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Conserved domains on  [gi|1907829278|ref|NP_001374036|]
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NEDD4-binding protein 2-like 2 isoform 13 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG0645 super family cl33991
Predicted kinase, contains AAA domain [General function prediction only];
404-436 1.73e-05

Predicted kinase, contains AAA domain [General function prediction only];


The actual alignment was detected with superfamily member COG0645:

Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 44.90  E-value: 1.73e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907829278 404 LILLRGLPGSGKTTLSRIlLGQNRDGIVFSTDD 436
Cdd:COG0645     1 LILVCGLPGSGKSTLARA-LAERLGAVRLRSDV 32
 
Name Accession Description Interval E-value
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
404-436 1.73e-05

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 44.90  E-value: 1.73e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907829278 404 LILLRGLPGSGKTTLSRIlLGQNRDGIVFSTDD 436
Cdd:COG0645     1 LILVCGLPGSGKSTLARA-LAERLGAVRLRSDV 32
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 404-438 4.17e-05

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 43.45  E-value: 4.17e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907829278 404 LILLRGLPGSGKTTLSRILLGQNrDGIVFSTDDYF 438
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEEL-GAVRLSSDDER 34
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 405-468 3.26e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 38.12  E-value: 3.26e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907829278  405 ILLRGLPGSGKTTLSRILLGQ----NRDGIVFSTDDYFHHQDGYRYNVNQLGDAHDWNQNRGHRKRIQ 468
Cdd:smart00382   5 ILIVGPPGSGKTTLARALARElgppGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALA 72
pseT PHA02530
polynucleotide kinase; Provisional
 404-447 3.76e-03

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 39.24  E-value: 3.76e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907829278 404 LILLRGLPGSGKTTLSRILLGQNRDGIVFSTDDY----FHHQ--DGYRYN 447
Cdd:PHA02530    4 IILTVGVPGSGKSTWAREFAAKNPKAVNVNRDDLrqslFGHGewGEYKFT 53
 
Name Accession Description Interval E-value
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
404-436 1.73e-05

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 44.90  E-value: 1.73e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907829278 404 LILLRGLPGSGKTTLSRIlLGQNRDGIVFSTDD 436
Cdd:COG0645     1 LILVCGLPGSGKSTLARA-LAERLGAVRLRSDV 32
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 404-440 3.32e-05

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 44.33  E-value: 3.32e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907829278 404 LILLRGLPGSGKTTLSRILLGQ----NRDGIVFSTDDYFHH 440
Cdd:COG4088     6 LLILTGPPGSGKTTFAKALAQRlyaeGIAVALLHSDDFRRF 46
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 404-438 4.17e-05

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 43.45  E-value: 4.17e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907829278 404 LILLRGLPGSGKTTLSRILLGQNrDGIVFSTDDYF 438
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEEL-GAVRLSSDDER 34
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 403-457 1.92e-04

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 42.52  E-value: 1.92e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907829278 403 LLILLRGLPGSGKTTLSR---ILLGQNRdGIVFSTDDYFHHQDGY----RYNVNQLG-DAHDW 457
Cdd:COG0572     8 RIIGIAGPSGSGKTTFARrlaEQLGADK-VVVISLDDYYKDREHLpldeRGKPNFDHpEAFDL 69
COG4639 COG4639
Predicted kinase [General function prediction only];
404-436 2.10e-04

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 41.35  E-value: 2.10e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907829278 404 LILLRGLPGSGKTTLSRILLgqnRDGIVFSTDD 436
Cdd:COG4639     4 LVVLIGLPGSGKSTFARRLF---APTEVVSSDD 33
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 405-468 3.26e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 38.12  E-value: 3.26e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907829278  405 ILLRGLPGSGKTTLSRILLGQ----NRDGIVFSTDDYFHHQDGYRYNVNQLGDAHDWNQNRGHRKRIQ 468
Cdd:smart00382   5 ILIVGPPGSGKTTLARALARElgppGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALA 72
pseT PHA02530
polynucleotide kinase; Provisional
 404-447 3.76e-03

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 39.24  E-value: 3.76e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907829278 404 LILLRGLPGSGKTTLSRILLGQNRDGIVFSTDDY----FHHQ--DGYRYN 447
Cdd:PHA02530    4 IILTVGVPGSGKSTWAREFAAKNPKAVNVNRDDLrqslFGHGewGEYKFT 53
Zeta_toxin pfam06414
Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is ...
 401-437 4.92e-03

Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is thought to be part of a postregulational killing system in bacteria. It relies on antitoxin/toxin systems that secure stable inheritance of low and medium copy number plasmids during cell division and kill cells that have lost the plasmid.


Pssm-ID: 428926  Cd Length: 192  Bit Score: 38.11  E-value: 4.92e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907829278 401 QKLLILLRGLPGSGKTTLSRIL---LGQNRDGIVFSTDDY 437
Cdd:pfam06414  10 RPKAILLGGQPGAGKTELARALldeLGRQGNVVRIDPDDF 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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