TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341064  963 CDNVLAPNVTKQECCCTS-GVGWGDNCEifPCPVLGTAEFTEMC 1005
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341064 1139 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1181
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341064   724 DIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRAsglGDHCE 764
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341064   848 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFqapQDGQGCV 889
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|..
gi 2035341064   300 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 330
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341064  765 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 795
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341064   561 DVDECLRPDVCGEG-HCVNTVGAFRCEyCDSGYrmTQRGRCE 601
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY--TDGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2035341064  602 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFRG 635
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTG 34

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341064  963 CDNVLAPNVTKQECCCTS-GVGWGDNCEifPCPVLGTAEFTEMC 1005
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341064 1139 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1181
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2035341064  806 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisadGRTCE 847
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 2035341064   683 DIDECQQGNLCVNG-QCKNTEGSFRCTCGQGYQ 714
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 2035341064  683 DIDECQQGNLCVN-GQCKNTEGSFRCTCGQGYQL 715
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2035341064   642 DVDECLEPNVCANG-DCSNLEGSYMCSCHKGYTrtpDHKHC 681
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|..
gi 2035341064   300 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 330
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341064  765 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 795
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341064  300 DINECQLQGVCPN-GECLNTMGSYRCTCKIGF 330
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341064  519 DIDECTQVQHLCSQ-GRCENTEGSFLCICPAG 549
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2035341064  519 DIDECTQvQHLCS-QGRCENTEGSFLCICPAGFmaseEGTNCI 560
Cdd:cd00054      1 DIDECAS-GNPCQnGGTCVNTVGSYRCSCPPGY----TGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2035341064 1266 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1300
Cdd:cd00054      1 DIDECASGNP----CQNgGTCVNTVGSYRCSCPPGY 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2035341064  765 DINEClEDKSVCQR-GDCINTAGSYDCTCPDGFQLD 799
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTGR 35

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341064  848 DIDECVNNT-VCDSHGFCDNTAGSFRCLCYQG 878
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 2035341064  561 DVDECLRPDVCGEGH-CVNTVGAFRCEyCDSGYR 593
Cdd:cd00054      1 DIDECASGNPCQNGGtCVNTVGSYRCS-CPPGYT 33

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341064  300 DINEC-QLQGVCP-NGECLNTMGSYRCTCKIG 329
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341064  963 CDNVLAPNVTKQECCCTS-GVGWGDNCEifPCPVLGTAEFTEMC 1005
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341064 1139 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1181
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2035341064  806 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisadGRTCE 847
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 2035341064   683 DIDECQQGNLCVNG-QCKNTEGSFRCTCGQGYQ 714
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 2035341064  683 DIDECQQGNLCVN-GQCKNTEGSFRCTCGQGYQL 715
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2035341064   642 DVDECLEPNVCANG-DCSNLEGSYMCSCHKGYTrtpDHKHC 681
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|..
gi 2035341064   300 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 330
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341064  765 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 795
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341064  300 DINECQLQGVCPN-GECLNTMGSYRCTCKIGF 330
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341064  519 DIDECTQVQHLCSQ-GRCENTEGSFLCICPAG 549
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2035341064  519 DIDECTQvQHLCS-QGRCENTEGSFLCICPAGFmaseEGTNCI 560
Cdd:cd00054      1 DIDECAS-GNPCQnGGTCVNTVGSYRCSCPPGY----TGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2035341064 1266 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1300
Cdd:cd00054      1 DIDECASGNP----CQNgGTCVNTVGSYRCSCPPGY 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2035341064  765 DINEClEDKSVCQR-GDCINTAGSYDCTCPDGFQLD 799
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTGR 35

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.

                           10        20
                   ....*....|....*....|..
gi 2035341064  830 HCVCQQGFSISADGRTCEDIDE 851
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22

Epidermal growth factor-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 2035341064   303 ECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPT 335
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2035341064 1266 DVNECDELNNrmsLC-KNAKCINTDGSYKCLCLPG 1299
Cdd:pfam07645    1 DVDECATGTH---NCpANTVCVNTIGSFECRCPDG 32

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                           10        20        30
                   ....*....|....*....|....*....|
gi 2035341064  809 ECEHPGLCGPQGECLNTEGSFHCVCQQGFS 838
Cdd:cd00053      1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYT 30

Epidermal growth factor-like domain;

                            10        20
                    ....*....|....*....|....*....
gi 2035341064   645 ECLEPNVCANGDCSNLEGSYMCSCHKGYT 673
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29