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Conserved domains on  [gi|1386806224|ref|NP_001349919|]
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plakophilin-4 isoform 3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 556-595 5.36e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 52.84  E-value: 5.36e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1386806224  556 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLV 595
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 862-897 4.35e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 4.35e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1386806224   862 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 897
Cdd:smart00185    5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 600-641 4.57e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 4.57e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1386806224   600 TDENKIAMKNVGGIPALLRLLRKSiDAEVRELVTGVLWNLSS 641
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 72-380 1.44e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.30  E-value: 1.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224   72 GAESPSIASTSSTE-------KSFPWRSTDVPNPGVSKPR-----VSDTihpnnylirTEPEQGTlysPEQTSLHERSLG 139
Cdd:pfam03154   43 GRNSPSAASTSSNDskaesmkKSSKKIKEEAPSPLKSAKRqrekgASDT---------EEPERAT---AKKSKTQEISRP 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  140 NSRSSTQMNSYSDSGYQEAGSfHNSQTVNKADSRQHPFTGS-TSNHVVRTSRAEGQTL-VQPSVANRAMRRVSSVPSRAQ 217
Cdd:pfam03154  111 NSPSEGEGESSDGRSVNDEGS-SDPKDIDQDNRSTSPSIPSpQDNESDSDSSAQQQILqTQPPVLQAQSGAASPPSPPPP 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  218 SPSYVTSTGVSPSRGSLRTSLGSGFGSPSVTDSRPLNPSAY--SSSTLPAQRAASPYSQ-RPASPTAVRRVGSVTSRQTS 294
Cdd:pfam03154  190 GTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLiqQTPTLHPQRLPSPHPPlQPMTQPPPPSQVSPQPLPQP 269

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  295 NPNGPVPQYQTTTRVGSPLTLTDAQTR----VASPSQGQVG-SSSPKRSGMTAVPQHLGPSLQRTvhdmdqfgQQQYDIY 369
Cdd:pfam03154  270 SLHGQMPPMPHSLQTGPSHMQHPVPPQpfplTPQSSQSQVPpGPSPAAPGQSQQRIHTPPSQSQL--------QSQQPPR 341

                          330
                   ....*....|.
gi 1386806224  370 ERMVPPRPDSL 380
Cdd:pfam03154  342 EQPLPPAPLSM 352
PLN03200 super family cl33659
cellulose synthase-interactive protein; Provisional
 845-966 1.17e-03

cellulose synthase-interactive protein; Provisional


The actual alignment was detected with superfamily member PLN03200:

Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 43.55  E-value: 1.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  845 GSLQNLSA---GNWkfAAYIRAAvrkekGLPILVELLRMDNDRVVSSVATALRNMAL---DVRNKeLIGKYAMRDLVNRL 918
Cdd:PLN03200   169 GALRNLCGstdGFW--SATLEAG-----GVDILVKLLSSGNSDAQANAASLLARLMMafeSSISK-VLDAGAVKQLLKLL 240

