=1.2.1.68), and other similar sequences, such as the Pseudomonas putida benzaldehyde dehydrogenase I that is involved in the metabolism of mandelate.


Pssm-ID: 143406 [Multi-domain]  Cd Length: 426  Bit Score: 114.16  E-value: 3.54e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 154 TVIQAEIDAAAELIDffrfnaKYAVELEGQQPISVPPSTNSTVYRGLeGFVAAISPFNF---TAIGgNLAGAPAlMGNVV 230
Cdd:cd07087  61 AVVLGEIDHALKHLK------KWMKPRRVSVPLLLQPAKAYVIPEPL-GVVLIIGPWNYplqLALA-PLIGAIA-AGNTV 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 231 LWKPSDTAMLASYAVYRILREAgLPPNIIQFVPADGPlfgdtVTS---SEHLCGINFTGSVPTFKHLWKQVAQNLdrfhT 307
Cdd:cd07087 132 VLKPSELAPATSALLAKLIPKY-FDPEAVAVVEGGVE-----VATallAEPFDHIFFTGSPAVGKIVMEAAAKHL----T 201
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 308 FPRLagECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSlwpqIKGRLLEEHSR-IKV---GDPAE- 382
Cdd:cd07087 202 PVTL--ELGGKSPCIVDKDANLEVAARRIAWGKFLNAGQTCIAPDYVLVHES----IKDELIEELKKaIKEfygEDPKEs 275
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 383 -DFGtffsAVIDAKSFARIKKWLEHArsspslTILAGGKCDDSvGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDd 461
Cdd:cd07087 276 pDYG----RIINERHFDRLASLLDDG------KVVIGGQVDKE-ERYIAPTILDDVSPDSPLMQEEIFGPILPILTYDD- 343
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25777734 462 kYKETLQLVDStTSYGLTGAVFSQDKDVVQeatKVLRN-AAGNFYINDKSTGSIVGQQPFGGARASG 527
Cdd:cd07087 344 -LDEAIEFINS-RPKPLALYLFSEDKAVQE---RVLAEtSSGGVCVNDVLLHAAIPNLPFGGVGNSG 405
ALDH_ACDHII-AcoD cd07116
Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Included in this CD is ...
74-527 5.70e-27

Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Included in this CD is the NAD+-dependent, acetaldehyde dehydrogenase II (AcDHII, AcoD, EC=1.2.1.3) from Ralstonia (Alcaligenes) eutrophus H16 involved in the catabolism of acetoin and ethanol, and similar proteins, such as, the dimeric dihydrolipoamide dehydrogenase of the acetoin dehydrogenase enzyme system of Klebsiella pneumonia. Also included are sequences similar to the NAD+-dependent chloroacetaldehyde dehydrogenases (AldA and AldB) of Xanthobacter autotrophicus GJ10 which are involved in the degradation of 1,2-dichloroethane. These proteins apparently require RpoN factors for expression.


Pssm-ID: 143434 [Multi-domain]  Cd Length: 479  Bit Score: 114.09  E-value: 5.70e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  74 WTSDV--QY--QVSPFNhGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTmV 149
Cdd:cd07116   9 WVAPVkgEYfdNITPVT-GKVFCEVPRSTAEDIELALDAAHAAKEAWGKTSVAERANILNKIADRMEANLEMLAVAET-W 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 150 GQGKTV---IQAEIDAAaelIDFFRFNAKYAVELEGqqpiSVPPSTNSTV-YRGLE--GFVAAISPFNFTAIGGNLAGAP 223
Cdd:cd07116  87 DNGKPVretLAADIPLA---IDHFRYFAGCIRAQEG----SISEIDENTVaYHFHEplGVVGQIIPWNFPLLMATWKLAP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 224 ALM-GNVVLWKPSDTAMLASYAVYRILREAgLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNL 302
Cdd:cd07116 160 ALAaGNCVVLKPAEQTPASILVLMELIGDL-LPPGVVNVVNGFGLEAGKPLASSKRIAKVAFTGETTTGRLIMQYASENI 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 303 drfhtFPrLAGECGGK--NFHF----VHRSADVESVVSGTLRSAFEYGgQKCSACSRLYVPHSLWPQIKGRLLEEHSRIK 376
Cdd:cd07116 239 -----IP-VTLELGGKspNIFFadvmDADDAFFDKALEGFVMFALNQG-EVCTCPSRALIQESIYDRFMERALERVKAIK 311
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 377 VGDPAeDFGTFFSAVIDAKSFARIKKWLEHARSSPSlTILAGGK----CDDSVGYFVEPCIVEsKDPQEPIMKEEIFGPV 452
Cdd:cd07116 312 QGNPL-DTETMIGAQASLEQLEKILSYIDIGKEEGA-EVLTGGErnelGGLLGGGYYVPTTFK-GGNKMRIFQEEIFGPV 388
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25777734 453 LSVYVYPDdkYKETLQLVDSTTsYGLTGAVFSQDkdvVQEATKVLRN-AAGNFYINdkSTGSIVGQQPFGGARASG 527
Cdd:cd07116 389 LAVTTFKD--EEEALEIANDTL-YGLGAGVWTRD---GNTAYRMGRGiQAGRVWTN--CYHLYPAHAAFGGYKQSG 456
ALDH_AlkH-like cd07134
Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Aldehyde dehydrogenase AlkH (locus name ...
184-527 4.47e-25

Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Aldehyde dehydrogenase AlkH (locus name P12693, EC=1.2.1.3) of the alkBFGHJKL operon that allows Pseudomonas putida to metabolize alkanes and the aldehyde dehydrogenase AldX of Bacillus subtilis (locus P46329, EC=1.2.1.3), and similar sequences, are present in this CD.


