NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1386806305|ref|NP_001349906|]
View 

DENN domain-containing protein 1A isoform 3 precursor [Mus musculus]

Protein Classification

DENN domain-containing protein( domain architecture ID 10264016)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  3.30.450.200|3.40.50.11500
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  21330364|11563850
SCOP:  4007417|4006687

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 63-241 4.32e-63

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214823  Cd Length: 183  Bit Score: 211.29  E-value: 4.32e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305   63 SCFCILSYLPWFEVFYKLLNILADYTTKRQESQwNELLETLHRLPIPDPG-----VSVHLSVHSYFTVPDSRELPSIPen 137
Cdd:smart00799   3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  138 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 217
Cdd:smart00799  80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                          170       180
                   ....*....|....*....|....
gi 1386806305  218 HLSLMEKVRNMALDDVVILNVDTN 241
Cdd:smart00799 160 HSSYFEEVKELPDEDVVVVDLDTG 183
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 273-339 1.78e-16

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 74.63  E-value: 1.78e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  273 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGR 339
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 617-943 2.12e-14

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 78.44  E-value: 2.12e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  617 PSKPSITSPEKPSAllGTSPAlPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAG 696
Cdd:PHA03247  2616 PLPPDTHAPDPPPP--SPSPA-ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV 2692

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  697 GPLGDFSSEPLQ--MDRERQAALSPALLSGLLPRAVPQG---PTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTI 771
Cdd:PHA03247  2693 GSLTSLADPPPPppTPEPAPHALVSATPLPPGPAAARQAspaLPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP 2772

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  772 PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPfVPSVPVVPPSMPLSSTPARPFGTPPASL--GPAYAPSIL---LS 846
Cdd:PHA03247  2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP-PAAVLAPAAALPPAASPAGPLPPPTSAQptAPPPPPGPPppsLP 2851

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  847 SSGFYAP----HRSQPNLSALSMPNLFGQIPMG-----AHTSPLQPLGPPAVAPSRIRTLPLARSSARAAEAKQglALRP 917
Cdd:PHA03247  2852 LGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRrlarpAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP--PPQP 2929

                          330       340
                   ....*....|....*....|....*.
gi 1386806305  918 GESPLLPPRPPQSLQPTPQPSVPTQA 943
Cdd:PHA03247  2930 QPPPPPPPRPQPPLAPTTDPAGAGEP 2955
uDENN super family cl04085
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 26-59 6.30e-09

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


The actual alignment was detected with superfamily member smart00800:

Pssm-ID: 470944  Cd Length: 89  Bit Score: 53.88  E-value: 6.30e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1386806305   26 TVTSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 59
Cdd:smart00800  56 DFVTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 63-241 4.32e-63

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 211.29  E-value: 4.32e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305   63 SCFCILSYLPWFEVFYKLLNILADYTTKRQESQwNELLETLHRLPIPDPG-----VSVHLSVHSYFTVPDSRELPSIPen 137
Cdd:smart00799   3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  138 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 217
Cdd:smart00799  80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                          170       180
                   ....*....|....*....|....
gi 1386806305  218 HLSLMEKVRNMALDDVVILNVDTN 241
Cdd:smart00799 160 HSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 64-241 5.16e-44

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 157.73  E-value: 5.16e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  64 CFCILSYLPWFEVFYKLLNILAdytTKRQESQWNELLET-----LHRLPIPDPGVSVHLSVHS-----YFTVPDSRELPS 133
Cdd:pfam02141   5 AYCIISRLPFFNLFKKFLDELY---RRRTISPLPNPIERfianlLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 134 ipENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPY 213
Cdd:pfam02141  82 --EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159

                         170       180
                  ....*....|....*....|....*...
gi 1386806305 214 LIGIHLSLMEKVRNmALDDVVILNVDTN 241
Cdd:pfam02141 160 IIGVHSRYFDLLED-PLDDVVLVDLDTG 186
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 273-339 1.78e-16

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 74.63  E-value: 1.78e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  273 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGR 339
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
PHA03247 PHA03247
large tegument protein UL36; Provisional
 617-943 2.12e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 78.44  E-value: 2.12e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  617 PSKPSITSPEKPSAllGTSPAlPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAG 696
Cdd:PHA03247  2616 PLPPDTHAPDPPPP--SPSPA-ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV 2692

