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Conserved domains on  [gi|1904926785|ref|NP_001373816|]
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solute carrier organic anion transporter family member 1A2 isoform 4 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
18-538 0e+00

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17458:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 527  Bit Score: 920.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  18 KLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMG 97
Cdd:cd17458     1 KLKIFLLALSYAYVAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  98 LGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILP 177
Cdd:cd17458    81 LGCFLASLPHFLMGRYEYESTVSTTSNSSSRVPLCLANQSLSHNVTQLPSECEKESMSLMWIFVLVGNLLRGIGETPVMP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 178 LGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNV 257
Cdd:cd17458   161 LGISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLGFLICAGVNF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 258 LTAIPFFFLPNTLPKEGLETNAD---IIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVN 334
Cdd:cd17458   241 LAGLPFWFLPKSLPKEGEENETEpskTLTVELEENKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFIIVTVLQFNAFSG 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 335 MISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSS 414
Cdd:cd17458   321 MISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFWMGCDNSP 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 415 VVGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSS 494
Cdd:cd17458   401 VAGLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNCSCVAASGFPS 480
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 1904926785 495 AV---LGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRC 538
Cdd:cd17458   481 QNssaVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
 
Name Accession Description Interval E-value
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
18-538 0e+00

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 920.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  18 KLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMG 97
Cdd:cd17458     1 KLKIFLLALSYAYVAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  98 LGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILP 177
Cdd:cd17458    81 LGCFLASLPHFLMGRYEYESTVSTTSNSSSRVPLCLANQSLSHNVTQLPSECEKESMSLMWIFVLVGNLLRGIGETPVMP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 178 LGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNV 257
Cdd:cd17458   161 LGISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLGFLICAGVNF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 258 LTAIPFFFLPNTLPKEGLETNAD---IIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVN 334
Cdd:cd17458   241 LAGLPFWFLPKSLPKEGEENETEpskTLTVELEENKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFIIVTVLQFNAFSG 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 335 MISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSS 414
Cdd:cd17458   321 MISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFWMGCDNSP 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 415 VVGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSS 494
Cdd:cd17458   401 VAGLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNCSCVAASGFPS 480
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 1904926785 495 AV---LGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRC 538
Cdd:cd17458   481 QNssaVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
1-609 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 887.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785   1 MGETEKRIETHRI--------RCL----SKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIG 68
Cdd:TIGR00805   1 MGETEKDIATHESsaglkprpRCLqslfSKIKMFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  69 NLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSS-NSFLCMENGTQILRPTQDPS 147
Cdd:TIGR00805  81 NLLLIIFVSYFGTKLHRPIVIGAGCAIMGLGSLLSSLPHFLMGRYSYSTTVSSTGNLSSaNSFLCMENLTQTLRPTQDPS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 148 ECTKEVKSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFV 227
Cdd:TIGR00805 161 ECQKQHKSLMWLLFLVSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 228 NTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGITKDFLP 307
Cdd:TIGR00805 241 NTEDLIITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGITKDFPK 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 308 FMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQA 387
Cdd:TIGR00805 321 FIKRLLCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKA 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 388 AHIGCWLSLLEYLLYFLSFLMTCENSSVVGINTsyEGIPQDLYVENDIfaDCNVDCNCPSKIWDPVCGNNGLSYLSACLA 467
Cdd:TIGR00805 401 AYFAICLSTLEYLLYSPKFLITCESAPVAGVNN--PSNDQPLYVENRT--DCNRQCSCDSSIWDPVCGDNGLAYLSPCHA 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 468 GCETSIGTGINMVFQNCSCIQTSGNSSAVLGLCDkgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLG 547
Cdd:TIGR00805 477 GCRMSVGTGSNMVFTNCSCIQTPGNSSAKKGLCD--PPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLG 554
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1904926785 548 VGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFSRdtesIFSGLY 609
Cdd:TIGR00805 555 LGLQWFCIRVFGTIPAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRV----IYLGLT 612
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
21-597 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 593.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  21 MFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 100
Cdd:pfam03137   1 FFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 101 FLKSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvYVLVGNIVRGMGETPILPLGI 180
Cdd:pfam03137  81 LLFALPHFL--------------------------------------------------SFFLGQLLLGIGGTPIYTLGI 110
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 181 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDdliITPTDTRWVGAWWFGFLICAGVNVLTA 260
Cdd:pfam03137 111 SYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGKVSIT---LTPKDPRWVGAWWLGFLIAGLLLLLTA 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 261 IPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGIT---KDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMIS 337
Cdd:pfam03137 188 IPFFFFPKSLPGAAKRRAKKKKEPHSQDIADLKKTKSLKKLGpslKDFPKALKRLLKNPVYMLLTLASVFEFLLIAGYAT 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 338 FMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVG 417
Cdd:pfam03137 268 FLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCPNSPVAG 347
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 418 INTSYEGIPQdlyVENDIFADCNVDCNCPSKIWDPVCGNNG-LSYLSACLAGCETSIGTGINMVFQNCSCI----QTSGN 492
Cdd:pfam03137 348 ITVPYGGTQQ---LSGNLTSSCNSDCSCSTSAYSPVCGSDGgYTSPCPCGAGCSSSSGAGKSTYICNCCCScgsqDSGGN 424
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 493 SSAVLGLCDkgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMD 572
Cdd:pfam03137 425 GSATPGKCP--SDCSNKLPPFLALLFLASFFSSLSRTPGTLVILRCVPPEDKSFALGLQFLILRLLGFIPGPILFGALID 502
                         570       580
                  ....*....|....*....|....*
gi 1904926785 573 STCLHWGTlKCGESGACRIYDSTTF 597
Cdd:pfam03137 503 STCLLWGK-TCGGRGNCWLYDNDKL 526
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
21-405 1.14e-13