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1386806224  919 PGGNGPSILsdetvAAICCALHEVTSKNMENAKALADSGGIEKLVNIT 966
Cdd:PLN03200   241 GQGNEVSVR-----AEAAGALEALSSQSKEAKQAIADAGGIPALINAT 283
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 946-990 3.70e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 3.70e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1386806224   946 NMENAKALADSGGIEKLVNITKgrgdRSSLKVVKAAAQVLNTLWQ 990
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLSS 41
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 556-595 5.36e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 52.84  E-value: 5.36e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1386806224  556 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLV 595
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 556-596 7.92e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.43  E-value: 7.92e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1386806224   556 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLVF 596
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 862-897 4.35e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 4.35e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1386806224   862 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 897
Cdd:smart00185    5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 600-641 4.57e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 4.57e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1386806224   600 TDENKIAMKNVGGIPALLRLLRKSiDAEVRELVTGVLWNLSS 641
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 600-641 2.13e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.52  E-value: 2.13e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1386806224  600 TDENKIAMKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSS 641
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 72-380 1.44e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.30  E-value: 1.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224   72 GAESPSIASTSSTE-------KSFPWRSTDVPNPGVSKPR-----VSDTihpnnylirTEPEQGTlysPEQTSLHERSLG 139
Cdd:pfam03154   43 GRNSPSAASTSSNDskaesmkKSSKKIKEEAPSPLKSAKRqrekgASDT---------EEPERAT---AKKSKTQEISRP 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  140 NSRSSTQMNSYSDSGYQEAGSfHNSQTVNKADSRQHPFTGS-TSNHVVRTSRAEGQTL-VQPSVANRAMRRVSSVPSRAQ 217
Cdd:pfam03154  111 NSPSEGEGESSDGRSVNDEGS-SDPKDIDQDNRSTSPSIPSpQDNESDSDSSAQQQILqTQPPVLQAQSGAASPPSPPPP 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  218 SPSYVTSTGVSPSRGSLRTSLGSGFGSPSVTDSRPLNPSAY--SSSTLPAQRAASPYSQ-RPASPTAVRRVGSVTSRQTS 294
Cdd:pfam03154  190 GTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLiqQTPTLHPQRLPSPHPPlQPMTQPPPPSQVSPQPLPQP 269

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  295 NPNGPVPQYQTTTRVGSPLTLTDAQTR----VASPSQGQVG-SSSPKRSGMTAVPQHLGPSLQRTvhdmdqfgQQQYDIY 369
Cdd:pfam03154  270 SLHGQMPPMPHSLQTGPSHMQHPVPPQpfplTPQSSQSQVPpGPSPAAPGQSQQRIHTPPSQSQL--------QSQQPPR 341

                          330
                   ....*....|.
gi 1386806224  370 ERMVPPRPDSL 380
Cdd:pfam03154  342 EQPLPPAPLSM 352
HEAT COG1413
HEAT repeat [General function prediction only];
523-645 1.98e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.69  E-value: 1.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  523 RDPE-LPEVIHMLQHQFPSVQANAAAYLQHLcfGDNKVkmevyrlggIKHLVDLLDHRVLEVQKNACGALRNLvfgkstd 601
Cdd:COG1413     13 GDPAaVPALIAALADEDPDVRAAAARALGRL--GDPRA---------VPALLEALKDPDPEVRAAAAEALGRI------- 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1386806224  602 enkiamKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSSCDAV 645
Cdd:COG1413     75 ------GDPEAVPALIAAL-KDEDPEVRRAAAEALGRLGDPAAV 111
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 862-897 2.55e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 2.55e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1386806224  862 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 897
Cdd:pfam00514    5 KQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 845-966 1.17e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 43.55  E-value: 1.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  845 GSLQNLSA---GNWkfAAYIRAAvrkekGLPILVELLRMDNDRVVSSVATALRNMAL---DVRNKeLIGKYAMRDLVNRL 918
Cdd:PLN03200   169 GALRNLCGstdGFW--SATLEAG-----GVDILVKLLSSGNSDAQANAASLLARLMMafeSSISK-VLDAGAVKQLLKLL 240

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1386806224  919 PGGNGPSILsdetvAAICCALHEVTSKNMENAKALADSGGIEKLVNIT 966
Cdd:PLN03200   241 GQGNEVSVR-----AEAAGALEALSSQSKEAKQAIADAGGIPALINAT 283
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 218-375 1.57e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 42.61  E-value: 1.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  218 SPSYVTSTGVSPSRGSLRTSlgsgfgspSVTDSRPLNPSAYSSSTLPA----------QRAASPY----------SQRPA 277
Cdd:PLN03209   385 SPIPTPPSSSPASSKSVDAV--------AKPAEPDVVPSPGSASNVPEvepaqveakkTRPLSPYaryedlkpptSPSPT 456

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  278 SPTAVRRVGSVTSRQTSNPNGPVPQYQTTT--------RVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGP 349
Cdd:PLN03209   457 APTGVSPSVSSTSSVPAVPDTAPATAATDAaapppanmRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSA 536

