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Conserved domains on  [gi|1827280125|ref|NP_001366288|]
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zinc finger protein 54 isoform 2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 52-92 2.03e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.14  E-value: 2.03e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1827280125  52 LLTFRDVTVDFSQEEWECLDSAQRALYIEVMLENYSNLVYV 92
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
138-544 7.58e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 7.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 138 NNYRCCKDQDASLDSSNPDRLKSTHTGKE--RCESKDCAKSSSLCSSIAQDQRTNSTNKEQRQEK--YDDHFISTHSlmq 213
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKpsQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKslPLSNSKASSS--- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 214 qaiyigENPHQCMKYGKCFSSASSLGVQQRTDTGNKP--YKCNICDKSFTECSSLKEHRKTHQRLRAGTNPykcNDCGKS 291
Cdd:COG5048   109 ------SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDllSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA---NSLSKD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 292 FSYLSALQSHHKRHTGEKRYKCKECGKSYAYRTGLKRHQKIHTAEECYSCQYCGKVFHQLSHFKSHFTLHTGEKPYKCNE 371
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 372 CHRSFPHYVFFRRHKKNHSL-------QKSHKCKECGKSFFILSHLKTHYR--IHTGE--KPYKCTK--CDKLFTQYSHL 438
Cdd:COG5048   260 SPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 439 RRHQRIYTGKKLYRC--EVCDKWFT-----LSSSLSRHQKIHTEAKTYKC--KDCDIFFNHYSSLRRHQKVHTGER--HY 507
Cdd:COG5048   340 KRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRpyNC 419

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1827280125 508 TCKQCGKSFTRGSTLRVHQRIHTGEKPYKCSECDKSF 544
Cdd:COG5048   420 KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 531-611 7.89e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 7.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 531 GEKPYKCS--ECDKSFTQASQLRTHqRVHtgekpyvcKECGKSLTTCAILRAHQKIHTGEKPYKCMECDRSYIQYSHLKR 608
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1827280125 609 HQK 611
Cdd:COG5189   417 HRK 419
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 52-92 2.03e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.14  E-value: 2.03e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1827280125  52 LLTFRDVTVDFSQEEWECLDSAQRALYIEVMLENYSNLVYV 92
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
53-113 7.29e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 86.11  E-value: 7.29e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1827280125   53 LTFRDVTVDFSQEEWECLDSAQRALYIEVMLENYSNLVYVEnYCIC--DTVCQhVKTEKESCN 113
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG-FQVPkpDLISQ-LEQGEEPWI 61
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 53-90 8.94e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 8.94e-18
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1827280125  53 LTFRDVTVDFSQEEWECLDSAQRALYIEVMLENYSNLV 90
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
138-544 7.58e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 7.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 138 NNYRCCKDQDASLDSSNPDRLKSTHTGKE--RCESKDCAKSSSLCSSIAQDQRTNSTNKEQRQEK--YDDHFISTHSlmq 213
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKpsQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKslPLSNSKASSS--- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 214 qaiyigENPHQCMKYGKCFSSASSLGVQQRTDTGNKP--YKCNICDKSFTECSSLKEHRKTHQRLRAGTNPykcNDCGKS 291
Cdd:COG5048   109 ------SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDllSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA---NSLSKD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 292 FSYLSALQSHHKRHTGEKRYKCKECGKSYAYRTGLKRHQKIHTAEECYSCQYCGKVFHQLSHFKSHFTLHTGEKPYKCNE 371
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 372 CHRSFPHYVFFRRHKKNHSL-------QKSHKCKECGKSFFILSHLKTHYR--IHTGE--KPYKCTK--CDKLFTQYSHL 438
Cdd:COG5048   260 SPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 439 RRHQRIYTGKKLYRC--EVCDKWFT-----LSSSLSRHQKIHTEAKTYKC--KDCDIFFNHYSSLRRHQKVHTGER--HY 507
Cdd:COG5048   340 KRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRpyNC 419

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1827280125 508 TCKQCGKSFTRGSTLRVHQRIHTGEKPYKCSECDKSF 544
Cdd:COG5048   420 KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
zf-H2C2_2 pfam13465
Zinc-finger double domain;
522-546 2.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.84e-04
                          10        20
                  ....*....|....*....|....*
gi 1827280125 522 LRVHQRIHTGEKPYKCSECDKSFTQ 546
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PRK04860 PRK04860
SprT family zinc-dependent metalloprotease;
478-513 6.93e-04