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 72.70  E-value: 1.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  21 MFLLAITCAFVSktLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 100
Cdd:COG2814    12 LLALALGAFLSG--LGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 101 FLkslphflmnqyeyestVSVSGNLSSnsflcmengtqilrptqdpsectkevkslmwvyVLVGNIVRGMGETPILPLGI 180
Cdd:COG2814    90 LL----------------CALAPSLWL---------------------------------LLAARFLQGLGAGALFPAAL 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 181 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYvdtgfvntddliitptdtrwvgAWWFGFLICAGVNVLTA 260
Cdd:COG2814   121 ALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF----------------------GWRWVFLVNAVLALLAL 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 261 IP-FFFLPNTLPKEgletnadiiknenedkqkeevkkekygiTKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFM 339
Cdd:COG2814   179 LLlLRLLPESRPAA----------------------------RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYL 230
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1904926785 340 PKYLEQQYGISSSDAIFLMGIYNLPPIcIGYIIGGLIMKKFKItvKQAAHIGCWLSLLEYLLYFLS 405
Cdd:COG2814   231 PLYLQEVLGLSASAAGLLLALFGLGGV-LGALLAGRLADRFGR--RRLLLIGLLLLALGLLLLALA 293
 
Name Accession Description Interval E-value
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
18-538 0e+00

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 920.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  18 KLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMG 97
Cdd:cd17458     1 KLKIFLLALSYAYVAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  98 LGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILP 177
Cdd:cd17458    81 LGCFLASLPHFLMGRYEYESTVSTTSNSSSRVPLCLANQSLSHNVTQLPSECEKESMSLMWIFVLVGNLLRGIGETPVMP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 178 LGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNV 257
Cdd:cd17458   161 LGISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLGFLICAGVNF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 258 LTAIPFFFLPNTLPKEGLETNAD---IIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVN 334
Cdd:cd17458   241 LAGLPFWFLPKSLPKEGEENETEpskTLTVELEENKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFIIVTVLQFNAFSG 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 335 MISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSS 414
Cdd:cd17458   321 MISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFWMGCDNSP 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 415 VVGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSS 494
Cdd:cd17458   401 VAGLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNCSCVAASGFPS 480
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 1904926785 495 AV---LGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRC 538
Cdd:cd17458   481 QNssaVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
1-609 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 887.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785   1 MGETEKRIETHRI--------RCL----SKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIG 68
Cdd:TIGR00805   1 MGETEKDIATHESsaglkprpRCLqslfSKIKMFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  69 NLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSS-NSFLCMENGTQILRPTQDPS 147
Cdd:TIGR00805  81 NLLLIIFVSYFGTKLHRPIVIGAGCAIMGLGSLLSSLPHFLMGRYSYSTTVSSTGNLSSaNSFLCMENLTQTLRPTQDPS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 148 ECTKEVKSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFV 227
Cdd:TIGR00805 161 ECQKQHKSLMWLLFLVSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 228 NTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGITKDFLP 307
Cdd:TIGR00805 241 NTEDLIITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGITKDFPK 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 308 FMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQA 387
Cdd:TIGR00805 321 FIKRLLCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKA 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 388 AHIGCWLSLLEYLLYFLSFLMTCENSSVVGINTsyEGIPQDLYVENDIfaDCNVDCNCPSKIWDPVCGNNGLSYLSACLA 467
Cdd:TIGR00805 401 AYFAICLSTLEYLLYSPKFLITCESAPVAGVNN--PSNDQPLYVENRT--DCNRQCSCDSSIWDPVCGDNGLAYLSPCHA 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 468 GCETSIGTGINMVFQNCSCIQTSGNSSAVLGLCDkgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLG 547
Cdd:TIGR00805 477 GCRMSVGTGSNMVFTNCSCIQTPGNSSAKKGLCD--PPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLG 554
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1904926785 548 VGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFSRdtesIFSGLY 609
Cdd:TIGR00805 555 LGLQWFCIRVFGTIPAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRV----IYLGLT 612
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
19-537 0e+00

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 694.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  19 LKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGL 98
Cdd:cd17400     1 LKMFLLALSCAFVAKTLSGSYMKSMITQIERRFNIPSSLVGFIDGSFEIGNLLVIIFVSYFGTKLHRPKMIGIGCVIMGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  99 GCFLKSLPHFLMNQYEYestvsvsgnlssnsflcmengtqilrptqdpsectkevkSLMWVYVLVGNIVRGMGETPILPL 178
Cdd:cd17400    81 GCFLKALPHFFMNQYEY---------------------------------------SLMWIYVFVGNILRGIGETPILPL 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 179 GISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVL 258
Cdd:cd17400   122 GISYIDDFAKEENSPLYIGLVETGAIIGPIIGFLLGSLCAKVYVDIGFVNLDDIIITPTDTRWVGAWWLGFLICGGVSVL 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 259 TAIPFFFLPntlpkegletnadiiknenedkqkeevkkekygitkdflpfmkslscnPIYMLFILVSVIQFNAFVNMISF 338
Cdd:cd17400   202 TAIPFFFLP------------------------------------------------PIYMLFILVSVIQFNSFVGMITY 233
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 339 MPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGI 418
Cdd:cd17400   234 MPKYLEQQYGQSSSDANFLMGIINIPPIAIGYFIGGLIMKKFKITVKGAAKIGCWLSVLEYLLYLLSFLMTCENSSVAGL 313
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 419 NTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAVLG 498
Cdd:cd17400   314 TTSYEGIPPVLYHENDIFSDCNSDCNCPEKIWEPVCGNNGITYLSACLAGCETSIGTGKNIVFYNCSCIQTSGNSSANLS 393
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 1904926785 499 LCDKG----PDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 537
Cdd:cd17400   394 LCDGGcprdPDCSLMFQYFLIISVMSSFIYSLGGIPGYMLLLR 436
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
19-538 0e+00