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1386806224  350 SLQRTVHDMDQFGQQQ-----YDIYERMVPP 375
Cdd:PLN03209   537 PPTALADEQHHAQPKPrplspYTMYEDLKPP 567
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 946-990 3.70e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 3.70e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1386806224   946 NMENAKALADSGGIEKLVNITKgrgdRSSLKVVKAAAQVLNTLWQ 990
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 527-641 6.23e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.86  E-value: 6.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  527 LPEVIHMLQHQFPSVQANAAAYLQHLCfGDNKVKMEVYrLGG-IKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDEnkI 605
Cdd:PLN03200    60 MPLLVSLLRSGTLGAKVNAAAVLGVLC-KEEDLRVKVL-LGGcIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDH--V 135

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1386806224  606 AMK---NVGGIPALLRLL--RKSIDAEVRELVTGVLWNLSS 641
Cdd:PLN03200   136 GSKifsTEGVVPSLWDQLqpGNKQDKVVEGLLTGALRNLCG 176
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 556-595 5.36e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 52.84  E-value: 5.36e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1386806224  556 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLV 595
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 556-596 7.92e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.43  E-value: 7.92e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1386806224   556 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLVF 596
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 862-897 4.35e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 4.35e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1386806224   862 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 897
Cdd:smart00185    5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 600-641 4.57e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 4.57e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1386806224   600 TDENKIAMKNVGGIPALLRLLRKSiDAEVRELVTGVLWNLSS 641
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 600-641 2.13e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.52  E-value: 2.13e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1386806224  600 TDENKIAMKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSS 641
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 72-380 1.44e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.30  E-value: 1.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224   72 GAESPSIASTSSTE-------KSFPWRSTDVPNPGVSKPR-----VSDTihpnnylirTEPEQGTlysPEQTSLHERSLG 139
Cdd:pfam03154   43 GRNSPSAASTSSNDskaesmkKSSKKIKEEAPSPLKSAKRqrekgASDT---------EEPERAT---AKKSKTQEISRP 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  140 NSRSSTQMNSYSDSGYQEAGSfHNSQTVNKADSRQHPFTGS-TSNHVVRTSRAEGQTL-VQPSVANRAMRRVSSVPSRAQ 217
Cdd:pfam03154  111 NSPSEGEGESSDGRSVNDEGS-SDPKDIDQDNRSTSPSIPSpQDNESDSDSSAQQQILqTQPPVLQAQSGAASPPSPPPP 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  218 SPSYVTSTGVSPSRGSLRTSLGSGFGSPSVTDSRPLNPSAY--SSSTLPAQRAASPYSQ-RPASPTAVRRVGSVTSRQTS 294
Cdd:pfam03154  190 GTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLiqQTPTLHPQRLPSPHPPlQPMTQPPPPSQVSPQPLPQP 269

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  295 NPNGPVPQYQTTTRVGSPLTLTDAQTR----VASPSQGQVG-SSSPKRSGMTAVPQHLGPSLQRTvhdmdqfgQQQYDIY 369
Cdd:pfam03154  270 SLHGQMPPMPHSLQTGPSHMQHPVPPQpfplTPQSSQSQVPpGPSPAAPGQSQQRIHTPPSQSQL--------QSQQPPR 341