Pssm-ID: 143452 [Multi-domain]  Cd Length: 433  Bit Score: 108.08  E-value: 4.47e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 184 QPISVPPS-----TNSTVYRGLEGFVAAISPFNF---TAIGgNLAGAPAlMGNVVLWKPSDTAMLASYAVYRILREAglp 255
Cdd:cd07134  79 KPKRVRTPlllfgTKSKIRYEPKGVCLIISPWNYpfnLAFG-PLVSAIA-AGNTAILKPSELTPHTSAVIAKIIREA--- 153
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 256 pniiqFVPADGPLF-GDTVTSSE-------HlcgINFTGSVPTFKHLWKQVAQNLdrfhTFPRLagECGGKNFHFVHRSA 327
Cdd:cd07134 154 -----FDEDEVAVFeGDAEVAQAllelpfdH---IFFTGSPAVGKIVMAAAAKHL----ASVTL--ELGGKSPTIVDETA 219
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 328 DVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHA 407
Cdd:cd07134 220 DLKKAAKKIAWGKFLNAGQTCIAPDYVFVHESVKDAFVEHLKAEIEKFYGKDAARKASPDLARIVNDRHFDRLKGLLDDA 299
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 408 RSSPSlTILAGGKCDDSvGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPD-DkyketlQLVDSTTSYG--LTGAVFS 484
Cdd:cd07134 300 VAKGA-KVEFGGQFDAA-QRYIAPTVLTNVTPDMKIMQEEIFGPVLPIITYEDlD------EVIEYINAKPkpLALYVFS 371
                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 25777734 485 QDKDVVQeatKVLRN-AAGNFYINDkstgSIV----GQQPFGGARASG 527
Cdd:cd07134 372 KDKANVN---KVLARtSSGGVVVND----VVLhflnPNLPFGGVNNSG 412
ALDH_F14-YMR110C cd07135
Saccharomyces cerevisiae aldehyde dehydrogenase family 14 and related proteins; Aldehyde ...
202-528 7.37e-24

Saccharomyces cerevisiae aldehyde dehydrogenase family 14 and related proteins; Aldehyde dehydrogenase family 14 (ALDH14), isolated mainly from the mitochondrial outer membrane of Saccharomyces cerevisiae (YMR110C) and most closely related to the plant and animal ALDHs and fatty ALDHs family 3 members, and similar fungal sequences, are present in this CD.


Pssm-ID: 143453 [Multi-domain]  Cd Length: 436  Bit Score: 104.22  E-value: 7.37e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 202 GFVAAISPFNF---TAIGgNLAGAPAlMGNVVLWKPSDTAMLASYAVYRILREAgLPPNIIQFVPADGPLFGDTVTSS-E 277
Cdd:cd07135 110 GVVLIIGPWNYpvlLALS-PLVGAIA-AGCTVVLKPSELTPHTAALLAELVPKY-LDPDAFQVVQGGVPETTALLEQKfD 186
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 278 HlcgINFTGSVPTFKHLWKQVAQNLDrfhtfPrLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVP 357
Cdd:cd07135 187 K---IFYTGSGRVGRIIAEAAAKHLT-----P-VTLELGGKSPVIVTKNADLELAAKRILWGKFGNAGQICVAPDYVLVD 257
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 358 HSLWPQIKGRLLEEHSRIKVGDPAEDfgTFFSAVIDAKSFARIKKWLEHARSspslTILAGGKCDDSVgYFVEPCIVESK 437
Cdd:cd07135 258 PSVYDEFVEELKKVLDEFYPGGANAS--PDYTRIVNPRHFNRLKSLLDTTKG----KVVIGGEMDEAT-RFIPPTIVSDV 330
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 438 DPQEPIMKEEIFGPVLSVYVYPD-DKYKETLQLVDSTtsygLTGAVFSQDKDVVQeatKVL-RNAAGNFYINDKSTGSIV 515
Cdd:cd07135 331 SWDDSLMSEELFGPVLPIIKVDDlDEAIKVINSRDTP----LALYIFTDDKSEID---HILtRTRSGGVVINDTLIHVGV 403
                       330
                ....*....|...
gi 25777734 516 GQQPFGGARASGT 528
Cdd:cd07135 404 DNAPFGGVGDSGY 416
PRK13968 PRK13968
putative succinate semialdehyde dehydrogenase; Provisional
82-527 1.12e-23