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 602.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  19 LKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGL 98
Cdd:cd17459     1 LKIFLAALSFAYFAKALSGSYMKSTITQIERRFDIPSSLIGVIDGSFEMGNLLVIAFVSYFGAKLHRPRIIGAGCLLMAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  99 GCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRP-----TQDPSECTKEVKSLMWVYVLVGNIVRGMGET 173
Cdd:cd17459    81 GTFLIALPHFFMGRYKYETAIQSSSNSTVSISPCSLEPSPQLHSiessdSKTGTGCEKEPGSSMWIYVFLGNLLRGIGET 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 174 PILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICA 253
Cdd:cd17459   161 PVQPLGISYIDDFAKEENAAFYIGCVQTIAIIGPVFGFLLGSLCAKLYVDIGFVNLDSITITPKDARWVGAWWLGYLIAG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 254 GVNVLTAIPFFFLPNTLPkegletnadiiknenedkqkeevkkekygitKDFLPFMKSLSCNPIYMLFILVSVIQFNAFV 333
Cdd:cd17459   241 VITLLSAVPFWFLPKSLP-------------------------------KDFLPSLKNLLGNPVYFLYLCTSILQFNSLI 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 334 NMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENS 413
Cdd:cd17459   290 GMVTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFGYLLLLSFFAMGCENS 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 414 SVVGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCI----QT 489
Cdd:cd17459   370 DVAGLTVSYNGTKQVSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKASNGSGKNTVFHNCSCIgipsSA 449
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1904926785 490 SGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRC 538
Cdd:cd17459   450 SGSSSAILGQCPKGNACARMFLYFLAISVISSFTLSLGGTPGYILLIRC 498
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
21-597 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 593.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  21 MFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 100
Cdd:pfam03137   1 FFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 101 FLKSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvYVLVGNIVRGMGETPILPLGI 180
Cdd:pfam03137  81 LLFALPHFL--------------------------------------------------SFFLGQLLLGIGGTPIYTLGI 110
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 181 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDdliITPTDTRWVGAWWFGFLICAGVNVLTA 260
Cdd:pfam03137 111 SYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGKVSIT---LTPKDPRWVGAWWLGFLIAGLLLLLTA 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 261 IPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGIT---KDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMIS 337
Cdd:pfam03137 188 IPFFFFPKSLPGAAKRRAKKKKEPHSQDIADLKKTKSLKKLGpslKDFPKALKRLLKNPVYMLLTLASVFEFLLIAGYAT 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 338 FMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVG 417
Cdd:pfam03137 268 FLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCPNSPVAG 347
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 418 INTSYEGIPQdlyVENDIFADCNVDCNCPSKIWDPVCGNNG-LSYLSACLAGCETSIGTGINMVFQNCSCI----QTSGN 492
Cdd:pfam03137 348 ITVPYGGTQQ---LSGNLTSSCNSDCSCSTSAYSPVCGSDGgYTSPCPCGAGCSSSSGAGKSTYICNCCCScgsqDSGGN 424
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 493 SSAVLGLCDkgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMD 572
Cdd:pfam03137 425 GSATPGKCP--SDCSNKLPPFLALLFLASFFSSLSRTPGTLVILRCVPPEDKSFALGLQFLILRLLGFIPGPILFGALID 502
                         570       580
                  ....*....|....*....|....*
gi 1904926785 573 STCLHWGTlKCGESGACRIYDSTTF 597
Cdd:pfam03137 503 STCLLWGK-TCGGRGNCWLYDNDKL 526
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
19-537 2.06e-177

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 510.54  E-value: 2.06e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  19 LKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGL 98
Cdd:cd17457     1 LKMFLAALSFSYFAKALSGIIMKSSITQIERRFDISSSTVGFIDGSFEIGNLLVIAFVSYFGAKLHRPKLIAAGCFIMGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  99 GCFLKSLPHFLMNQYEYEstvsvsgnlssnsflcmengtqilrptqdpseCTKEVKSLMWVYVLVGNIVRGMGETPILPL 178
Cdd:cd17457    81 GSVLTALPHFFMGYYKYG--------------------------------CLKESGSYMWVYVLMGNMLRGIGETPIVPL 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 179 GISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVL 258
Cdd:cd17457   129 GISYLDDFAKEENSPLYLACLHTIAMIGPMIGFTLGSLFAKLYVDIGFVDLSTIRITPQDSRWVGAWWLGFLVSGLFSII 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 259 TAIPFFFLPntlpkegletnadiiknenedkqkeevkkekygitkDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISF 338
Cdd:cd17457   209 SAIPFFFLP------------------------------------GFFQSLKSILTNRLYVMFVCLTLLQVSSFIGFFTY 252
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 339 MPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGI 418
Cdd:cd17457   253 KPKYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACFTSVMALSFYLLYFFIGCENKSVAGI 332
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 419 NTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSG----NSS 494
Cdd:cd17457   333 TMTYDGNNPVTSHRDVILSYCNSDCNCDESQWDPVCGNNGITYISACLAGCKSSSGNGKPIVFHNCSCLEVTGsqnrNYS 412
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 1904926785 495 AVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 537
Cdd:cd17457   413 AHLGECPRDDDCSRMFYFYVVIQVLNLFFSALGGTSAYMLIVK 455
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
19-537 3.45e-135

