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Conserved domains on  [gi|1380941584|ref|NP_001349570|]
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V-type proton ATPase 116 kDa subunit a 1 isoform 9 [Mus musculus]

Protein Classification

V-type ATPase subunit a family protein( domain architecture ID 1000701)

V-type ATPase 116kDa subunit a family protein such as vertebrate V-type proton ATPase 116 kDa subunit a and plant/yeast V-type proton ATPase subunit a, an essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes

Gene Ontology:  GO:0042625|GO:0033176|GO:1902600
PubMed:  9210392|10224039
SCOP:  4001703

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
V_ATPase_I super family cl38044
V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase ...
 27-211 3.99e-89

V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal. It has roles in proton transport and assembly of the V-type ATPase complex. This subunit is encoded by two homologous gene in yeast VPH1 and STV1.


The actual alignment was detected with superfamily member pfam01496:

Pssm-ID: 460232 [Multi-domain]  Cd Length: 748  Bit Score: 278.21  E-value: 3.99e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941584  27 SELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEIRKANIPIM---DTGENPEVPFPRDMIDLEANFEK 103
Cdd:pfam01496   1 SELGELGLVQFRDLNPDVNAFQRTFVNEIRRCDEMERKLRFFEEEIEKLDIIPIkdtLDLETPEAPSPREIDELEEKLEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941584 104 IENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEM-ADPDLLEESSSLLEPNEMGRGAPLRLGFVAGVINRERIPT 182
Cdd:pfam01496  81 LENELRELNENYETLKRNYNELTELRHVLRKAQEFFDRAsGEQEEIRAASSDQEEDNALLLDDVELGFVAGVIPREKVPA 160

                         170       180
                  ....*....|....*....|....*....
gi 1380941584 183 FERMLWRVCRGNVFLRQAEIENPLEDPVT 211
Cdd:pfam01496 161 FERILWRATRGNLFLRQAEIEEPLEDPVT 189
 
Name Accession Description Interval E-value
V_ATPase_I pfam01496
V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase ...
 27-211 3.99e-89

V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal. It has roles in proton transport and assembly of the V-type ATPase complex. This subunit is encoded by two homologous gene in yeast VPH1 and STV1.


Pssm-ID: 460232 [Multi-domain]  Cd Length: 748  Bit Score: 278.21  E-value: 3.99e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941584  27 SELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEIRKANIPIM---DTGENPEVPFPRDMIDLEANFEK 103
Cdd:pfam01496   1 SELGELGLVQFRDLNPDVNAFQRTFVNEIRRCDEMERKLRFFEEEIEKLDIIPIkdtLDLETPEAPSPREIDELEEKLEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941584 104 IENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEM-ADPDLLEESSSLLEPNEMGRGAPLRLGFVAGVINRERIPT 182
Cdd:pfam01496  81 LENELRELNENYETLKRNYNELTELRHVLRKAQEFFDRAsGEQEEIRAASSDQEEDNALLLDDVELGFVAGVIPREKVPA 160

                         170       180
                  ....*....|....*....|....*....
gi 1380941584 183 FERMLWRVCRGNVFLRQAEIENPLEDPVT 211
Cdd:pfam01496 161 FERILWRATRGNLFLRQAEIEEPLEDPVT 189
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 26-132 7.66e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 37.21  E-value: 7.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941584  26 VSELGELGKVQFRDLNPDVNVFQrkfVNEVRR-CEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKI 104
Cdd:PRK05771   22 LEALHELGVVHIEDLKEELSNER---LRKLRSlLTKLSEALDKLRSYLPKLNPLREEKKKVSVKSLEELIKDVEEELEKI 98

                          90       100
                  ....*....|....*....|....*...
gi 1380941584 105 ENELKEINTNQEALKRNFLELTELKFIL 132
Cdd:PRK05771   99 EKEIKELEEEISELENEIKELEQEIERL 126
 
Name Accession Description Interval E-value
V_ATPase_I pfam01496
V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase ...
 27-211 3.99e-89

V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal. It has roles in proton transport and assembly of the V-type ATPase complex. This subunit is encoded by two homologous gene in yeast VPH1 and STV1.


Pssm-ID: 460232 [Multi-domain]  Cd Length: 748  Bit Score: 278.21  E-value: 3.99e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941584  27 SELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEIRKANIPIM---DTGENPEVPFPRDMIDLEANFEK 103
Cdd:pfam01496   1 SELGELGLVQFRDLNPDVNAFQRTFVNEIRRCDEMERKLRFFEEEIEKLDIIPIkdtLDLETPEAPSPREIDELEEKLEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941584 104 IENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEM-ADPDLLEESSSLLEPNEMGRGAPLRLGFVAGVINRERIPT 182
Cdd:pfam01496  81 LENELRELNENYETLKRNYNELTELRHVLRKAQEFFDRAsGEQEEIRAASSDQEEDNALLLDDVELGFVAGVIPREKVPA 160

                         170       180
                  ....*....|....*....|....*....
gi 1380941584 183 FERMLWRVCRGNVFLRQAEIENPLEDPVT 211
Cdd:pfam01496 161 FERILWRATRGNLFLRQAEIEEPLEDPVT 189
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 26-132 7.66e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 37.21  E-value: 7.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380941584  26 VSELGELGKVQFRDLNPDVNVFQrkfVNEVRR-CEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKI 104
Cdd:PRK05771   22 LEALHELGVVHIEDLKEELSNER---LRKLRSlLTKLSEALDKLRSYLPKLNPLREEKKKVSVKSLEELIKDVEEELEKI 98

                          90       100
                  ....*....|....*....|....*...
gi 1380941584 105 ENELKEINTNQEALKRNFLELTELKFIL 132
Cdd:PRK05771   99 EKEIKELEEEISELENEIKELEQEIERL 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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