putative succinate semialdehyde dehydrogenase; Provisional


Pssm-ID: 184426 [Multi-domain]  Cd Length: 462  Bit Score: 104.17  E-value: 1.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   82 VSPFNhGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQiflKAADMLSGPR-RAEILAKTMVGQ-GKTVIQA- 158
Cdd:PRK13968  12 VNPAT-GEQLSVLPWAGADDIENALQLAAAGFRDWRETNIDYRAQ---KLRDIGKALRaRSEEMAQMITREmGKPINQAr 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  159 -EIDAAAELIDFFrfnAKYAVELEGQQPISVPPSTNSTVYRGLeGFVAAISPFNFtAIGGNLAGA-PALM-GNVVLWKPS 235
Cdd:PRK13968  88 aEVAKSANLCDWY---AEHGPAMLKAEPTLVENQQAVIEYRPL-GTILAIMPWNF-PLWQVMRGAvPILLaGNGYLLKHA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  236 DTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEhLCGINFTGSVPTFKHLWKQVAQNLDRfhtfprLAGEC 315
Cdd:PRK13968 163 PNVMGCAQLIAQVFKDAGIPQGVYGWLNADNDGVSQMINDSR-IAAVTVTGSVRAGAAIGAQAGAALKK------CVLEL 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  316 GGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGtffsaviDAK 395
Cdd:PRK13968 236 GGSDPFIVLNDADLELAVKAAVAGRYQNTGQVCAAAKRFIIEEGIASAFTERFVAAAAALKMGDPRDEEN-------ALG 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  396 SFARIKKWLE-HARSSPSL----TILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYkeTLQLV 470
Cdd:PRK13968 309 PMARFDLRDElHHQVEATLaegaRLLLGGEKIAGAGNYYAPTVLANVTPEMTAFREELFGPVAAITVAKDAEH--ALELA 386
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 25777734  471 DStTSYGLTGAVFSQDKDVVQEATKVLRnaAGNFYINDKSTGSivGQQPFGGARASG 527
Cdd:PRK13968 387 ND-SEFGLSATIFTTDETQARQMAARLE--CGGVFINGYCASD--ARVAFGGVKKSG 438
PLN00412 PLN00412
NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional
75-488 1.07e-22

NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional


Pssm-ID: 215110 [Multi-domain]  Cd Length: 496  Bit Score: 101.37  E-value: 1.07e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734   75 TSDVQYQVSPfnhghkvakfCYADKslLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRR--AEILAKTMVGQG 152
Cdd:PLN00412  40 TRKTQYKVQA----------CTQEE--VNKAMESAKAAQKAWAKTPLWKRAELLHKAAAILKEHKApiAECLVKEIAKPA 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  153 KTVIqAEIDAAAELIDffrfnakYAVElEGQQPISVPPSTNSTVYRGLE------------GFVAAISPFNFTAiggNLA 220
Cdd:PLN00412 108 KDAV-TEVVRSGDLIS-------YTAE-EGVRILGEGKFLVSDSFPGNErnkycltskiplGVVLAIPPFNYPV---NLA 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  221 G---APALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSvptfkhlwk 296
Cdd:PLN00412 176 VskiAPALIaGNAVVLKPPTQGAVAALHMVHCFHLAGFPKGLISCVTGKGSEIGDFLTMHPGVNCISFTGG--------- 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  297 qvaqnlDRFHTFPRLAG------ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLE 370
Cdd:PLN00412 247 ------DTGIAISKKAGmvplqmELGGKDACIVLEDADLDLAAANIIKGGFSYSGQRCTAVKVVLVMESVADALVEKVNA 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  371 EHSRIKVGDPAEDfgTFFSAVIDAKSFARIKKWLEHARSSPSlTILAGGKCDdsvGYFVEPCIVESKDPQEPIMKEEIFG 450
Cdd:PLN00412 321 KVAKLTVGPPEDD--CDITPVVSESSANFIEGLVMDAKEKGA-TFCQEWKRE---GNLIWPLLLDNVRPDMRIAWEEPFG 394
                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 25777734  451 PVLSVYVYPDDkyKETLQLVDStTSYGLTGAVFSQDKD 488
Cdd:PLN00412 395 PVLPVIRINSV--EEGIHHCNA-SNFGLQGCVFTRDIN 429
PTZ00381 PTZ00381
aldehyde dehydrogenase family protein; Provisional
155-527 3.61e-22