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 401.23  E-value: 3.45e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  19 LKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGL 98
Cdd:cd17336     1 PKVFVVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  99 GCFLKSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvyvLVGNIVRGMGETPILPL 178
Cdd:cd17336    81 GCFLLALPHFL----------------------------------------------------FVGQFLLGIGSSPLYTL 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 179 GISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDdliITPTDTRWVGAWWFGFLICAGVNVL 258
Cdd:cd17336   109 GITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRIYVDFSRVPLG---ITPDDPRWIGAWWLGFLILGILLLI 185
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 259 TAIPFFFLPntlpkegletnadiiknenedkqkeevkkekygitkdflpfmkslscnPIYMLFILVSVIQFNAFVNMISF 338
Cdd:cd17336   186 VSIPLFFFP------------------------------------------------PIFILLLLAIVFESFAISGFSTF 217
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 339 MPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGI 418
Cdd:cd17336   218 LPKYLETQFRLSASLASLLTGLILVPGAALGILLGGLIIKKFKLTARGLAKFVLILSLLSVILYISLFFLGCDNPPIAGV 297
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 419 NTSYEGIPqdlyveNDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQT-SGNSSAVL 497
Cdd:cd17336   298 TTPYGSSS------SPITSSCNSDCNCSDSSFSPVCGSDGITYFSPCHAGCTSSDAGNGTKTYSNCSCINSgTATSSGCP 371
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 1904926785 498 GLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 537
Cdd:cd17336   372 PDCSVAPNCCSKLIPFLAVLFLSSFLLSLSIVPSTMITLR 411
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
19-537 2.91e-101

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 315.98  E-value: 2.91e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  19 LKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGL 98
Cdd:cd17461     2 IKVFVLCHGLLQLSQLLYSAYFKSSLTTIEKRFGLSSLSSGLISSLHEIGNAVLIIFVSYFGSRVHRPRLIGIGGLLLAL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  99 GCFLKSLPHFLMNQYEYEstvsvsgnlssnsflcmengtqilrptqdpsectkevkslMWVYVLVGNIVRGMGETPILPL 178
Cdd:cd17461    82 GAFLLTLPHFLSEPYQYS----------------------------------------MWVLMVVAQLLAGIGTVPIQPF 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 179 GISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVL 258
Cdd:cd17461   122 GISYVDDFAEPSNSPLYIAILFAISVFGPAFGYLLGSVVLRIFVDIGRVNTATVELTPADPRWIGAWWLGLLISSGLLVL 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 259 TAIPFFFLPNTLPKE---GLETNADIIKNENEDKQKEEVkkekyGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNM 335
Cdd:cd17461   202 TSLPYFFFPREMLVGkkpSPEGDMLRKKEDEKKEEGSLL-----DFIKRFPKMFVKLLLNPLFMLLVLAQCTFSSVIAGL 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 336 ISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSV 415
Cdd:cd17461   277 STFLNKFLEKQYGASASYANFLIGAVNLPAAALGMLLGGIIMKRFGFSLRAIPRFSVVILSISIMLCVPLFFMGCSTQDV 356
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 416 VGINTSYEGIPQDLYvendifADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSI---GTGINMVFQNCSCIQT-SG 491
Cdd:cd17461   357 AGVYPKTSNSSDGPH------LSCSANCSCPESAFNPVCGENGIEYISPCHAGCTNSNmdsSTYRQQIYSNCSCIPDlSG 430
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1904926785 492 NSSAVLGLCDKgpDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 537
Cdd:cd17461   431 EKPAKTGSCPN--SCSHLLLPVMFLISFAGLIACLTHNPLYMMVLR 474
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
19-537 2.03e-96

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 303.61  E-value: 2.03e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  19 LKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGL 98
Cdd:cd17460     1 IKFFVLCHGLLQLSQLLVSGYLKSSISTIEKRFGLSSQTSGLLASFNEVGNTVLIVFVSYFGSRVHRPRFIGCGAILVSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  99 GCFLKSLPHFLMNQYEYestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwVYVLVGNIVRGMGETPILPL 178
Cdd:cd17460    81 AGFLMALPHFISEPYEY-------------------------------------------GILFLGQLLLGIGGVPIQPF 117
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 179 GISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVL 258
Cdd:cd17460   118 GISYIDDFASESNSPLYLGILFAVTVLGPGFGFMLGSAMLRFYVDIDKMSEDEISLEIGDPRWVGAWWLGFLIAATLVAL 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 259 TAIPFFFLPNTLPKEGLE-------TNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLScNPIYMLFILVSVIQFNA 331
Cdd:cd17460   198 SAVPYFFFPREMPKEVVElqprekkLAKTMLKKLKSLSDILQNLSLLQFIKKFPRILLRTLR-NPIYLLVVLAQVNLSAM 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 332 FVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIgCWLSLLEYLLYFLSFL-MTC 410
Cdd:cd17460   277 VAGLATFMGKFLERQFSITASFANLMIGGLNIPSAMVGIVVGGVILKRLQLTVRGCGAM-CVLGMLLCLFFALPLLfIGC 355
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 411 ENSSVVGINTSYEGIPQdlyveNDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCET---SIGTGINMVFQNCSCI 487
Cdd:cd17460   356 STQKIAGITHRTSSSPG-----LELSSQCSEACSCPPEAFNPVCGSDGVEYISPCHAGCKSvnvQALDNSVVNYTDCSCV 430
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1904926785 488 QTSGN-SSAVLGLCDKGpdCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 537
Cdd:cd17460   431 SEGGPvGAASPGTCGSG--CSHLLVPFMLLVSLGGFLASLSHTPSFMLILR 479
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
19-537 6.93e-90