                          330
                   ....*....|.
gi 1386806224  370 ERMVPPRPDSL 380
Cdd:pfam03154  342 EQPLPPAPLSM 352
HEAT COG1413
HEAT repeat [General function prediction only];
523-645 1.98e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.69  E-value: 1.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  523 RDPE-LPEVIHMLQHQFPSVQANAAAYLQHLcfGDNKVkmevyrlggIKHLVDLLDHRVLEVQKNACGALRNLvfgkstd 601
Cdd:COG1413     13 GDPAaVPALIAALADEDPDVRAAAARALGRL--GDPRA---------VPALLEALKDPDPEVRAAAAEALGRI------- 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1386806224  602 enkiamKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSSCDAV 645
Cdd:COG1413     75 ------GDPEAVPALIAAL-KDEDPEVRRAAAEALGRLGDPAAV 111
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 862-897 2.55e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 2.55e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1386806224  862 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 897
Cdd:pfam00514    5 KQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 845-966 1.17e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 43.55  E-value: 1.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  845 GSLQNLSA---GNWkfAAYIRAAvrkekGLPILVELLRMDNDRVVSSVATALRNMAL---DVRNKeLIGKYAMRDLVNRL 918
Cdd:PLN03200   169 GALRNLCGstdGFW--SATLEAG-----GVDILVKLLSSGNSDAQANAASLLARLMMafeSSISK-VLDAGAVKQLLKLL 240

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1386806224  919 PGGNGPSILsdetvAAICCALHEVTSKNMENAKALADSGGIEKLVNIT 966
Cdd:PLN03200   241 GQGNEVSVR-----AEAAGALEALSSQSKEAKQAIADAGGIPALINAT 283
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 71-355 1.45e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 42.64  E-value: 1.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224   71 LGAESPSIASTSSTEKSFPWRSTDVPNPgVSKPRVSDTIHPNNYLIRTE-PEQGTLYSPEQTSLHERSLGNSRSSTQMNS 149
Cdd:pfam17823   42 ASGDAVPRADNKSSEQ*NFCAATAAPAP-VTLTKGTSAAHLNSTEVTAEhTPHGTDLSEPATREGAADGAASRALAAAAS 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  150 YSDSGYQEAGSFHNSQTVNKADSRqhPFTGSTSNHVVRTSRAEGQTLVQPSVANRAMRRVSSVPSRAQSPSYVTStgvSP 229
Cdd:pfam17823  121 SSPSSAAQSLPAAIAALPSEAFSA--PRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASS---AP 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  230 SRGSLRTSlgsgfgsPSVTDSRPLNPSAYSSSTlPAqrAASPYSQRPASPTAVRRVGSVTSRQTSNPNGPVPQY-QTTTR 308
Cdd:pfam17823  196 TTAASSAP-------ATLTPARGISTAATATGH-PA--AGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAaGTVAS 265

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1386806224  309 VGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGPSLQRTV 355
Cdd:pfam17823  266 AAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVST 312
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 218-375 1.57e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 42.61  E-value: 1.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  218 SPSYVTSTGVSPSRGSLRTSlgsgfgspSVTDSRPLNPSAYSSSTLPA----------QRAASPY----------SQRPA 277
Cdd:PLN03209   385 SPIPTPPSSSPASSKSVDAV--------AKPAEPDVVPSPGSASNVPEvepaqveakkTRPLSPYaryedlkpptSPSPT 456

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  278 SPTAVRRVGSVTSRQTSNPNGPVPQYQTTT--------RVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGP 349
Cdd:PLN03209   457 APTGVSPSVSSTSSVPAVPDTAPATAATDAaapppanmRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSA 536

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1386806224  350 SLQRTVHDMDQFGQQQ-----YDIYERMVPP 375
Cdd:PLN03209   537 PPTALADEQHHAQPKPrplspYTMYEDLKPP 567
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 946-990 3.70e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 3.70e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1386806224   946 NMENAKALADSGGIEKLVNITKgrgdRSSLKVVKAAAQVLNTLWQ 990
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 527-641 6.23e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.86  E-value: 6.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806224  527 LPEVIHMLQHQFPSVQANAAAYLQHLCfGDNKVKMEVYrLGG-IKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDEnkI 605
Cdd:PLN03200    60 MPLLVSLLRSGTLGAKVNAAAVLGVLC-KEEDLRVKVL-LGGcIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDH--V 135

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1386806224  606 AMK---NVGGIPALLRLL--RKSIDAEVRELVTGVLWNLSS 641
Cdd:PLN03200   136 GSKifsTEGVVPSLWDQLqpGNKQDKVVEGLLTGALRNLCG 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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