aldehyde dehydrogenase family protein; Provisional


Pssm-ID: 240392  Cd Length: 493  Bit Score: 99.72  E-value: 3.61e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  155 VIQAEIDAAAELIDffrfnaKYAVELEGQQPISVPPSTNSTVYRGLeGFVAAISPFNF---TAIGgNLAGAPAlMGNVVL 231
Cdd:PTZ00381  71 LTVAEIEHLLKHLD------EYLKPEKVDTVGVFGPGKSYIIPEPL-GVVLVIGAWNYplnLTLI-PLAGAIA-AGNTVV 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  232 WKPSDTAMLASYAVYRILREAgLPPNIIQFVPADgplfgdtVTSSEHLCG-----INFTGSVPTFKHLWKQVAQNLdrfh 306
Cdd:PTZ00381 142 LKPSELSPHTSKLMAKLLTKY-LDPSYVRVIEGG-------VEVTTELLKepfdhIFFTGSPRVGKLVMQAAAENL---- 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  307 TFPRLagECGGKNFHFVHRSADV----ESVVSGTLRSAfeygGQKCSACSRLYVPHSlwpqIKGRLLEE--HSRIKV--G 378
Cdd:PTZ00381 210 TPCTL--ELGGKSPVIVDKSCNLkvaaRRIAWGKFLNA----GQTCVAPDYVLVHRS----IKDKFIEAlkEAIKEFfgE 279
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  379 DP--AEDFgtffSAVIDAKSFARIKKWLEHARSspslTILAGGKCDDSVGYfVEPCIVESKDPQEPIMKEEIFGPVLSVY 456
Cdd:PTZ00381 280 DPkkSEDY----SRIVNEFHTKRLAELIKDHGG----KVVYGGEVDIENKY-VAPTIIVNPDLDSPLMQEEIFGPILPIL 350
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25777734  457 VYPDdkYKETLQLVDStTSYGLTGAVFSQDKDVVQeatKVLRN-AAGNFYINDKSTGSIVGQQPFGGARASG 527
Cdd:PTZ00381 351 TYEN--IDEVLEFINS-RPKPLALYYFGEDKRHKE---LVLENtSSGAVVINDCVFHLLNPNLPFGGVGNSG 416
ALDH_YwdH-P39616 cd07136
Bacillus subtilis aldehyde dehydrogenase ywdH-like; Uncharacterized Bacillus subtilis ywdH ...
202-527 2.80e-21

Bacillus subtilis aldehyde dehydrogenase ywdH-like; Uncharacterized Bacillus subtilis ywdH aldehyde dehydrogenase (locus P39616) most closely related to the ALDHs and fatty ALDHs of families 3 and 14, and similar sequences, are included in this CD.


Pssm-ID: 143454 [Multi-domain]  Cd Length: 449  Bit Score: 96.80  E-value: 2.80e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 202 GFVAAISPFN--FTAIGGNLAGAPAlMGNVVLWKPSDTAMLASYAVYRILREAgLPPNIIQFVPadgplfGDTVTSSEHL 279
Cdd:cd07136 102 GVVLIIAPWNypFQLALAPLIGAIA-AGNTAVLKPSELTPNTSKVIAKIIEET-FDEEYVAVVE------GGVEENQELL 173
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 280 CG----INFTGSVPTFKHLWKQVAQNLdrfhTFPRLagECGGKNFHFVHRSADVE----SVVSGTLRSAfeygGQKCSAC 351
Cdd:cd07136 174 DQkfdyIFFTGSVRVGKIVMEAAAKHL----TPVTL--ELGGKSPCIVDEDANLKlaakRIVWGKFLNA----GQTCVAP 243
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 352 SRLYVPHSlwpqIKGRLLEE---HSRIKVGDPA---EDFGTffsaVIDAKSFARIKKWLEHArsspslTILAGGKCDDSV 425
Cdd:cd07136 244 DYVLVHES----VKEKFIKElkeEIKKFYGEDPlesPDYGR----IINEKHFDRLAGLLDNG------KIVFGGNTDRET 309
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 426 GYfVEPCIVESKDPQEPIMKEEIFGPVLSVYVYpdDKYKETLQLVDStTSYGLTGAVFSQDKDVvqeATKVLRNAA-GNF 504
Cdd:cd07136 310 LY-IEPTILDNVTWDDPVMQEEIFGPILPVLTY--DTLDEAIEIIKS-RPKPLALYLFSEDKKV---EKKVLENLSfGGG 382
                       330       340
                ....*....|....*....|...
gi 25777734 505 YINDKSTGSIVGQQPFGGARASG 527
Cdd:cd07136 383 CINDTIMHLANPYLPFGGVGNSG 405
ALDH_CALDH_CalB cd07133
Coniferyl aldehyde dehydrogenase-like; Coniferyl aldehyde dehydrogenase (CALDH, EC=1.2.1.68) ...
190-527 2.57e-19

Coniferyl aldehyde dehydrogenase-like; Coniferyl aldehyde dehydrogenase (CALDH, EC=1.2.1.68) of Pseudomonas sp. strain HR199 (CalB) which catalyzes the NAD+-dependent oxidation of coniferyl aldehyde to ferulic acid, and similar sequences, are present in this CD.


Pssm-ID: 143451 [Multi-domain]  Cd Length: 434  Bit Score: 90.62  E-value: 2.57e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 190 PSTNSTVYRGLeGFVAAISPFNF---TAIGGnLAGAPAlMGNVVLWKPSDTAMLASYAVYRILREAgLPPNIIQFV---P 263
Cdd:cd07133  92 PAKAEVEYQPL-GVVGIIVPWNYplyLALGP-LIAALA-AGNRVMIKPSEFTPRTSALLAELLAEY-FDEDEVAVVtggA 167
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 264 ADGPLFgdtvtSS---EHLCginFTGSVPTFKHLWKQVAQNLdrfhTFPRLagECGGKNFHFVHRSADVESVVSGTLRSA 340
Cdd:cd07133 168 DVAAAF-----SSlpfDHLL---FTGSTAVGRHVMRAAAENL----TPVTL--ELGGKSPAIIAPDADLAKAAERIAFGK 233
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 341 FEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIkvgdpaedFGTF-----FSAVIDAKSFARIKKWLEHARSSPS-LT 414
Cdd:cd07133 234 LLNAGQTCVAPDYVLVPEDKLEEFVAAAKAAVAKM--------YPTLadnpdYTSIINERHYARLQGLLEDARAKGArVI 305
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 415 ILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYpdDKYKETLQLVDSTTS----YgltgaVFSQDKdvv 490
Cdd:cd07133 306 ELNPAGEDFAATRKLPPTLVLNVTDDMRVMQEEIFGPILPILTY--DSLDEAIDYINARPRplalY-----YFGEDK--- 375
                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 25777734 491 QEATKVLRN-AAGNFYINDksTGSIVGQ--QPFGGARASG 527
Cdd:cd07133 376 AEQDRVLRRtHSGGVTIND--TLLHVAQddLPFGGVGASG 413
PLN02419 PLN02419
methylmalonate-semialdehyde dehydrogenase [acylating]
103-484 4.04e-18

