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Conserved domains on  [gi|14589889|ref|NP_001783|]
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cadherin-2 isoform 1 preproprotein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 31-121 4.65e-39

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


:

Pssm-ID: 462590  Cd Length: 90  Bit Score: 139.77  E-value: 4.65e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889    31 LCKTGFPEDVYSAVLSKDVHEGQPLLNVKFSNCNGKRKVQYESSEPaDFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKE 110
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDP-RFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSH 79

                          90
                  ....*....|.
gi 14589889   111 TQEKWQVAVKL 121
Cdd:pfam08758  80 GEKMASVKVTV 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 273-378 4.49e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 4.49e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889 273 NGTVPEGSKPGTYVMTVTAIDADDPNalNGMLRYRIVSQapstPSPNMFTINNETGdIITVAAGLDREKVQQYTLIIQAT 352
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSG----NEDGLFSIDPSTG-EITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*.
gi 14589889 353 DMEGNPtygLSNTATAVITVTDVNDN 378
Cdd:cd11304  76 DGGGPP---LSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 843-902 6.03e-27

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 104.16  E-value: 6.03e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889   843 ADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYG 902
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 508-601 1.81e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 1.81e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889 508 EGLHAGTMLTTFTAQDPDRYMQQNIRYTKLS-DPANWLKIDPVNGQITTIAVLDRESPNVknniYNATFLASDNGIPPMS 586
Cdd:cd11304   8 ENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREEQSS----YTLTVTATDGGGPPLS 83

                        90
                ....*....|....*
gi 14589889 587 GTGTLQIYLLDINDN 601
Cdd:cd11304  84 STATVTITVLDVNDN 98
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 163-263 1.53e-20

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member cd00031:

Pssm-ID: 481204  Cd Length: 98  Bit Score: 87.01  E-value: 1.53e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889 163 IPPINLPENSRGPfpQELVRIRSDRDKNLSLRYSVTGPGADQPPtGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDI 242
Cdd:cd00031   1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                        90       100
                ....*....|....*....|.
gi 14589889 243 NGNQVENPIDIVINVIDMNDN 263
Cdd:cd00031  78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 386-494 9.65e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 9.65e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889 386 TFYGEVPEN-RVDIIVANLTVTDKDQPhtPAWNAVYRISGGDPTGRFAIqtdpNSNDGLVTVVKPIDFETNRMFVLTVAA 464
Cdd:cd11304   1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTA 74

                        90       100       110
                ....*....|....*....|....*....|
gi 14589889 465 ENqvplakGIQHPPQSTATVSVTVIDVNEN 494
Cdd:cd11304  75 TD------GGGPPLSSTATVTITVLDVNDN 98
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 608-701 4.01e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 4.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889   608 QEAETCET--PDPNSINITALDYDIDPNAGPFAFDLPLSPvtiKRNWTITRLNGDfaqLNLK--IKFLEAGIYEVPIIIT 683
Cdd:pfam00028   1 YSASVPENapVGTEVLTVTATDPDLGPNGRIFYSILGGGP---GGNFRIDPDTGD---ISTTkpLDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 14589889   684 DSGNPPKSNISILRVKVC 701
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 31-121 4.65e-39

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 139.77  E-value: 4.65e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889    31 LCKTGFPEDVYSAVLSKDVHEGQPLLNVKFSNCNGKRKVQYESSEPaDFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKE 110
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDP-RFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSH 79

                          90
                  ....*....|.
gi 14589889   111 TQEKWQVAVKL 121
Cdd:pfam08758  80 GEKMASVKVTV 90
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 32-119 3.65e-34

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 125.47  E-value: 3.65e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889     32 CKTGFPEDVYSAVLSKDVHEGQPLLNVKFSNCNGKRKVQYESSEPaDFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKET 111
Cdd:smart01055   1 CKPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQFESSDP-DFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQG 79


                   ....*...
gi 14589889    112 QEKWQVAV 119
Cdd:smart01055  80 QEKKEIKV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 273-378 4.49e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 4.49e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889 273 NGTVPEGSKPGTYVMTVTAIDADDPNalNGMLRYRIVSQapstPSPNMFTINNETGdIITVAAGLDREKVQQYTLIIQAT 352
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSG----NEDGLFSIDPSTG-EITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*.
gi 14589889 353 DMEGNPtygLSNTATAVITVTDVNDN 378
Cdd:cd11304  76 DGGGPP---LSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 843-902 6.03e-27

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 104.16  E-value: 6.03e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889   843 ADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYG 902
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 290-380 1.30e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.11  E-value: 1.30e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889    290 TAIDADDPNalNGMLRYRIVSQAPstpsPNMFTINNETGdIITVAAGLDREKVQQYTLIIQATDMEGNPtygLSNTATAV 369
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGND----DGLFSIDPETG-EITTTKPLDREEQPEYTLTVEATDGGGPP---LSSTATVT 70

