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Conserved domains on  [gi|1402371415|ref|NP_001351340|]
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phosphorylase b kinase regulatory subunit beta isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Bac_rhamnosid6H super family cl46875
Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain; This family consists of bacterial ...
2-411 3.89e-34

Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain; This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.


The actual alignment was detected with superfamily member pfam00723:

Pssm-ID: 481215  Cd Length: 417  Bit Score: 136.42  E-value: 3.89e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415    2 LMYQSPTTGLF---PTKTCGGEEKSKVHESLYCAAGAWALALayrrIDDDKGRTHELEHSAIKCMRGILYCYMRQADKVQ 78
Cdd:pfam00723   16 LLIYGPVTGLViasPSTSLPDYYYTWVRDSALTILALLGLGY----RDEDDAFRYGLETSLAKLMRGYLQAMYRQQGKSE 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415   79 QFKQdpRPTTCLHSVFSVHTGDELLSYEEYGHLQINAVSLFLLYLVEMISSGLQIIYNTDEVsfIQNLVFCVERVYRVPD 158
Cdd:pfam00723   92 PFGE--RESGGLGEPGFNGDGPVRVGNDAWGRLQLDGPALRALALIQYTANGLVIIDTLDEV--VKNLLDYVEAAWNEPD 167
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415  159 FGVWErgskYNNGSTELhsSSVGLAKAALEAINGFNLFGnqgcswsvifvdldahnrnrqtlcsllpresrshntdaall 238
Cdd:pfam00723  168 FGLWE----ENGGRSFF--SSAMMWKALLEAIDFAELFG----------------------------------------- 200
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415  239 pcisypafALDDEALFSQTLDKVIRKLKGKyGFkrflrdgyrtpledpnrryykpaeiklfdgieceFPIFFLYMMIDGV 318
Cdd:pfam00723  201 --------DHGSAQLWESTADEILNKLQKR-GF----------------------------------WPLFNTYIQLYGS 237
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415  319 FrgnleqvkEYQDLLTPLLhqttegyPVVPKYYYVPADfvecekrnpgsqkrfpsncgrdgKLFLWGQALYIIAKLLADE 398
Cdd:pfam00723  238 F--------EYRSGLDASL-------LLLPILGFDPPD-----------------------DPRILATLKYILDSLLSDG 279
                          410
                   ....*....|....
gi 1402371415  399 LISPKDIDP-VQRF 411
Cdd:pfam00723  280 FLNSGESDPlVRRY 293
KPBB_C super family cl44726
Phosphorylase b kinase C-terminal domain; This entry represents the C-terminal domain found in ...
839-1000 6.43e-29

Phosphorylase b kinase C-terminal domain; This entry represents the C-terminal domain found in Phosphorylase b kinase regulatory alpha and beta subunits, which control the catalytic activity of the Phosphorylase kinase catalytic gamma subunit. this domain has been proposed as the second calcineurin B-like (CBL-2) domain containing a gamma subunit-binding site.


The actual alignment was detected with superfamily member pfam19292:

Pssm-ID: 437124  Cd Length: 238  Bit Score: 116.11  E-value: 6.43e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415  839 DLYQLSPSEVKQLLLDIL--------QPQQ------SGRC--------------------WLNRRQIDGSLNRTPPEFYD 884
Cdd:pfam19292   13 ALMSLSPHEIKRRLRQVLadyqgandLLQQqeslhvKGDEgeidwvvfpaaldelgpagdWLQWRQRQGALGRVPDDFYA 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415  885 RVWQILERTPnGIVVAGK-----HLPQQPTLSDMTMYEMNFSLLVEDMLGNIDQPKYRQIIVELLMVVSIVLERNPELEF 959
Cdd:pfam19292   93 GVWDLLHHCK-GLVIGDKlerrnRLDSELLLSEMTPGEKNFALRVEHLLNKIQAPEYRQLTIEALMALAAIFEANPDLQI 171
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1402371415  960 QDKVDLDRL----VKEAFHEFQKDESRLKEIEKQDDMTSFYNTPP 1000
Cdd:pfam19292  172 EDYLVLDVLighaVRLAWLEQHPERADNYDEHKAAAWQAFYQLPP 216
Bac_rhamnosid6H super family cl46875
Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain; This family consists of bacterial ...
692-819 7.02e-09

Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain; This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.