methylmalonate-semialdehyde dehydrogenase [acylating]


Pssm-ID: 166060 [Multi-domain]  Cd Length: 604  Bit Score: 87.88  E-value: 4.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  103 NKAIEAALAARKE----WDLKPIADRAQIFLKAADMLSgpRRAEILAKTMVG-QGKTVIQAEIDAAAELiDFFRFNAKYA 177
Cdd:PLN02419 150 NEEFKAAVSAAKQafplWRNTPITTRQRVMLKFQELIR--KNMDKLAMNITTeQGKTLKDSHGDIFRGL-EVVEHACGMA 226
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  178 VELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIggnlagAPALM-------GNVVLWKPSDTAMLASYAVYRILR 250
Cdd:PLN02419 227 TLQMGEYLPNVSNGVDTYSIREPLGVCAGICPFNFPAM------IPLWMfpvavtcGNTFILKPSEKDPGASVILAELAM 300
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  251 EAGLPPNIIQFVPADGplfgDTVTS---SEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTfprlagECGGKNFHFVHRSA 327
Cdd:PLN02419 301 EAGLPDGVLNIVHGTN----DTVNAicdDEDIRAVSFVGSNTAGMHIYARAAAKGKRIQS------NMGAKNHGLVLPDA 370
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  328 DVESVVSGTLRSAFEYGGQKCSACSRLYV--PHSLWpqiKGRLLEEHSRIKV---GDPAEDFGtffsAVIDAKSFARIKK 402
Cdd:PLN02419 371 NIDATLNALLAAGFGAAGQRCMALSTVVFvgDAKSW---EDKLVERAKALKVtcgSEPDADLG----PVISKQAKERICR 443
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  403 WLEHARSSPSLTILAGgkcDDSV------GYFVEPCIVESKDPQEPIMKEEIFGPVLsvYVYPDDKYKETLQLVDStTSY 476
Cdd:PLN02419 444 LIQSGVDDGAKLLLDG---RDIVvpgyekGNFIGPTILSGVTPDMECYKEEIFGPVL--VCMQANSFDEAISIINK-NKY 517

                 ....*...
gi 25777734  477 GLTGAVFS 484
Cdd:PLN02419 518 GNGAAIFT 525
ALDH_F3AB cd07132
Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins; NAD(P)+-dependent, ...
314-527 1.43e-16

Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins; NAD(P)+-dependent, aldehyde dehydrogenase, family 3 members A1 and B1 (ALDH3A1, ALDH3B1, EC=1.2.1.5) and fatty aldehyde dehydrogenase, family 3 member A2 (ALDH3A2, EC=1.2.1.3), and similar sequences are included in this CD. Human ALDH3A1 is a homodimer with a critical role in cellular defense against oxidative stress; it catalyzes the oxidation of various cellular membrane lipid-derived aldehydes. Corneal crystalline ALDH3A1 protects the cornea and underlying lens against UV-induced oxidative stress. Human ALDH3A2, a microsomal homodimer, catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Human ALDH3B1 is highly expressed in the kidney and liver and catalyzes the oxidation of various medium- and long-chain saturated and unsaturated aliphatic aldehydes.


Pssm-ID: 143450 [Multi-domain]  Cd Length: 443  Bit Score: 82.27  E-value: 1.43e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 314 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSA-----CSrlyvphslwPQIKGRLLEE-HSRIKV---GDPAE-- 382
Cdd:cd07132 206 ELGGKSPCYVDKSCDIDVAARRIAWGKFINAGQTCIApdyvlCT---------PEVQEKFVEAlKKTLKEfygEDPKEsp 276
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 383 DFGTffsaVIDAKSFARIKKWLEharsspSLTILAGGKCDDSVGYfVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDdk 462
Cdd:cd07132 277 DYGR----IINDRHFQRLKKLLS------GGKVAIGGQTDEKERY-IAPTVLTDVKPSDPVMQEEIFGPILPIVTVNN-- 343
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25777734 463 YKETLQLVDSTTSyGLTGAVFSQDKDVVQeatKVLRN-AAGNFYINDKSTGSIVGQQPFGGARASG 527
Cdd:cd07132 344 LDEAIEFINSREK-PLALYVFSNNKKVIN---KILSNtSSGGVCVNDTIMHYTLDSLPFGGVGNSG 405
ALDH_MaoC-N cd07128
N-terminal domain of the monoamine oxidase C dehydratase; The N-terminal domain of the MaoC ...
200-512 4.23e-12

