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Conserved domains on  [gi|1820395068|ref|NP_001365762|]
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glucose-6-phosphate exchanger SLC37A4 isoform c [Mus musculus]

Protein Classification

glucose-6-phosphate exchanger SLC37A4( domain architecture ID 13023823)

glucose-6-phosphate (G6P) exchanger SLC37A4 is a major facilitator superfamily (MFS) transporter that functions as a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
20-409 0e+00

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 556.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  20 AGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKW 99
Cdd:cd17343    40 LGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKW 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 100 FEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGK- 178
Cdd:cd17343   120 FSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKk 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 179 KGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRA 258
Cdd:cd17343   200 KKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWA 279
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 259 MAKAGLSLYGNPRHGLLLLMMAGMAASMFLFRVTVTSDSPkdafwtpalhplaeltgftehEIWILVLGAVFGFSSYGPI 338
Cdd:cd17343   280 VAKHGSSSRGNPRMPLALVFMAGLTVSLHLFRVHITSDSS---------------------ELFILLLGFLIGFSLYGPI 338
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395068 339 ALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLRNI 409
Cdd:cd17343   339 AIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYDWRTAFLLLEILCAITVVILFLLRNI 409
 
Name Accession Description Interval E-value
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
20-409 0e+00

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 556.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  20 AGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKW 99
Cdd:cd17343    40 LGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKW 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 100 FEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGK- 178
Cdd:cd17343   120 FSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKk 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 179 KGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRA 258
Cdd:cd17343   200 KKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWA 279
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 259 MAKAGLSLYGNPRHGLLLLMMAGMAASMFLFRVTVTSDSPkdafwtpalhplaeltgftehEIWILVLGAVFGFSSYGPI 338
Cdd:cd17343   280 VAKHGSSSRGNPRMPLALVFMAGLTVSLHLFRVHITSDSS---------------------ELFILLLGFLIGFSLYGPI 338
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395068 339 ALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLRNI 409
Cdd:cd17343   339 AIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYDWRTAFLLLEILCAITVVILFLLRNI 409
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
21-389 1.26e-114

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 340.12  E-value: 1.26e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWF 100
Cdd:TIGR00881  33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWF 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 101 EPSQFGTWWAVLSTSMNLAGSLGP-ILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDPAPS---- 175
Cdd:TIGR00881 113 SRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNeepd 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 176 ----KGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAA 251
Cdd:TIGR00881 193 gdaeKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLA 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 252 GYLSDRamakaglsLYGNPRHGLLLLMMAGMAASMFLFRVTVTSDSPkdafwtpalhplaeltgfteheiWILVLGAVFG 331
Cdd:TIGR00881 273 GWLSDK--------LFNGRRGPLAVFFMALIIVSLLVYWLNPAANPL-----------------------MDLICLFALG 321
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1820395068 332 FSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAF 389
Cdd:TIGR00881 322 FLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
PRK11663 PRK11663
glucose-6-phosphate receptor/MFS transporter UhpC;
31-405 6.55e-53

glucose-6-phosphate receptor/MFS transporter UhpC;


Pssm-ID: 183266 [Multi-domain]  Cd Length: 434  Bit Score: 182.60  E-value: 6.55e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  31 YAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWA 110
Cdd:PRK11663   71 YGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWA 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 111 VLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGL------RN--LDPAPSKGKKGSS 182
Cdd:PRK11663  151 IWNTAHNVGGALIPLVVGAIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLpsvgewRHdaLELAQQQEGAGLS 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 183 KEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamaka 262
Cdd:PRK11663  231 RKEILTKYVLLNPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDK----- 305
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 263 glsLYGNPRHGLLLLMMAGMAASMflfrvtvtsdspkDAFWtpaLHPLAELtgfteheiwiLVLGAVF---GFSSYGPIA 339
Cdd:PRK11663  306 ---LFNGNRGPMNLIFAAGILLSV-------------GSLW---LMPFASY----------VMQAACFftiGFFVFGPQM 356
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1820395068 340 LFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWsTAFWVAEVVCGASTVVFFL 405
Cdd:PRK11663  357 LIGMAAAECSHKEAAGAATGFVGLFAYLGAALSGYPLAKVLEIWHW-TGFFVVISIAAGISALLLL 421
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
17-407 1.65e-39

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 145.01  E-value: 1.65e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:COG2271    44 AAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLI 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFclllihnepadvglrnldpapsk 176
Cdd:COG2271   124 AEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL----------------------- 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 gkkgsskeestlqdlllspYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:COG2271   181 -------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 257 RamakaglslYGNPRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeltGFTEHEIWILVLGAVFGFSSYG 336
Cdd:COG2271   242 R---------LGRRRKLVLAIGLLLAALALLLL-------------------------ALLPSPALAIALLFLAGFGLGG 287
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395068 337 PIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLR 407
Cdd:COG2271   288 AFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
MFS_1 pfam07690
Major Facilitator Superfamily;
17-372 7.13e-23

