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Conserved domains on  [gi|4504033|ref|NP_002057|]
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glycosyl-phosphatidylinositol-anchored molecule-like protein precursor [Homo sapiens]

Protein Classification

Ly-6/uPAR domain-containing protein; Ly-6/uPAR domain-containing protein; acrosomal protein SP-10; acrosomal protein SP-10( domain architecture ID 10639047)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2); LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2); acrosomal protein SP-10 (ACRV1) is a testis-specific, intra-acrosomal protein that is associated with the membranes and matrix of the acrosomal vesicle; acrosomal protein SP-10 (ACRV1) is a testis-specific, intra-acrosomal protein that is associated with the membranes and matrix of the acrosomal vesicle

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_GML cd23555
extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like ...
 29-115 3.55e-51

extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like protein (GML) and similar proteins; GML may play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467085  Cd Length: 87  Bit Score: 158.31  E-value: 3.55e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504033   29 LRCHDCAVINDFNCPNIRVCPYHIRRCMTISIRINSRELLVYKNCTNNCTFVYAAEQPPEAPGKIFKTNSFYWVCCCNSM 108
Cdd:cd23555   1 LRCHSCAVINTFNCPAHRTCPYDIRRCMTVAIRVNSRELLVYKNCTKNCTFVYAEEQPPEAPRKIPKTNSFYFVMCCSSM 80


                ....*..
gi 4504033  109 VCNAGGP 115
Cdd:cd23555  81 FCNEGGP 87
 
Name Accession Description Interval E-value
TFP_LU_ECD_GML cd23555
extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like ...
 29-115 3.55e-51

extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like protein (GML) and similar proteins; GML may play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467085  Cd Length: 87  Bit Score: 158.31  E-value: 3.55e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504033   29 LRCHDCAVINDFNCPNIRVCPYHIRRCMTISIRINSRELLVYKNCTNNCTFVYAAEQPPEAPGKIFKTNSFYWVCCCNSM 108
Cdd:cd23555   1 LRCHSCAVINTFNCPAHRTCPYDIRRCMTVAIRVNSRELLVYKNCTKNCTFVYAEEQPPEAPRKIPKTNSFYFVMCCSSM 80


                ....*..
gi 4504033  109 VCNAGGP 115
Cdd:cd23555  81 FCNEGGP 87
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 29-116 1.07e-16

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 70.26  E-value: 1.07e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504033      29 LRCHDCAVINDFNCPNIRVCPYHIRRCMTISIRIN--SRELLVYKNCT--NNCTFVYAAEqppeapgkIFKTNSFYWVCC 104
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEECRSPDDVCLTVVAEVIsdSRGSVVYKGCAtsPICPGSHGYE--------INLTIAFLKVSC 72

                           90
                   ....*....|..
gi 4504033     105 CNSMVCNAGGPT 116
Cdd:smart00134  73 CQTDLCNAAGPG 84
 
Name Accession Description Interval E-value
TFP_LU_ECD_GML cd23555
extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like ...
 29-115 3.55e-51

extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like protein (GML) and similar proteins; GML may play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467085  Cd Length: 87  Bit Score: 158.31  E-value: 3.55e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504033   29 LRCHDCAVINDFNCPNIRVCPYHIRRCMTISIRINSRELLVYKNCTNNCTFVYAAEQPPEAPGKIFKTNSFYWVCCCNSM 108
Cdd:cd23555   1 LRCHSCAVINTFNCPAHRTCPYDIRRCMTVAIRVNSRELLVYKNCTKNCTFVYAEEQPPEAPRKIPKTNSFYFVMCCSSM 80


                ....*..
gi 4504033  109 VCNAGGP 115
Cdd:cd23555  81 FCNEGGP 87
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 29-116 1.07e-16

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 70.26  E-value: 1.07e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504033      29 LRCHDCAVINDFNCPNIRVCPYHIRRCMTISIRIN--SRELLVYKNCT--NNCTFVYAAEqppeapgkIFKTNSFYWVCC 104
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEECRSPDDVCLTVVAEVIsdSRGSVVYKGCAtsPICPGSHGYE--------INLTIAFLKVSC 72

                           90
                   ....*....|..
gi 4504033     105 CNSMVCNAGGPT 116
Cdd:smart00134  73 CQTDLCNAAGPG 84
TFP_LU_ECD_Ly6K cd23550
extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K ...
 29-115 9.84e-12

extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467080  Cd Length: 86  Bit Score: 57.71  E-value: 9.84e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504033   29 LRCHDCAVINDFNCPNIRVCPYHIRRCMTISIRINSRELLVYKNCTNNCTFVyAAEQPPEAPGKIFKTNSFYWVCCCNSM 108
Cdd:cd23550   1 LTCHVCEVENSFNCTNPVTCTWEETYCVLAAVRIFPRFFLVSKQCSKYCPVV-EVPPPPPKSFVLEKPMPFLYIKCCREN 79


                ....*..
gi 4504033  109 VCNAGGP 115
Cdd:cd23550  80 LCNEEGP 86
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 27-78 1.28e-04

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 38.55  E-value: 1.28e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 4504033   27 YSLRCHDCavINDFNCPNIRVCPYHIRRCMTiSIRINSRELLVYKNCTNNCT 78
Cdd:cd23542   4 NALQCHVC--NSSSNCTNPVNCEGSERYCKT-TTVVQPSGNLVKKGCAETCP 52
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 29-111 3.00e-04

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 37.85  E-value: 3.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504033   29 LRCHDCAVINDFNC----PNIRVCPYHIRRCMTISIRINSRELLVYKNCTNNCtfvyaaEQPPEAPGKIFKTNSFYWVCC 104
Cdd:cd00117   1 LKCYQCNSSNDPNCcnssPTLVTCSSPETFCRKIVGKVGGGETLVIRGCATEC------ECGCTECCSGTGTSGTTCTSC 74


                ....*..
gi 4504033  105 CNSMVCN 111
Cdd:cd00117  75 CDTDLCN 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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