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Conserved domains on  [gi|1827280119|ref|NP_001366286|]
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zinc finger protein 54 isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 1.89e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.14  E-value: 1.89e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1827280119  12 LLTFRDVTVDFSQEEWECLDSAQRALYIEVMLENYSNLVYV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
98-504 3.53e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 3.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119  98 NNYRCCKDQDASLDSSNPDRLKSTHTGKE--RCESKDCAKSSSLCSSIAQDQRTNSTNKEQRQEK--YDDHFISTHSlmq 173
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKpsQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKslPLSNSKASSS--- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 174 qaiyigENPHQCMKYGKCFSSASSLGVQQRTDTGNKP--YKCNICDKSFTECSSLKEHRKTHQRLRAGTNPykcNDCGKS 251
Cdd:COG5048   109 ------SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDllSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA---NSLSKD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 252 FSYLSALQSHHKRHTGEKRYKCKECGKSYAYRTGLKRHQKIHTAEECYSCQYCGKVFHQLSHFKSHFTLHTGEKPYKCNE 331
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 332 CHRSFPHYVFFRRHKKNHSL-------QKSHKCKECGKSFFILSHLKTHYR--IHTGE--KPYKCTK--CDKLFTQYSHL 398
Cdd:COG5048   260 SPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 399 RRHQRIYTGKKLYRC--EVCDKWFT-----LSSSLSRHQKIHTEAKTYKC--KDCDIFFNHYSSLRRHQKVHTGER--HY 467
Cdd:COG5048   340 KRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRpyNC 419

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1827280119 468 TCKQCGKSFTRGSTLRVHQRIHTGEKPYKCSECDKSF 504
Cdd:COG5048   420 KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 491-571 1.03e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 491 GEKPYKCS--ECDKSFTQASQLRTHqRVHtgekpyvcKECGKSLTTCAILRAHQKIHTGEKPYKCMECDRSYIQYSHLKR 568
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1827280119 569 HQK 571
Cdd:COG5189   417 HRK 419
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 1.89e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.14  E-value: 1.89e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1827280119  12 LLTFRDVTVDFSQEEWECLDSAQRALYIEVMLENYSNLVYV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-73 6.78e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 86.11  E-value: 6.78e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1827280119   13 LTFRDVTVDFSQEEWECLDSAQRALYIEVMLENYSNLVYVEnYCIC--DTVCQhVKTEKESCN 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG-FQVPkpDLISQ-LEQGEEPWI 61
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-50 7.67e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 7.67e-18
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1827280119  13 LTFRDVTVDFSQEEWECLDSAQRALYIEVMLENYSNLV 50
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
98-504 3.53e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 3.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119  98 NNYRCCKDQDASLDSSNPDRLKSTHTGKE--RCESKDCAKSSSLCSSIAQDQRTNSTNKEQRQEK--YDDHFISTHSlmq 173
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKpsQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKslPLSNSKASSS--- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 174 qaiyigENPHQCMKYGKCFSSASSLGVQQRTDTGNKP--YKCNICDKSFTECSSLKEHRKTHQRLRAGTNPykcNDCGKS 251
Cdd:COG5048   109 ------SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDllSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA---NSLSKD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 252 FSYLSALQSHHKRHTGEKRYKCKECGKSYAYRTGLKRHQKIHTAEECYSCQYCGKVFHQLSHFKSHFTLHTGEKPYKCNE 331
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 332 CHRSFPHYVFFRRHKKNHSL-------QKSHKCKECGKSFFILSHLKTHYR--IHTGE--KPYKCTK--CDKLFTQYSHL 398
Cdd:COG5048   260 SPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 399 RRHQRIYTGKKLYRC--EVCDKWFT-----LSSSLSRHQKIHTEAKTYKC--KDCDIFFNHYSSLRRHQKVHTGER--HY 467
Cdd:COG5048   340 KRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRpyNC 419

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1827280119 468 TCKQCGKSFTRGSTLRVHQRIHTGEKPYKCSECDKSF 504
Cdd:COG5048   420 KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
zf-H2C2_2 pfam13465
Zinc-finger double domain;
482-506 4.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.44e-04
                          10        20
                  ....*....|....*....|....*
gi 1827280119 482 LRVHQRIHTGEKPYKCSECDKSFTQ 506
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PRK04860 PRK04860
SprT family zinc-dependent metalloprotease;
438-473 8.20e-04

SprT family zinc-dependent metalloprotease;


