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Conserved domains on  [gi|21361146|ref|NP_003418|]
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zinc finger protein 76 isoform 1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11779416)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-366 2.67e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 2.67e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361146 179 AHHLKVHERAHTG-DRPYRCdfPSCGKAFATGYGLKSHVRT--HTGE--KPYKCPEELCSKAFKTSGDLQKHVRTHTGER 253
Cdd:COG5048 273 SSPNESDSSSEKGfSLPIKS--KQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361146 254 PFQCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFT- 327
Cdd:COG5048 351 PAKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNr 430

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 21361146 328 EYSSlyKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRS 366
Cdd:COG5048 431 HYNL--IPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 106-220 4.09e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 4.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361146 106 SESTILAVQTEVGLEDLAAED-DEGFSADAVVALEQYAS-------KVLHDSQ--IPRNGKGQQV-GDRAFRCGYKGCGR 174
Cdd:COG5189 280 FEESSLGFDYEFIHKSVGNKEiRGGISTGEMIDVRKLPCtnsssngKLAHGGErnIDTPSRMLKVkDGKPYKCPVEGCNK 359

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21361146 175 LYTTAHHLKVH---------------ERAHTG----DRPYRCDFpsCGKAFATGYGLKSHvRTHT 220
Cdd:COG5189 360 KYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEV--CDKRYKNLNGLKYH-RKHS 421
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-366 2.67e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 2.67e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361146 179 AHHLKVHERAHTG-DRPYRCdfPSCGKAFATGYGLKSHVRT--HTGE--KPYKCPEELCSKAFKTSGDLQKHVRTHTGER 253
Cdd:COG5048 273 SSPNESDSSSEKGfSLPIKS--KQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361146 254 PFQCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFT- 327
Cdd:COG5048 351 PAKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNr 430

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 21361146 328 EYSSlyKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRS 366
Cdd:COG5048 431 HYNL--IPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
212-238 1.59e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.67  E-value: 1.59e-06
                          10        20
                  ....*....|....*....|....*..
gi 21361146   212 LKSHVRTHTGEKPYKCPEelCSKAFKT 238
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 106-220 4.09e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 4.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361146 106 SESTILAVQTEVGLEDLAAED-DEGFSADAVVALEQYAS-------KVLHDSQ--IPRNGKGQQV-GDRAFRCGYKGCGR 174
Cdd:COG5189 280 FEESSLGFDYEFIHKSVGNKEiRGGISTGEMIDVRKLPCtnsssngKLAHGGErnIDTPSRMLKVkDGKPYKCPVEGCNK 359

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21361146 175 LYTTAHHLKVH---------------ERAHTG----DRPYRCDFpsCGKAFATGYGLKSHvRTHT 220
Cdd:COG5189 360 KYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEV--CDKRYKNLNGLKYH-RKHS 421
PHA00733 PHA00733
hypothetical protein
 314-363 5.39e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 5.39e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 21361146  314 PYVCtvPGCGKRFTEYSSLYKHHVVHTHCKpyTCSTCGKTYRQTSTLAMH 363
Cdd:PHA00733  73 PYVC--PLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-366 2.67e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 2.67e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361146 179 AHHLKVHERAHTG-DRPYRCdfPSCGKAFATGYGLKSHVRT--HTGE--KPYKCPEELCSKAFKTSGDLQKHVRTHTGER 253
Cdd:COG5048 273 SSPNESDSSSEKGfSLPIKS--KQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361146 254 PFQCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFT- 327
Cdd:COG5048 351 PAKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNr 430

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 21361146 328 EYSSlyKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRS 366
Cdd:COG5048 431 HYNL--IPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-336 1.21e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 1.21e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361146 170 KGCGRLYTTAHHLKVHERA--HTG--DRPYRCDFPSCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAF------KTS 239
Cdd:COG5048 293 KQCNISFSRSSPLTRHLRSvnHSGesLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFspllnnEPP 372