                           90
                   ....*....|.
gi 14589889    370 ITVTDVNDNPP 380
Cdd:smart00112  71 ITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
273-373 4.12e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.29  E-value: 4.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889   273 NGTVPEGSKPGTYVMTVTAIDADDPnaLNGMLRYRIVSQapstPSPNMFTINNETGDIiTVAAGLDREKVQQYTLIIQAT 352
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDI-STTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
gi 14589889   353 DmegNPTYGLSNTATAVITVT 373
Cdd:pfam00028  75 D---SGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 508-601 1.81e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 1.81e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889 508 EGLHAGTMLTTFTAQDPDRYMQQNIRYTKLS-DPANWLKIDPVNGQITTIAVLDRESPNVknniYNATFLASDNGIPPMS 586
Cdd:cd11304   8 ENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREEQSS----YTLTVTATDGGGPPLS 83

                        90
                ....*....|....*
gi 14589889 587 GTGTLQIYLLDINDN 601
Cdd:cd11304  84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
504-596 5.74e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.82  E-value: 5.74e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889   504 IRQEEGLHAGTMLTTFTAQDPDRYMQQNIRYTKLSD-PANWLKIDPVNGQITTIAVLDRESpnvkNNIYNATFLASDNGI 582
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 14589889   583 PPMSGTGTLQIYLL 596
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 163-263 1.53e-20

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 87.01  E-value: 1.53e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889 163 IPPINLPENSRGPfpQELVRIRSDRDKNLSLRYSVTGPGADQPPtGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDI 242
Cdd:cd00031   1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                        90       100
                ....*....|....*....|.
gi 14589889 243 NGNQVENPIDIVINVIDMNDN 263
Cdd:cd00031  78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 386-494 9.65e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 9.65e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889 386 TFYGEVPEN-RVDIIVANLTVTDKDQPhtPAWNAVYRISGGDPTGRFAIqtdpNSNDGLVTVVKPIDFETNRMFVLTVAA 464
Cdd:cd11304   1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTA 74

                        90       100       110
                ....*....|....*....|....*....|
gi 14589889 465 ENqvplakGIQHPPQSTATVSVTVIDVNEN 494
Cdd:cd11304  75 TD------GGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 520-603 2.51e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 2.51e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889    520 TAQDPDRYMQQNIRYTKLS-DPANWLKIDPVNGQITTIAVLDREspnvKNNIYNATFLASDNGIPPMSGTGTLQIYLLDI 598
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 14589889    599 NDNAP 603
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
387-489 1.16e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 1.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889   387 FYGEVPEN-RVDIIVANLTVTDKDQPhtPAWNAVYRISGGDPTGRFAIQTDPnsndGLVTVVKPIDFETNRMFVLTVAAE 465
Cdd:pfam00028   1 YSASVPENaPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 14589889   466 NQVPlakgiqHPPQSTATVSVTVI 489
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 185-265 6.17e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 6.17e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889    185 SDRDKNLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNR 264
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 14589889    265 P 265
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 404-495 5.80e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 5.80e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889    404 TVTDKDQPhtPAWNAVYRISGGDPTGRFAIqtdpNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPlakgiqHPPQSTAT 483
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGG------PPLSSTAT 68

                           90
                   ....*....|..
gi 14589889    484 VSVTVIDVNENP 495
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
164-258 7.75e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 7.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889   164 PPINLPENSR-GPFPQELVRIRSDRDKNLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDI 242
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 14589889   243 NGNQVENPIDIVINVI 258
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
608-701 4.01e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 4.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889   608 QEAETCET--PDPNSINITALDYDIDPNAGPFAFDLPLSPvtiKRNWTITRLNGDfaqLNLK--IKFLEAGIYEVPIIIT 683
Cdd:pfam00028   1 YSASVPENapVGTEVLTVTATDPDLGPNGRIFYSILGGGP---GGNFRIDPDTGD---ISTTkpLDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 14589889   684 DSGNPPKSNISILRVKVC 701
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 31-121 4.65e-39

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 139.77  E-value: 4.65e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889    31 LCKTGFPEDVYSAVLSKDVHEGQPLLNVKFSNCNGKRKVQYESSEPaDFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKE 110
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDP-RFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSH 79

                          90
                  ....*....|.
gi 14589889   111 TQEKWQVAVKL 121
Cdd:pfam08758  80 GEKMASVKVTV 90
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 32-119 3.65e-34

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 125.47  E-value: 3.65e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889     32 CKTGFPEDVYSAVLSKDVHEGQPLLNVKFSNCNGKRKVQYESSEPaDFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKET 111
Cdd:smart01055   1 CKPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQFESSDP-DFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQG 79


                   ....*...
gi 14589889    112 QEKWQVAV 119
Cdd:smart01055  80 QEKKEIKV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 273-378 4.49e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 4.49e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889 273 NGTVPEGSKPGTYVMTVTAIDADDPNalNGMLRYRIVSQapstPSPNMFTINNETGdIITVAAGLDREKVQQYTLIIQAT 352
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSG----NEDGLFSIDPSTG-EITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*.
gi 14589889 353 DMEGNPtygLSNTATAVITVTDVNDN 378
Cdd:cd11304  76 DGGGPP---LSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 843-902 6.03e-27