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  697 GPLGDFSSEPLQ--MDRERQAALSPALLSGLLPRAVPQG---PTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTI 771
Cdd:PHA03247  2693 GSLTSLADPPPPppTPEPAPHALVSATPLPPGPAAARQAspaLPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP 2772

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  772 PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPfVPSVPVVPPSMPLSSTPARPFGTPPASL--GPAYAPSIL---LS 846
Cdd:PHA03247  2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP-PAAVLAPAAALPPAASPAGPLPPPTSAQptAPPPPPGPPppsLP 2851

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  847 SSGFYAP----HRSQPNLSALSMPNLFGQIPMG-----AHTSPLQPLGPPAVAPSRIRTLPLARSSARAAEAKQglALRP 917
Cdd:PHA03247  2852 LGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRrlarpAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP--PPQP 2929

                          330       340
                   ....*....|....*....|....*.
gi 1386806305  918 GESPLLPPRPPQSLQPTPQPSVPTQA 943
Cdd:PHA03247  2930 QPPPPPPPRPQPPLAPTTDPAGAGEP 2955
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 26-59 6.30e-09

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 53.88  E-value: 6.30e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1386806305   26 TVTSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 59
Cdd:smart00800  56 DFVTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 305-356 5.14e-07

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 47.19  E-value: 5.14e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1386806305 305 FSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGRLDllnSGEGFSDVFEEE 356
Cdd:pfam03455   1 FDKEAFLKS-LPSDSRPFLSQFLETQMFNEFIEERLE---SSDPSIDLFDEE 48
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 618-947 1.97e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 52.08  E-value: 1.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 618 SKPSITSPEK------PSALLGTSPALPLRPQNQEGILSPSikeETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAK 691
Cdd:pfam03154 144 TSPSIPSPQDnesdsdSSAQQQILQTQPPVLQAQSGAASPP---SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQ 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 692 LQAAGGPLGDFSSEPlQMDRERQAALSPALLSGLLPRAVPQGPTELLQPPS------PAPGAAGTGsdallalldplnta 765
Cdd:pfam03154 221 TQSTAAPHTLIQQTP-TLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgqmpPMPHSLQTG-------------- 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 766 wsgstiPSHPATPSAATPF-IPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAYA---- 840
Cdd:pfam03154 286 ------PSHMQHPVPPQPFpLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIkppp 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 841 ----PSILLSSSGFYAPHRSQPnlSALSMPNLFGQIPMGAHTSPLQPLGPPAVAPSRIRTLPLARSSARAAEAKQGLAlr 916
Cdd:pfam03154 360 ttpiPQLPNPQSHKHPPHLSGP--SPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLT-- 435

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1386806305 917 pgESPLLPprPPQSLQPTPQPSVPTQARDPF 947
Cdd:pfam03154 436 --QSQSLP--PPAASHPPTSGLHQVPSQSPF 462
PPE COG5651
PPE-repeat protein [Function unknown];
683-893 3.51e-05

PPE-repeat protein [Function unknown];


Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 47.20  E-value: 3.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 683 PPPTARPAKLQAAGGPLGDFSSEPLQMD---RERQAALSPALLSGLLPRAVPQGPTELLQPPSPApGAAGTGSDALLALL 759
Cdd:COG5651   165 TPFTQPPPTITNPGGLLGAQNAGSGNTSsnpGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNT-GFAGTGAAAGAAAA 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 760 DPLNTAWSGSTIPSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMP----LSSTPARPFGTPPASL 835
Cdd:COG5651   244 AAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAaatgLGLGAGGAAGAAGATG 323

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1386806305 836 GPAYAPSILLSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPLGPPAVAPSR 893
Cdd:COG5651   324 AGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGG 381
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 31-57 4.84e-03

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 36.43  E-value: 4.84e-03
                          10        20
                  ....*....|....*....|....*..
gi 1386806305  31 TVSQVGQNFTFVLTDIDSKQRFGFCRL 57
Cdd:pfam03456  33 LSSREPTFFSFVLTDEDGSRLYGACLT 59
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 63-241 4.32e-63

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 211.29  E-value: 4.32e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305   63 SCFCILSYLPWFEVFYKLLNILADYTTKRQESQwNELLETLHRLPIPDPG-----VSVHLSVHSYFTVPDSRELPSIPen 137
Cdd:smart00799   3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  138 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 217
Cdd:smart00799  80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                          170       180
                   ....*....|....*....|....
gi 1386806305  218 HLSLMEKVRNMALDDVVILNVDTN 241
Cdd:smart00799 160 HSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 64-241 5.16e-44