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 98.64  E-value: 7.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:pfam07690  31 PTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALI 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPAdvglrnldPAPSK 176
Cdd:pfam07690 111 ADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPES--------KRPKP 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 GKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTdwGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:pfam07690 183 AEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT--YLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 257 RAmakaglslygNPRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeLTGFTEHEIWILVLGAVFGFSSYG 336
Cdd:pfam07690 261 RL----------GRRRRLLLALLLLILAALGLL-----------------------LLSLTLSSLWLLLALLLLGFGFGL 307
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1820395068 337 PIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLA 372
Cdd:pfam07690 308 VFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
 
Name Accession Description Interval E-value
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
20-409 0e+00

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 556.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  20 AGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKW 99
Cdd:cd17343    40 LGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKW 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 100 FEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGK- 178
Cdd:cd17343   120 FSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKk 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 179 KGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRA 258
Cdd:cd17343   200 KKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWA 279
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 259 MAKAGLSLYGNPRHGLLLLMMAGMAASMFLFRVTVTSDSPkdafwtpalhplaeltgftehEIWILVLGAVFGFSSYGPI 338
Cdd:cd17343   280 VAKHGSSSRGNPRMPLALVFMAGLTVSLHLFRVHITSDSS---------------------ELFILLLGFLIGFSLYGPI 338
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395068 339 ALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLRNI 409
Cdd:cd17343   339 AIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYDWRTAFLLLEILCAITVVILFLLRNI 409
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
21-389 1.26e-114

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 340.12  E-value: 1.26e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWF 100
Cdd:TIGR00881  33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWF 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 101 EPSQFGTWWAVLSTSMNLAGSLGP-ILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDPAPS---- 175
Cdd:TIGR00881 113 SRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNeepd 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 176 ----KGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAA 251
Cdd:TIGR00881 193 gdaeKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLA 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 252 GYLSDRamakaglsLYGNPRHGLLLLMMAGMAASMFLFRVTVTSDSPkdafwtpalhplaeltgfteheiWILVLGAVFG 331
Cdd:TIGR00881 273 GWLSDK--------LFNGRRGPLAVFFMALIIVSLLVYWLNPAANPL-----------------------MDLICLFALG 321
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1820395068 332 FSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAF 389
Cdd:TIGR00881 322 FLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
21-407 1.96e-88

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 272.61  E-value: 1.96e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWF 100
Cdd:cd17312    41 GIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWF 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 101 EPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPadvglrnldpapskgkkg 180
Cdd:cd17312   121 SKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP------------------ 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 181 sskeestlqdlllsPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRama 260
Cdd:cd17312   183 --------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDK--- 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 261 kaglsLYGNPRHGLLLLMMAGMAASMFLFrvtvtsdspkdaFWTPAlhplaeltgfteHEIWILVLGAVFGFSSYGPIAL 340
Cdd:cd17312   246 -----LFGGRRAPIAVIYMLLMTLSLALF------------WFFPH------------NKLLSIVLLFLIGFFVGGPINL 296
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1820395068 341 FGVIANESAPP-NLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLR 407
Cdd:cd17312   297 IGGAAAQDIGRkEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSLW 364
PRK11663 PRK11663
glucose-6-phosphate receptor/MFS transporter UhpC;
31-405 6.55e-53

glucose-6-phosphate receptor/MFS transporter UhpC;


Pssm-ID: 183266 [Multi-domain]  Cd Length: 434  Bit Score: 182.60  E-value: 6.55e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  31 YAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWA 110
Cdd:PRK11663   71 YGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWA 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 111 VLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGL------RN--LDPAPSKGKKGSS 182
Cdd:PRK11663  151 IWNTAHNVGGALIPLVVGAIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLpsvgewRHdaLELAQQQEGAGLS 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 183 KEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamaka 262
Cdd:PRK11663  231 RKEILTKYVLLNPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDK----- 305
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 263 glsLYGNPRHGLLLLMMAGMAASMflfrvtvtsdspkDAFWtpaLHPLAELtgfteheiwiLVLGAVF---GFSSYGPIA 339
Cdd:PRK11663  306 ---LFNGNRGPMNLIFAAGILLSV-------------GSLW---LMPFASY----------VMQAACFftiGFFVFGPQM 356
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1820395068 340 LFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWsTAFWVAEVVCGASTVVFFL 405
Cdd:PRK11663  357 LIGMAAAECSHKEAAGAATGFVGLFAYLGAALSGYPLAKVLEIWHW-TGFFVVISIAAGISALLLL 421
MFS_UhpC cd17488
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ...
21-406 2.25e-46

Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341041 [Multi-domain]  Cd Length: 364  Bit Score: 163.35  E-value: 2.25e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWF 100
Cdd:cd17488    41 GILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWY 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 101 EPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPadvglrnldpapskgkkg 180
Cdd:cd17488   121 SRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPGIIAILMGIVLCWRLRDRP------------------ 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 181 sskeestlqdlllsPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRama 260
Cdd:cd17488   183 --------------PYIWLLAFCYVLVYVVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDK--- 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 261 kaglsLYGNPRHGLLLLMMAGMAASMFLFRVTvtsdsPKDAFWTPAlhplaeltgfteheiwilVLGAVFGFSSYGPIAL 340
Cdd:cd17488   246 -----LFKGNRGPMNLIFALGLLVSVGALWLV-----PVHSYWLLA------------------TCFFTIGFFVFGPQML 297
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1820395068 341 FGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLL 406
Cdd:cd17488   298 IGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVISIAAAISGLLLLPL 363
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
21-407 4.63e-44