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 104.16  E-value: 6.03e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889   843 ADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYG 902
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 290-380 1.30e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.11  E-value: 1.30e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889    290 TAIDADDPNalNGMLRYRIVSQAPstpsPNMFTINNETGdIITVAAGLDREKVQQYTLIIQATDMEGNPtygLSNTATAV 369
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGND----DGLFSIDPETG-EITTTKPLDREEQPEYTLTVEATDGGGPP---LSSTATVT 70

                           90
                   ....*....|.
gi 14589889    370 ITVTDVNDNPP 380
Cdd:smart00112  71 ITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
273-373 4.12e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.29  E-value: 4.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889   273 NGTVPEGSKPGTYVMTVTAIDADDPnaLNGMLRYRIVSQapstPSPNMFTINNETGDIiTVAAGLDREKVQQYTLIIQAT 352
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDI-STTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
gi 14589889   353 DmegNPTYGLSNTATAVITVT 373
Cdd:pfam00028  75 D---SGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 508-601 1.81e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 1.81e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889 508 EGLHAGTMLTTFTAQDPDRYMQQNIRYTKLS-DPANWLKIDPVNGQITTIAVLDRESPNVknniYNATFLASDNGIPPMS 586
Cdd:cd11304   8 ENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREEQSS----YTLTVTATDGGGPPLS 83

                        90
                ....*....|....*
gi 14589889 587 GTGTLQIYLLDINDN 601
Cdd:cd11304  84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
504-596 5.74e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.82  E-value: 5.74e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889   504 IRQEEGLHAGTMLTTFTAQDPDRYMQQNIRYTKLSD-PANWLKIDPVNGQITTIAVLDRESpnvkNNIYNATFLASDNGI 582
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 14589889   583 PPMSGTGTLQIYLL 596
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 163-263 1.53e-20

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 87.01  E-value: 1.53e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889 163 IPPINLPENSRGPfpQELVRIRSDRDKNLSLRYSVTGPGADQPPtGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDI 242
Cdd:cd00031   1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                        90       100
                ....*....|....*....|.
gi 14589889 243 NGNQVENPIDIVINVIDMNDN 263
Cdd:cd00031  78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 386-494 9.65e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 9.65e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889 386 TFYGEVPEN-RVDIIVANLTVTDKDQPhtPAWNAVYRISGGDPTGRFAIqtdpNSNDGLVTVVKPIDFETNRMFVLTVAA 464
Cdd:cd11304   1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTA 74

                        90       100       110
                ....*....|....*....|....*....|
gi 14589889 465 ENqvplakGIQHPPQSTATVSVTVIDVNEN 494
Cdd:cd11304  75 TD------GGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 520-603 2.51e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 2.51e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889    520 TAQDPDRYMQQNIRYTKLS-DPANWLKIDPVNGQITTIAVLDREspnvKNNIYNATFLASDNGIPPMSGTGTLQIYLLDI 598
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 14589889    599 NDNAP 603
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 166-263 5.52e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.66  E-value: 5.52e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889 166 INLPENSrgPFPQELVRIR-SDRDK--NLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDI 242
Cdd:cd11304   4 VSVPENA--PPGTVVLTVSaTDPDSgeNGEVTYSIVSGNED----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 14589889 243 NGNQVENPIDIVINVIDMNDN 263
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
387-489 1.16e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 1.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889   387 FYGEVPEN-RVDIIVANLTVTDKDQPhtPAWNAVYRISGGDPTGRFAIQTDPnsndGLVTVVKPIDFETNRMFVLTVAAE 465
Cdd:pfam00028   1 YSASVPENaPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 14589889   466 NQVPlakgiqHPPQSTATVSVTVI 489
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 185-265 6.17e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 6.17e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889    185 SDRDKNLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNR 264
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 14589889    265 P 265
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 404-495 5.80e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 5.80e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889    404 TVTDKDQPhtPAWNAVYRISGGDPTGRFAIqtdpNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPlakgiqHPPQSTAT 483
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGG------PPLSSTAT 68

                           90
                   ....*....|..
gi 14589889    484 VSVTVIDVNENP 495
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
164-258 7.75e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 7.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889   164 PPINLPENSR-GPFPQELVRIRSDRDKNLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDI 242
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 14589889   243 NGNQVENPIDIVINVI 258
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
608-701 4.01e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 4.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14589889   608 QEAETCET--PDPNSINITALDYDIDPNAGPFAFDLPLSPvtiKRNWTITRLNGDfaqLNLK--IKFLEAGIYEVPIIIT 683
Cdd:pfam00028   1 YSASVPENapVGTEVLTVTATDPDLGPNGRIFYSILGGGP---GGNFRIDPDTGD---ISTTkpLDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 14589889   684 DSGNPPKSNISILRVKVC 701
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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