SprT family zinc-dependent metalloprotease;


Pssm-ID: 179886  Cd Length: 160  Bit Score: 40.66  E-value: 6.93e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1827280125 478 TYKCKDCDIFFnhysSLRRHQKVHTGERHYTCKQCG 513
Cdd:PRK04860  119 PYRCKCQEHQL----TVRRHNRVVRGEAVYRCRRCG 150
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 531-611 7.89e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 7.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 531 GEKPYKCS--ECDKSFTQASQLRTHqRVHtgekpyvcKECGKSLTTCAILRAHQKIHTGEKPYKCMECDRSYIQYSHLKR 608
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1827280125 609 HQK 611
Cdd:COG5189   417 HRK 419
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 535-557 8.46e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.46e-03
                          10        20
                  ....*....|....*....|...
gi 1827280125 535 YKCSECDKSFTQASQLRTHQRVH 557
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 52-92 2.03e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.14  E-value: 2.03e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1827280125  52 LLTFRDVTVDFSQEEWECLDSAQRALYIEVMLENYSNLVYV 92
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
53-113 7.29e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 86.11  E-value: 7.29e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1827280125   53 LTFRDVTVDFSQEEWECLDSAQRALYIEVMLENYSNLVYVEnYCIC--DTVCQhVKTEKESCN 113
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG-FQVPkpDLISQ-LEQGEEPWI 61
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 53-90 8.94e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 8.94e-18
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1827280125  53 LTFRDVTVDFSQEEWECLDSAQRALYIEVMLENYSNLV 90
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
138-544 7.58e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 7.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 138 NNYRCCKDQDASLDSSNPDRLKSTHTGKE--RCESKDCAKSSSLCSSIAQDQRTNSTNKEQRQEK--YDDHFISTHSlmq 213
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKpsQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKslPLSNSKASSS--- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 214 qaiyigENPHQCMKYGKCFSSASSLGVQQRTDTGNKP--YKCNICDKSFTECSSLKEHRKTHQRLRAGTNPykcNDCGKS 291
Cdd:COG5048   109 ------SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDllSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA---NSLSKD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 292 FSYLSALQSHHKRHTGEKRYKCKECGKSYAYRTGLKRHQKIHTAEECYSCQYCGKVFHQLSHFKSHFTLHTGEKPYKCNE 371
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 372 CHRSFPHYVFFRRHKKNHSL-------QKSHKCKECGKSFFILSHLKTHYR--IHTGE--KPYKCTK--CDKLFTQYSHL 438
Cdd:COG5048   260 SPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 439 RRHQRIYTGKKLYRC--EVCDKWFT-----LSSSLSRHQKIHTEAKTYKC--KDCDIFFNHYSSLRRHQKVHTGER--HY 507
Cdd:COG5048   340 KRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRpyNC 419

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1827280125 508 TCKQCGKSFTRGSTLRVHQRIHTGEKPYKCSECDKSF 544
Cdd:COG5048   420 KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
248-599 1.52e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 248 NKPYKCNICDKSFtecsSLKEHRKTHQRLRAGTNPYKCND--CGKSFSYLSALQSHHKRHTGEK-RYKCKECGKSYAYRT 324
Cdd:COG5048    31 PRPDSCPNCTDSF----SRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPsDLNSKSLPLSNSKAS 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 325 GLKRHQKIHTAEECYSCQYCGKVFHQlshfkSHFTLHTGEKPYKC-NECHRSFPHYVFFRRHKKNHSLQKSHKCKECGKS 403
Cdd:COG5048   107 SSSLSSSSSNSNDNNLLSSHSLPPSS-----RDPQLPDLLSISNLrNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 404 FFILSHlkTHYRIHTGEKPYKCTKCDKLFTQYSHLRRHQRIytgkklyrcevcdkwFTLSSSLSRHQKIHTEAKTYKCKd 483
Cdd:COG5048   182 SNLSLL--ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL---------------ENSSSSLPLTTNSQLSPKSLLSQ- 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 484 cdiffNHYSSLRRHQKVHTGERHYTCKQcGKSFTRGSTLRVHQRIHTG-EKPYKCSECDKSFTQASQLRTHQR--VHTGE 560
Cdd:COG5048   244 -----SPSSLSSSDSSSSASESPRSSLP-TASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1827280125 561 --KPYVCKE--CGKSLTTCAILRAHQKIHTGEKPYKCMECDRS 599
Cdd:COG5048   318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSS 360
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 247-331 2.14e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 2.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 247 GNKPYKCNI--CDKSFTECSSLKEHRKT-HQRLRAGTNPykcndcgksfsylsALQSHHKRHTGEKRYKCKECGKSYAYR 323
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQKLHENP--------------SPEKMNIFSAKDKPYRCEVCDKRYKNL 411