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 158.56  E-value: 4.63e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVF----SWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17345    41 GLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIgfvpSATSSVGLMFILLFLNGWFQGMGWPPSGRTM 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQ---SYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNL--- 170
Cdd:cd17345   121 VHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAifgDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIeey 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 171 --DPAPSKGKKGSSKEESTLQDL----LLSPYLWVLSTG----YLVVFGVktccTDWGQFFLIQERGQSALVGSSYISAL 240
Cdd:cd17345   201 kgDYPEEADGEEEEQELSAWEIFvkyvLKNKLLWYIAIAnvfvYLVRYGI----LDWAPTYLSEVKGFSKAQAMWAFSLF 276
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 241 EVGGLVGSIAAGYLSDRamakaglsLYGNPRHGLLLLMMAGMAASMFlfrvtvtsdspkdAFWtpalhplaeltgFTEHE 320
Cdd:cd17345   277 EWAAIPGTLLAGWLSDK--------LFKGRRAPTGIIFMILVIVALI-------------VYW------------LAPNV 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 321 IWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGG-FLAGLPFSTIAKHYSWSTAFWVAEVVCGAS 399
Cdd:cd17345   324 LVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGsVLATALIGIIVDHFGWNGGFIVLLASCILA 403

                  ....*...
gi 1820395068 400 TVVFFLLR 407
Cdd:cd17345   404 IIFLALVA 411
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
17-407 1.65e-39

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 145.01  E-value: 1.65e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:COG2271    44 AAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLI 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFclllihnepadvglrnldpapsk 176
Cdd:COG2271   124 AEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL----------------------- 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 gkkgsskeestlqdlllspYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:COG2271   181 -------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 257 RamakaglslYGNPRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeltGFTEHEIWILVLGAVFGFSSYG 336
Cdd:COG2271   242 R---------LGRRRKLVLAIGLLLAALALLLL-------------------------ALLPSPALAIALLFLAGFGLGG 287
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395068 337 PIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLR 407
Cdd:COG2271   288 AFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
glpT TIGR00712
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted ...
21-406 1.81e-28

glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted to span the membrane at least 8 times. The two members confirmed experimentally as glycerol-3-phosphate transporters, from E. coli and B. subtilis, share more than 50 % amino acid identity. Proteins of the hexose phosphate and phosphoglycerate transport systems are also quite similar. [Transport and binding proteins, Other]


Pssm-ID: 129795 [Multi-domain]  Cd Length: 438  Bit Score: 116.10  E-value: 1.81e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSS---GLLLVGLVNVVFSW-SSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:TIGR00712  64 GFALSAISIAYGFSKFIMGSVSDRSNPRVFLPAgliLSAAVMLLMGFVPWaTSSIAIMFVLLFLNGWFQGMGWPPCGRTM 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATI-LAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNL----- 170
Cdd:TIGR00712 144 VHWWSQSERGTIVSIWNCAHNIGGGIPPLLVLLgMAWFNDWHAALYFPAICAIIVALFAFAMMRDTPQSCGLPPIeeyrn 223
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 171 ---DPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGqSALVGSSYISAL-EVGGLV 246
Cdd:TIGR00712 224 dypDDYNEKAEQELTAKEIFMQYVLPNKLLWYIAIANVFVYLLRYGVLDWSPTYLKEVKH-FALDKSSWAYFLyEYAGIP 302
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 247 GSIAAGYLSDRamakaglsLYGNPRHGLLLLMMAGMAASMFlfrvtvtsdspkdAFW-TPALHPLAEltgfteheiwiLV 325
Cdd:TIGR00712 303 GTLLCGWMSDK--------VFKGNRGATGVFFMTLVTIAVI-------------VYWmNPAGNPLVD-----------MI 350
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 326 LGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFL-AGLPFSTIAKHYSWSTAFWVaeVVCGASTVVFF 404
Cdd:TIGR00712 351 CMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFMV--MIGGSILAVIL 428

                  ..
gi 1820395068 405 LL 406
Cdd:TIGR00712 429 LI 430
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
17-407 2.43e-24

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 103.81  E-value: 2.43e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:COG2223    39 AAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALV 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVglrnldpapsk 176
Cdd:COG2223   119 SKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGA----------- 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 gKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:COG2223   188 -AAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 257 RAmakaglslygnPRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeltGFTEHEIWILVLGAVFGFSSYG 336
Cdd:COG2223   267 RI-----------GGRRVLLIVFALMALGLLLL-------------------------ALALGSLWLFLVLFLLLGLALG 310
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1820395068 337 PI--ALFGVIAnESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHY-SWSTAFWVAEVVCGASTVVFFLLR 407
Cdd:COG2223   311 GGngAVFALVP-DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLY 383
MFS_1 pfam07690
Major Facilitator Superfamily;
17-372 7.13e-23

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 98.64  E-value: 7.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:pfam07690  31 PTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALI 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPAdvglrnldPAPSK 176
Cdd:pfam07690 111 ADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPES--------KRPKP 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 GKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTdwGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:pfam07690 183 AEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT--YLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 257 RAmakaglslygNPRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeLTGFTEHEIWILVLGAVFGFSSYG 336
Cdd:pfam07690 261 RL----------GRRRRLLLALLLLILAALGLL-----------------------LLSLTLSSLWLLLALLLLGFGFGL 307
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1820395068 337 PIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLA 372
Cdd:pfam07690 308 VFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
17-372 1.78e-22