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 157.73  E-value: 5.16e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  64 CFCILSYLPWFEVFYKLLNILAdytTKRQESQWNELLET-----LHRLPIPDPGVSVHLSVHS-----YFTVPDSRELPS 133
Cdd:pfam02141   5 AYCIISRLPFFNLFKKFLDELY---RRRTISPLPNPIERfianlLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 134 ipENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPY 213
Cdd:pfam02141  82 --EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159

                         170       180
                  ....*....|....*....|....*...
gi 1386806305 214 LIGIHLSLMEKVRNmALDDVVILNVDTN 241
Cdd:pfam02141 160 IIGVHSRYFDLLED-PLDDVVLVDLDTG 186
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 273-339 1.78e-16

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 74.63  E-value: 1.78e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  273 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGR 339
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
PHA03247 PHA03247
large tegument protein UL36; Provisional
 617-943 2.12e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 78.44  E-value: 2.12e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  617 PSKPSITSPEKPSAllGTSPAlPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAG 696
Cdd:PHA03247  2616 PLPPDTHAPDPPPP--SPSPA-ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV 2692

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  697 GPLGDFSSEPLQ--MDRERQAALSPALLSGLLPRAVPQG---PTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTI 771
Cdd:PHA03247  2693 GSLTSLADPPPPppTPEPAPHALVSATPLPPGPAAARQAspaLPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP 2772

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  772 PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPfVPSVPVVPPSMPLSSTPARPFGTPPASL--GPAYAPSIL---LS 846
Cdd:PHA03247  2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP-PAAVLAPAAALPPAASPAGPLPPPTSAQptAPPPPPGPPppsLP 2851

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  847 SSGFYAP----HRSQPNLSALSMPNLFGQIPMG-----AHTSPLQPLGPPAVAPSRIRTLPLARSSARAAEAKQglALRP 917
Cdd:PHA03247  2852 LGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRrlarpAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP--PPQP 2929

                          330       340
                   ....*....|....*....|....*.
gi 1386806305  918 GESPLLPPRPPQSLQPTPQPSVPTQA 943
Cdd:PHA03247  2930 QPPPPPPPRPQPPLAPTTDPAGAGEP 2955
PHA03247 PHA03247
large tegument protein UL36; Provisional
 617-942 6.08e-13

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 73.43  E-value: 6.08e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  617 PSKPSITSPE-KPSAllgtsPALPLRPQnqegilspsikeeTPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAA 695
Cdd:PHA03247  2577 PSEPAVTSRArRPDA-----PPQSARPR-------------APVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP 2638

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  696 GGPLGDFSSEPLQMD------RERQAALSPALLSGLLPRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAW-SG 768
Cdd:PHA03247  2639 DPHPPPTVPPPERPRddpapgRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALvSA 2718

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  769 STIPSHPATPSAATPFIPQLSFPPTVTPTPfvQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAYAPSILLSSS 848
Cdd:PHA03247  2719 TPLPPGPAAARQASPALPAAPAPPAVPAGP--ATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  849 GFYAPHRSQPNLSALSMPNlfgqIPMGAHTSPLQPLGPPavaPSRIRTLPLARSSARAAEAKQGLALRPG---------- 918
Cdd:PHA03247  2797 SLPSPWDPADPPAAVLAPA----AALPPAASPAGPLPPP---TSAQPTAPPPPPGPPPPSLPLGGSVAPGgdvrrrppsr 2869

                          330       340
                   ....*....|....*....|....*..
gi 1386806305  919 ---ESPLLPPRPPQSLQPTPQPSVPTQ 942
Cdd:PHA03247  2870 spaAKPAAPARPPVRRLARPAVSRSTE 2896
PHA03247 PHA03247
large tegument protein UL36; Provisional
 434-944 1.36e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 72.28  E-value: 1.36e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  434 PLPKTMPSPQAETQDPrlredrrpitvhfgqvrPPRPhvVRRPkSNITVEGRRTSVSSPEQPQPYRTlkesdsaEGDETE 513
Cdd:PHA03247  2554 PLPPAAPPAAPDRSVP-----------------PPRP--APRP-SEPAVTSRARRPDAPPQSARPRA-------PVDDRG 2606