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 285.67  E-value: 6.93e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  19 LKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGL 98
Cdd:cd17402     1 IKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  99 GCFLKSLPHFLMNQYEyestvsvsgnlssnsflcmengtqilrptqdpsectkevKSLMWVYVLVGNIVRGMGETPILPL 178
Cdd:cd17402    81 GALLSALPEFLTHQYK---------------------------------------TNMMYLLLIGAQVLLGIGATPVQPL 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 179 GISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVL 258
Cdd:cd17402   122 GVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSKLDITPDDPRWIGAWWGGFLLCGALLFF 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 259 TAIPFFFLPNTLPKegletnadiiknenedkqkeevkkekygiTKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISF 338
Cdd:cd17402   202 SALLMFGFPQSLQQ-----------------------------LRVIPKVTKHLLSNPVFTCIVLAACMEIAVVAGFAAF 252
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 339 MPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGI 418
Cdd:cd17402   253 LGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGV 332
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 419 NTSYeGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGinmvfqnCSCIQT--SGNSSAV 496
Cdd:cd17402   333 TVPY-GNDTAPGSSLDPYAPCNSNCECQTDSFSPVCGADGITYLSACFAGCSSTNLSG-------CACLSSvpAENATVV 404
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 1904926785 497 LGLCDKgPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 537
Cdd:cd17402   405 PGKCPS-PGCQEAFLTFLCVMCVCSMIGAMAQTPSVIILIR 444
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
19-537 5.32e-89

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 282.89  E-value: 5.32e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  19 LKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGL 98
Cdd:cd17401     1 IKVFVLCHGLLQLCQLLYSGYLKSSITTIEKRFGLSSSSSGLLASFNEVGNTILIVFVSYFGSRVHRPRLIGIGGLFLAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  99 GCFLKSLPHFLMNQYEYestvsvsgnlssnsflcmengtqilrptqdpsectkevkSLMwvyvLVGNIVRGMGETPILPL 178
Cdd:cd17401    81 GAFLLTLPHFISEPYQY---------------------------------------GIM----VVAQLLLGIGGVPIQPF 117
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 179 GISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVL 258
Cdd:cd17401   118 GISYIDDFAEPSNSPLYLGILFAVTVFGPAFGYLLGSVMLRLYVDIGRMNTAAVNLVPGDPRWIGAWWLGFLIAAALLVL 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 259 TAIPFFFLPNTLpkegletnadiiknenedkqkeevkkekygitKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISF 338
Cdd:cd17401   198 TSFPYFFFPRFI--------------------------------KRFPCIFLRTLRNPIFLLVVLAQVTLSSMIAGLATF 245
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 339 MPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGI 418
Cdd:cd17401   246 LNKFLEKQFGTTASYANFLIGAVNLPSAALGILFGGVLMKRLVLSLQAIPAICTTIITISMIFCVPLFFIGCSTPTIAGV 325
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 419 N---TSYEGIPQDlyvendifADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCET----SIGTGINMVFQNCSCIqTSG 491
Cdd:cd17401   326 YppsSSSSIHPQS--------PACRRDCSCPDSIFNPVCGDNGVEYLSPCHAGCSNinmsTSATSKQVIYTNCSCV-TGG 396
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1904926785 492 NSSAVLGLCDKGpdCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 537
Cdd:cd17401   397 SASAKTGSCPSP--CSHLLLPFIFLISLVSLIACLSHTPSFMMILR 440
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
20-537 1.35e-88

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 281.55  E-value: 1.35e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  20 KMFLLAITC-AFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGL 98
Cdd:cd17404     1 KAFLVCMCLlIFIQSALSSGYLNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  99 GCFLKSLPHFLMnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvyvlVGNIVRGMGETPILPL 178
Cdd:cd17404    81 GSFLFSLPHFFI----------------------------------------------------LAQILIGMGGTPIFTL 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 179 GISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTgfvNTDDLIITPTDTRWVGAWWFGFLICAGVNVL 258
Cdd:cd17404   109 GTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGLLINFYVDP---LSTPPDISPGDPRWIGAWWGGFLLCGIALLL 185
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 259 TAIPFFFLPNtlpkegletnadiiknenedkqkeevkkekygitkdflpfmkslscnPIYMLFILVSVIQFNAFVNMISF 338
Cdd:cd17404   186 VAFPFFTFPK-----------------------------------------------MTFLVVSLGYCMELAIVSGFITF 218
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 339 MPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGI 418
Cdd:cd17404   219 LPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGAAKLALICNFLSLLLFLTLFFLGCESIKLAGI 298
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 419 NTSYEGIPQ-DLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMV-FQNCSCIQTSGNSS-- 494
Cdd:cd17404   299 TIPYTTGPSlSSTHGRNLTSECNVNCGCSINEYEPVCGSDGITYFSPCLAGCTSVGNTSTGIRnYTNCACLQSRSSISpp 378
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 1904926785 495 --AVLGLCDKGP--DCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLR 537
Cdd:cd17404   379 tvGQGSQLQAGPcsRTCNTLIPFLILLFIVTLITACAQMPALMITLR 425
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
20-537 4.10e-87