                  ....*...
gi 1827280125 324 TGLKRHQK 331
Cdd:COG5189   412 NGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
522-546 2.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.84e-04
                          10        20
                  ....*....|....*....|....*
gi 1827280125 522 LRVHQRIHTGEKPYKCSECDKSFTQ 546
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PRK04860 PRK04860
SprT family zinc-dependent metalloprotease;
478-513 6.93e-04

SprT family zinc-dependent metalloprotease;


Pssm-ID: 179886  Cd Length: 160  Bit Score: 40.66  E-value: 6.93e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1827280125 478 TYKCKDCDIFFnhysSLRRHQKVHTGERHYTCKQCG 513
Cdd:PRK04860  119 PYRCKCQEHQL----TVRRHNRVVRGEAVYRCRRCG 150
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 531-611 7.89e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 7.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 531 GEKPYKCS--ECDKSFTQASQLRTHqRVHtgekpyvcKECGKSLTTCAILRAHQKIHTGEKPYKCMECDRSYIQYSHLKR 608
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1827280125 609 HQK 611
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
409-434 1.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.30e-03
                          10        20
                  ....*....|....*....|....*.
gi 1827280125 409 HLKTHYRIHTGEKPYKCTKCDKLFTQ 434
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
493-518 2.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.67e-03
                          10        20
                  ....*....|....*....|....*.
gi 1827280125 493 SLRRHQKVHTGERHYTCKQCGKSFTR 518
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-413 4.76e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 4.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 249 KPYKCNICDKSFTECSSLKEHRKTHQRLRAGTNPYKC--NDCGKSFSYLSALQSHHKRHTGEKRYKCKEC-------GKS 319
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 320 YAYRTGLKRHQKIHTAEECYSCQY--CGKVFHQLSHFKSHFTLHTGEKPYKCnechRSFPHYVFFRRHKKNHSLQKSHKC 397
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNC----KNPPCSKSFNRHYNLIPHKKIHTN 443

                         170       180
                  ....*....|....*....|.
gi 1827280125 398 KECG-----KSFFILSHLKTH 413
Cdd:COG5048   444 HAPLlcsilKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
335-615 4.84e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 335 AEECYSCQYCGKVFHQLSHFKSHFTLHTGEKPYKCNE----CHRSFPHyvFFRRHKKNHSLQKSHKC-KECGKSFFILSH 409
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgcdKSFSRPL--ELSRHLRTHHNNPSDLNsKSLPLSNSKASS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 410 LKTHYRIHTGEKPYKCTKCDKLFTQY----------SHLRRHQ-RIYTGKKLYRCEVCDKWFTLSS-----------SLS 467
Cdd:COG5048   108 SSLSSSSSNSNDNNLLSSHSLPPSSRdpqlpdllsiSNLRNNPlPGNNSSSVNTPQSNSLHPPLPAnslskdpssnlSLL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 468 RHQKIHTEAKTYKCKDCDIFFNHYSSLRRHQKVHTGERHYTCKQCGKSFTRGSTLRVHQRIHTGEKPYKCSEC------D 541
Cdd:COG5048   188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESprsslpT 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280125 542 KSFTQASQLRTHQRVHTG-EKPYVCKECGKSLTTCAILRAHQ--KIHTGE--KPYKCME--CDRSYIQYSHLKRHQKVHT 614
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347


                  .
gi 1827280125 615 G 615
Cdd:COG5048   348 S 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
297-322 6.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.27e-03
                          10        20
                  ....*....|....*....|....*.
gi 1827280125 297 ALQSHHKRHTGEKRYKCKECGKSYAY 322
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 535-557 8.46e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.46e-03
                          10        20
                  ....*....|....*....|...
gi 1827280125 535 YKCSECDKSFTQASQLRTHQRVH 557
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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