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  514 SPeqlvREPWGPTPAPPDRAASidlleDVFSSLDVEAPLQPLGQAKSLEDLRAPKDLREQPGSFDYQRlDLCRSERGLSM 593
Cdd:PHA03247  2607 DP----RGPAPPSPLPPDTHAP-----DPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPR-RARRLGRAAQA 2676

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  594 AAALKLAHPYTKLWSLGQ-DDMAIPSKPSITSPEKPSAllgTSPALPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQG 672
Cdd:PHA03247  2677 SSPPQRPRRRAARPTVGSlTSLADPPPPPPTPEPAPHA---LVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG 2753

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  673 RKTPElgivPPPPTARPAKLQAAGGPLGdfsSEPLQMDRERQAALSPALLSGLLPRAvPQGPTELLQPPSPAPGAAGTGS 752
Cdd:PHA03247  2754 PARPA----RPPTTAGPPAPAPPAAPAA---GPPRRLTRPAVASLSESRESLPSPWD-PADPPAAVLAPAAALPPAASPA 2825

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  753 DALLALLDPLNTAWSGSTIPSHPATP--SAATPFIPQLSFPPTVTPTPFVQTPLNPfvpsvPVVPPSMPLSSTPARPFGT 830
Cdd:PHA03247  2826 GPLPPPTSAQPTAPPPPPGPPPPSLPlgGSVAPGGDVRRRPPSRSPAAKPAAPARP-----PVRRLARPAVSRSTESFAL 2900

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  831 PPASLGPAYAPSIllsssgfYAPHRSQPNLSALSMPNLFGQIPmGAHTSPLQPLGPPAVAPSRIRTLPlarssaraaeAK 910
Cdd:PHA03247  2901 PPDQPERPPQPQA-------PPPPQPQPQPPPPPQPQPPPPPP-PRPQPPLAPTTDPAGAGEPSGAVP----------QP 2962

                          490       500       510
                   ....*....|....*....|....*....|....
gi 1386806305  911 QGLALRPGESPLLPPRPPQSLQPTPQPSVPTQAR 944
Cdd:PHA03247  2963 WLGALVPGRVAVPRFRVPQPAPSREAPASSTPPL 2996
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 26-59 6.30e-09

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 53.88  E-value: 6.30e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1386806305   26 TVTSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 59
Cdd:smart00800  56 DFVTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
PHA03247 PHA03247
large tegument protein UL36; Provisional
 429-798 2.18e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.33  E-value: 2.18e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  429 SSAEDPLPKTMPSPQAETQDPRLREDRRPITVHFGQVRPPRPHV------VRRPKsNITVEGRRTSVSSPEQPQPYRTLK 502
Cdd:PHA03247  2611 PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDdpapgrVSRPR-RARRLGRAAQASSPPQRPRRRAAR 2689

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  503 E-----SDSAEGDETESPEQLVREPWGP-TPAPP----DRAASIDLLEDVFSSLDVEAPLQPLGQAKsledlRAPKDLRE 572
Cdd:PHA03247  2690 PtvgslTSLADPPPPPPTPEPAPHALVSaTPLPPgpaaARQASPALPAAPAPPAVPAGPATPGGPAR-----PARPPTTA 2764

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  573 QPGSFDYQRLDLCRSERGLSMAAALKLAHPYTKL---WSLGQDDMAIPSK-PSITSPEKPSALLGTSP-ALPLRPQNQEG 647
Cdd:PHA03247  2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLpspWDPADPPAAVLAPaAALPPAASPAGPLPPPTsAQPTAPPPPPG 2844

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  648 ILSPSIKEETPIpTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAGGPLGDFSSEPLQMDRERQ-AALSPALLSGLL 726
Cdd:PHA03247  2845 PPPPSLPLGGSV-APGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQpQAPPPPQPQPQP 2923

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1386806305  727 PRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTIPSHPATPSAATPfIPQLSFPPTVTPTP 798
Cdd:PHA03247  2924 PPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVP-QPAPSREAPASSTP 2994
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 305-356 5.14e-07

