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Conserved domains on  [gi|1773401168|ref|NP_001362917|]
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major facilitator superfamily domain-containing protein 6 isoform a [Homo sapiens]

Protein Classification

major facilitator superfamily domain-containing protein 6( domain architecture ID 13023754)

major facilitator superfamily domain-containing protein 6 (MFSD6) may play a role in energy homeostasis

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26098515|26758938
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 70-622 1.23e-172

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 501.34  E-value: 1.23e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  70 ISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGI 149
Cdd:cd17335     1 RLKLFYFFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 150 GFVkpatlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptlqpq 229
Cdd:cd17335    81 FFV----------------------------------------------------------------------------- 83

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 230 tgeitnrmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqevEAIFLVILVVVIIGEFFSASSVTIV 309
Cdd:cd17335    84 -------------------------------------------------------AQIFWLLLLLVILGAFFSAPVVPLV 108

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 310 DTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIevlidgkgckppeYRNYQIVFIVFGVLMTMALIVATQF 389
Cdd:cd17335   109 DSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSST-------------YKNYTIAFYVFAVLMLLALLLALKF 175

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 390 RFRYNHfknddskgkeveipqvernnstesseetptttsHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLY 469
Cdd:cd17335   176 PFRPKH---------------------------------PEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLF 222

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 470 WHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAA 549
Cdd:cd17335   223 WHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFAL 302

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1773401168 550 IWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQW 622
Cdd:cd17335   303 VWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
 
Name Accession Description Interval E-value
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 70-622 1.23e-172

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 501.34  E-value: 1.23e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  70 ISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGI 149
Cdd:cd17335     1 RLKLFYFFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 150 GFVkpatlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptlqpq 229
Cdd:cd17335    81 FFV----------------------------------------------------------------------------- 83

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 230 tgeitnrmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqevEAIFLVILVVVIIGEFFSASSVTIV 309
Cdd:cd17335    84 -------------------------------------------------------AQIFWLLLLLVILGAFFSAPVVPLV 108

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 310 DTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIevlidgkgckppeYRNYQIVFIVFGVLMTMALIVATQF 389
Cdd:cd17335   109 DSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSST-------------YKNYTIAFYVFAVLMLLALLLALKF 175

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 390 RFRYNHfknddskgkeveipqvernnstesseetptttsHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLY 469
Cdd:cd17335   176 PFRPKH---------------------------------PEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLF 222

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 470 WHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAA 549
Cdd:cd17335   223 WHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFAL 302

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1773401168 550 IWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQW 622
Cdd:cd17335   303 VWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 68-604 8.94e-73

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 241.77  E-value: 8.94e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  68 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNL 147
Cdd:pfam12832   1 LWRLKGFYFFYFAALGCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 148 GIGFVKPatlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptlq 227
Cdd:pfam12832  81 SVLFIPI------------------------------------------------------------------------- 87

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 228 pqtgeitnrmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqevEAIFLVILVVVIIGEFFSASSVT 307
Cdd:pfam12832  88 ---------------------------------------------------------SLTFWWLALLVVLFSFFWNAILP 110

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 308 IVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLidgkgckppeyrnYQIVFIVFGVLMTMALIVat 387
Cdd:pfam12832 111 QFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHYSVGLL-------------PSVLFYLFAALMLLSLLL-- 175

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 388 qfrfrynhfknddskgkeveipqvernnstesSEETPTTTSHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTF 467
Cdd:pfam12832 176 --------------------------------PLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTF 223

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 468 LYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYL-ENAWTVLPMEVLQGVT 546
Cdd:pfam12832 224 LFLYLENLGASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFvENPWLVLPIQFLHAIS 303

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1773401168 547 HAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFR 604
Cdd:pfam12832 304 FGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFGARFTFR 361
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
450-627 6.17e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 83.10  E-value: 6.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 450 VLFVAWFM-GFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 528
Cdd:COG2814    14 ALALGAFLsGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 529 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFrgigM 608
Cdd:COG2814    94 LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAG-LGLGPALGPLLGGLLADLFGWRWVF----L 168

                         170
                  ....*....|....*....
gi 1773401168 609 ACLVILLLFALIQWLAVPD 627
Cdd:COG2814   169 VNAVLALLALLLLLRLLPE 187
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
76-140 6.69e-05

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 46.07  E-value: 6.69e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  76 FFFYSAYGSLYPLLPVYYKQLGMSPSQ-----SGLLVGIRYFIEFCSAPFWGVVADRfKKGKIVLLFSLL 140
Cdd:PRK09874   24 FLTGAAFSLVMPFLPLYVEQLGVTGHSalnmwSGLVFSITFLFSAIASPFWGGLADR-KGRKIMLLRSAL 92
 
Name Accession Description Interval E-value
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 70-622 1.23e-172

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 501.34  E-value: 1.23e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  70 ISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGI 149
Cdd:cd17335     1 RLKLFYFFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 150 GFVkpatlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptlqpq 229
Cdd:cd17335    81 FFV----------------------------------------------------------------------------- 83

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 230 tgeitnrmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqevEAIFLVILVVVIIGEFFSASSVTIV 309
Cdd:cd17335    84 -------------------------------------------------------AQIFWLLLLLVILGAFFSAPVVPLV 108

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 310 DTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIevlidgkgckppeYRNYQIVFIVFGVLMTMALIVATQF 389
Cdd:cd17335   109 DSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSST-------------YKNYTIAFYVFAVLMLLALLLALKF 175

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 390 RFRYNHfknddskgkeveipqvernnstesseetptttsHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLY 469
Cdd:cd17335   176 PFRPKH---------------------------------PEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLF 222

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 470 WHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAA 549
Cdd:cd17335   223 WHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFAL 302

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1773401168 550 IWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQW 622
Cdd:cd17335   303 VWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 68-604 8.94e-73

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 241.77  E-value: 8.94e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  68 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNL 147
Cdd:pfam12832   1 LWRLKGFYFFYFAALGCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 148 GIGFVKPatlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptlq 227
Cdd:pfam12832  81 SVLFIPI------------------------------------------------------------------------- 87

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 228 pqtgeitnrmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqevEAIFLVILVVVIIGEFFSASSVT 307
Cdd:pfam12832  88 ---------------------------------------------------------SLTFWWLALLVVLFSFFWNAILP 110

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 308 IVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLidgkgckppeyrnYQIVFIVFGVLMTMALIVat 387
Cdd:pfam12832 111 QFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHYSVGLL-------------PSVLFYLFAALMLLSLLL-- 175

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 388 qfrfrynhfknddskgkeveipqvernnstesSEETPTTTSHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTF 467
Cdd:pfam12832 176 --------------------------------PLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTF 223

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 468 LYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYL-ENAWTVLPMEVLQGVT 546
Cdd:pfam12832 224 LFLYLENLGASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFvENPWLVLPIQFLHAIS 303

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1773401168 547 HAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFR 604
Cdd:pfam12832 304 FGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFGARFTFR 361
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
 71-618 2.52e-44

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 164.02  E-value: 2.52e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  71 SKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLgig 150
Cdd:cd17479     1 ASLFHFFHSAGKACLLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYL--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 151 fvkpatlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptLQPQt 230
Cdd:cd17479    78 ---------------------------------------------------------------------------LYHQ- 81