The actual alignment was detected with superfamily member pfam00723:

Pssm-ID: 481215  Cd Length: 417  Bit Score: 59.38  E-value: 7.02e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415  692 EGPNFITMEGTVSDHIERVYRRAGsKKLWSVVRRAASLLNKVVDSlapsitnvlvqgkqvTLGAFGHEEEVISNPLSPRV 771
Cdd:pfam00723  306 GNPWYLCTFWAAEQLYDELYHWAG-RGRWTLTRYARGFFEKLVSS---------------TVGTPYSSSSFISIPLAVKE 369
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1402371415  772 IKNIIYYKCNTHDEREAVIQQELVIHIGWIISNSPELFSGMLKIRIGW 819
Cdd:pfam00723  370 YADGFVKAVEEYANSLGLLSEEVDVYTGEQLGAFPLTFSHAALLRAAL 417
 
Name Accession Description Interval E-value
Glyco_hydro_15 pfam00723
Glycosyl hydrolases family 15; In higher organizms this family is represented by phosphorylase ...
2-411 3.89e-34

Glycosyl hydrolases family 15; In higher organizms this family is represented by phosphorylase kinase subunits.


Pssm-ID: 395586  Cd Length: 417  Bit Score: 136.42  E-value: 3.89e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415    2 LMYQSPTTGLF---PTKTCGGEEKSKVHESLYCAAGAWALALayrrIDDDKGRTHELEHSAIKCMRGILYCYMRQADKVQ 78
Cdd:pfam00723   16 LLIYGPVTGLViasPSTSLPDYYYTWVRDSALTILALLGLGY----RDEDDAFRYGLETSLAKLMRGYLQAMYRQQGKSE 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415   79 QFKQdpRPTTCLHSVFSVHTGDELLSYEEYGHLQINAVSLFLLYLVEMISSGLQIIYNTDEVsfIQNLVFCVERVYRVPD 158
Cdd:pfam00723   92 PFGE--RESGGLGEPGFNGDGPVRVGNDAWGRLQLDGPALRALALIQYTANGLVIIDTLDEV--VKNLLDYVEAAWNEPD 167
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415  159 FGVWErgskYNNGSTELhsSSVGLAKAALEAINGFNLFGnqgcswsvifvdldahnrnrqtlcsllpresrshntdaall 238
Cdd:pfam00723  168 FGLWE----ENGGRSFF--SSAMMWKALLEAIDFAELFG----------------------------------------- 200
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415  239 pcisypafALDDEALFSQTLDKVIRKLKGKyGFkrflrdgyrtpledpnrryykpaeiklfdgieceFPIFFLYMMIDGV 318
Cdd:pfam00723  201 --------DHGSAQLWESTADEILNKLQKR-GF----------------------------------WPLFNTYIQLYGS 237
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415  319 FrgnleqvkEYQDLLTPLLhqttegyPVVPKYYYVPADfvecekrnpgsqkrfpsncgrdgKLFLWGQALYIIAKLLADE 398
Cdd:pfam00723  238 F--------EYRSGLDASL-------LLLPILGFDPPD-----------------------DPRILATLKYILDSLLSDG 279
                          410
                   ....*....|....
gi 1402371415  399 LISPKDIDP-VQRF 411
Cdd:pfam00723  280 FLNSGESDPlVRRY 293
KPBB_C pfam19292
Phosphorylase b kinase C-terminal domain; This entry represents the C-terminal domain found in ...
839-1000 6.43e-29

Phosphorylase b kinase C-terminal domain; This entry represents the C-terminal domain found in Phosphorylase b kinase regulatory alpha and beta subunits, which control the catalytic activity of the Phosphorylase kinase catalytic gamma subunit. this domain has been proposed as the second calcineurin B-like (CBL-2) domain containing a gamma subunit-binding site.


