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Conserved domains on  [gi|1374340135|ref|NP_001348892|]
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vacuolar protein sorting-associated protein 37C isoform 2 [Mus musculus]

Protein Classification

vacuolar protein sorting family 37 protein( domain architecture ID 12073684)

vacuolar protein sorting family 37 protein similar to vacuolar protein sorting-associated protein 37 (Vps37), which is a component of the ESCRT-I complex, a regulator of vesicular trafficking process

CATH:  1.10.287.660
Gene Ontology:  GO:0000813|GO:0043162|GO:0006623|GO:0006612

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mod_r pfam07200
Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region ...
 2-41 2.69e-13

Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homolog of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors.


:

Pssm-ID: 462117 [Multi-domain]  Cd Length: 146  Bit Score: 65.33  E-value: 2.69e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1374340135   2 KIEEESEAMAEKFLEGEVPLETFLESFSSMRTLLHLRRVR 41
Cdd:pfam07200 106 EAEEESEALAESFLEGEIDLDEFLKQFKEKRKLYHLRREK 145
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 76-205 8.42e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 8.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374340135   76 ATPPETEEQPPQPSVVTPYPLPYSPSPGLPVGPTAQGALQPAPFPVVAQPSSYGGPLGPYPSPHPGPRAMVGYSWSPQRS 155
Cdd:PHA03247  2646 VPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGP 2725

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1374340135  156 GPPQPGYPTAPTSTSGPGYPlVGGRTPGPGYPQQSPYLPSGnkPPYPTQP 205
Cdd:PHA03247  2726 AAARQASPALPAAPAPPAVP-AGPATPGGPARPARPPTTAG--PPAPAPP 2772
 
Name Accession Description Interval E-value
Mod_r pfam07200
Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region ...
 2-41 2.69e-13

Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homolog of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors.


Pssm-ID: 462117 [Multi-domain]  Cd Length: 146  Bit Score: 65.33  E-value: 2.69e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1374340135   2 KIEEESEAMAEKFLEGEVPLETFLESFSSMRTLLHLRRVR 41
Cdd:pfam07200 106 EAEEESEALAESFLEGEIDLDEFLKQFKEKRKLYHLRREK 145
PHA03247 PHA03247
large tegument protein UL36; Provisional
 76-205 8.42e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 8.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374340135   76 ATPPETEEQPPQPSVVTPYPLPYSPSPGLPVGPTAQGALQPAPFPVVAQPSSYGGPLGPYPSPHPGPRAMVGYSWSPQRS 155
Cdd:PHA03247  2646 VPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGP 2725

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1374340135  156 GPPQPGYPTAPTSTSGPGYPlVGGRTPGPGYPQQSPYLPSGnkPPYPTQP 205
Cdd:PHA03247  2726 AAARQASPALPAAPAPPAVP-AGPATPGGPARPARPPTTAG--PPAPAPP 2772
 
Name Accession Description Interval E-value
Mod_r pfam07200
Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region ...
 2-41 2.69e-13

Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homolog of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors.


Pssm-ID: 462117 [Multi-domain]  Cd Length: 146  Bit Score: 65.33  E-value: 2.69e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1374340135   2 KIEEESEAMAEKFLEGEVPLETFLESFSSMRTLLHLRRVR 41
Cdd:pfam07200 106 EAEEESEALAESFLEGEIDLDEFLKQFKEKRKLYHLRREK 145
PHA03247 PHA03247
large tegument protein UL36; Provisional
 76-205 8.42e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 8.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1374340135   76 ATPPETEEQPPQPSVVTPYPLPYSPSPGLPVGPTAQGALQPAPFPVVAQPSSYGGPLGPYPSPHPGPRAMVGYSWSPQRS 155
Cdd:PHA03247  2646 VPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGP 2725

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1374340135  156 GPPQPGYPTAPTSTSGPGYPlVGGRTPGPGYPQQSPYLPSGnkPPYPTQP 205
Cdd:PHA03247  2726 AAARQASPALPAAPAPPAVP-AGPATPGGPARPARPPTTAG--PPAPAPP 2772
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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