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361146 240 GDLQKHVRTHTgERPFQCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCtv 319
Cdd:COG5048 373 QSLQQYKDLKN-DKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-- 449

                       170
                ....*....|....*..
gi 21361146 320 pgCGKRFTEYSSLYKHH 336
Cdd:COG5048 450 --SILKSFRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 311-368 3.80e-08

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 55.88  E-value: 3.80e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21361146 311 GEKPYVCTVPGCGKRFTEYSSLyKHHVVHTHC--------------------KPYTCSTCGKTYRQTSTLAMHKRSAH 368
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGL-KYHMLHGHQnqklhenpspekmnifsakdKPYRCEVCDKRYKNLNGLKYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-340 1.40e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.40e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21361146 283 RPYTCPEphCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFTEYSSLYKHHVVHT 340
Cdd:COG5048  32 RPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
212-238 1.59e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.67  E-value: 1.59e-06
                          10        20
                  ....*....|....*....|....*..
gi 21361146   212 LKSHVRTHTGEKPYKCPEelCSKAFKT 238
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-250 5.17e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 5.17e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21361146 192 DRPYRCDFpsCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAFKTSGDLQKHVRTHT 250
Cdd:COG5048  31 PRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-268 1.51e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.51e-05
                          10        20
                  ....*....|....*....|....*...
gi 21361146   241 DLQKHVRTHTGERPFQCPFegCGRSFTT 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 191-280 2.67e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 2.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361146 191 GDRPYRCDFPSCGKAFATGYGLKSH-VRTHTGEKPYKCPEELCSKAFKTSgdlqkhvrthtgERPFQCPFegCGRSFTTS 269
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSAK------------DKPYRCEV--CDKRYKNL 411

                        90
                ....*....|.
gi 21361146 270 NIRKVHvRTHT 280
Cdd:COG5189 412 NGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 106-220 4.09e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 4.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361146 106 SESTILAVQTEVGLEDLAAED-DEGFSADAVVALEQYAS-------KVLHDSQ--IPRNGKGQQV-GDRAFRCGYKGCGR 174
Cdd:COG5189 280 FEESSLGFDYEFIHKSVGNKEiRGGISTGEMIDVRKLPCtnsssngKLAHGGErnIDTPSRMLKVkDGKPYKCPVEGCNK 359

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21361146 175 LYTTAHHLKVH---------------ERAHTG----DRPYRCDFpsCGKAFATGYGLKSHvRTHT 220
Cdd:COG5189 360 KYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEV--CDKRYKNLNGLKYH-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-375 1.51e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361146 223 KPYKCPEelCSKAFKTSGDLQKHVRTHTGERPFQCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCpephcgrgftSATNY 302
Cdd:COG5048  32 RPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLN----------SKSLP 99

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21361146 303 KNHVrihtgeKPYVCTVPGCGKRFTEYSSLYKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRSAHGELEATE 375
Cdd:COG5048 100 LSNS------KASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNS 166
zf-H2C2_2 pfam13465
Zinc-finger double domain;
301-327 1.55e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.55e-04
                          10        20
                  ....*....|....*....|....*..
gi 21361146   301 NYKNHVRIHTGEKPYVCTVpgCGKRFT 327
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
181-208 6.94e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.94e-04
                          10        20
                  ....*....|....*....|....*...
gi 21361146   181 HLKVHERAHTGDRPYRCdfPSCGKAFAT 208
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
273-298 1.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.41e-03
                          10        20
                  ....*....|....*....|....*.
gi 21361146   273 KVHVRTHTGERPYTCPEphCGRGFTS 298
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPE--CGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 314-363 5.39e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 5.39e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 21361146  314 PYVCtvPGCGKRFTEYSSLYKHHVVHTHCKpyTCSTCGKTYRQTSTLAMH 363
Cdd:PHA00733  73 PYVC--PLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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