N-terminal domain of the monoamine oxidase C dehydratase; The N-terminal domain of the MaoC dehydratase, a monoamine oxidase regulatory protein. Orthologs of MaoC include PaaZ (Escherichia coli) and PaaN (Pseudomonas putida), which are putative ring-opening enzymes of the aerobic phenylacetic acid (PA) catabolic pathway. The C-terminal domain of MaoC has sequence similarity to enoyl-CoA hydratase. Also included in this CD is a novel Burkholderia xenovorans LB400 ALDH of the aerobic benzoate oxidation (box) pathway. This pathway involves first the synthesis of a CoA thio-esterified aromatic acid, with subsequent dihydroxylation and cleavage steps, yielding the CoA thio-esterified aliphatic aldehyde, 3,4-dehydroadipyl-CoA semialdehyde, which is further converted into its corresponding CoA acid by the Burkholderia LB400 ALDH.


Pssm-ID: 143446 [Multi-domain]  Cd Length: 513  Bit Score: 68.45  E-value: 4.23e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 200 LEGFVAAISPFNFTAIGGNLAGAPALMGNV-VLWKP-SDTAMLAsYAVYRILREAG-LPPNIIQFVPAD-GPLFgDTVTS 275
Cdd:cd07128 144 RRGVAVHINAFNFPVWGMLEKFAPALLAGVpVIVKPaTATAYLT-EAVVKDIVESGlLPEGALQLICGSvGDLL-DHLGE 221
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 276 SEHlcgINFTGSVPTFKHLwkQVAQNLDRFHTfpRLAGECGGKNFHFVhrSADVES-------VVSGTLRSAFEYGGQKC 348
Cdd:cd07128 222 QDV---VAFTGSAATAAKL--RAHPNIVARSI--RFNAEADSLNAAIL--GPDATPgtpefdlFVKEVAREMTVKAGQKC 292
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 349 SACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfGTFFSAVIDAKSFARIKKWLEHARSSPslTILAGGK-------C 421
Cdd:cd07128 293 TAIRRAFVPEARVDAVIEALKARLAKVVVGDPRLE-GVRMGPLVSREQREDVRAAVATLLAEA--EVVFGGPdrfevvgA 369
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 422 DDSVGYFVEPCIVESKDPQEP--IMKEEIFGPVLSVYVYpdDKYKETLQLVdsttSYG---LTGAVFSQDKDvvqEATKV 496
Cdd:cd07128 370 DAEKGAFFPPTLLLCDDPDAAtaVHDVEAFGPVATLMPY--DSLAEAIELA----ARGrgsLVASVVTNDPA---FAREL 440
                       330       340
                ....*....|....*....|....
gi 25777734 497 LRNAA---GNFYINDK-----STG 512
Cdd:cd07128 441 VLGAApyhGRLLVLNRdsakeSTG 464
ALDH_F3FHI cd07137
Plant aldehyde dehydrogenase family 3 members F1, H1, and I1 and related proteins; Aldehyde ...
185-528 1.71e-11

Plant aldehyde dehydrogenase family 3 members F1, H1, and I1 and related proteins; Aldehyde dehydrogenase family members 3F1, 3H1, and 3I1 (ALDH3F1, ALDH3H1, and ALDH3I1), and similar plant sequences, are in this CD. In Arabidopsis thaliana, stress-regulated expression of ALDH3I1 was observed in leaves and osmotic stress expression of ALDH3H1 was observed in root tissue, whereas, ALDH3F1 expression was not stress responsive. Functional analysis of ALDH3I1 suggest it may be involved in a detoxification pathway in plants that limits aldehyde accumulation and oxidative stress.


Pssm-ID: 143455 [Multi-domain]  Cd Length: 432  Bit Score: 66.28  E-value: 1.71e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 185 PISVPPSTNSTVYRGLeGFVAAISPFNFtAIGGNL---AGAPAlMGNVVLWKPSDTAMLASYAVYRILrEAGLPPNIIQF 261
Cdd:cd07137  87 PLTTFPAKAEIVSEPL-GVVLVISAWNF-PFLLSLepvIGAIA-AGNAVVLKPSELAPATSALLAKLI-PEYLDTKAIKV 162
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 262 VPAdgplfgdTVTSSEHLC-----GINFTGSVPTFKHLWKQVAQNLDrfhtfPrLAGECGGKNFHFVHRSADVESVVSGT 336
Cdd:cd07137 163 IEG-------GVPETTALLeqkwdKIFFTGSPRVGRIIMAAAAKHLT-----P-VTLELGGKCPVIVDSTVDLKVAVRRI 229
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 337 LrsAFEYG---GQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDfgTFFSAVIDAKSFARIKKWLEHARSSPSl 413
Cdd:cd07137 230 A--GGKWGcnnGQACIAPDYVLVEESFAPTLIDALKNTLEKFFGENPKES--KDLSRIVNSHHFQRLSRLLDDPSVADK- 304
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 414 tILAGGKCDDSvGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYpdDKYKETLQLVdSTTSYGLTGAVFSQDKDVvqEA 493
Cdd:cd07137 305 -IVHGGERDEK-NLYIEPTILLDPPLDSSIMTEEIFGPLLPIITV--KKIEESIEII-NSRPKPLAAYVFTKNKEL--KR 377
                       330       340       350
                ....*....|....*....|....*....|....*
gi 25777734 494 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGT 528
Cdd:cd07137 378 RIVAETSSGGVTFNDTVVQYAIDTLPFGGVGESGF 412
ALDH_F12_P5CDH cd07126
Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH family 12; Delta(1) ...
82-543 9.76e-11

Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH family 12; Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH, EC=1.5.1.12), family 12: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. P5CDH is a mitochondrial enzyme involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. The P5CDH, ALDH12A1 gene, in Arabidopsis, has been identified as an osmotic-stress-inducible ALDH gene. This CD contains both Viridiplantae and Alveolata P5CDH sequences.