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 277.60  E-value: 4.10e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  20 KMFLLAIT-CAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGL 98
Cdd:cd17403     2 KGFLFFLCiFAFLQGMVVNGFVNVSITTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMGI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  99 GCFLKSLPHFLMnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvyVLVGNIVRGMGETPILPL 178
Cdd:cd17403    82 GSLVFALPHFTV--------------------------------------------------FILAQLLHGAGATPLYTL 111
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 179 GISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVnTDDLIITPTDTRWVGAWWFGFLICAGVNVL 258
Cdd:cd17403   112 GVTYLDENVSTKMSPLYIGIFYAMAILGPAIGYVLGGFLLNLYTDIDQV-DSELGLTPDDPRWVGAWWLGFLISGALALI 190
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 259 TAIPFFFLPntlpkegletnadiiknenedkqkeevkkekygitkdflpfmkslscnPIYMLFILVSVIQFNAFVNMISF 338
Cdd:cd17403   191 IAFPLLGFP------------------------------------------------PTFMFLNLAGASEGMLLAGFATF 222
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 339 MPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLyFLSFLMTCENSSVVGI 418
Cdd:cd17403   223 LPKLIESQFSLSASLAALLVGVVVVPGGILGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFLF-SFILLIYCPNAPFAGV 301
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 419 NTSYEGIPqdLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQ---TSGNSSA 495
Cdd:cd17403   302 TVPYGNSP--LEGTSNLTSTCNADCHCSEDFYDPVCGSDGVTYYSPCHAGCTTSHGDDGQKVYSNCSCIQsnsSKTSTAA 379
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 1904926785 496 VLGLCDKGPDCSLMLQYFLILSAMSSFIYsLAAIPGYMVLLR 537
Cdd:cd17403   380 TGKACPCETCCQKLYLFLAVFFLLIVFTF-MSSTPALSATLR 420
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
29-537 1.35e-63

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 215.85  E-value: 1.35e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  29 AFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHF 108
Cdd:cd17462    12 SFLQGMTVNGFINTVITSIERRFDLRSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLIMGLGSLVFALPHF 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 109 lmnqyeyesTVsvsgnlssnsflcmengtqilrptqdpsectkevkslmwvyVLVGNIVRGMGETPILPLGISYIEDFAK 188
Cdd:cd17462    92 ---------TV-----------------------------------------FMLGQFLHGIGATPLYTLGVTYLDENVK 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 189 FENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGfVNTDdliITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPN 268
Cdd:cd17462   122 SNYSPVYIGIFYTAAIVGPAAGYLLGGFFLNIYTEIG-RQTE---LTPENPLWVGAWWIGFLGAGAAALLIALPILGYPR 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 269 TLPkegletnadiiknenedkqkeevkkekyGITKdflpfmkslscNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYG 348
Cdd:cd17462   198 QLP----------------------------GLLK-----------NPTFIFLCLAGATEATLIAGMSTFGPKFLESQFS 238
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 349 ISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIgCWLSLLEYLLYFLSFLMTCENSSVVGINTSYEG--IP 426
Cdd:cd17462   239 LSASEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIKF-CLICTVVSLLAIFIFSLHCPNVPMAGVTASYRGsvLP 317
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 427 QDLyveNDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGIN--MVFQNCSCIqtSGNSSAVLGLCDKGP 504
Cdd:cd17462   318 EGS---LNLTALCNADCRCLEEIYSPVCGADGLMYYSPCHAGCSEAYSDIRNgqKVYQDCSCV--AGNLSVGFGEASAGK 392
                         490       500       510
                  ....*....|....*....|....*....|....*
gi 1904926785 505 DCSLMLQYFLILSAMSSFIY--SLAAIPGYMVLLR 537
Cdd:cd17462   393 CTSNCNHMPLLLAFVFLVILftFLCSIPALTATLR 427
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
23-537 5.43e-62

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 211.53  E-value: 5.43e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  23 LLAITCAFVSKTLsgsyMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFL 102
Cdd:cd17463    10 LLAVVQGIVVNGL----VNISISTIEKRYELSSSLTGLISSSYDISFCLLSLFVSFYGERGHKPRWLAFSAFMIGLGSLV 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 103 KSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslmwVYVLvGNIVRGMGETPILPLGISY 182
Cdd:cd17463    86 FSLPHFF-------------------------------------------------VFIL-GQLLLGVGGTPLYTLGTAY 115
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 183 IEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLiiTPTDTRWVGAWWFGFLICAGVNVLTAIP 262
Cdd:cd17463   116 IDDSVPTHKSSLYIGIGYGMSVLGPAIGYLLGGQLLNIYIDVNKGQSVDL--TEEDPRWLGAWWIGFLMCWLIAWCLIAP 193
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 263 FFFLPNTLPkegletnadiiknenedkqkeevkkekyGITKdflpfmkslscNPIYMLFILVSVIQFNAFVNMISFMPKY 342
Cdd:cd17463   194 FSCFPKHLP----------------------------GLLK-----------NPVFMCLTISSCSEALITTGFATFLPKF 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 343 LEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINTSY 422
Cdd:cd17463   235 IENQFGQTSSFAAILGGLVLIPGAAIGQILGGIIVSKFKLKCKNMIKFAIITTTVSLLLLSVFIFAKCGNDPFAGVSETY 314
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 423 EGIPQdlyvENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQ-TSGNSSAVLGLCD 501
Cdd:cd17463   315 NGTGK----IGNLTAPCNANCSCLSSFYYPVCGADGVQYFSPCFAGCTNENLHDKKKVYYNCSCIGnFTEEFSANTTKCE 390
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 1904926785 502 KGPDCSLM---LQYFLILSAMSSFIYSLAAIPGYMVLLR 537
Cdd:cd17463   391 EGKKCETTcknLPIFLCFFFFVVIFTFMTSTPITVAILR 429
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
48-537 1.93e-34