Pssm-ID: 179886  Cd Length: 160  Bit Score: 40.28  E-value: 8.20e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1827280119 438 TYKCKDCDIFFnhysSLRRHQKVHTGERHYTCKQCG 473
Cdd:PRK04860  119 PYRCKCQEHQL----TVRRHNRVVRGEAVYRCRRCG 150
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 491-571 1.03e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 491 GEKPYKCS--ECDKSFTQASQLRTHqRVHtgekpyvcKECGKSLTTCAILRAHQKIHTGEKPYKCMECDRSYIQYSHLKR 568
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1827280119 569 HQK 571
Cdd:COG5189   417 HRK 419
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 1.89e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.14  E-value: 1.89e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1827280119  12 LLTFRDVTVDFSQEEWECLDSAQRALYIEVMLENYSNLVYV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-73 6.78e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 86.11  E-value: 6.78e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1827280119   13 LTFRDVTVDFSQEEWECLDSAQRALYIEVMLENYSNLVYVEnYCIC--DTVCQhVKTEKESCN 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG-FQVPkpDLISQ-LEQGEEPWI 61
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-50 7.67e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 7.67e-18
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1827280119  13 LTFRDVTVDFSQEEWECLDSAQRALYIEVMLENYSNLV 50
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
98-504 3.53e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 3.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119  98 NNYRCCKDQDASLDSSNPDRLKSTHTGKE--RCESKDCAKSSSLCSSIAQDQRTNSTNKEQRQEK--YDDHFISTHSlmq 173
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKpsQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKslPLSNSKASSS--- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 174 qaiyigENPHQCMKYGKCFSSASSLGVQQRTDTGNKP--YKCNICDKSFTECSSLKEHRKTHQRLRAGTNPykcNDCGKS 251
Cdd:COG5048   109 ------SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDllSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA---NSLSKD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 252 FSYLSALQSHHKRHTGEKRYKCKECGKSYAYRTGLKRHQKIHTAEECYSCQYCGKVFHQLSHFKSHFTLHTGEKPYKCNE 331
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 332 CHRSFPHYVFFRRHKKNHSL-------QKSHKCKECGKSFFILSHLKTHYR--IHTGE--KPYKCTK--CDKLFTQYSHL 398
Cdd:COG5048   260 SPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 399 RRHQRIYTGKKLYRC--EVCDKWFT-----LSSSLSRHQKIHTEAKTYKC--KDCDIFFNHYSSLRRHQKVHTGER--HY 467
Cdd:COG5048   340 KRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRpyNC 419

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1827280119 468 TCKQCGKSFTRGSTLRVHQRIHTGEKPYKCSECDKSF 504
Cdd:COG5048   420 KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 207-291 2.92e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 2.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 207 GNKPYKCNI--CDKSFTECSSLKEHRKT-HQRLRAGTNPykcndcgksfsylsALQSHHKRHTGEKRYKCKECGKSYAYR 283
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQKLHENP--------------SPEKMNIFSAKDKPYRCEVCDKRYKNL 411


                  ....*...
gi 1827280119 284 TGLKRHQK 291
Cdd:COG5189   412 NGLKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
208-559 7.71e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 7.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 208 NKPYKCNICDKSFtecsSLKEHRKTHQRLRAGTNPYKCND--CGKSFSYLSALQSHHKRHTGEK-RYKCKECGKSYAYRT 284
Cdd:COG5048    31 PRPDSCPNCTDSF----SRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPsDLNSKSLPLSNSKAS 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 285 GLKRHQKIHTAEECYSCQYCGKVFHQlshfkSHFTLHTGEKPYKC-NECHRSFPHYVFFRRHKKNHSLQKSHKCKECGKS 363
Cdd:COG5048   107 SSSLSSSSSNSNDNNLLSSHSLPPSS-----RDPQLPDLLSISNLrNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 364 FFILSHlkTHYRIHTGEKPYKCTKCDKLFTQYSHLRRHQRIytgkklyrcevcdkwFTLSSSLSRHQKIHTEAKTYKCKd 443
Cdd:COG5048   182 SNLSLL--ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL---------------ENSSSSLPLTTNSQLSPKSLLSQ- 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 444 cdiffNHYSSLRRHQKVHTGERHYTCKQcGKSFTRGSTLRVHQRIHTG-EKPYKCSECDKSFTQASQLRTHQR--VHTGE 520
Cdd:COG5048   244 -----SPSSLSSSDSSSSASESPRSSLP-TASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1827280119 521 --KPYVCKE--CGKSLTTCAILRAHQKIHTGEKPYKCMECDRS 559
Cdd:COG5048   318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSS 360
zf-H2C2_2 pfam13465
Zinc-finger double domain;
482-506 4.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.44e-04
                          10        20
                  ....*....|....*....|....*
gi 1827280119 482 LRVHQRIHTGEKPYKCSECDKSFTQ 506
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PRK04860 PRK04860
SprT family zinc-dependent metalloprotease;
438-473 8.20e-04

SprT family zinc-dependent metalloprotease;


Pssm-ID: 179886  Cd Length: 160  Bit Score: 40.28  E-value: 8.20e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1827280119 438 TYKCKDCDIFFnhysSLRRHQKVHTGERHYTCKQCG 473
Cdd:PRK04860  119 PYRCKCQEHQL----TVRRHNRVVRGEAVYRCRRCG 150
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 491-571 1.03e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280119 491 GEKPYKCS--ECDKSFTQASQLRTHqRVHtgekpyvcKECGKSLTTCAILRAHQKIHTGEKPYKCMECDRSYIQYSHLKR 568
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1827280119 569 HQK 571
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-394 1.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.99e-03
                          10        20
                  ....*....|....*....|....*.
gi 1827280119 369 HLKTHYRIHTGEKPYKCTKCDKLFTQ 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-478 4.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.05e-03
                          10        20
                  ....*....|....*....|....*.
gi 1827280119 453 SLRRHQKVHTGERHYTCKQCGKSFTR 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-282 9.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.15e-03
                          10        20
                  ....*....|....*....|....*.
gi 1827280119 257 ALQSHHKRHTGEKRYKCKECGKSYAY 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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