Pssm-ID: 143444  Cd Length: 489  Bit Score: 64.05  E-value: 9.76e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  82 VSPFNhGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIA--DRAQ----IFLKAADMLSGPRRAEILAK-TMVGQGKT 154
Cdd:cd07126  17 LDPLN-GDKFISVPDTDEDEINEFVDSLRQCPKSGLHNPLKnpERYLlygdVSHRVAHELRKPEVEDFFARlIQRVAPKS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 155 VIQA--EIDAAAELIDFF-----RFNAK-YAV--ELEGQQpisvppstnSTVYRGLEGFVAAISPFNFT----AIggNLA 220
Cdd:cd07126  96 DAQAlgEVVVTRKFLENFagdqvRFLARsFNVpgDHQGQQ---------SSGYRWPYGPVAIITPFNFPleipAL--QLM 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 221 GApALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCgINFTGSvptfkhlwKQVAQ 300
Cdd:cd07126 165 GA-LFMGNKPLLKVDSKVSVVMEQFLRLLHLCGMPATDVDLIHSDGPTMNKILLEANPRM-TLFTGS--------SKVAE 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 301 NLDRfHTFPRLAGECGGKNFHFVHRS-ADVESVVSGTLRSAFEYGGQKCSACSRLYVpHSLWPQ--IKGRLLEEHSRIKV 377
Cdd:cd07126 235 RLAL-ELHGKVKLEDAGFDWKILGPDvSDVDYVAWQCDQDAYACSGQKCSAQSILFA-HENWVQagILDKLKALAEQRKL 312
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 378 GD----PAEDFGTffsavidaksfARIKKWLEHARSSPSLTILAGGK-----CDDSVGYFVEPC-----IVESKDPQE-P 442
Cdd:cd07126 313 EDltigPVLTWTT-----------ERILDHVDKLLAIPGAKVLFGGKpltnhSIPSIYGAYEPTavfvpLEEIAIEENfE 381
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 443 IMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYgLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQ--QPF 520
Cdd:cd07126 382 LVTTEVFGPFQVVTEYKDEQLPLVLEALERMHAH-LTAAVVSNDIRFLQEVLANTVNGTTYAGIRARTTGAPQNHwfGPA 460
                       490       500
                ....*....|....*....|....
gi 25777734 521 GGARASGTndkpGGPHYI-LRWTS 543
Cdd:cd07126 461 GDPRGAGI----GTPEAIrLVWSC 480
PRK11903 PRK11903
3,4-dehydroadipyl-CoA semialdehyde dehydrogenase;
198-460 4.82e-10

3,4-dehydroadipyl-CoA semialdehyde dehydrogenase;


Pssm-ID: 237016 [Multi-domain]  Cd Length: 521  Bit Score: 62.03  E-value: 4.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  198 RGLEGFVAAispFNFTAIGGNLAGAPALMGNV-VLWKP-SDTAMLASYAVyRILREAG-LPPNIIQFV---PAD-----G 266
Cdd:PRK11903 149 RGVALFINA---FNFPAWGLWEKAAPALLAGVpVIVKPaTATAWLTQRMV-KDVVAAGiLPAGALSVVcgsSAGlldhlQ 224
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  267 PlfGDTVTssehlcginFTGSVPTFKHLwkqvaqnldRFHtfPRLAGecggknfHFVHRSADVESVVSGTL-------RS 339
Cdd:PRK11903 225 P--FDVVS---------FTGSAETAAVL---------RSH--PAVVQ-------RSVRVNVEADSLNSALLgpdaapgSE 275
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  340 AFEY------------GGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAED---FGTFFSAVIDAKSFARIKKWL 404
Cdd:PRK11903 276 AFDLfvkevvremtvkSGQKCTAIRRIFVPEALYDAVAEALAARLAKTTVGNPRNDgvrMGPLVSRAQLAAVRAGLAALR 355
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25777734  405 EHArsspslTILAGGK------CDDSVGYFVEPCIVESKDPQEP--IMKEEIFGPVLSVYVYPD 460
Cdd:PRK11903 356 AQA------EVLFDGGgfalvdADPAVAACVGPTLLGASDPDAAtaVHDVEVFGPVATLLPYRD 413
PLN02174 PLN02174
aldehyde dehydrogenase family 3 member H1
227-527 1.19e-05