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 231 geitnrmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqeveaIFLVILVVVIIGEFFSASSVTIVD 310
Cdd:cd17479    82 --------------------------------------------------------IFLLVLLVIIIWELLSAPLEKVAD 105

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 311 TVTLQYLGKHR--DRYGLQRMWGSLGwgLAMLSVGIGidythieVLIDGKGCKPPEYRN-YQIVFIVFGVLMTMALIVAT 387
Cdd:cd17479   106 DSLYEYLDFVDatERYGKLKVWSALG--AAFGPCGIT-------LLVDNLDCFLPPKISrILLHFYTYGGFMILTFLLSF 176

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 388 QFrfrynhfknddskgkEVEIPQVERNNStesseetptttSHSQAFNFwdlikLLCSVQ---YGSVLFVawfMGFGYGFV 464
Cdd:cd17479   177 FY---------------PIPVPKKEEHSS-----------KVVKGLRL-----LGGDGRailYALTVFL---VGFVGSTV 222

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 465 FTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQG 544
Cdd:cd17479   223 QNFLFWLMQDKGGSELHMGLSIALALLSEILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHA 302

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1773401168 545 VTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFA 618
Cdd:cd17479   303 FSNGALWWAVNSQVEFLASPGMERSLQLVLRALYYGIGFALGSFVSGFIYDRFGLAILYQACCVVLGLWLIIFA 376
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 73-622 4.56e-33

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 131.78  E-value: 4.56e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  73 VFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFV 152
Cdd:cd06174     3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGR-RPVLLLGLLLFALGALLFAFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 153 KPatlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptlqpqtge 232
Cdd:cd06174    82 PS------------------------------------------------------------------------------ 83

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 233 itnrmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqeveaiFLVILVVVIIGEFFSASSVTIVDTV 312
Cdd:cd06174    84 -------------------------------------------------------FWLLLLGRFLLGLGSGLIDPAVLAL 108

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 313 TLQYLGKHR--DRYGLQRMWGSLGWGLAMLSVGIGIDYThievlidgkgckppeyrnYQIVFIVFGVLMTMALIVATQFR 390
Cdd:cd06174   109 IADLFPERErgRALGLLQAFGSVGGILGPLLGGILASSL------------------GFGWRAVFLIAAALALLAAILLL 170

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 391 FRYNHFKNDDSKGKEVEipqvernnstesseetptttshSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLYW 470
Cdd:cd06174   171 LVVPDPPESARAKNEEA----------------------SSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPL 228

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 471 HLEDLNG-TTTLFGVCSVLSHVSELTAYFFSHKLIE-LIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHA 548
Cdd:cd06174   229 FLLDLGGlSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLG 308

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1773401168 549 AIWAACISYLSAAVPPELRTSAQGIlqglhLGLGRGCGAMIGGVLVNYFGAAAT-FRGIGMACLVILLLFALIQW 622
Cdd:cd06174   309 GLLPLSFALIAELFPPEIRGTAFGL-----LNTFGFLGGAIGPLLAGFLLAATFgLTGAFLVLAVLLLLAAILLL 378
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 76-620 8.39e-20

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 92.25  E-value: 8.39e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  76 FFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFVkpa 155
Cdd:cd17325     6 FLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGR-KRLLLLGLLLLAVSTLLFAFA--- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 156 tlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptlqpqtgeitn 235
Cdd:cd17325       --------------------------------------------------------------------------------

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 236 rmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqeveAIFLVILVVVIIGEFFSASSVT-----IVD 310
Cdd:cd17325    82 --------------------------------------------------TSYWQLLLARFLQGLASAAVWPaamalIAD 111

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 311 TVTLQYLGKhrdRYGLqrMWGSLGWGlAMLSVGIGIdythieVLIDGKGckppeyrnYQIVFIVFGVLMTMALIVATQFR 390
Cdd:cd17325   112 IAPPEERGR---AMGI--FSSAIGLG-FLIGPLLGG------LLADALG--------YRAPFLVCAALALLALVLALLLL 171

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 391 frynhfknddskgkeveipqvernnstESSEETPTTTSHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLYW 470
Cdd:cd17325   172 ---------------------------PEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPL 224

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 471 HLEDLNGTTT-----LFGVcSVLSHVseLTAYFFShKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGV 545
Cdd:cd17325   225 YAAELGGLSPaqiglLFGA-QGLASA--LSQPPAG-KLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGL 300

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1773401168 546 THAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALI 620
Cdd:cd17325   301 GLGLVFPATLALLADIVPPEGRGTAMGLFNTA-FSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
450-627 6.17e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 83.10  E-value: 6.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 450 VLFVAWFM-GFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 528
Cdd:COG2814    14 ALALGAFLsGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 529 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFrgigM 608
Cdd:COG2814    94 LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAG-LGLGPALGPLLGGLLADLFGWRWVF----L 168

                         170
                  ....*....|....*....
gi 1773401168 609 ACLVILLLFALIQWLAVPD 627
Cdd:COG2814   169 VNAVLALLALLLLLRLLPE 187
MFS_1 pfam07690
Major Facilitator Superfamily;
450-630 4.03e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 80.54  E-value: 4.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 450 VLFVAWFMGFGYGFVFTFLYWHL-EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 528
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 529 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFGaaatFRGIGM 608
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLV-SAGFGLGAALGPLLGGLLASLFG----WRAAFL 155

                         170       180
                  ....*....|....*....|..
gi 1773401168 609 ACLVILLLFALIQWLAVPDEEE 630
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPES 177
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 450-630 2.16e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 72.61  E-value: 2.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 450 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 529
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 530 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFrgigMA 609
Cdd:cd17325    81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSA-IGLGFLIGPLLGGLLADALGYRAPF----LV 155

                         170       180
                  ....*....|....*....|.
gi 1773401168 610 CLVILLLFALIQWLAVPDEEE 630
Cdd:cd17325   156 CAALALLALVLALLLLPEPRP 176
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 450-649 2.88e-12

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 69.12  E-value: 2.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 450 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 529
Cdd:cd17477     1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 530 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRtsaqGILQGLHlGLGRGCGAMIGGVLVNYFG-AAATFRGIGM 608
Cdd:cd17477    81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENR----GRVLGLY-STVLGLGFALGPLLLALVGtAGALPFLIAA 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1773401168 609 ACLVILLLFALIQWLAVPDEEEDKTMLAERIpVPSSPVPIA 649
Cdd:cd17477   156 VLLLLALVPLLLTRRAAPEIEEAESISLRRL-LRIAPLALL 195
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
287-583 1.35e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 66.92  E-value: 1.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 287 IFLVILVVVIIGEFFSASSVTIVDTVTLQYLGKhrdRYGLQRMWGSLGWGLAMLSVGIGIDYThievlidgkgckppeyr 366
Cdd:COG2814   102 LAARFLQGLGAGALFPAALALIADLVPPERRGR---ALGLLGAGLGLGPALGPLLGGLLADLF----------------- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 367 NYQIVFIVFGVLMTMALIVATQFrfrynhfknddskgkeveIPqvernnstesseETPTTTSHSQAFNFWDLIKllcSVQ 446
Cdd:COG2814   162 GWRWVFLVNAVLALLALLLLLRL------------------LP------------ESRPAARARLRGSLRELLR---RPR 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 447 YGSVLFVAWFMGFGYGFVFTFLYWHLEDLNG-TTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYI 525
Cdd:COG2814   209 LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL 288

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1773401168 526 YISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGR 583
Cdd:COG2814   289 LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 421-620 2.96e-11

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 66.05  E-value: 2.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 421 EETPTTTSHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTT-----LFGVCSVLShvsELT 495
Cdd:cd17474   174 PEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPiiiglLFAGWSVLL---ALG 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 496 AYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQ 575
Cdd:cd17474   251 SLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYN 330

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1773401168 576 GLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALI 620
Cdd:cd17474   331 FV-RFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_1 pfam07690
Major Facilitator Superfamily;
287-590 1.27e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 63.59  E-value: 1.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 287 IFLVILVVVIIGeFFSASSVTIVDTVTLQYLGK-HRDR-YGLQRMWGSLGWGLAMLSVGIGIDYThievlidgkgckppe 364
Cdd:pfam07690  85 LWLLLVLRVLQG-LGAGALFPAALALIADWFPPeERGRaLGLVSAGFGLGAALGPLLGGLLASLF--------------- 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 365 yrNYQIVFIVFGVLMTMALIVAtqFRFRYNHFKNDDSKGKEVEIPQVErnnstesseetptttshsqafnfwdLIKLLCS 444
Cdd:pfam07690 149 --GWRAAFLILAILSLLAAVLL--LLPRPPPESKRPKPAEEARLSLIV-------------------------AWKALLR 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 445 VQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACN---T 521
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLilaA 279

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1773401168 522 ARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQglhlgLGRGCGAMIG 590
Cdd:pfam07690 280 LGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYN-----TAGSLGGALG 343
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
450-625 1.67e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 63.35  E-value: 1.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 450 VLFVAWFMGFGYGFVFTFLYWHL-EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 528
Cdd:COG2271    14 LLFLAYFLNYLDRSNLSVAAPPLqADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 529 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHlGLGRGCGAMIGGVLVNYFGAAATFRGIGM 608
Cdd:COG2271    94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGG-PLGGALAPPLLGWLLAAFGWRAAFLILGL 172

                         170
                  ....*....|....*..
gi 1773401168 609 ACLVILLLFALIQWLAV 625
Cdd:COG2271   173 PGLLLALLRFWLLALAY 189
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 452-619 3.36e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 62.61  E-value: 3.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 452 FVAWFMGFGYGFVFTFLYWHLEDLNGTT-----TLFGVCSVLSHvseltayFFSHKLIELIGHIRVLYIGLACNTARYIY 526
Cdd:cd17489   201 LILFLASIAYGAISTFLPLYAAERGISNaglffTVYAIALLLSR-------PFSGKLSDRKGPKTVIIPGLLLLALGLLL 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 527 ISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGI 606
Cdd:cd17489   274 LSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIF-FDLGIGLGGLLLGLVAELFGYRAMFLLA 352

                         170
                  ....*....|...
gi 1773401168 607 GMACLVILLLFAL 619
Cdd:cd17489   353 AVVVLLALVLYIF 365
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 449-620 9.25e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 61.07  E-value: 9.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 449 SVLFVawFMGFGYGFVFTFLYwhLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 528
Cdd:cd17489     4 ANFFF--FLSFYLLLPVLPLY--AHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 529 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGM 608
Cdd:cd17489    80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYY-GLATTLAMALGPALGLFLYQHLGFAVLFIVAAV 158

                         170
                  ....*....|..
gi 1773401168 609 ACLVILLLFALI 620
Cdd:cd17489   159 LALLALLLVFLV 170
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 457-616 1.09e-09

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 61.08  E-value: 1.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 457 MGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSE-LTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWT 535
Cdd:cd17490   207 QMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNaLASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTL 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 536 VLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHlGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILL 615
Cdd:cd17490   287 LYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIY-ALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAI 365


                  .
gi 1773401168 616 L 616
Cdd:cd17490   366 L 366
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 450-651 1.35e-09

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 60.90  E-value: 1.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 450 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 529
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 530 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGlhlglGRGCGAMIGGVLVNYFGAA--ATFRGIG 607
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQA-----FGSVGGILGPLLGGILASSlgFGWRAVF 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1773401168 608 MACLVILLLFALIQWLAVPDEEEDKTMLAERIPVPSSPVPIATI 651
Cdd:cd06174   156 LIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRV 199
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 450-619 2.19e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 59.44  E-value: 2.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 450 VLFVAWFM-GFGYGFVFTFLYWHLEDLNGTTTLFGVcsVLShvseltAYFFSH--------KLIELIGHIRVLYIGLACN 520
Cdd:COG0477    18 ALALGTFLeGLDFTIVNVALPSIAADLGASSAQLGW--IVS------AYLLGRaiglllfgRLGDRYGRKRVLLIGLLLF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 521 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAA 600
Cdd:COG0477    90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAA-IGLGLALGPLLGGLLVAALGWR 168

                         170
                  ....*....|....*....
gi 1773401168 601 ATFrGIGMACLVILLLFAL 619
Cdd:COG0477   169 WIF-LINAPLGLLALVLRL 186
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 450-620 2.47e-09

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 59.94  E-value: 2.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 450 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 529
Cdd:cd06173   214 LLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 530 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMA 609
Cdd:cd06173   294 SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNAL-NSGAMPLGALLAGLLADALGLSAVFLLAGAL 372

                         170
                  ....*....|.
gi 1773401168 610 CLVILLLFALI 620
Cdd:cd06173   373 LLLAALLLLLL 383
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
324-620 2.58e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 60.30  E-value: 2.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 324 YGLQRMWGSLGWGLAMLSVGIgidythievLIDGKGCKPPEyrNYQIVFIVFGVLMTMALIVAtqFRFRynhfknddskg 403
Cdd:COG2211   149 SSWRFAFAGLGGLLASVLPPP---------LVAAFGGDAAL--GYRLTALIFAVLGLLAFLLT--FFGT----------- 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 404 KEVEIPQVERnnstesseetptttshsqaFNFWDLIKLLCSV-QYGSVLFVAWFMGFGYGFVFT-FLYWHLEDLNGTTTL 481
Cdd:COG2211   205 KERPVPEEEK-------------------VSLKESLKALLKNrPFLLLLLAYLLFFLALALVAAlLLYYFKYVLGLSAAL 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 482 FGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYI--YISYLENAWTVLPMEVLQGVTHAAIWAACISYLS 559
Cdd:COG2211   266 VGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLllFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLA 345

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1773401168 560 AAVPP-ELRT--SAQGILQGLH---LGLGRGCGAMIGGVLVNYFG-------AAATFRGIGMACLVILLLFALI 620
Cdd:COG2211   346 DVVDYdEWKTgrRREGLYFGIFtfaIKLGQALAGALAGLLLALFGyvagaaqSPSALTGIRLLFFLLPAVLLLL 419
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 458-617 3.38e-09

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 59.51  E-value: 3.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 458 GFGYGFVFTFLYWHLEDLNGT----------TTLFGVCSVLShvseltAYFFShKLIELIGHIRVLYIGLACNTARYIYI 527
Cdd:cd17330     9 ALGFGIVFPVLPFYVREFNKLgasgyyvgllQSSYSLGQFLA------SPLWG-RLSDRYGRKPVLLLSLAGSAVSYVLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 528 SYLENAWTVLPMEVLQGVTHAAIwAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFGAAATF---R 604
Cdd:cd17330    82 GLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGII-SAAFGLGFILGPALGGFLSTPYGYALPFlvaA 159