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 47.19  E-value: 5.14e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1386806305 305 FSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGRLDllnSGEGFSDVFEEE 356
Cdd:pfam03455   1 FDKEAFLKS-LPSDSRPFLSQFLETQMFNEFIEERLE---SSDPSIDLFDEE 48
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 618-947 1.97e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 52.08  E-value: 1.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 618 SKPSITSPEK------PSALLGTSPALPLRPQNQEGILSPSikeETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAK 691
Cdd:pfam03154 144 TSPSIPSPQDnesdsdSSAQQQILQTQPPVLQAQSGAASPP---SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQ 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 692 LQAAGGPLGDFSSEPlQMDRERQAALSPALLSGLLPRAVPQGPTELLQPPS------PAPGAAGTGsdallalldplnta 765
Cdd:pfam03154 221 TQSTAAPHTLIQQTP-TLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgqmpPMPHSLQTG-------------- 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 766 wsgstiPSHPATPSAATPF-IPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAYA---- 840
Cdd:pfam03154 286 ------PSHMQHPVPPQPFpLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIkppp 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 841 ----PSILLSSSGFYAPHRSQPnlSALSMPNLFGQIPMGAHTSPLQPLGPPAVAPSRIRTLPLARSSARAAEAKQGLAlr 916
Cdd:pfam03154 360 ttpiPQLPNPQSHKHPPHLSGP--SPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLT-- 435

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1386806305 917 pgESPLLPprPPQSLQPTPQPSVPTQARDPF 947
Cdd:pfam03154 436 --QSQSLP--PPAASHPPTSGLHQVPSQSPF 462
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 616-939 5.56e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.54  E-value: 5.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 616 IPSKPSITSPEKPSALLGTSPALPLRPQNQEGILS-PSIKEETPIPTPGSITIPRPQGRKTPelgiVPPPPTARPAKLQA 694
Cdd:pfam03154 231 IQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPlPQPSLHGQMPPMPHSLQTGPSHMQHP----VPPQPFPLTPQSSQ 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 695 AGGPLGDFSSEPLQM-DRERQAALSPALLSGLLPRAVPQGPTEL----LQPP--SPAPGAAGTGSDallalldplntaws 767
Cdd:pfam03154 307 SQVPPGPSPAAPGQSqQRIHTPPSQSQLQSQQPPREQPLPPAPLsmphIKPPptTPIPQLPNPQSH-------------- 372

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 768 gstipSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMP----LSSTPARPFG-------TPPASLG 836
Cdd:pfam03154 373 -----KHPPHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPqsqqLPPPPAQPPVltqsqslPPPAASH 447

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 837 PAYAPSILLSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPlgPPAVAPSRIRTLPLARSSARAAEAKQGLALR 916
Cdd:pfam03154 448 PPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQP--PSSASVSSSGPVPAAVSCPLPPVQIKEEALD 525

                         330       340
                  ....*....|....*....|...
gi 1386806305 917 PGESPLLPPRPPQSlqPTPQPSV 939
Cdd:pfam03154 526 EAEEPESPPPPPRS--PSPEPTV 546
PHA03247 PHA03247
large tegument protein UL36; Provisional
 608-951 5.61e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 5.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  608 SLGQDDMAIPSKPSITSPekpSALLGTSPALPLRPQNQEGI--LSPSIKEETPIPTPGSITIPRPqgrKTPELGIVPPPP 685
Cdd:PHA03247  2500 GGGPPDPDAPPAPSRLAP---AILPDEPVGEPVHPRMLTWIrgLEELASDDAGDPPPPLPPAAPP---AAPDRSVPPPRP 2573

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  686 TARPaklqaaggplgdfsSEPLQMDRERQAALSPALLSGLLPRAVPQGP------------TELLQPPSPAPGAAGT--- 750
Cdd:PHA03247  2574 APRP--------------SEPAVTSRARRPDAPPQSARPRAPVDDRGDPrgpappsplppdTHAPDPPPPSPSPAANepd 2639

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  751 -GSDALLALLDPLNTAWSGSTI--------PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLS 821
Cdd:PHA03247  2640 pHPPPTVPPPERPRDDPAPGRVsrprrarrLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSAT 2719

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  822 STPARPFGTPPASLGPAYAPSILLSSSGFYAP--HRSQPNLSALSMPNLfGQIPMGAHTSPLQPLGPPAVAPSRIRTLPL 899
Cdd:PHA03247  2720 PLPPGPAAARQASPALPAAPAPPAVPAGPATPggPARPARPPTTAGPPA-PAPPAAPAAGPPRRLTRPAVASLSESRESL 2798