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 135.75  E-value: 1.93e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  48 ERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFlmnqyeyestvsvsgnlss 127
Cdd:cd17405    30 QVQFSLTRTEKYLLDFSYDISSFLVAIIIAHYGSRGNRTRWIAASCFLMGLGSMLFAFPFF------------------- 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 128 nsflcmengtqilrptqdpsectkevkslmwVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGP 207
Cdd:cd17405    91 -------------------------------TFHIAGQCIQGIAGMPIYILGITFIFDNIPTSSAGIYLGIAHSAYLIGY 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 208 LIGLLLASfcANVYVDtgfVNTDDLIITPTDT--RWVGAWWFGFLICAGVNVLTAIPFFFLPNTLPkegletnadiikne 285
Cdd:cd17405   140 LLGYVGGL--PNFQPP---PNEKSVEIEVNKVyqLWQSGWWKTFLIAAAIAWCTSFPLVCFPTSLP-------------- 200
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 286 nedkqkeevkkekyGITKdflpfmkslscNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPP 365
Cdd:cd17405   201 --------------GLLK-----------NPLLLCQAICKATEYLTFIGALEFLPHYLENQFLLTPGIASLLTGAFLIPG 255
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 366 ICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINTSYEGIPQdlyvENDIFADCNVDCNC 445
Cdd:cd17405   256 GAIGHFLGGLIVSRLEMSCKNKMRFILVTSVISLGLFVLIFFVECQTVTFAGINEDYDGYGQ----LGNLTAPCNEYCDC 331
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 446 PSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSS--------AVLGLCDKgpDCsLMLQYFLILS 517
Cdd:cd17405   332 TSSLYTSICGRDEIEYFSPCFAGCKASKVSNTEKTYYNCSCIKEGLAAAddegdfidAIAGKCDS--KC-YKLPLFFAFY 408
                         490       500
                  ....*....|....*....|
gi 1904926785 518 AMSSFIYSLAAIPGYMVLLR 537
Cdd:cd17405   409 FSATVFSNMCSIPIILIILR 428
KAZAL_SLC21 cd01330
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop ...
435-488 1.80e-22

The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238650 [Multi-domain]  Cd Length: 54  Bit Score: 90.44  E-value: 1.80e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1904926785 435 IFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQ 488
Cdd:cd01330     1 LTSSCNSNCSCSESAYSPVCGENGITYFSPCHAGCTNSTGSGGSKIYTNCSCVG 54
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
26-406 5.63e-21

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 95.19  E-value: 5.63e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  26 ITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSL 105
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 106 PHflmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsectkevkslMWVYVLVGNIVRGMGETPILPLGISYIED 185
Cdd:cd06174    81 AP-------------------------------------------------SFWLLLLGRFLLGLGSGLIDPAVLALIAD 111
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 186 FAKFENSPLYIGLVETGAIIGPLIGLLLASFCAnvyvdtgfvntddliitptdTRWVGAWWFGFLICAGVNVLTAIPFFF 265
Cdd:cd06174   112 LFPERERGRALGLLQAFGSVGGILGPLLGGILA--------------------SSLGFGWRAVFLIAAALALLAAILLLL 171
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 266 LPNTLPKEGLETNADIIKnenedkqkeevkkekygitKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQ 345
Cdd:cd06174   172 VVPDPPESARAKNEEASS-------------------KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD 232
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1904926785 346 QYGISSSDAIFLMGIYNLPPIcIGYIIGGLIMKKFkITVKQAAHIGCWLSLLEYLLYFLSF 406
Cdd:cd06174   233 LGGLSVAVAGLLLSLFGLAGA-LGSLLLGLLSDRL-IGRKPLLLIGLLLMALGLALLLLAP 291
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
21-405 1.14e-13

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 72.70  E-value: 1.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  21 MFLLAITCAFVSktLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 100
Cdd:COG2814    12 LLALALGAFLSG--LGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 101 FLkslphflmnqyeyestVSVSGNLSSnsflcmengtqilrptqdpsectkevkslmwvyVLVGNIVRGMGETPILPLGI 180
Cdd:COG2814    90 LL----------------CALAPSLWL---------------------------------LLAARFLQGLGAGALFPAAL 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 181 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYvdtgfvntddliitptdtrwvgAWWFGFLICAGVNVLTA 260
Cdd:COG2814   121 ALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF----------------------GWRWVFLVNAVLALLAL 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 261 IP-FFFLPNTLPKEgletnadiiknenedkqkeevkkekygiTKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFM 339
Cdd:COG2814   179 LLlLRLLPESRPAA----------------------------RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYL 230
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1904926785 340 PKYLEQQYGISSSDAIFLMGIYNLPPIcIGYIIGGLIMKKFKItvKQAAHIGCWLSLLEYLLYFLS 405
Cdd:COG2814   231 PLYLQEVLGLSASAAGLLLALFGLGGV-LGALLAGRLADRFGR--RRLLLIGLLLLALGLLLLALA 293
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
440-486 5.44e-13