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 97.74  E-value: 1.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:COG2814    44 PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALI 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIhnepadvglrnldpaPSK 176
Cdd:COG2814   124 ADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLL---------------PES 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 GKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:COG2814   189 RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD 268
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 257 RAmakaglslygnPRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeltGFTEHEIWILVLGAVFGFSSYG 336
Cdd:COG2814   269 RF-----------GRRRLLLIGLLLLALGLLLL-------------------------ALAGSLWLLLLALFLLGFGFGL 312
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1820395068 337 PIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLA 372
Cdd:COG2814   313 LFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
15-405 7.45e-20

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 90.56  E-value: 7.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  15 LLPFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGK 94
Cdd:cd06174    28 LSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLA 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  95 ILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQ--SYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDP 172
Cdd:cd06174   108 LIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEA 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 173 APSKGKKGsskeestLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAG 252
Cdd:cd06174   188 SSKSVLKL-------LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLG 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 253 YLSDRamakaglslyGNPRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeltGFTEHEIWILVLGAVFGF 332
Cdd:cd06174   261 LLSDR----------LIGRKPLLLIGLLLMALGLALL-------------------------LLAPSLLLLLLLLLLLGF 305
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1820395068 333 SSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFL 405
Cdd:cd06174   306 GLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
glpT PRK11273
glycerol-3-phosphate transporter;
21-405 1.23e-19

glycerol-3-phosphate transporter;


Pssm-ID: 236889 [Multi-domain]  Cd Length: 452  Bit Score: 90.54  E-value: 1.23e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSW----SSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:PRK11273   66 GFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTM 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  97 RKWFEPSQFGTWWAVLSTSMNLAGSL-GPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGL------RN 169
Cdd:PRK11273  146 VHWWSQKERGGIVSVWNCAHNVGGGLpPLLFLLGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLppieeyKN 225
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 170 LDPA--PSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLiQERGQSALVGSSYISAL-EVGGLV 246
Cdd:PRK11273  226 DYPDdyNEKHEQELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYL-KEVKHFALDKSSWAYFLyEYAGIP 304
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 247 GSIAAGYLSDRAMAkaglslyGNprhgllllmmAGMAASMFLFRVTVTSdspkDAFW-TPALHPLAELTGFTeheiwilv 325
Cdd:PRK11273  305 GTLLCGWMSDKVFR-------GN----------RGATGVFFMTLVTIAT----IVYWlNPAGNPTVDMACMI-------- 355
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 326 lgaVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGlpfSTI----AKHYSWSTAFWVAEVVCGASTV 401
Cdd:PRK11273  356 ---VIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAA---SAIvgytVDFFGWDGGFMVMIGGSILAVI 429

                  ....
gi 1820395068 402 VFFL 405
Cdd:PRK11273  430 LLIV 433
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
17-406 1.11e-18

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 86.86  E-value: 1.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17319    37 PTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKAL 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIhnePADVGLrnldpapsk 176
Cdd:cd17319   117 AEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL---RQVWGL--------- 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 gkkgsskeesTLQDLLLSPYLWVLSTgylvvfgvktcctdWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:cd17319   185 ----------ALGYFGINYALYGLLT--------------WLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSD 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 257 RAMAKAglslygnpRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeltGFTEHEIWILVLGAVFGFSSYG 336
Cdd:cd17319   241 RLLRGA--------RRLVIIIGLLLAAVGLLLA-------------------------YLTTSPVVAVILLSLAGFGIGA 287
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395068 337 PIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKH-YSWSTAFWVAEVVCGASTVVFFLL 406
Cdd:cd17319   288 ASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAALLVLLL 358
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
19-403 2.26e-15

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 77.28  E-value: 2.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  19 AAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRK 98
Cdd:cd17475    32 QVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMR 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  99 WFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEpadvglrnldPAPSKGK 178
Cdd:cd17475   112 WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREP----------PAASAAT 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 179 KGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRa 258
Cdd:cd17475   182 ESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDR- 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 259 makaglsLYGNPRHGLLLLMMAGMAASMFLFRVTVTSdspkdafwtpalhplaeltgfteHEIWILVLG-AVFGFSSYGP 337
Cdd:cd17475   261 -------VFGGRRRPVLVITAAIAAAALLVLSLLSPG-----------------------TPLWLLVLLlILLGLFAIGW 310
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1820395068 338 IALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPF-STIAKHYSWSTAFWVAEVVCGASTVVF 403
Cdd:cd17475   311 NGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFgLLVDATHSYAPAWLALALLLVLAALLL 377
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
17-407 4.09e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 76.46  E-value: 4.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17325    30 VAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALI 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPadvglrnldPAPSK 176
Cdd:cd17325   110 ADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPR---------PPPNK 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 GKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:cd17325   181 RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 257 RAmakaglslygnPRHGLLLLMMAGMAASMFLFRVTvtsdspkDAFWTpalhplaeltgfteheiwILVLGAVFGFSSYG 336
Cdd:cd17325   261 RI-----------GRKPLILIGLLLSAVALLLLPLA-------TSFWL------------------LLLLLALLGLGLGL 304
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395068 337 PIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLR 407
Cdd:cd17325   305 VFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
17-406 3.03e-12

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 67.59  E-value: 3.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:COG2807    52 ATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLI 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  97 RKWFePSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADvglrnldpapsk 176
Cdd:COG2807   132 KRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAA------------ 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 gkKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLiQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:COG2807   199 --AAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLAD 275
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 257 RAmakaglslygNPRHGLLLLMMAGMAASMFLFrvtvtsdspkdaFWTPALHPLaeltgfteheIWILVLGAVFGFSsyg 336
Cdd:COG2807   276 RL----------GDRRPLLLLLGLLGLAGLLGL------------LLAPGSLPW----------LWAVLLGLGQGGL--- 320
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1820395068 337 PIALFGVIANESAPPN----LCGTSHAIVGLMANVGGFLAGLPFSTIAkhySWSTAFWVAEVVCGASTVVFFLL 406
Cdd:COG2807   321 FPLALTLIGLRARTPAeaaaLSGMAQSVGYLLAALGPLLVGALHDATG---SWTAALLLLAALAVLMLVAGLLA 391
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
21-404 1.15e-11

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 65.76  E-value: 1.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQ--GLGWPPCGKILRK 98
Cdd:cd17355    41 SLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGagTLAAVAFATVAAW 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  99 WFEPSQfGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGk 178
Cdd:cd17355   121 WFERRR-GLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPAS- 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 179 kgsskEESTLQDLLLSPYLWVLSTGYLVVfGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRa 258
Cdd:cd17355   199 -----PGSTLKEALRSASFWLLALAFFLC-GFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDR- 271
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 259 makaglslyGNPRHGLLLLMMAGMAASMFLFRVTVTSdspkdafwtpalhplaeltgfteheIWILVLGAVFGFSSYGPI 338
Cdd:cd17355   272 ---------YSPRRLLAASYALRALGLALLLLLPFPP-------------------------LALLLFAALFGLGWGATV 317
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1820395068 339 ALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHY-SWSTAFWVAEVVCGASTVVFF 404
Cdd:cd17355   318 PLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTgSYTAAWALAVALGLIAALLVL 384
uhpT PRK09556
hexose-6-phosphate:phosphate antiporter;
21-411 1.23e-11

hexose-6-phosphate:phosphate antiporter;


Pssm-ID: 236564 [Multi-domain]  Cd Length: 467  Bit Score: 66.22  E-value: 1.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWS-----STVSAFAALWFLNGLAQGLGWPPCGKI 95
Cdd:PRK09556   67 GMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASlgsgsVSLGLMIALWALSGFFQSTGGPCSYST 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  96 LRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLAL---SGALCVVVSFFCLLLIHNEPADVGLRN--- 169
Cdd:PRK09556  147 ITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYFFDGHVIGMfifPSIIALIIGFIGLRYGSDSPEELGWGKaee 226
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 170 -LDPAPSKGKKGS-----SKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVG 243
Cdd:PRK09556  227 iFGEPISEEDKETestdmTKWQIFVEYVLKNPVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIG 306
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 244 GLVGSIAAGYLSDRAmakaglslygNPRHGLLLLMMAGMAASMFLFRVTVTSDspkdafwtpalhplaeltgfteheiwI 323
Cdd:PRK09556  307 ALVGSLLWGWLSDLA----------NGRRALVACIALALIIFTLGVYQHATSE--------------------------Y 350
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 324 LVLGAVF--GFSSYGPIALFGVIANESAPPN--------------LCGTSHAIVGLMANVGGFLAGLPFSTIAKHySWS- 386
Cdd:PRK09556  351 MYLASLFalGFLVFGPQLLIGVAAVGFVPKKaigvangikgtfayLFGDSFAKVGLGMIADPTKNGTPIFGYTLT-GWAg 429
                         410       420
                  ....*....|....*....|....*....
gi 1820395068 387 --TAFWVAEVVCGA--STVVFFLLRNIRT 411
Cdd:PRK09556  430 tfAALDIAAIGCIClmAIVAVMEERKIRR 458
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
18-404 7.38e-11

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 63.34  E-value: 7.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  18 FAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILR 97
Cdd:cd17478    31 AQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLAS 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  98 KwFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHnepadvglRNLDPAPSKG 177
Cdd:cd17478   111 Q-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP--------LKKPEAKKAA 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 178 KKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTdwgqfFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDR 257
Cdd:cd17478   182 AKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLP-----FYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDR 256
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 258 AMAKAglslygnprhgLLLLMMAGMAASMFLFrvtvtsdspkdaFWTPAlhplaeltgfteheIWILVLGAVFGFSSYGP 337
Cdd:cd17478   257 FGRRR-----------VIIASLLLAAPFLLLF------------LLTPG--------------IWSYILLVLAGFLLFAS 299
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1820395068 338 IALFGVIANESAPPNLcGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFF 404
Cdd:cd17478   300 FPVTVVLAQELLPGNV-GLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
19-404 2.69e-10