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1386806305  900 ARSSARAAEAKQGLALRPGESPLLPPRPPQSLQPTPQPSVPTQARDPFEDLL 951
Cdd:PHA03247  2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL 2850
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
638-884 8.15e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 49.87  E-value: 8.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 638 LPLRPQNQEGILSPsikeetpiPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAGgplgdfSSEPLQMDRERQAAL 717
Cdd:PRK12323  361 LAFRPGQSGGGAGP--------ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA------AAAAARAVAAAPARR 426

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 718 SPAL--LSGLLPRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTIPSHPATPSAATPFIPQLSFPPTVT 795
Cdd:PRK12323  427 SPAPeaLAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEF 506

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 796 PTPFVQtPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAYAPSILLSSSGFYAPHRsqPNLSALSMPNLF-GQIPM 874
Cdd:PRK12323  507 ASPAPA-QPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRP--PRASASGLPDMFdGDWPA 583

                         250
                  ....*....|
gi 1386806305 875 GAHTSPLQPL 884
Cdd:PRK12323  584 LAARLPVRGL 593
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 614-958 3.04e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.24  E-value: 3.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  614 MAIPSKPSITSPEKPSALLGTSPALPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQ 693
Cdd:PHA03307    60 AACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLR 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  694 AAG--GPLGDFSSEPLQMDRERQAA-----LSPALLSGLLPRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAW 766
Cdd:PHA03307   140 PVGspGPPPAASPPAAGASPAAVASdaassRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASS 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  767 SGSTIPSHPATPSAATPFIPQLSFPP-------TVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASlGPAY 839
Cdd:PHA03307   220 PAPAPGRSAADDAGASSSDSSSSESSgcgwgpeNECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRER-SPSP 298

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  840 APSillSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPLGPPAVAPSRIRTLPlarssaraaeakqglalrPGE 919
Cdd:PHA03307   299 SPS---SPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPS------------------RPP 357

                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 1386806305  920 SPLLPPRPPQSlqPTPQPSVPTQARDPFEDLLRKTKQDV 958
Cdd:PHA03307   358 PPADPSSPRKR--PRPSRAPSSPAASAGRPTRRRARAAV 394
PPE COG5651
PPE-repeat protein [Function unknown];
683-893 3.51e-05

PPE-repeat protein [Function unknown];


Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 47.20  E-value: 3.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 683 PPPTARPAKLQAAGGPLGDFSSEPLQMD---RERQAALSPALLSGLLPRAVPQGPTELLQPPSPApGAAGTGSDALLALL 759
Cdd:COG5651   165 TPFTQPPPTITNPGGLLGAQNAGSGNTSsnpGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNT-GFAGTGAAAGAAAA 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 760 DPLNTAWSGSTIPSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMP----LSSTPARPFGTPPASL 835
Cdd:COG5651   244 AAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAaatgLGLGAGGAAGAAGATG 323

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1386806305 836 GPAYAPSILLSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPLGPPAVAPSR 893
Cdd:COG5651   324 AGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGG 381
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 616-886 1.81e-04

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 45.30  E-value: 1.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 616 IPSKPsiTSPEKPSALLGTSPAlPLRPQNQEGILSPSIKEetpiPTPGSITIPRPQGRKTPELGIVPPpptARPAKLQAA 695
Cdd:PLN03209  323 IPSQR--VPPKESDAADGPKPV-PTKPVTPEAPSPPIEEE----PPQPKAVVPRPLSPYTAYEDLKPP---TSPIPTPPS 392

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 696 GGPLGDFSSEPLQMDRERQAALSPALLSGLLPRAVPQGPTELLQPPSPApgaagtgsdallalldplnTAWSGSTIPSHP 775
Cdd:PLN03209  393 SSPASSKSVDAVAKPAEPDVVPSPGSASNVPEVEPAQVEAKKTRPLSPY-------------------ARYEDLKPPTSP 453

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 776 aTPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAyapsillSSSGFYAPHR 855
Cdd:PLN03209  454 -SPTAPTGVSPSVSSTSSVPAVPDTAPATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPA-------APVGKVAPSS 525