                         170
                  ....*....|...
gi 1773401168 605 GIGMACLVILLLF 617
Cdd:cd17330   160 ALALLNLVLVLFF 172
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
450-619 6.64e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 58.74  E-value: 6.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 450 VLFVAWFmgfgyGFVFTFLYWHL---------EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACN 520
Cdd:COG2223     6 VLLLATL-----AFFLAFGVWYLwsvlapplaEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 521 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAA 600
Cdd:COG2223    81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGG-GNLGAAVAAFLAPLLIAAFGWR 159

                         170
                  ....*....|....*....
gi 1773401168 601 ATFRGIGMACLVILLLFAL 619
Cdd:COG2223   160 NAFLILGILLLVVAVLAWL 178
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
73-152 1.36e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 57.57  E-value: 1.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  73 VFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFkkG-KIVLLFSLLCWVLFNLGIGF 151
Cdd:COG2271    17 LAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRF--GrRRVLAIGLLLWGLATLLFGF 94


                  .
gi 1773401168 152 V 152
Cdd:COG2271    95 A 95
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
68-157 2.00e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 57.22  E-value: 2.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  68 LLISKVFYFFFYSAYGSLYPLLPVYYkqLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNL 147
Cdd:COG2211   233 LLLAYLLFFLALALVAALLLYYFKYV--LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGK-KKAFIIGLLLAALGLL 309

                          90
                  ....*....|
gi 1773401168 148 GIGFVKPATL 157
Cdd:COG2211   310 LLFFLGPGNL 319
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 456-633 2.94e-08

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 56.47  E-value: 2.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 456 FMGFGYGFVFTFLYWHL-EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAW 534
Cdd:cd17329    10 LNRLGFFMVWPFMAIYLhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 535 TVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFgaaatFRGIGMACLVIL 614
Cdd:cd17329    90 LFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLL-YWAINLGVAIGPLLGGLLLLYS-----FRLLFLAAAVLF 163

                         170
                  ....*....|....*....
gi 1773401168 615 LLFALIQWLAVPDEEEDKT 633
Cdd:cd17329   164 LLAALVLLFLLPETRPKRR 182
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 450-620 5.81e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 55.69  E-value: 5.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 450 VLFVAWFMGFGYGFVFTFL-YWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACnTARYIYIS 528
Cdd:cd17316   182 LILLWFFISFGYYGLTTFLpTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIL-SGILALPL 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 529 YL---ENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAqgilqglhLGLGRGCGAMIGGVLVNYFGAAATFRG 605
Cdd:cd17316   261 FYllsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATG--------VGLSYNLGRLGGGGAPPLIALLLASTG 332

                         170
                  ....*....|....*
gi 1773401168 606 IGMACLVILLLFALI 620
Cdd:cd17316   333 GTGVPALILALLAIV 347
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 502-618 7.80e-08

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 55.26  E-value: 7.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 502 KLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGL 581
Cdd:cd17321    53 RLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLW-GAVVGI 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1773401168 582 GRGCGAMIGGVLVNYFGAAATF--------------RGIGMACLVILLLFA 618
Cdd:cd17321   132 GAALGPLLGGLLLELFGWRWIFlinvpiglvalllaRTFSGAVLAAFLLGA 182
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 450-617 7.91e-08

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 55.24  E-value: 7.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 450 VLFVAWFMGFGYgFVFTFLYWHLEDLNGTTTLFGVCSVLSH-VSELTAYFFSHkLIELIGHIRVLYIGLACNTARYIYIS 528
Cdd:cd17370   205 YLLAVALFALGN-FSFAFLILRAQELGLSAALIPLLYALFNlVYALAAYPAGR-LSDRIGRKKLLILGYLSLALAYLGFA 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 529 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGIlqglhLGLGRGCGAMIG----GVLVNYFGAAATFR 604
Cdd:cd17370   283 LGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGL-----FNTVVGIGWLLAsliaGYLWDLISPSAAFL 357

                         170
                  ....*....|....
gi 1773401168 605 -GIGMACLVILLLF 617
Cdd:cd17370   358 fSAVLALIALLLLL 371
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 287-621 1.97e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 54.16  E-value: 1.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 287 IFLVILVVVIIGE--FFSASSVTIVDTVTlqylGKHRDR-YGLQRMWGSLGWGLAMLSVGIGIDYthievlidgkgckpp 363
Cdd:cd17329    90 LFAIALVLTGFGGglFEPASEAMIADVTT----PENRTRaFSLLYWAINLGVAIGPLLGGLLLLY--------------- 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 364 eyrNYQIVFIVFGVLMTM-ALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNnstesseetptttshsQAFnfwdlikll 442
Cdd:cd17329   151 ---SFRLLFLAAAVLFLLaALVLLFLLPETRPKRRAAEKTEILRGYKIVLRD----------------RAF--------- 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 443 csvqygsVLFVAWFMG--FGYGFVFTFLYWHLEDLNGTTT-----LFGVCSVLShvseLTAYFFSHKLIELIGHIRVLYI 515
Cdd:cd17329   203 -------LLFLLASFLisLIYFQLESTLPVYVVEILGLGEsllglLLALNALLI----VLLQFPVARLVERFRLRKILMI 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 516 GLACNTARYIyISYLENAWTVLPM--------EVLqGVTHAAIWAACISylsaavPPELRTSAQGiLQGLHLGLGRGCGA 587
Cdd:cd17329   272 GILLFAIGFA-VLAFANTLAVLILamivltlgEML-VFPAVQTLVAALA------PPDKRGSYMG-FYALAWGLGRAIGP 342

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1773401168 588 MIGGVLVNYFGAAATFRGIGMACLVILLLFALIQ 621
Cdd:cd17329   343 LVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 450-621 2.59e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 53.73  E-value: 2.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 450 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLF--GVCSVLSHVSELTAYFFShKLIELIGHIRVLYIGLACNTARYIYI 527
Cdd:cd17473   202 IYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALigLALAIASLAGAIGALLFG-RLKRRLGKRRLLAIGFALMALGFLLL 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 528 SYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVN-YFGAAATFRGI 606
Cdd:cd17473   281 ALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSA-FFLGQFLSPLVLGPLVNlTGGLSGAFLIL 359

                         170
                  ....*....|....*
gi 1773401168 607 GMACLVILLLFALIQ 621
Cdd:cd17473   360 GVLALVLAIVLLLLR 374
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 65-157 2.70e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 53.58  E-value: 2.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  65 NNDLLISKVFYFFFYSAYGSLYPLLPVYYKQLGM-SPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWV 143
Cdd:cd06174   202 NPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGlSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMA 281

                          90
                  ....*....|....
gi 1773401168 144 LFNLGIGFVKPATL 157
Cdd:cd06174   282 LGLALLLLAPSLLL 295
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 503-627 4.18e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 52.94  E-value: 4.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 503 LIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQ-GLHLG- 580
Cdd:cd17324    57 LSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFsGLTLGl 136

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1773401168 581 -LGRgcgaMIGGVLVNYFGAAATFRGIGmaclVILLLFALIQWLAVPD 627
Cdd:cd17324   137 vLGR----PLGGLLGQLLGWRAAFLAIA----VLALLAALLLWRLLPS 176
MFS_NHS cd06177
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ...
 488-619 6.22e-07

Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340866 [Multi-domain]  Cd Length: 386  Bit Score: 52.63  E-value: 6.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 488 LSHVSE----LTAYFFSHKLieliGHIRVLYIGLACNTARYIYISYL---ENAWTVLPMEVLQGVTHAAIWAACISYLSA 560
Cdd:cd06177   242 LGQISEilfmLAIPFFLKRL----GIKKVMLIGMLAWVLRFGLFAYGdpsPGVWMLVLSIILHGVCYDFFFVTGYIYVDK 317

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1773401168 561 AVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAAT---FRGI-----GMAcLVILLLFAL 619
Cdd:cd06177   318 KAPKDIRASAQGLFMLMTNGVGALVGSILSGKVVDKFTTVEGtkdWQTIwlvpaIYA-LVLAILFAL 383
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
68-157 6.47e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 52.58  E-value: 6.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  68 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFkKGKIVLLFSLLCWVLFNL 147
Cdd:COG2223     7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRF-GPRRVLLIGLLLLGIGLL 85

                          90
                  ....*....|
gi 1773401168 148 GIGFVKPATL 157
Cdd:COG2223    86 LLALAVSYWL 95
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 31-152 7.12e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 52.19  E-value: 7.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  31 REPEPPSNETPSSTETSAIPEEEIdwiekhcvKINNDLLISKVFYFFFYSAYGSLYPLLPVYYKQL-GMSPSQSGLLVGI 109
Cdd:cd17325   172 PEPRPPPNKRAVSAARLRSGLRLL--------LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGA 243

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1773401168 110 RYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFV 152
Cdd:cd17325   244 QGLASALSQPPAGKLSDRIGR-KPLILIGLLLSAVALLLLPLA 285
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
450-620 7.28e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 52.18  E-value: 7.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 450 VLFVAWF-MGFGYGFVFTFLYWHLEDLNG--------TTTLFGVCSVlshVSELTAYFFSHKLIEliGHIRVLYIGLACN 520
Cdd:COG2271   184 LLALAYFlVYFALYGFLTWLPTYLVEVRGlslaqaglLLSLPFLAGI---VGSLLGGWLSDRLGR--RRKLVLAIGLLLA 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 521 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLgLGRGCGAMIGGVLVNYFGAA 600
Cdd:COG2271   259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGF-LGGALGPLLVGYLLDATGYQ 337

                         170       180
                  ....*....|....*....|
gi 1773401168 601 ATFrGIGMACLVILLLFALI 620
Cdd:COG2271   338 AAF-LLLAALALLAALLALL 356
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 494-620 1.17e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 51.42  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 494 LTAYF--------FSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIwAACISYLSAAVPPE 565
Cdd:cd17504    37 LTAYLlvgavstpILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPE 115

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1773401168 566 LRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALI 620
Cdd:cd17504   116 RVPVAQGILSAT-FGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLI 169
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
73-152 1.25e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.13  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  73 VFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIV---LLFSLLCWVLFNLG 148
Cdd:COG2814   214 LLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLligLLLLALGLLLLALA 293


                  ....
gi 1773401168 149 IGFV 152
Cdd:COG2814   294 GSLW 297
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
73-157 1.46e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.02  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  73 VFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRF-KKGKIVLLFSLLCWVLFNLGIG 150
Cdd:COG2271   187 LAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAALALLLLA 266


                  ....*..
gi 1773401168 151 FVKPATL 157
Cdd:COG2271   267 LLPSPAL 273
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 64-152 1.50e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 51.06  E-value: 1.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  64 INNDLLISKVFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCW 142
Cdd:cd17316   175 LRRRTLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGR-KKTLVIGLILS 253

                          90
                  ....*....|
gi 1773401168 143 VLFNLGIGFV 152
Cdd:cd17316   254 GILALPLFYL 263
MFS_1 pfam07690
Major Facilitator Superfamily;
36-156 1.58e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 50.88  E-value: 1.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  36 PSNETPSSTETSAIPEEEIDWIEKHCVKINNDLLISKVFyFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEF 115
Cdd:pfam07690 171 PRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGA 249

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1773401168 116 CSAPFWGVVADRFKKGKIVLLFSLLCwVLFNLGIGFVKPAT 156
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRRRLLLALLLL-ILAALGLLLLSLTL 289
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
73-157 1.76e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 51.03  E-value: 1.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  73 VFYFFFYSA-YGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGIGF 151
Cdd:COG2807   221 TLFFGLQSLlYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLL 300


                  ....*.
gi 1773401168 152 VkPATL 157
Cdd:COG2807   301 A-PGSL 305
MFS_unc93_like cd17338
Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is ...
 460-617 5.42e-06

Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is composed of Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93) and similar proteins including three vertebrate members: protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. The unc93-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340896 [Multi-domain]  Cd Length: 388  Bit Score: 49.65  E-value: 5.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 460 GYGFVFTFLYWHL---------EDLNGTTTLFGVcsvlsHVSELTAYFFSHKLIELIGHIRVLYIGLaCNTARYIYISYL 530
Cdd:cd17338     5 SFGFLLIFLAYSAlqnlqtslhENGLGSISLGIL-----YSSFAVSSFIAPLLVKLLGEKITLVLGG-LGYAIFIASNIF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 531 ENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAA-------ATF 603
Cdd:cd17338    79 PIWGTLVPASIILGFAAAILWTAQGTYITRISDESNIGRNFGIFWSI-FQLSQVFGNLISLALLNHSKGSsgttilfIVF 157

                         170
                  ....*....|....
gi 1773401168 604 RGIgMACLVILLLF 617
Cdd:cd17338   158 MAI-MLVGIILLFF 170
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 76-152 6.39e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.15  E-value: 6.39e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1773401168  76 FFFYSAYGSLYPLLPVY-YKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFV 152
Cdd:cd17329     9 FLNRLGFFMVWPFMAIYlHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGR-KPVMLAGLLLRALGFALLGFA 85
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 450-620 6.94e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 49.11  E-value: 6.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 450 VLFVAWFMGFGY-GFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAY-FFSHKLIELIGHIRVLYIGLACNTARYIYI 527
Cdd:cd17330   179 LLLVYFLIALAFaGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLLAIIGLLLL 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 528 SYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHlGLGRGCGAMIGGVLVNYFGAAATFrGIG 607
Cdd:cd17330   259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQ-SLARIIGPLLAGPLYSFLGPGVPF-LLA 336

                         170
                  ....*....|...
gi 1773401168 608 MACLVILLLFALI 620
Cdd:cd17330   337 AGLLLIALFLLSL 349
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
73-145 1.55e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.95  E-value: 1.55e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1773401168  73 VFYFFFYSAYGSLYPLLPVYYK-QLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLF 145
Cdd:COG2223   212 LLYFGTFGSFIGFSSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGL 285
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 452-639 3.10e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 47.22  E-value: 3.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 452 FVAWFMG-----FGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLyigLACNTAR--- 523
Cdd:cd06173     1 FRLLWLAqllsaLGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLL---ILADLLRall 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 524 -----YIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFG 598
Cdd:cd06173    78 aavlaLLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLA-TQLARIIGPALGGLLVALLG 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1773401168 599 AAATFRGIGMACLVILLLFALIQWLAVPDEEEDKTMLAERI 639
Cdd:cd06173   157 PGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDL 197
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 76-152 3.20e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 46.87  E-value: 3.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  76 FFFYSAYGSLYPLLPVYYKQLGMSPSQ-----SGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIG 150
Cdd:cd17391     6 FFTGIGFSLIAPFLPLYIEQLGVTSGGlvelwSGLAFSSTFLVSAIFSPIWGRLADRYGR-KPMLLRASLGMAIVIGLMA 84