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 61.41  E-value: 2.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  19 AAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRK 98
Cdd:cd17324    35 QAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAAD 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  99 WFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIhnepadvglrnldPAPSKGK 178
Cdd:cd17324   115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL-------------PSLPPKK 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 179 KGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRA 258
Cdd:cd17324   182 PGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG 261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 259 MAKAglslygnprhglLLLMMAGMAASMFLfrvtvtsdspkdafwtpalhplaeLTGFTEHEIWILVLGAVFGFSSYGPI 338
Cdd:cd17324   262 GRRA------------LLIALLLLAAALLL------------------------LTLLGPSPLLLLVGLVLWGLGFFAAH 305
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1820395068 339 ALFGVIANESAPPNLcGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFF 404
Cdd:cd17324   306 SALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
17-406 2.16e-08

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 55.65  E-value: 2.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17474    33 PAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLI 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAqSYSWRSTLALSGALCVVvSFFCLLLIHNEPadvglrnLDPAPSK 176
Cdd:cd17474   113 GDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPV-AFLAILFLLPEP-------KEKAKSS 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 GKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTcctdWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:cd17474   184 SATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLT----YLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLK 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 257 RAmakaglslygNPRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeltGFTEHEIWILVLGAVFGFSSYG 336
Cdd:cd17474   260 KR----------FGARRILVIGLLLYALSLLLL-------------------------GFVPSLALLLIAIVLFGLGLGL 304
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 337 PIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLL 406
Cdd:cd17474   305 NLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
17-406 1.34e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 53.39  E-value: 1.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWL-----FSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPP 91
Cdd:cd06173    33 ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPA 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  92 CGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSgALCVVVSFFCLLLIHNEPADVGLRNLD 171
Cdd:cd06173   113 RQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAIN-ALSFLLSALLLLFIRRPPPAAPGESSS 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 172 PAPSKGKKGsskeestLQDLLLSPYLWVLSTGYLVVFGVKTCCtdWGQF-FLIQERGQSALVGSSYISALE-VGGLVGSI 249
Cdd:cd06173   192 LLLRDLREG-------LRYLRRSPLLRLLLLALALFALLGGAL--TVLLpLLAKEVLGGGAAGYGLLLAAFgVGALLGAL 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 250 AAGYLSDRamakaglslygNPRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeltGFTEHEIWILVLGAV 329
Cdd:cd06173   263 LLGRLSKR-----------RRRGRLLLIGALLLGLALLVL-------------------------GLSPSLWLLLAALFL 306
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1820395068 330 FGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLL 406
Cdd:cd06173   307 LGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
12-412 6.00e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 51.39  E-value: 6.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  12 SCSLLPFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPP 91
Cdd:COG0738    37 AFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVA 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  92 CGKILRkWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQ---SYSWRSTLALSGALCVVVSFFCLLLIHnepadvglr 168
Cdd:COG0738   117 ANPYVA-ALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlglSLSWHLPYLILAVLLLLLALLFLRSKL--------- 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 169 nldPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGS 248
Cdd:COG0738   187 ---PEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGR 263
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 249 IAAGYLSDRAmakaglslygnPRHGLLLLMMAGMAASMFLFrvtVTSDSPKDAFWtpalhplaeltgfteheiWILVLGa 328
Cdd:COG0738   264 FLGGFLLKRF-----------GPVRLLRLSALLAAVGLLLA---LLAPGPWLALI------------------GLALVG- 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 329 vFGFSSYGPIALfgVIANESAPPNLCGTShAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLRN 408
Cdd:COG0738   311 -LGLSLMFPTIF--SLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKR 386

                  ....
gi 1820395068 409 IRTK 412
Cdd:COG0738   387 KRRK 390
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
18-268 3.93e-06

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 48.47  E-value: 3.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  18 FAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGwPPCGKILR 97
Cdd:cd17333    31 ADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGIL-DTGANTFV 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  98 KWFEPSQFGTWWAVLSTSMNLAGSLGPILAT-ILAQSYSWRSTLALSGALCVVVsfFCLLLIHNEPADVGLRNLDPAPSK 176
Cdd:cd17333   110 GALFEESSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLIYLLL--AILILLTLFPELPSARNPQQSVGA 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 GKKGSSKEestlqdlLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:cd17333   188 FSASASRL-------LRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISR 260
                         250
                  ....*....|..
gi 1820395068 257 RAMAKAGLSLYG 268
Cdd:cd17333   261 RIKPHTLLVLSG 272
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
17-404 9.47e-06

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 47.62  E-value: 9.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17328    33 DSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTII 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQS-YSWRSTLALSGALCVVVSFFCLLLIHNEPadvglRNldpAPS 175
Cdd:cd17328   113 ADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLLLFVREPP-----RG---AAE 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 176 KGKKGSSKEESTLQDL--LLS--PYLWVLSTGYLVVFGVKTCCTDWGQFFLiqeRGQSALVGSSYISALE------VGGL 245
Cdd:cd17328   185 GGVMAKSTATSFLADLkaLAKnpSFILSTLGFTAVSFVTGALAFWAPTFFL---RAFGVGDLSSADVGLIfgaitcIAGV 261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 246 VGSIAAGYLSDRAMAKaglslygNPRHGLLLLMMAGMAASMFLFRVTVTSDSPKDAFWTpalhplaeltgfteheiwILV 325
Cdd:cd17328   262 LGVLLGGILADRLRRK-------TPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWV------------------LLF 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 326 LGAVFGFSSYGPIAlfgVIANESAPPNLCGTSHAIVGLMAN-----VGGFLAGLPFSTIAKHY--------SWSTAFWVA 392
Cdd:cd17328   317 LGEFLLSLNWAPVF---AILLYVVIPTRRSTASAIQILLSHllgdaGSPYLIGLISDLLRQNKdsplaeaaSLQYALLLC 393
                         410
                  ....*....|..
gi 1820395068 393 EVVCGASTVVFF 404
Cdd:cd17328   394 SFVLVLGGFFFL 405
MFS_SLC37A3 cd17342
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
29-156 2.79e-05

Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340900 [Multi-domain]  Cd Length: 399  Bit Score: 46.15  E-value: 2.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  29 AAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAF------AALWFLNGLAQGLGWPPCGKILRKWFEP 102
Cdd:cd17342    74 FSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFynkylyCILWVLNGLLQSTGWPCVVAIMGNWFGK 153
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395068 103 SQFGTWWAVLSTSmnlaGSLGPILATILAQS-------YSWRSTLALSGALCVVVsFFCLL 156
Cdd:cd17342   154 SSRGFVLGLWSAC----ASVGNIIGALLASSvldygyeYAFLVTSSLLFAGAIVV-FFGLL 209
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
14-374 5.32e-05

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 45.04  E-value: 5.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  14 SLLPFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCG 93
Cdd:TIGR00895  48 GLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLN 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  94 KILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCL--------LLIHNEPADV 165
Cdd:TIGR00895 128 ALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMrflpesidFLVSKRPETV 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 166 GLRNLDPAPSKGKKGSSK--EESTLQDLLLSPYLWVLSTGYL---VVFGVKTCCTDWGQFF-------LIQERGQSALVG 233
Cdd:TIGR00895 208 RRIVNAIAPQMQAEAQSAlpEQKSTQGTKRSVFKALFQGKTAritVLLWLLYFMLLVGVYFltnwlpkLMVELGFSLSLA 287
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 234 SSYISALEVGGLVGSIAAGYLSDRAmakaglslygNPRHGLLLLMMAGMAASMFLFRVTVTSDspkdafwtpalhplael 313
Cdd:TIGR00895 288 ATGGALFNFGGVIGSIIFGWLADRL----------GPRVTALLLLLGAVFAVLVGSTLFSPTL----------------- 340
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395068 314 tgfteheiwILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTShaiVGLMANVGGFLAGL 374
Cdd:TIGR00895 341 ---------LLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATG---VGWAIGIGRLGAII 389
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
19-179 7.35e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.53  E-value: 7.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  19 AAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRK 98
Cdd:cd17329    36 IVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIAD 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  99 WFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSwrSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGK 178
Cdd:cd17329   116 VTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF--RLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGY 193

                  .
gi 1820395068 179 K 179
Cdd:cd17329   194 K 194
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
21-158 1.35e-04

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 43.76  E-value: 1.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVS--AFAALWFLNGLAQGLGWPPCGKILRK 98
Cdd:cd17318    59 GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGygALIVLRILQGLAQGVTFPAMHALWAK 138
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1820395068  99 WFEPSQFGtwwaVLSTSMNLAGSLGPI----LATILAQSYSWRSTLALSGALCVVVSFFCLLLI 158
Cdd:cd17318   139 WAPPLERS----RLTSIAYSGSQFGTViampLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV 198
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
17-157 1.80e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 43.26  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:COG0477    48 SAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALI 127
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395068  97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLL 157
Cdd:COG0477   128 AELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
MFS_SLC37A1_2 cd17344
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ...
21-165 2.16e-04

Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340902 [Multi-domain]  Cd Length: 400  Bit Score: 43.07  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTvSAFAALWF------LNGLAQGLGWPPCGK 94
Cdd:cd17344    65 GALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYY-WNIHSLWYfvvvqiLAGLFQSTGWPSVVA 143
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1820395068  95 ILRKWFEPSQ----FGTWwavlstsmNLAGSLGPILATILAQ---SYSWRSTLALSGALCVVVSFFCLLLIHNEPADV 165
Cdd:cd17344   144 CVGNWFGKGKrgliMGIW--------NSHTSVGNILGSLIAGifvSSAWGLSFIVPGIIIAAMGVLVFLFLVEHPPGV 213
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
17-404 2.49e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.97  E-value: 2.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17316    35 LLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYV 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  97 RKWFEPSQFGTWWAVLSTSMN----LAGSLGPILATILAQSYSWRSTLALSGALCVVVsffclllihnepadvglrnldp 172
Cdd:cd17316   115 AEFAPSKRRGFALGLLQSGWAlgalLAALVASLLIPLLSGDWGWRILFLIGALPALLA---------------------- 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 173 apskgkkgsskeestlqdLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAG 252
Cdd:cd17316   173 ------------------LLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAG 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 253 YLSDRAmakaglslygnPRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeLTGFTEHEIWILVLGAVFGF 332
Cdd:cd17316   235 LLSDRI-----------GRKKTLVIGLILSGILALPL-----------------------FYLLSGSPTLLLLLLFILSF 280
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1820395068 333 SSYGPIALFGVIANESAPPNLCGTSHAIVGLMAN-VGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFF 404
Cdd:cd17316   281 FVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRlGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
17-163 5.75e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.81  E-value: 5.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17489    30 EAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLV 109
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1820395068  97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRStLALSGALCVVVSFFCLLLIHNEPA 163
Cdd:cd17489   110 ADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAV-LFIVAAVLALLALLLVFLVKDPPP 175
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
32-392 1.20e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 40.67  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  32 AISKFVSGVLSDQMSARW--LFSSGLLLVGLVNVVFSwSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFePSQFGtww 109
Cdd:cd17353    52 AISAPFAGRLVDRGGPRKaiLIGGILFGLGFILSAFA-ISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWF-PDKRG--- 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 110 avLSTSMNLAG-SLGPI----LATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGlrNLDPAPSKGKKGSSKE 184
Cdd:cd17353   127 --LATGIVIAGfGLGSLifspLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWV--PPGVDPLANNAENSPR 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 185 ESTLQDLLLSPYLWVLstgYLVVFgvktCCTDWGQF-------FLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDR 257
Cdd:cd17353   203 DYTPREMLRTPTFWLL---WLMFF----LNATAGLMligqakpIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDK 275
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 258 amakaglslYGnpRHGLLLLMMAGMAASMFLfrvtvtsdspkdafwtpalhplaeLTGFTEHEIWILVLGAVFGFSSYGP 337
Cdd:cd17353   276 ---------IG--RKNTLSIAFLIQGVAMFL------------------------LPFIGSVAVLFVLGVALIGFCYGGG 320
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1820395068 338 IALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVA 392
Cdd:cd17353   321 FALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIA 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
221-406 2.62e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.57  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 221 FLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAmakaglslygnPRHGLLLLMMAGMAASMFLFrvtvtsdspkd 300
Cdd:COG2814    35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-----------GRRRVLLLGLLLFALGSLLC----------- 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 301 afwtpalhplaeltGFTEHEIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIA 380
Cdd:COG2814    93 --------------ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
                         170       180
                  ....*....|....*....|....*.
gi 1820395068 381 KHYSWSTAFWVAEVVCGASTVVFFLL 406
Cdd:COG2814   159 DLFGWRWVFLVNAVLALLALLLLLRL 184
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
220-406 3.16e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 39.53  E-value: 3.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 220 FFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamakaglslYGNPRhgLLLLMMAGMAASMFLFRVTvtsdspk 299
Cdd:cd17475    20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDR---------FGERR--VLAVGLLLMGAAALLMALV------- 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 300 dafwtpalhplaeltgfteHEIWILVLGAVFGFSSYGPIALFGVIA-NESAPPNLCGTSHAIVGLMANVGGFLAGLPFST 378
Cdd:cd17475    82 -------------------GSYPVLLVLLFLVGAGYGSVQPGGGRAiMRWFPPRERGLAMGIRQTGVPLGGALAAALLPP 142
                         170       180
                  ....*....|....*....|....*...
gi 1820395068 379 IAKHYSWSTAFWVAEVVCGASTVVFFLL 406
Cdd:cd17475   143 LALHYGWRAAFVVAGLVSILAAVLFWLF 170
2_A_01_02 TIGR00880
Multidrug resistance protein;
29-159 3.73e-03

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 37.63  E-value: 3.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  29 AAYAISKFVSGVLSDQMSARW------LFSSGLLLVGLVNVVFSWSSTVsaFAALWFLNGLAQGLGWPPCGKILRKWFEP 102
Cdd:TIGR00880   5 AGYALGQLIYSPLSGLLTDRFgrkpvlLVGLFIFVLSTAMFALSSNITV--LIIARFLQGFGAAFALVAGAALIADIYPP 82
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1820395068 103 SQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIH 159
Cdd:TIGR00880  83 EERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
17-146 6.49e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 38.33  E-value: 6.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068  17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSW---SSTVSAFAALWFLNGLAQGLGWPPCG 93
Cdd:cd17503   213 AFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFltpDTSLWLIILPLFIRGLGMGLVFMPLN 292
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1820395068  94 KILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGAL 146
Cdd:cd17503   293 TLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFHHSRLSELL 345
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
110-404 7.07e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 38.30  E-value: 7.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 110 AVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLihnepadvglrnldPAPSKGKKGSSKEESTLQ 189
Cdd:cd17471   128 SVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFL--------------LPSVKPPAQKATPASSLV 193
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 190 DLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSA-LVGS--SYISALEVgglVGSIAAGYLSDRAmakaglsl 266
Cdd:cd17471   194 KAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSEsWVGLlfGLAAALEI---PIMLLAGLLAKRF-------- 262
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 267 ygnprhGLLLLMMAGMAASMFLFRVTVTSDSPkdafWtpalhplaeltgfteHEIWILVLGAVFgfssYGPIALFGVIAN 346
Cdd:cd17471   263 ------GKRRLLLAGFLAGVLFYLGLALATSL----W---------------QLIALQLLNAIF----IGITAGLGISYF 313
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1820395068 347 ESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFF 404
Cdd:cd17471   314 QDLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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