NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1336503594|ref|NP_001347132|]
View 

ATPase MORC2B [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 18-135 1.95e-62

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


:

Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 207.26  E-value: 1.95e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503594   18 YLHTNSTTHAFLFGALAELIDNARDADATRIDIYAEKREDLQGGFMLCFLDNGVGMDPNDVINVIQFGKSAKRTPESTQI 97
Cdd:cd16931      1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHDHI 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1336503594   98 GRYGNGLKSGSMRIGKDFILFTKKENTMSCLFLSRTFH 135
Cdd:cd16931     81 GRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 495-540 1.22e-13

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 65.79  E-value: 1.22e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1336503594  495 TTIQCDLCLKWRTLPFQLSAVEEgyPINWVCSMNPDPEQDQCEAFE 540
Cdd:pfam07496    1 YWVQCDSCLKWRRLPTEIDPYEL--PEPWYCSMNPDPKYNSCDAPE 44
Morc6_S5 super family cl39387
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 238-451 1.87e-09

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


The actual alignment was detected with superfamily member pfam17942:

Pssm-ID: 465579  Cd Length: 139  Bit Score: 56.78  E-value: 1.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503594  238 HSFCAYAAVLY--IDPRMRIFIHGHKVQTKKLC-------CCLYKPrkytftshrfktraeqevkkadqvaqlaeekare 308
Cdd:pfam17942    1 YSLRAYASILYlrLPPNFQIILRGKKVEHHNIAddlkypeKITYKP---------------------------------- 46

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503594  309 aeskartleiHMGGDitrdsrvmlrqVQNTAITlrreadvkkrirdakqqalkepkelTFVFGVNIEHRDHDGMFIYNCS 388
Cdd:pfam17942   47 ----------QVGGG-----------KEVVVIT-------------------------TIGFLKEAPHINVHGFNVYHKN 80

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1336503594  389 RLIKMYEKVGPQ-----------LEKGmvcggvvgvidvpylVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYW 451
Cdd:pfam17942   81 RLIKPFWRVGNQagskgrgvigvLEAN---------------FIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
 
Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 18-135 1.95e-62

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 207.26  E-value: 1.95e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503594   18 YLHTNSTTHAFLFGALAELIDNARDADATRIDIYAEKREDLQGGFMLCFLDNGVGMDPNDVINVIQFGKSAKRTPESTQI 97
Cdd:cd16931      1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHDHI 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1336503594   98 GRYGNGLKSGSMRIGKDFILFTKKENTMSCLFLSRTFH 135
Cdd:cd16931     81 GRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 29-169 5.50e-44

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 155.57  E-value: 5.50e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503594   29 LFGALAELIDNARDADATRIDIYAEKREdlQGGFMLCFLDNGVGMDPNDVINVIQFGKSAKRTP-ESTQIGRYGNGLKSG 107
Cdd:pfam13589    1 LEGALAELIDNSIDADATNIKIEVNKNR--GGGTEIVIEDDGHGMSPEELINALRLATSAKEAKrGSTDLGRYGIGLKLA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1336503594  108 SMRIGKDFILFTKKENTMSCLFLSRTFHEEEGiDEVIVPLPTWnsqtREPVTDNMEKFAIET 169
Cdd:pfam13589   79 SLSLGAKLTVTSKKEGKSSTLTLDRDKISNEN-DWLLPLLTPA----PIENFDELDKDAHGT 135
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 495-540 1.22e-13

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 65.79  E-value: 1.22e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1336503594  495 TTIQCDLCLKWRTLPFQLSAVEEgyPINWVCSMNPDPEQDQCEAFE 540
Cdd:pfam07496    1 YWVQCDSCLKWRRLPTEIDPYEL--PEPWYCSMNPDPKYNSCDAPE 44
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 238-451 1.87e-09

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 56.78  E-value: 1.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503594  238 HSFCAYAAVLY--IDPRMRIFIHGHKVQTKKLC-------CCLYKPrkytftshrfktraeqevkkadqvaqlaeekare 308
Cdd:pfam17942    1 YSLRAYASILYlrLPPNFQIILRGKKVEHHNIAddlkypeKITYKP---------------------------------- 46

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503594  309 aeskartleiHMGGDitrdsrvmlrqVQNTAITlrreadvkkrirdakqqalkepkelTFVFGVNIEHRDHDGMFIYNCS 388
Cdd:pfam17942   47 ----------QVGGG-----------KEVVVIT-------------------------TIGFLKEAPHINVHGFNVYHKN 80

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1336503594  389 RLIKMYEKVGPQ-----------LEKGmvcggvvgvidvpylVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYW 451
Cdd:pfam17942   81 RLIKPFWRVGNQagskgrgvigvLEAN---------------FIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
MutL COG0323
DNA mismatch repair ATPase MutL [Replication, recombination and repair];
35-78 8.19e-04

DNA mismatch repair ATPase MutL [Replication, recombination and repair];


Pssm-ID: 440092 [Multi-domain]  Cd Length: 515  Bit Score: 43.11  E-value: 8.19e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1336503594   35 ELIDNARDADATRIDIYAEkredlQGGFML-CFLDNGVGMDPNDV 78
Cdd:COG0323     30 ELVENAIDAGATRIEVEIE-----EGGKSLiRVTDNGCGMSPEDL 69
mutL PRK00095
DNA mismatch repair endonuclease MutL;
35-78 1.02e-03

DNA mismatch repair endonuclease MutL;


Pssm-ID: 234630 [Multi-domain]  Cd Length: 617  Bit Score: 42.90  E-value: 1.02e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1336503594   35 ELIDNARDADATRIDIYAEkredlQGGfmlcfL------DNGVGMDPNDV 78
Cdd:PRK00095    29 ELVENALDAGATRIDIEIE-----EGG-----LklirvrDNGCGISKEDL 68
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 32-104 1.61e-03