Pssm-ID: 437124  Cd Length: 238  Bit Score: 116.11  E-value: 6.43e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415  839 DLYQLSPSEVKQLLLDIL--------QPQQ------SGRC--------------------WLNRRQIDGSLNRTPPEFYD 884
Cdd:pfam19292   13 ALMSLSPHEIKRRLRQVLadyqgandLLQQqeslhvKGDEgeidwvvfpaaldelgpagdWLQWRQRQGALGRVPDDFYA 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415  885 RVWQILERTPnGIVVAGK-----HLPQQPTLSDMTMYEMNFSLLVEDMLGNIDQPKYRQIIVELLMVVSIVLERNPELEF 959
Cdd:pfam19292   93 GVWDLLHHCK-GLVIGDKlerrnRLDSELLLSEMTPGEKNFALRVEHLLNKIQAPEYRQLTIEALMALAAIFEANPDLQI 171
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1402371415  960 QDKVDLDRL----VKEAFHEFQKDESRLKEIEKQDDMTSFYNTPP 1000
Cdd:pfam19292  172 EDYLVLDVLighaVRLAWLEQHPERADNYDEHKAAAWQAFYQLPP 216
Glyco_hydro_15 pfam00723
Glycosyl hydrolases family 15; In higher organizms this family is represented by phosphorylase ...
692-819 7.02e-09

Glycosyl hydrolases family 15; In higher organizms this family is represented by phosphorylase kinase subunits.


Pssm-ID: 395586  Cd Length: 417  Bit Score: 59.38  E-value: 7.02e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415  692 EGPNFITMEGTVSDHIERVYRRAGsKKLWSVVRRAASLLNKVVDSlapsitnvlvqgkqvTLGAFGHEEEVISNPLSPRV 771
Cdd:pfam00723  306 GNPWYLCTFWAAEQLYDELYHWAG-RGRWTLTRYARGFFEKLVSS---------------TVGTPYSSSSFISIPLAVKE 369
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1402371415  772 IKNIIYYKCNTHDEREAVIQQELVIHIGWIISNSPELFSGMLKIRIGW 819
Cdd:pfam00723  370 YADGFVKAVEEYANSLGLLSEEVDVYTGEQLGAFPLTFSHAALLRAAL 417
 
Name Accession Description Interval E-value
Glyco_hydro_15 pfam00723
Glycosyl hydrolases family 15; In higher organizms this family is represented by phosphorylase ...
2-411 3.89e-34

Glycosyl hydrolases family 15; In higher organizms this family is represented by phosphorylase kinase subunits.