                  ..
gi 1773401168 151 FV 152
Cdd:cd17391    85 FV 86
Nuc_H_symport pfam03825
Nucleoside H+ symporter;
488-619 3.83e-05

Nucleoside H+ symporter;


Pssm-ID: 461066 [Multi-domain]  Cd Length: 399  Bit Score: 46.69  E-value: 3.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 488 LSHVSE----LTAYFFSHKLieliGHIRVLYIGLACNTARYIYISYLEN------AWTVLPMeVLQGVTHAAIWAACISY 557
Cdd:pfam03825 251 LGQISEilfmLTLPFFLKRF----GIKNVMLIGIVAWALRFAFFAYGADptpfgtALLLLSM-IVHGVAYDFFNITGYIF 325

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1773401168 558 LSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFR-------GIGMAcLVILLLFAL 619
Cdd:pfam03825 326 VDKEVPPAIRASAQGLFLLMTNGFGCILGSILSGMVVEMFTQDGITDwqtvwlvFAGMA-LVLAVLFMA 393
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 507-633 5.05e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 46.44  E-value: 5.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 507 IGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVthAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCG 586
Cdd:cd17472    59 IGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMALI-GASIGIAFAIS 135

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1773401168 587 AMIGGVLVNYFGAAATFrgIGMACLVILLLFalIQWLAVPDEEEDKT 633
Cdd:cd17472   136 MVLGPLLAAHLGVSGLF--LITAILSLVSLL--ILLFFVPDPPKIVQ 178
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
76-140 6.69e-05

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 46.07  E-value: 6.69e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  76 FFFYSAYGSLYPLLPVYYKQLGMSPSQ-----SGLLVGIRYFIEFCSAPFWGVVADRfKKGKIVLLFSLL 140
Cdd:PRK09874   24 FLTGAAFSLVMPFLPLYVEQLGVTGHSalnmwSGLVFSITFLFSAIASPFWGGLADR-KGRKIMLLRSAL 92
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
292-620 6.94e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.00  E-value: 6.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 292 LVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRM-WGSLGWGL-AMLSVGIGIdythieVLIDGKGckPPEYRnyq 369
Cdd:COG0738    96 YPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLnLLHAFFSLgALLGPLLGG------LLILLGL--SLSWH--- 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 370 IVFIVFGVLMTMALIVATQFRFrynhfknddskgkeveiPQVErnnsTESSEETPTTTSHSQAFNFwdlikllcsvqygS 449
Cdd:COG0738   165 LPYLILAVLLLLLALLFLRSKL-----------------PEIE----EEEEEAAGSAASLKSLLKN-------------P 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 450 VLFVAWFMGFGYGFV----FTFLYWHLEDLNG-TTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARY 524
Cdd:COG0738   211 RLLLGGLAIFLYVGAegaiGDWLPLYLKDVLGlSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGL 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 525 IYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPelRTSAQGilqGLHLGLGrGCGAMIG----GVLVNYFGAA 600
Cdd:COG0738   291 LLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGK--RTAAAV---SAVLIMG-IVGGAIGppliGFLADAFGLR 364

                         330       340
                  ....*....|....*....|
gi 1773401168 601 ATFrGIGMACLVILLLFALI 620
Cdd:COG0738   365 AAF-LVPLVCYLLILLLALA 383
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 450-618 7.02e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 46.00  E-value: 7.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 450 VLFVAWFMGFGYGF-VFTFLYWHLEDLNGTTT--------LFGVCSVLShvseltAYFFShKLIELIGHIRVLYIGLACN 520
Cdd:cd17324   202 LAYLITFLLFGGFFaLYTYLAPFLTDVPGFSSsaiiglllLFGVAGVVG------SPLAG-RLADRGGRRALLIALLLLA 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 521 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPpelrtSAQGILQGLHLG---LGRGCGAMIGGVLVNYF 597
Cdd:cd17324   275 AALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-----EARGLASSLYLAaynLGGALGAALGGLVLDHG 349

                         170       180
                  ....*....|....*....|.
gi 1773401168 598 GAAATFRGIGMACLVILLLFA 618
Cdd:cd17324   350 GWAGVGWVGAALLLLALLLAL 370
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 81-154 8.39e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 45.65  E-value: 8.39e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1773401168  81 AYGSLYPLLPVY---YKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFVKP 154
Cdd:cd17330    11 GFGIVFPVLPFYvreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGR-KPVLLLSLAGSAVSYVLLGLSRN 86
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 514-619 8.60e-05

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 45.73  E-value: 8.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 514 YIGLACNTARYIYISYLENAWTV---LPMEVLQGVT--HAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAM 588
Cdd:cd17386    67 LVGLLLSSLILVLIVYFTTVPSVwwfYLSAIPLALFggFTAFLSASFAYISDISSEKKRTYRMAILEVA-LGLGGFLGSL 145

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1773401168 589 IGGVLVNYFGAAATFrGIGMACLVILLLFAL 619
Cdd:cd17386   146 LSGHLFKALGYAWSF-SISAALLLIALLYIL 175
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 68-151 2.11e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 44.03  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  68 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIrYFIEFCS-APFWGVVADRFkkG-KIVLLFSLLCWVLF 145
Cdd:COG0477    16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSA-YLLGRAIgLLLFGRLGDRY--GrKRVLLIGLLLFGLA 92


                  ....*.
gi 1773401168 146 NLGIGF 151
Cdd:COG0477    93 SLLCGL 98
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
325-626 2.77e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.10  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 325 GLQRMWGSLGWGLAMLSVGigidythieVLIDGKGckppeyrnYQIVFIVFGVLMTMALIVATQFrfrynhfknddskgk 404
Cdd:COG2223   132 GLAAGGGNLGAAVAAFLAP---------LLIAAFG--------WRNAFLILGILLLVVAVLAWLF--------------- 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 405 eveipqvernnstesSEETPTTTSHSQAFNFWDLIKLLCSVQYGsVLFVAWFMGFGYGFVFTF---LYWHLE---DLNGT 478
Cdd:COG2223   180 ---------------LRDPPAGAAAAAKASLRDQLEALRDPRFW-LLSLLYFGTFGSFIGFSSwlpPYLVDQfglSAATA 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 479 TTLFGVCSVLSHVSELTAYFFSHKlielIGHIRVLYIGLACNTARYIYISY-LENAWTVLPMEVLQGVTHAAIWAACISY 557
Cdd:COG2223   244 GLLAALFALLGALGRPLGGWLSDR----IGGRRVLLIVFALMALGLLLLALaLGSLWLFLVLFLLLGLALGGGNGAVFAL 319