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1386806305 856 SQPNLSALSMPNLFGQIPMGAHTSPLQ-PLGP 886
Cdd:PLN03209  526 TNEVVKVGNSAPPTALADEQHHAQPKPrPLSP 557
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 503-783 2.08e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 2.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  503 ESDSAEGDETESPEQLVREPWGPTPAPPDRAASIDLLEDVFSSLDVEAPLQPLGQAKSLEDLRAPKDLREQPGSfdyqrL 582
Cdd:PHA03307    49 ELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPP-----P 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  583 DLCRSERGLSMAAALKLAHPYTklwSLGQDDMAIPSKPSITSPEKPSALLGTSPALPLRPQNQEGILSPSikEETPIPTP 662
Cdd:PHA03307   124 ASPPPSPAPDLSEMLRPVGSPG---PPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPP--AEPPPSTP 198

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305  663 GSITIPRPQGRKTPeLGIVPPPPTARPAKLQAAGGPLGDFSSEPLQM----DRERQAALSPALLSGLLPRAVPQGPTELL 738
Cdd:PHA03307   199 PAAASPRPPRRSSP-ISASASSPAPAPGRSAADDAGASSSDSSSSESsgcgWGPENECPLPRPAPITLPTRIWEASGWNG 277

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1386806305  739 QPPSPAPGAAGTGSDALlalldplntawSGSTIPSHPATPSAATP 783
Cdd:PHA03307   278 PSSRPGPASSSSSPRER-----------SPSPSPSSPGSGPAPSS 311
PHA03379 PHA03379
EBNA-3A; Provisional
 611-950 3.44e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 41.20  E-value: 3.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 611 QDDMAIPSKPSITSPEKPsallgTSPALPLRPQNQEGILSPSIKEETPiPTPGSITIPRPQGRKTPELGIVPPPPTARPA 690
Cdd:PHA03379  429 QSLETATSHGSAQVPEPP-----PVHDLEPGPLHDQHSMAPCPVAQLP-PGPLQDLEPGDQLPGVVQDGRPACAPVPAPA 502

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 691 klqaaGGPLGDFSSEPLQMDRERQAALSPALLSGllpRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGST 770
Cdd:PHA03379  503 -----GPIVRPWEASLSQVPGVAFAPVMPQPMPV---EPVPVPTVALERPVCPAPPLIAMQGPGETSGIVRVRERWRPAP 574

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 771 IPSHPATPSAATPFIPQLS----------FPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAYA 840
Cdd:PHA03379  575 WTPNPPRSPSQMSVRDRLArlraeaqpyqASVEVQPPQLTQVSPQQPMEYPLEPEQQMFPGSPFSQVADVMRAGGVPAMQ 654

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 841 PsillsssgfyaPHRSQPnlsaLSMPNLFGQ--IPMGAHTSPLQPLgpPAVAPSRIRtLPLARSSARAAEAKQGLALRPG 918
Cdd:PHA03379  655 P-----------QYFDLP----LQQPISQGAplAPLRASMGPVPPV--PATQPQYFD-IPLTEPINQGASAAHFLPQQPM 716

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1386806305 919 ESPLLPPRPPQSLQPTPQPSVPTQARDPFEDL 950
Cdd:PHA03379  717 EGPLVPERWMFQGATLSQSVRPGVAQSQYFDL 748
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 31-57 4.84e-03

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 36.43  E-value: 4.84e-03
                          10        20
                  ....*....|....*....|....*..
gi 1386806305  31 TVSQVGQNFTFVLTDIDSKQRFGFCRL 57
Cdd:pfam03456  33 LSSREPTFFSFVLTDEDGSRLYGACLT 59
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
673-848 7.38e-03

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 39.97  E-value: 7.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 673 RKTPELGIVPPPPTARPAKLQAAGGPLGDFSSEPLQMDRERQAALSPALLSGL-------LPRAVPQG-PTELLQPPSPA 744
Cdd:PRK12727   60 SDTPATAAAPAPAPQAPTKPAAPVHAPLKLSANANMSQRQRVASAAEDMIAAMalrqpvsVPRQAPAAaPVRAASIPSPA 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386806305 745 PGAAGTGSDALLALLDPLNTAWSGSTI-------PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPS 817
Cdd:PRK12727  140 AQALAHAAAVRTAPRQEHALSAVPEQLfadflttAPVPRAPVQAPVVAAPAPVPAIAAALAAHAAYAQDDDEQLDDDGFD 219

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1386806305 818 MPLSSTPA-RPFGTPPASLGPAyAPSILLSSS 848
Cdd:PRK12727  220 LDDALPQIlPPAALPPIVVAPA-APAALAAVA 250
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH