N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  426 KHKCRFCAKVFGSDSALQIHLRSHTgerpFKCNICGNRFSTKGNLKVHF-QRHKEKYPHIqMNPYPVPEYLD-NVPTCSG 503
Cdd:cd20908      1 KPWCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHClQVHKETLTKV-PNALPGRDDPEiEIFGMEG 75

                   ....*
gi 1595439315  504 IPYGM 508
Cdd:cd20908     76 IPEGD 80

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1595439315 1135 CQSCGKTFSSASALQIHERTHTgekpFGCTICGRAFTTKGNLKVHM 1180
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45

FOG: Zn-finger [General function prediction only];

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  419 SAEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCN--ICGNRFSTKGNLKVHFQRHKEKYPH-----IQMNPYPV 491
Cdd:COG5048     26 SLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlnsksLPLSNSKA 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  492 PEYLDNVPTCSG----IPYGMSLPPEKPVttWLDSKPVLPTV------------------PTSVGLQLPPTVPGTHNYTD 549
Cdd:COG5048    106 SSSSLSSSSSNSndnnLLSSHSLPPSSRD--PQLPDLLSISNlrnnplpgnnsssvntpqSNSLHPPLPANSLSKDPSSN 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  550 SPSITPVSRSPQRPSPASSECTSLSPGLNNTESGITVRPESP-----QPLLGGPSLTKAEPVSLPCTSTRTGDAPVVGGQ 624
Cdd:COG5048    184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSslpltTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  625 VSGLPTSAATAVTDSACTSLGSPGLPAVSDQFKAQFpfgglldSMQTSETSKLQQLVENIDKKMTDPNQCVICHRVLSCQ 704
Cdd:COG5048    264 SLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISF-------SRSSPLTRHLRSVNHSGESLKPFSCPYSLCGKLFSRN 336

                          330       340
                   ....*....|....*....|...
gi 1595439315  705 SALKMHYRTHTGERPFKCKICGR 727
Cdd:COG5048    337 DALKRHILLHTSISPAKEKLLNS 359

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  426 KHKCRFCAKVFGSDSALQIHLRSHTgerpFKCNICGNRFSTKGNLKVHF-QRHKEKYPHIqMNPYPVPEYLD-NVPTCSG 503
Cdd:cd20908      1 KPWCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHClQVHKETLTKV-PNALPGRDDPEiEIFGMEG 75

                   ....*
gi 1595439315  504 IPYGM 508
Cdd:cd20908     76 IPEGD 80

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1595439315 1135 CQSCGKTFSSASALQIHERTHTgekpFGCTICGRAFTTKGNLKVHM 1180
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45

FOG: Zn-finger [General function prediction only];

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  718 RPFKCKICGRAFTTKGNLKTHFGVHRAKPPlrvqHSC--PICQKKFTNAVVLQQHIRMHMGGQIPNTPLPEGLQEAmdaD 795
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKP----SQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNS---K 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  796 LPFDEKNAETLSSFDDDIDENSMEEDSELKDTASDSSKPLLSYSGSCPPSPPSVISSIAALENQMKMIdsvmncqqlANL 875
Cdd:COG5048    105 ASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLP---------ANS 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  876 KSVENGSGESDRLSNDSSSAVGDLESRSAGSPALSESSSSQALSPAHSNGESFRSKSPGLGHQEDPQEIPLKTERLDSPP 955
Cdd:COG5048    176 LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  956 PGPGNGGALDLTAGHPGrplikeeAPFSLLFLSRERGKCASTVCGVCGKPFACKSALEIHYRS--HTKE--RPFVCTV-- 1029
Cdd:COG5048    256 SASESPRSSLPTASSQS-------SSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYsl 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315 1030 CRRGCSTMGNLKQHLLTHklkelPSQVFDPNFTLGPSHSTPSLASSPAPTMIKMEVNGHSKAIALGEGPALPAGvqvptg 1109
Cdd:COG5048    329 CGKLFSRNDALKRHILLH-----TSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRN------ 397

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1595439315 1110 pqTVMSPGLAPMLAPPPRRTPKQHNCQSCGKTFSSASALQIHERTHTGEKPFGCTICGR 1168
Cdd:COG5048    398 --FKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                           10        20
                   ....*....|....*....|.
gi 1595439315 1163 CTICGRAFTTKGNLKVHMGTH 1183
Cdd:pfam00096    3 CPDCGKSFSRKSNLKRHLRTH 23

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                           10        20
                   ....*....|....*....|...
gi 1595439315  752 HSCPICQKKFTNAVVLQQHIRMH 774
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23

large tegument protein UL36; Provisional

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  242 PGPPLKPSASAPGTAsvqlQGLTPHAALQLSAGPATASAGSGSTLPAAFDGPQHLSQPASGTSTPCSTSAAPPDSGA--- 318
Cdd:PHA03247  2551 PPPPLPPAAPPAAPD----RSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHApdp 2626

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  319 HPACSTGPAPGAVAAASSTVGNAVQPQNASTPPALGPGPLLSSASNLPNPLLPQTSSSSVIFPNPLVSIAATANALDPls 398
Cdd:PHA03247  2627 PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPP-- 2704

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  399 almkhrkGKPPnvsvfEPKASAEDPffkhkcrfcakvfgsdsALQIHLRSHTGERPFkcnicgnrfstkgnlkvhfqrhk 478
Cdd:PHA03247  2705 -------PPTP-----EPAPHALVS-----------------ATPLPPGPAAARQAS----------------------- 2732

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  479 ekyPHIQMNPYPVPeyldnVPTCSGIPYGMSLPPEKPVTtwldSKPVLPTVPTSVGLQLPPTVPGTHNYTDSPSiTPVSR 558
Cdd:PHA03247  2733 ---PALPAAPAPPA-----VPAGPATPGGPARPARPPTT----AGPPAPAPPAAPAAGPPRRLTRPAVASLSES-RESLP 2799

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  559 SPQRPSPASSECTSLSPGLNNTESGITVRPESPQPLLGGPSLTKAEPVslpcTSTRTGDAPVVGGQVSGLPTSAATAVTD 638
Cdd:PHA03247  2800 SPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPP----PSLPLGGSVAPGGDVRRRPPSRSPAAKP 2875

                          410       420
                   ....*....|....*....|...
gi 1595439315  639 SACT-----SLGSPGLPAVSDQF 656
Cdd:PHA03247  2876 AAPArppvrRLARPAVSRSTESF 2898

zinc finger;

                            10        20
                    ....*....|....*....|...
gi 1595439315   427 HKCRFCAKVFGSDSALQIHLRSH 449
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  426 KHKCRFCAKVFGSDSALQIHLRSHTgerpFKCNICGNRFSTKGNLKVHF-QRHKEKYPHIqMNPYPVPEYLD-NVPTCSG 503
Cdd:cd20908      1 KPWCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHClQVHKETLTKV-PNALPGRDDPEiEIFGMEG 75

                   ....*
gi 1595439315  504 IPYGM 508
Cdd:cd20908     76 IPEGD 80

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1595439315 1135 CQSCGKTFSSASALQIHERTHTgekpFGCTICGRAFTTKGNLKVHM 1180
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45

FOG: Zn-finger [General function prediction only];

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  718 RPFKCKICGRAFTTKGNLKTHFGVHRAKPPlrvqHSC--PICQKKFTNAVVLQQHIRMHMGGQIPNTPLPEGLQEAmdaD 795
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKP----SQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNS---K 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  796 LPFDEKNAETLSSFDDDIDENSMEEDSELKDTASDSSKPLLSYSGSCPPSPPSVISSIAALENQMKMIdsvmncqqlANL 875
Cdd:COG5048    105 ASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLP---------ANS 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  876 KSVENGSGESDRLSNDSSSAVGDLESRSAGSPALSESSSSQALSPAHSNGESFRSKSPGLGHQEDPQEIPLKTERLDSPP 955
Cdd:COG5048    176 LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  956 PGPGNGGALDLTAGHPGrplikeeAPFSLLFLSRERGKCASTVCGVCGKPFACKSALEIHYRS--HTKE--RPFVCTV-- 1029
Cdd:COG5048    256 SASESPRSSLPTASSQS-------SSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYsl 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315 1030 CRRGCSTMGNLKQHLLTHklkelPSQVFDPNFTLGPSHSTPSLASSPAPTMIKMEVNGHSKAIALGEGPALPAGvqvptg 1109
Cdd:COG5048    329 CGKLFSRNDALKRHILLH-----TSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRN------ 397

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1595439315 1110 pqTVMSPGLAPMLAPPPRRTPKQHNCQSCGKTFSSASALQIHERTHTGEKPFGCTICGR 1168
Cdd:COG5048    398 --FKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                           10        20
                   ....*....|....*....|...
gi 1595439315  720 FKCKICGRAFTTKGNLKTHFGVH 742
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                           10        20
                   ....*....|....*....|...
gi 1595439315  455 FKCNICGNRFSTKGNLKVHFQRH 477
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                           10        20
                   ....*....|....*....|...
gi 1595439315 1133 HNCQSCGKTFSSASALQIHERTH 1155
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23

large tegument protein UL36; Provisional

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  242 PGPPLKPSASAPGTASVQLQGLTPHAALQLSAGPATASAGSGstlPAAfdGPQHLSQPASGTSTPCSTSAAP--PDSGAH 319
Cdd:PHA03247  2733 PALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA---PAA--GPPRRLTRPAVASLSESRESLPspWDPADP 2807

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595439315  320 PACSTGPAPGAVAAASSTVGNAVQPQNASTPPALGPGPLLSS---------------------------------ASNLP 366
Cdd:PHA03247  2808 PAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSlplggsvapggdvrrrppsrspaakpaaparppVRRLA 2887

                          170
                   ....*....|....*...
gi 1595439315  367 NPLLPQTSSSSVIFPNPL 384
Cdd:PHA03247  2888 RPAVSRSTESFALPPDQP 2905

C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in fungi, plants and metazoa. It is often found at the C-terminus of HIT-domain-containing proteins, pfam01230. In fungi the fourth ligand is a Glu, in plants it is Cys and in metazoans it is usually a His. The fourth ligand is often mutated in neurogenerative disease-states.

                           10        20
                   ....*....|....*....|....*..
gi 1595439315 1021 KERPFVCTVCRRGCSTMGNLKQHLLTH 1047
Cdd:pfam16278   31 LKTPLKCHRCGNFGNNFPKLKAHLEEH 57

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.

                           10        20
                   ....*....|....*....|...
gi 1595439315  455 FKCNICGNRFSTKGNLKVHFQRH 477
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTH 23

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.

                           10        20
                   ....*....|....*....|....
gi 1595439315 1132 QHNCQSCGKTFSSASALQIHERTH 1155
Cdd:pfam12171    1 QFYCVLCDKYFKSENALQNHLKSK 24