tRNA (adenine(37)-N6)-methyltransferase isoform 2 [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| UPF0066 super family | cl00749 | Escherichia coli YaeB and related proteins; Uncharacterized protein family UPF0066. This ... |
1-23 | 3.27e-06 | ||
Escherichia coli YaeB and related proteins; Uncharacterized protein family UPF0066. This domain includes Escherichia coli YeaB, Archeoglobus fulgidus AF0241, and Agrobacterium tumefaciens VirR. Proteins with this domain are probable S-adenosylmethionine-dependent methyltransferases but they have not been functionally characterized and the substrate is unknown. The actual alignment was detected with superfamily member COG1720: Pssm-ID: 469902 Cd Length: 152 Bit Score: 45.91 E-value: 3.27e-06
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| TrmO_C super family | cl39727 | TrmO C-terminal domain; This domain is found at the C-terminus of TrmO tRNA methyltransferase ... |
189-257 | 5.03e-05 | ||
TrmO C-terminal domain; This domain is found at the C-terminus of TrmO tRNA methyltransferase proteins. This domain has a RelE fold. The actual alignment was detected with superfamily member pfam18389: Pssm-ID: 465738 Cd Length: 65 Bit Score: 40.67 E-value: 5.03e-05
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| Name | Accession | Description | Interval | E-value | ||
| TrmO | COG1720 | tRNA (Thr-GGU) A37 N6-methylase [Translation, ribosomal structure and biogenesis]; tRNA ... |
1-23 | 3.27e-06 | ||
tRNA (Thr-GGU) A37 N6-methylase [Translation, ribosomal structure and biogenesis]; tRNA (Thr-GGU) A37 N6-methylase is part of the Pathway/BioSystem: tRNA modification Pssm-ID: 441326 Cd Length: 152 Bit Score: 45.91 E-value: 3.27e-06
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| TrmO | pfam01980 | tRNA-methyltransferase O; This family includes members such as TrmO (tRNA-methyltransferase O) ... |
1-18 | 5.55e-06 | ||
tRNA-methyltransferase O; This family includes members such as TrmO (tRNA-methyltransferase O) also known as YaeB, which contains a single-sheeted beta-barrel structure. TrmO is an AdoMet-dependent methyltransferase responsible for m6t6A formation. Its human homolog, is responsible for formation of m6t6A37 in cytoplasmic tRNASer. Lack of TrmO decreases attenuation activity of the thr operon, indicating that N6 methylation of m6t6A37 ensures efficient decoding of ACY codons. In bacteria and eukaryotes, TrmO has a C-terminal domain containing the conserved DPRxxY motif. Where the Asp194 and Arg196 in this motif of E. coli TrmO are necessary for N6-methylation. However, no archaeal YaeB has a C-terminal domain containing the DPRxxY motif that is conserved in bacterial and mammalian TrmO homologs. Pssm-ID: 460402 Cd Length: 116 Bit Score: 44.70 E-value: 5.55e-06
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| TrmO_C | pfam18389 | TrmO C-terminal domain; This domain is found at the C-terminus of TrmO tRNA methyltransferase ... |
189-257 | 5.03e-05 | ||
TrmO C-terminal domain; This domain is found at the C-terminus of TrmO tRNA methyltransferase proteins. This domain has a RelE fold. Pssm-ID: 465738 Cd Length: 65 Bit Score: 40.67 E-value: 5.03e-05
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| UPF0066 | cd09281 | Escherichia coli YaeB and related proteins; Uncharacterized protein family UPF0066. This ... |
1-13 | 3.09e-03 | ||
Escherichia coli YaeB and related proteins; Uncharacterized protein family UPF0066. This domain includes Escherichia coli YeaB, Archeoglobus fulgidus AF0241, and Agrobacterium tumefaciens VirR. Proteins with this domain are probable S-adenosylmethionine-dependent methyltransferases but they have not been functionally characterized and the substrate is unknown. Pssm-ID: 187753 Cd Length: 124 Bit Score: 37.09 E-value: 3.09e-03
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| Name | Accession | Description | Interval | E-value | ||
| TrmO | COG1720 | tRNA (Thr-GGU) A37 N6-methylase [Translation, ribosomal structure and biogenesis]; tRNA ... |
1-23 | 3.27e-06 | ||
tRNA (Thr-GGU) A37 N6-methylase [Translation, ribosomal structure and biogenesis]; tRNA (Thr-GGU) A37 N6-methylase is part of the Pathway/BioSystem: tRNA modification Pssm-ID: 441326 Cd Length: 152 Bit Score: 45.91 E-value: 3.27e-06
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| TrmO | pfam01980 | tRNA-methyltransferase O; This family includes members such as TrmO (tRNA-methyltransferase O) ... |
1-18 | 5.55e-06 | ||
tRNA-methyltransferase O; This family includes members such as TrmO (tRNA-methyltransferase O) also known as YaeB, which contains a single-sheeted beta-barrel structure. TrmO is an AdoMet-dependent methyltransferase responsible for m6t6A formation. Its human homolog, is responsible for formation of m6t6A37 in cytoplasmic tRNASer. Lack of TrmO decreases attenuation activity of the thr operon, indicating that N6 methylation of m6t6A37 ensures efficient decoding of ACY codons. In bacteria and eukaryotes, TrmO has a C-terminal domain containing the conserved DPRxxY motif. Where the Asp194 and Arg196 in this motif of E. coli TrmO are necessary for N6-methylation. However, no archaeal YaeB has a C-terminal domain containing the DPRxxY motif that is conserved in bacterial and mammalian TrmO homologs. Pssm-ID: 460402 Cd Length: 116 Bit Score: 44.70 E-value: 5.55e-06
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| TrmO_C | pfam18389 | TrmO C-terminal domain; This domain is found at the C-terminus of TrmO tRNA methyltransferase ... |
189-257 | 5.03e-05 | ||
TrmO C-terminal domain; This domain is found at the C-terminus of TrmO tRNA methyltransferase proteins. This domain has a RelE fold. Pssm-ID: 465738 Cd Length: 65 Bit Score: 40.67 E-value: 5.03e-05
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| UPF0066 | cd09281 | Escherichia coli YaeB and related proteins; Uncharacterized protein family UPF0066. This ... |
1-13 | 3.09e-03 | ||
Escherichia coli YaeB and related proteins; Uncharacterized protein family UPF0066. This domain includes Escherichia coli YeaB, Archeoglobus fulgidus AF0241, and Agrobacterium tumefaciens VirR. Proteins with this domain are probable S-adenosylmethionine-dependent methyltransferases but they have not been functionally characterized and the substrate is unknown. Pssm-ID: 187753 Cd Length: 124 Bit Score: 37.09 E-value: 3.09e-03
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| Blast search parameters | ||||
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