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 63.67  E-value: 5.44e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1904926785 440 NVDCNCPSKIWDPVCGNNGLSYLSAC---LAGCETSIGTGINMVFQNCSC 486
Cdd:pfam07648   1 NCNCQCPKTEYEPVCGSDGVTYPSPCalcAAGCKLGKEVKEEKVKYDGSC 50
MFS_1 pfam07690
Major Facilitator Superfamily;
28-408 1.18e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 60.12  E-value: 1.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  28 CAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLkslph 107
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL----- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 108 flmnqyeyestvsvsGNLSSNSFLcmengtqilrptqdpsectkevkslmwvyVLVGNIVRGMGETPILPLGISYIEDFA 187
Cdd:pfam07690  79 ---------------LLFASSLWL-----------------------------LLVLRVLQGLGAGALFPAALALIADWF 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 188 KFENSPLYIGLVETGAIIGPLIGLLLASFcanvyvdtgfvntddlIITPTDTRWVgawwfgFLICAGVNVLTAIPFFFLP 267
Cdd:pfam07690 115 PPEERGRALGLVSAGFGLGAALGPLLGGL----------------LASLFGWRAA------FLILAILSLLAAVLLLLPR 172
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 268 NTLPKEGLETNADIIknenedkqkeevkkekygitKDFLPFMKSLSCNPIyMLFILVSVIQFNAFVNMISFMPKYLEqQY 347
Cdd:pfam07690 173 PPPESKRPKPAEEAR--------------------LSLIVAWKALLRDPV-LWLLLALLLFGFAFFGLLTYLPLYQE-VL 230
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1904926785 348 GISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLM 408
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSS 291
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
445-486 9.56e-08

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 48.42  E-value: 9.56e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1904926785 445 CPsKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSC 486
Cdd:cd00104     1 CP-KEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
158-378 4.05e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 46.03  E-value: 4.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 158 WVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVET----GAIIGPLIGLLLASFcanvyvdtgfvntddli 233
Cdd:cd17325    84 YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSaiglGFLIGPLLGGLLADA----------------- 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 234 itptdtrwvGAWWFGFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIKnenedkqkeevkkekygitkdFLPFMKSLS 313
Cdd:cd17325   147 ---------LGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAAR---------------------LRSGLRLLL 196
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1904926785 314 CNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMK 378
Cdd:cd17325   197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDR 261
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
18-381 8.69e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 45.23  E-value: 8.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  18 KLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMG 97
Cdd:COG0738     5 NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  98 LGCFLkslphflmnqyeyestVSVSGNlssnsflcmengtqilrptqdpsectkevkslmWVYVLVGNIVRGMG----ET 173
Cdd:COG0738    85 LGLLL----------------FALAPS---------------------------------YPLLLLALFLLGLGlgllDV 115
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 174 PILPLGISyIEDfakfENSPLYIGLVET----GAIIGPLIGLLLASFCANVyvdtgfvntddliitptdtrwvgAWWFGF 249
Cdd:COG0738   116 AANPYVAA-LGP----ETAASRLNLLHAffslGALLGPLLGGLLILLGLSL-----------------------SWHLPY 167
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 250 LICAGVNVLTAIPFFFLPntLPKEGLETNADIIKNENedkqkeevkkekygitkdflpfMKSLSCNPIYMLFILVSVIQF 329
Cdd:COG0738   168 LILAVLLLLLALLFLRSK--LPEIEEEEEEAAGSAAS----------------------LKSLLKNPRLLLGGLAIFLYV 223
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1904926785 330 NAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLpPICIGYIIGGLIMKKFK 381
Cdd:COG0738   224 GAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWG-GMTIGRFLGGFLLKRFG 274
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
21-408 3.00e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 43.31  E-value: 3.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  21 MFLLAItCAFVSKTlSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGC 100
Cdd:cd17324     1 LLALAL-AAFAIGT-TEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGN 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 101 FLKSLphflmnqyeyestvsvsgnlsSNSFLCMengtqilrptqdpsectkevkslmwvyvLVGNIVRGMGETPILPLGI 180
Cdd:cd17324    79 LLAAL---------------------APSFALL----------------------------LLARALAGLAHGGFWAIAA 109
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 181 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYvdtGFvntddliitptdtRWVgawwfgFLICAGVNVLTA 260
Cdd:cd17324   110 AYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL---GW-------------RAA------FLAIAVLALLAA 167
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 261 IPF-FFLPNTLPKEGletnadiiknenedkqkeevkkekygITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFM 339
Cdd:cd17324   168 LLLwRLLPSLPPKKP--------------------------GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYL 221
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1904926785 340 PKYLEQQYGISSSDAIFLMGIYNLPPIcIGYIIGGLIMKKFKITVKQAAhiGCWLSLLEYLLYFLSFLM 408
Cdd:cd17324   222 APFLTDVPGFSSSAIIGLLLLFGVAGV-VGSPLAGRLADRGGRRALLIA--LLLLAAALLLLTLLGPSP 287
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
21-380 3.87e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 43.33  E-value: 3.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785  21 MFLLAITCAFVSktLSGSYMNSML-TQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLG 99
Cdd:COG2223     6 VLLLATLAFFLA--FGVWYLWSVLaPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 100 CFLKSLphflmnqyeyestvsvsgnlsSNSFlcmengtqilrptqdpsectkevkslmWVYVLVGNIVrGMGETPILPLG 179
Cdd:COG2223    84 LLLLAL---------------------AVSY---------------------------WLLLLLGLLL-GIGGGGSFAVG 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 180 ISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYvdtgfvntddliitptdtrwvgAWWFGFLICAGVNVLT 259
Cdd:COG2223   115 IALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF----------------------GWRNAFLILGILLLVV 172
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1904926785 260 AIPFFFLPNTLPKEGLETNAdiiknenedkqkeevkkekygitKDFLPFMKSLScNPIYMLFILVSVIQFNAFVNMISFM 339
Cdd:COG2223   173 AVLAWLFLRDPPAGAAAAAK-----------------------ASLRDQLEALR-DPRFWLLSLLYFGTFGSFIGFSSWL 228
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1904926785 340 PKYLEQQYGISSSDAIFLMGIYNLPPIcIGYIIGGLIMKKF 380
Cdd:COG2223   229 PPYLVDQFGLSAATAGLLAALFALLGA-LGRPLGGWLSDRI 268
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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