Pssm-ID: 395586  Cd Length: 417  Bit Score: 136.42  E-value: 3.89e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415    2 LMYQSPTTGLF---PTKTCGGEEKSKVHESLYCAAGAWALALayrrIDDDKGRTHELEHSAIKCMRGILYCYMRQADKVQ 78
Cdd:pfam00723   16 LLIYGPVTGLViasPSTSLPDYYYTWVRDSALTILALLGLGY----RDEDDAFRYGLETSLAKLMRGYLQAMYRQQGKSE 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415   79 QFKQdpRPTTCLHSVFSVHTGDELLSYEEYGHLQINAVSLFLLYLVEMISSGLQIIYNTDEVsfIQNLVFCVERVYRVPD 158
Cdd:pfam00723   92 PFGE--RESGGLGEPGFNGDGPVRVGNDAWGRLQLDGPALRALALIQYTANGLVIIDTLDEV--VKNLLDYVEAAWNEPD 167
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415  159 FGVWErgskYNNGSTELhsSSVGLAKAALEAINGFNLFGnqgcswsvifvdldahnrnrqtlcsllpresrshntdaall 238
Cdd:pfam00723  168 FGLWE----ENGGRSFF--SSAMMWKALLEAIDFAELFG----------------------------------------- 200
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415  239 pcisypafALDDEALFSQTLDKVIRKLKGKyGFkrflrdgyrtpledpnrryykpaeiklfdgieceFPIFFLYMMIDGV 318
Cdd:pfam00723  201 --------DHGSAQLWESTADEILNKLQKR-GF----------------------------------WPLFNTYIQLYGS 237
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415  319 FrgnleqvkEYQDLLTPLLhqttegyPVVPKYYYVPADfvecekrnpgsqkrfpsncgrdgKLFLWGQALYIIAKLLADE 398
Cdd:pfam00723  238 F--------EYRSGLDASL-------LLLPILGFDPPD-----------------------DPRILATLKYILDSLLSDG 279
                          410
                   ....*....|....
gi 1402371415  399 LISPKDIDP-VQRF 411
Cdd:pfam00723  280 FLNSGESDPlVRRY 293
KPBB_C pfam19292
Phosphorylase b kinase C-terminal domain; This entry represents the C-terminal domain found in ...
839-1000 6.43e-29

Phosphorylase b kinase C-terminal domain; This entry represents the C-terminal domain found in Phosphorylase b kinase regulatory alpha and beta subunits, which control the catalytic activity of the Phosphorylase kinase catalytic gamma subunit. this domain has been proposed as the second calcineurin B-like (CBL-2) domain containing a gamma subunit-binding site.


Pssm-ID: 437124  Cd Length: 238  Bit Score: 116.11  E-value: 6.43e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415  839 DLYQLSPSEVKQLLLDIL--------QPQQ------SGRC--------------------WLNRRQIDGSLNRTPPEFYD 884
Cdd:pfam19292   13 ALMSLSPHEIKRRLRQVLadyqgandLLQQqeslhvKGDEgeidwvvfpaaldelgpagdWLQWRQRQGALGRVPDDFYA 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415  885 RVWQILERTPnGIVVAGK-----HLPQQPTLSDMTMYEMNFSLLVEDMLGNIDQPKYRQIIVELLMVVSIVLERNPELEF 959
Cdd:pfam19292   93 GVWDLLHHCK-GLVIGDKlerrnRLDSELLLSEMTPGEKNFALRVEHLLNKIQAPEYRQLTIEALMALAAIFEANPDLQI 171
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1402371415  960 QDKVDLDRL----VKEAFHEFQKDESRLKEIEKQDDMTSFYNTPP 1000
Cdd:pfam19292  172 EDYLVLDVLighaVRLAWLEQHPERADNYDEHKAAAWQAFYQLPP 216
Glyco_hydro_15 pfam00723
Glycosyl hydrolases family 15; In higher organizms this family is represented by phosphorylase ...
692-819 7.02e-09

Glycosyl hydrolases family 15; In higher organizms this family is represented by phosphorylase kinase subunits.


Pssm-ID: 395586  Cd Length: 417  Bit Score: 59.38  E-value: 7.02e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402371415  692 EGPNFITMEGTVSDHIERVYRRAGsKKLWSVVRRAASLLNKVVDSlapsitnvlvqgkqvTLGAFGHEEEVISNPLSPRV 771
Cdd:pfam00723  306 GNPWYLCTFWAAEQLYDELYHWAG-RGRWTLTRYARGFFEKLVSS---------------TVGTPYSSSSFISIPLAVKE 369
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1402371415  772 IKNIIYYKCNTHDEREAVIQQELVIHIGWIISNSPELFSGMLKIRIGW 819
Cdd:pfam00723  370 YADGFVKAVEEYANSLGLLSEEVDVYTGEQLGAFPLTFSHAALLRAAL 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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