aldehyde dehydrogenase family 3 member H1


Pssm-ID: 177831  Cd Length: 484  Bit Score: 48.12  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  227 GNVVLWKPSDTAMlASYAVYRILREAGLPPNIIQFVpaDGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRfh 306
Cdd:PLN02174 140 GNAVVLKPSELAP-ASSALLAKLLEQYLDSSAVRVV--EGAVTETTALLEQKWDKIFYTGSSKIGRVIMAAAAKHLTP-- 214
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  307 tfprLAGECGGKNFHFVHRSADVESVVSGTLrsAFEYG---GQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAED 383
Cdd:PLN02174 215 ----VVLELGGKSPVVVDSDTDLKVTVRRII--AGKWGcnnGQACISPDYILTTKEYAPKVIDAMKKELETFYGKNPMES 288
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  384 fgTFFSAVIDAKSFARIKKWLEHARSSPSltILAGGKcDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYpdDKY 463
Cdd:PLN02174 289 --KDMSRIVNSTHFDRLSKLLDEKEVSDK--IVYGGE-KDRENLKIAPTILLDVPLDSLIMSEEIFGPLLPILTL--NNL 361
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25777734  464 KETLQLVDSTTSyGLTGAVFSQDKDVVQE-ATKVlrnAAGNFYINDKSTGSIVGQQPFGGARASG 527
Cdd:PLN02174 362 EESFDVIRSRPK-PLAAYLFTHNKKLKERfAATV---SAGGIVVNDIAVHLALHTLPFGGVGESG 422
PLN02203 PLN02203
aldehyde dehydrogenase
175-527 4.11e-05

aldehyde dehydrogenase


Pssm-ID: 165847 [Multi-domain]  Cd Length: 484  Bit Score: 46.26  E-value: 4.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  175 KYAVELEGQQPISVPPSTNSTVYRGLeGFVAAISPFNFtAIGGNL---AGAPAlMGNVVLWKPSDtamlasyavyrilre 251
Cdd:PLN02203  84 KWMAPKKAKLPLVAFPATAEVVPEPL-GVVLIFSSWNF-PIGLSLeplIGAIA-AGNAVVLKPSE--------------- 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  252 agLPPNIIQFVPADGPLFGDT---------VTSSEHLC-----GINFTGSVPTFKHLWKQVAQnldrfHTFPrLAGECGG 317
Cdd:PLN02203 146 --LAPATSAFLAANIPKYLDSkavkvieggPAVGEQLLqhkwdKIFFTGSPRVGRIIMTAAAK-----HLTP-VALELGG 217
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  318 KN---FHFVHRSADVESVVSGTLRSAFEY-GGQKCSACSRLYVPHSLWPqIKGRLLEEHSRIKVGDPAEDFGTFfSAVID 393
Cdd:PLN02203 218 KCpciVDSLSSSRDTKVAVNRIVGGKWGScAGQACIAIDYVLVEERFAP-ILIELLKSTIKKFFGENPRESKSM-ARILN 295
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734  394 AKSFARIKKWLEHARSSPSltILAGGKCDDSvGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYpdDKYKETLQLVDST 473
Cdd:PLN02203 296 KKHFQRLSNLLKDPRVAAS--IVHGGSIDEK-KLFIEPTILLNPPLDSDIMTEEIFGPLLPIITV--KKIEDSIAFINSK 370
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 25777734  474 TSyGLTGAVFSQDKDVVQEAtkVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 527
Cdd:PLN02203 371 PK-PLAIYAFTNNEKLKRRI--LSETSSGSVTFNDAIIQYACDSLPFGGVGESG 421
ALDH_PAD-PaaZ cd07127
Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida) ...
227-507 5.12e-05

Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida)-like; Phenylacetic acid degradation (PAD) proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida) are putative aromatic ring cleavage enzymes of the aerobic PA catabolic pathway. PaaZ mutants were defective for growth with PA as a sole carbon source due to interruption of the putative ring opening system. This CD is limited to bacterial monofunctional enzymes.


Pssm-ID: 143445  Cd Length: 549  Bit Score: 45.93  E-value: 5.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 227 GNVVLWKPSDTAMLASYAVYRILR----EAGLPPNIIQFV--PADGPLFGDTVTSSEhLCGINFTGSVPTFKHLWKQVAQ 300
Cdd:cd07127 221 GNPVIVKPHPAAILPLAITVQVARevlaEAGFDPNLVTLAadTPEEPIAQTLATRPE-VRIIDFTGSNAFGDWLEANARQ 299
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 301 NLdrfhtfprLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVP---------HSLWPQIKGRLLEE 371
Cdd:cd07127 300 AQ--------VYTEKAGVNTVVVDSTDDLKAMLRNLAFSLSLYSGQMCTTPQNIYVPrdgiqtddgRKSFDEVAADLAAA 371
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25777734 372 HSRIkVGDPAEDFGtFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYfvEPCIVESKDPQEPIMKEEIFGP 451
Cdd:cd07127 372 IDGL-LADPARAAA-LLGAIQSPDTLARIAEARQLGEVLLASEAVAHPEFPDARVR--TPLLLKLDASDEAAYAEERFGP 447
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 25777734 452 VLsvYVYPDDKYKETLQLVDST--TSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYIN 507
Cdd:cd07127 448 IA--FVVATDSTDHSIELARESvrEHGAMTVGVYSTDPEVVERVQEAALDAGVALSIN 503
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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