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1773401168 558 LSAAVPPELRTSAQGILqglhlGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQWLAVP 626
Cdd:COG2223   320 VPDIFPTKNAGAVYGLV-----GAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLY 383
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 87-152 3.65e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 43.69  E-value: 3.65e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1773401168  87 PLLPVYYKQLGMSPSQSGLLVGIrYFIEFC-SAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFV 152
Cdd:cd17324    20 GLLPDIARDFGVSVAQAGLLVSA-YALGYAlGALLLGPLSDRIER-RRLLLVLLLLFILGNLLAALA 84
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 408-623 3.70e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 43.75  E-value: 3.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 408 IPQVERNNSTESSEETPTTTShsqAFNFWDLIKLLCSVQYGSVLFVAWFMGFG---YGFVFTFL---YWHL--EDLNGTT 479
Cdd:cd17331   173 IPSNTKSKREKEAKESASPPS---VFNLKEILRLLRLPGVAFLLLVKLLSGLPigmFQSMFSLVamdFFGLtpEENGYLM 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 480 TLFGVCSVLSH---VSELTAYFFSHKLIEL-IGHIRVLYIGLA-CNTaryIYISYLenawTVLPMEVLQGVTHAAIWAAc 554
Cdd:cd17331   250 SYAGVLGMVVQgllVGPLTKRFGERSLLKLsVALLAIGYLLLAfVTT---VWQLLV----LLLPLVIGGSVLYTVITSL- 321

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1773401168 555 isyLSAAVPPELRTSAQGILQGLHlGLGRGCGAMIGGVLVNYFGaaatFRGIGMACLVILLLFALIQWL 623
Cdd:cd17331   322 ---LTKAVPPEDTGTALGLSHALF-SLVRTVSPTIGGALLQAYG----FPSFGLLGAAINGLLTVYLLL 382
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 62-157 3.97e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 43.75  E-value: 3.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  62 VKINNDLLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLC 141
Cdd:cd17332   217 LLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGK-KKAFFIGLLL 295

                          90
                  ....*....|....*.
gi 1773401168 142 WVLFNLGIGFVKPATL 157
Cdd:cd17332   296 AILGLLLLFFLPPGNL 311
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 70-156 4.51e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 43.33  E-value: 4.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  70 ISKVFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFkKGKIVLLFSLLCWVLFNLG 148
Cdd:cd17503   182 LGLLLSFLLGLGLFGAMFLLPLYLQNvLGYSAFESGLVLAPGGLASAILSPLVGRLLDKF-GPRLLLLAGLLLLALGTLL 260


                  ....*...
gi 1773401168 149 IGFVKPAT 156
Cdd:cd17503   261 LAFLTPDT 268
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 76-137 4.81e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 43.30  E-value: 4.81e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1773401168  76 FFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLF 137
Cdd:cd17370     9 LFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVIL 70
PRK05122 PRK05122
major facilitator superfamily transporter; Provisional
 69-141 5.70e-04

major facilitator superfamily transporter; Provisional


Pssm-ID: 235348 [Multi-domain]  Cd Length: 399  Bit Score: 42.95  E-value: 5.70e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1773401168  69 LISKVFYFFF-YSAYGSLYPLLPVY-YKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLC 141
Cdd:PRK05122   17 IVSIVMFTFIsYLTIGLPLAVLPGYvHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGC 91
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
498-633 6.65e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.92  E-value: 6.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 498 FFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLsAAVPPELRTSAQGILQGL 577
Cdd:COG0738    61 LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYV-AALGPETAASRLNLLHAF 139

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1773401168 578 HlGLGRGCGAMIGGVLVNYFGAAAT---FRGIGMACLVILLLFALIQWLAVPDEEEDKT 633
Cdd:COG0738   140 F-SLGALLGPLLGGLLILLGLSLSWhlpYLILAVLLLLLALLFLRSKLPEIEEEEEEAA 197
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 68-157 7.25e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 42.53  E-value: 7.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  68 LLISKVFYFFFYSaygslYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKiVLLFSLLCWVLFNL 147
Cdd:cd17370   206 LLAVALFALGNFS-----FAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKK-LLILGYLSLALAYL 279

                          90
                  ....*....|
gi 1773401168 148 GIGFVKPATL 157
Cdd:cd17370   280 GFALGSSLWL 289
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 87-140 9.61e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 42.21  E-value: 9.61e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1773401168  87 PLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLL 140
Cdd:cd17390    17 PLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGR-RPVLLICLL 69
MFS_LacY cd06172
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ...
 69-145 1.05e-03

LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340862 [Multi-domain]  Cd Length: 389  Bit Score: 42.22  E-value: 1.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1773401168  69 LISKVFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLF 145
Cdd:cd06172     2 WKFSLFFFLFFFIWSASFSFFPIWLTQiNHLSGSETGIVFSANSLFALLFQPVYGLISDKLGLKKHLLWFISGLLVLF 79
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 80-145 1.21e-03

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 41.82  E-value: 1.21e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  80 SAYGSLYPLLPVYYKQLGMSPSQSGL---LVGIRYFIefcSAPFWGVVADRFKKGKIVLLF-SLLCWVLF 145
Cdd:cd17385   215 VSLGFLDPTLSPHLRQFKLSPGQVGLmflILAGSYAI---SAPLWGWLSDKKKIPKWLMVIgSIITGVGF 281
lacY PRK09528
galactoside permease; Reviewed
 65-130 1.34e-03

galactoside permease; Reviewed


Pssm-ID: 236549  Cd Length: 420  Bit Score: 41.81  E-value: 1.34e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1773401168  65 NNDLLISKVFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADR--FKK 130
Cdd:PRK09528    9 NPNYWIFSLFFFFFFFIWSSWFSFFPIWLHDiNGLSGTDTGIIFSANSLFALLFQPLYGLISDKlgLKK 77
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 73-152 1.76e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.43  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  73 VFYFFFYSAYGSLYPLLpVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFV 152
Cdd:cd17316     9 FFDAYDFFLIGFVAPVL-AAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGR-KKALILTLLLFGLATLLIGLL 86
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 463-619 2.33e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 41.05  E-value: 2.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 463 FVFTFLYW------------HLEDLNGTTTLFGVCsvlshvseLTAYFFSHKLIEL-IG--------HIRVLYIGLACNT 521
Cdd:cd17490     2 LIIVFLFWfsqyvyvpflspYAESLGASLSMIGII--------LGAYGISQMLLRIpLGilsdrigkRKLFIIIGLLFTV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 522 ARYIYISYLENAWTVLPMEVLQGVThAAIWAACISYLSAAVPPELRTSAQGILQgLHLGLGRGCGAMIGGVLVNYFGAAA 601
Cdd:cd17490    74 LASLIMILFPSPWGLLIARFLSGIA-AATWVSFTVLYASYFPPDEAAKAMGLIN-LVNNLGQLIAFLIGGLIAEHFGMRA 151

                         170
                  ....*....|....*....
gi 1773401168 602 TFR-GIGMACLVILLLFAL 619
Cdd:cd17490   152 PFLlAALAGVLGFILSLFI 170
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 474-621 2.68e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 40.71  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 474 DLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAA 553
Cdd:cd17391   234 DASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPA 313

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1773401168 554 CISYLSAAVPPELRTSAQGILQGLHLgLGRGCGAMIGGVLVNYFGAAATFRGIGmaclvILLLFALIQ 621
Cdd:cd17391   314 INSLLAKITPKEVAGRIFGYNQSFQY-LGNVAGPLLGSAIAAHFGYRAVFVVTA-----LLVLLNAIW 375
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 473-616 2.71e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 40.99  E-value: 2.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 473 EDLNGTTT----LFGVCSVLshvsELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHA 548
Cdd:cd17471   228 NELGGSESwvglLFGLAAAL----EIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIG 303

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1773401168 549 AIWAACISYLSAAVPPE------LRTSAQGIlqglhlglgrgcGAMIGGVLVNYFGAAATFRGIGMACLVILLL 616
Cdd:cd17471   304 ITAGLGISYFQDLMPGQpglattLYSNASRI------------GSLLGGLLAGVIAQYFGYRAVFLVCAVLALL 365
PRK11128 PRK11128
3-phenylpropionate MFS transporter;
292-617 2.80e-03

3-phenylpropionate MFS transporter;


Pssm-ID: 236856 [Multi-domain]  Cd Length: 382  Bit Score: 40.65  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 292 LVVVIIGEF--FSASSVTIVDTV--TLQYLgKHRDrYGLQRMWGSLGWGLAMLSVGIgidythievLIDGKGckppeYRN 367
Cdd:PRK11128   96 LLFVAIGLFnlFFSPLVPLTDALanTWQKQ-IGLD-YGKVRLWGSIAFVIGSALTGK---------LVSWFG-----EQA 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 368 yqIVFIVFGVLMTMALIVATQfrfrynhfknddskgkeveiPQVernnstesseeTPTTTSHSQA----FNFWDLIK--- 440
Cdd:PRK11128  160 --ILWILTAGVASMLLGQLLR--------------------PTI-----------MPQGESRQQEsagwPAWKALLKept 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 441 ----LLCsvqygsvlfVAWFMG--FGYgFVFTFLYW----HLEDLNGTTTLFGVcsvlshVSELTAYFFSHKlieLIGHI 510
Cdd:PRK11128  207 vwrfLLC---------VSLLQGshAAY-YGFSAIYWqaagYSASTIGYLWSLGV------VAEVLIFAFSNR---LFRRW 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 511 RV---LYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAvPPELRTSAQGILQGLHLGLGRGCGA 587
Cdd:PRK11128  268 SArdlLLLSAICGVVRWGLMGSTTALPWLIVIQILHCGTFTVCHLAAMRYIAAR-PGSEVIRLQALYSALAMGGSIAIMT 346

                         330       340       350
                  ....*....|....*....|....*....|
gi 1773401168 588 MIGGVLVNYFGaAATFrgIGMACLVILLLF 617
Cdd:PRK11128  347 VLSGFLYQHLG-AGVF--WVMALVALPALF 373
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 451-647 2.96e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 40.61  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 451 LFVAWFMGFGYGFVFTFL-YWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVL-YIGLACNTARYIYIS 528
Cdd:cd17471     2 LLATLLTGLAGAFVLPYLsLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLiLLALLAGALGYLLFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 529 YLENAWTVLpmevLQGVTHAAIWAACISYLSA-------AVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAA 601
Cdd:cd17471    82 FLRNYWVLL----LVGVVLLSLGAAAFPQLFAlareyadRSSGRDATLFNSVLRAA-FSLAWVIGPPLAFLLLDVLGFTG 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1773401168 602 TFRGIGmaclVILLLFALIQWLAVPDEEEDKTMLAERIPVPSSPVP 647
Cdd:cd17471   157 LFLLAA----LLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVN 198
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
68-152 3.58e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.61  E-value: 3.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168  68 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFkkG-KIVLLFSLLCWVLFN 146
Cdd:COG0738    10 LIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRF--GyKRGLLLGLLLMALGL 87


                  ....*.
gi 1773401168 147 LGIGFV 152
Cdd:COG0738    88 LLFALA 93
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 83-154 3.83e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 40.23  E-value: 3.83e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1773401168  83 GSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFVKP 154
Cdd:cd17477   205 GAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDR-RRVLLGCALLGALAALLLPLVPG 275
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 78-152 4.90e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.85  E-value: 4.90e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1773401168  78 FYSayGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLfSLLCWVLFNLGIGFV 152
Cdd:cd17478    10 FYQ--GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPL-GPLLTGLGLSLLGFA 81
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 76-152 4.94e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 39.84  E-value: 4.94e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1773401168  76 FFFYSAYGSLYPL-LPVYY-KQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKiVLLFSLLCWVLFNLGIGFV 152
Cdd:cd17471   208 FTLLFAANSMYIIaMPLYVtNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRR-LLLAGFLAGVLFYLGLALA 285
PRK11128 PRK11128
3-phenylpropionate MFS transporter;
75-115 5.28e-03

3-phenylpropionate MFS transporter;


Pssm-ID: 236856 [Multi-domain]  Cd Length: 382  Bit Score: 39.88  E-value: 5.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1773401168  75 YFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEF 115
Cdd:PRK11128   13 YFGYFFAYGVFLPFWSVWLKGQGYTPETIGLLLGAGLVARF 53
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 280-581 6.26e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 39.92  E-value: 6.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 280 DQQEVEAIFLVILVVVIIgEFFSAssvtIVDTVTLQYLG-----KHRDR-YGLQRMWGSLGWGLAMLSVGIGIDYTHIEV 353
Cdd:cd17313    98 DGPRTWALVLFVLGIVLL-DFAMN----VCQGPVRALLPdlvppEQRSKaNGIINFMGGLGGVLGYLLGAILWDHNWFGF 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 354 LIDGkgckppeyrNYQIVFIVFGVLMTMALIVaTQFRFRynhfknddskgkeveipqvERNNSTESSEETPTTTSHSQAF 433
Cdd:cd17313   173 ALGG---------NLKVPFYIGAIILLVCVLV-TLFFVK-------------------EPPLSPEAGEHSENPSLGEVLK 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 434 NFWDLIK-------LLCSVQygsvLFvaWFMGFGYGFVFTFLYWHLEDLNGTTTL------------FGVCsVLSHVSEL 494
Cdd:cd17313   224 SLLKLLKimprsllRLLLVI----FF--WWIAFFPFELFFTDYMGEEVYHGTSAAsshygagvrmgaWGLL-IFSLAFLI 296

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 495 TAyFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTsaqgil 574
Cdd:cd17313   297 FS-LPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRG------ 369


                  ....*..
gi 1773401168 575 QGLHLGL 581
Cdd:cd17313   370 QGTDTGL 376
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 78-153 6.35e-03

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 39.48  E-value: 6.35e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1773401168  78 FYSAYGS--LYPLLPVYYKQLGMSPSQSGLLVGIrYFIEFCSAP-FWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFVK 153
Cdd:cd17323     9 FVVTFGSsiYSPALPQIAEDFHVSEEVANLGVSL-FVLGFGLGPlIWAPLSELYGR-RPVYLVSLFIFVIFQIGCALAP 85
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 481-620 7.87e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 39.54  E-value: 7.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1773401168 481 LFGVCSVLSHVseltayFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEV---LQGVTHAAIWAacisY 557
Cdd:cd17388   250 VFGLLHALFQA------FVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILIllaLGGIAGPALQG----L 319

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1773401168 558 LSAAVPPElrtsAQGILQGLHLGLgRGCGAMIGGVLVN--YFGAAATFRGIGMACLVILLLFALI 620
Cdd:cd17388   320 LSRQVPEN----EQGELQGVLTSL-TSLTSIIGPLLFTgiFAASPATWPGLAWIIGAALYLICLV 379
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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