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 39.17  E-value: 1.61e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1336503594    32 ALAELIDNARDA--DATRIDIYAEKREDlqgGFMLCFLDNGVGMDPNDVINViqFGKSAKRTPESTQIGRYGNGL 104
Cdd:smart00387    9 VLSNLLDNAIKYtpEGGRITVTLERDGD---HVEITVEDNGPGIPPEDLEKI--FEPFFRTDKRSRKIGGTGLGL 78
 
Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 18-135 1.95e-62

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 207.26  E-value: 1.95e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503594   18 YLHTNSTTHAFLFGALAELIDNARDADATRIDIYAEKREDLQGGFMLCFLDNGVGMDPNDVINVIQFGKSAKRTPESTQI 97
Cdd:cd16931      1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHDHI 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1336503594   98 GRYGNGLKSGSMRIGKDFILFTKKENTMSCLFLSRTFH 135
Cdd:cd16931     81 GRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 29-169 5.50e-44

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 155.57  E-value: 5.50e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503594   29 LFGALAELIDNARDADATRIDIYAEKREdlQGGFMLCFLDNGVGMDPNDVINVIQFGKSAKRTP-ESTQIGRYGNGLKSG 107
Cdd:pfam13589    1 LEGALAELIDNSIDADATNIKIEVNKNR--GGGTEIVIEDDGHGMSPEELINALRLATSAKEAKrGSTDLGRYGIGLKLA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1336503594  108 SMRIGKDFILFTKKENTMSCLFLSRTFHEEEGiDEVIVPLPTWnsqtREPVTDNMEKFAIET 169
Cdd:pfam13589   79 SLSLGAKLTVTSKKEGKSSTLTLDRDKISNEN-DWLLPLLTPA----PIENFDELDKDAHGT 135
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 495-540 1.22e-13

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 65.79  E-value: 1.22e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1336503594  495 TTIQCDLCLKWRTLPFQLSAVEEgyPINWVCSMNPDPEQDQCEAFE 540
Cdd:pfam07496    1 YWVQCDSCLKWRRLPTEIDPYEL--PEPWYCSMNPDPKYNSCDAPE 44
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 238-451 1.87e-09

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 56.78  E-value: 1.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503594  238 HSFCAYAAVLY--IDPRMRIFIHGHKVQTKKLC-------CCLYKPrkytftshrfktraeqevkkadqvaqlaeekare 308
Cdd:pfam17942    1 YSLRAYASILYlrLPPNFQIILRGKKVEHHNIAddlkypeKITYKP---------------------------------- 46

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503594  309 aeskartleiHMGGDitrdsrvmlrqVQNTAITlrreadvkkrirdakqqalkepkelTFVFGVNIEHRDHDGMFIYNCS 388
Cdd:pfam17942   47 ----------QVGGG-----------KEVVVIT-------------------------TIGFLKEAPHINVHGFNVYHKN 80

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1336503594  389 RLIKMYEKVGPQ-----------LEKGmvcggvvgvidvpylVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYW 451
Cdd:pfam17942   81 RLIKPFWRVGNQagskgrgvigvLEAN---------------FIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 35-78 2.04e-04

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 43.19  E-value: 2.04e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1336503594   35 ELIDNARDADATRIDIYAEKredlqGGfmLCFL---DNGVGMDPNDV 78
Cdd:cd16926     20 ELVENSIDAGATRIDVEIEE-----GG--LKLIrvtDNGSGISREDL 59
MutL COG0323
DNA mismatch repair ATPase MutL [Replication, recombination and repair];
35-78 8.19e-04

DNA mismatch repair ATPase MutL [Replication, recombination and repair];


Pssm-ID: 440092 [Multi-domain]  Cd Length: 515  Bit Score: 43.11  E-value: 8.19e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1336503594   35 ELIDNARDADATRIDIYAEkredlQGGFML-CFLDNGVGMDPNDV 78
Cdd:COG0323     30 ELVENAIDAGATRIEVEIE-----EGGKSLiRVTDNGCGMSPEDL 69
mutL PRK00095
DNA mismatch repair endonuclease MutL;
35-78 1.02e-03

DNA mismatch repair endonuclease MutL;


Pssm-ID: 234630 [Multi-domain]  Cd Length: 617  Bit Score: 42.90  E-value: 1.02e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1336503594   35 ELIDNARDADATRIDIYAEkredlQGGfmlcfL------DNGVGMDPNDV 78
Cdd:PRK00095    29 ELVENALDAGATRIDIEIE-----EGG-----LklirvrDNGCGISKEDL 68
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 32-104 1.61e-03

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 39.17  E-value: 1.61e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1336503594    32 ALAELIDNARDA--DATRIDIYAEKREDlqgGFMLCFLDNGVGMDPNDVINViqFGKSAKRTPESTQIGRYGNGL 104
Cdd:smart00387    9 VLSNLLDNAIKYtpEGGRITVTLERDGD---HVEITVEDNGPGIPPEDLEKI--FEPFFRTDKRSRKIGGTGLGL 78
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 28-104 7.59e-03

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 37.35  E-value: 7.59e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1336503594   28 FLFGALAELIDNARD--ADATRIDIYAEKREDLQggfmLCFLDNGVGMDPNDVINViqFGKSAkrTPESTQIGRYGNGL 104
Cdd:pfam02518    5 RLRQVLSNLLDNALKhaAKAGEITVTLSEGGELT----LTVEDNGIGIPPEDLPRI--FEPFS--TADKRGGGGTGLGL 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH