NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1277529363|ref|NP_001344964|]
View 

adenylyl cyclase-associated protein 1 [Mus musculus]

Protein Classification

adenylyl cyclase-associated protein( domain architecture ID 12014817)

adenylyl cyclase-associated family protein similar to Saccharomyces cerevisiae adenylyl cyclase-associated protein (CAP) which is a modular actin monomer binding protein that directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CAP_C pfam08603
Adenylate cyclase associated (CAP) C terminal;
317-472 3.67e-91

Adenylate cyclase associated (CAP) C terminal;


:

Pssm-ID: 462532 [Multi-domain]  Cd Length: 157  Bit Score: 273.98  E-value: 3.67e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277529363 317 EPALLELEGKKWRVENQENVSNLVIDDTELKQVAYIYKCVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSRDV 396
Cdd:pfam08603   1 KPPKKELEGNKWIVENQENNKPIVIEDTEMNQSVYIFNCKNSTIQIKGKVNAISLDNCKKTSVVVDSLVSSVEVINCQSF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1277529363 397 KVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVSAKSSEMNVLIPT-EGGDFNEFPVPEQFKTLWNGQKLVTTVTEI 472
Cdd:pfam08603  81 QVQVLGKVPTISIDKTDGGQIYLSKESLDTEIVTSKSSEMNVNVPGgEDGDYVEFPIPEQFKTTIKDGKLVTEVVEH 157
CAP_N pfam01213
Adenylate cyclase associated (CAP) N terminal;
5-61 1.46e-10

Adenylate cyclase associated (CAP) N terminal;


:

Pssm-ID: 460113  Cd Length: 72  Bit Score: 56.99  E-value: 1.46e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1277529363   5 QNLVERLERAVGRLEAVSHTSDMHCGYGDSPSKG---------------AVPYVQAFDSLLANPVAEYLKMS 61
Cdd:pfam01213   1 TTLVKRLEAATSRLEDIAISASGSSASSSASSSGggapsaaapapaaspAPPSVEAFDELISGPVAPFVELS 72
 
Name Accession Description Interval E-value
CAP_C pfam08603
Adenylate cyclase associated (CAP) C terminal;
317-472 3.67e-91

Adenylate cyclase associated (CAP) C terminal;


Pssm-ID: 462532 [Multi-domain]  Cd Length: 157  Bit Score: 273.98  E-value: 3.67e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277529363 317 EPALLELEGKKWRVENQENVSNLVIDDTELKQVAYIYKCVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSRDV 396
Cdd:pfam08603   1 KPPKKELEGNKWIVENQENNKPIVIEDTEMNQSVYIFNCKNSTIQIKGKVNAISLDNCKKTSVVVDSLVSSVEVINCQSF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1277529363 397 KVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVSAKSSEMNVLIPT-EGGDFNEFPVPEQFKTLWNGQKLVTTVTEI 472
Cdd:pfam08603  81 QVQVLGKVPTISIDKTDGGQIYLSKESLDTEIVTSKSSEMNVNVPGgEDGDYVEFPIPEQFKTTIKDGKLVTEVVEH 157
CAP_N pfam01213
Adenylate cyclase associated (CAP) N terminal;
5-61 1.46e-10

Adenylate cyclase associated (CAP) N terminal;


Pssm-ID: 460113  Cd Length: 72  Bit Score: 56.99  E-value: 1.46e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1277529363   5 QNLVERLERAVGRLEAVSHTSDMHCGYGDSPSKG---------------AVPYVQAFDSLLANPVAEYLKMS 61
Cdd:pfam01213   1 TTLVKRLEAATSRLEDIAISASGSSASSSASSSGggapsaaapapaaspAPPSVEAFDELISGPVAPFVELS 72
CARP smart00673
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;
393-430 3.37e-08

Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;


Pssm-ID: 197827  Cd Length: 38  Bit Score: 49.44  E-value: 3.37e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1277529363  393 SRDVKVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVS 430
Cdd:smart00673   1 CESCTIQVSGKVNTISIDKCKKCSIYLGPVSGSPEIVN 38
 
Name Accession Description Interval E-value
CAP_C pfam08603
Adenylate cyclase associated (CAP) C terminal;
317-472 3.67e-91

Adenylate cyclase associated (CAP) C terminal;


Pssm-ID: 462532 [Multi-domain]  Cd Length: 157  Bit Score: 273.98  E-value: 3.67e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277529363 317 EPALLELEGKKWRVENQENVSNLVIDDTELKQVAYIYKCVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSRDV 396
Cdd:pfam08603   1 KPPKKELEGNKWIVENQENNKPIVIEDTEMNQSVYIFNCKNSTIQIKGKVNAISLDNCKKTSVVVDSLVSSVEVINCQSF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1277529363 397 KVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVSAKSSEMNVLIPT-EGGDFNEFPVPEQFKTLWNGQKLVTTVTEI 472
Cdd:pfam08603  81 QVQVLGKVPTISIDKTDGGQIYLSKESLDTEIVTSKSSEMNVNVPGgEDGDYVEFPIPEQFKTTIKDGKLVTEVVEH 157
CAP_N pfam01213
Adenylate cyclase associated (CAP) N terminal;
5-61 1.46e-10

Adenylate cyclase associated (CAP) N terminal;


Pssm-ID: 460113  Cd Length: 72  Bit Score: 56.99  E-value: 1.46e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1277529363   5 QNLVERLERAVGRLEAVSHTSDMHCGYGDSPSKG---------------AVPYVQAFDSLLANPVAEYLKMS 61
Cdd:pfam01213   1 TTLVKRLEAATSRLEDIAISASGSSASSSASSSGggapsaaapapaaspAPPSVEAFDELISGPVAPFVELS 72
CARP smart00673
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;
393-430 3.37e-08

Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;


Pssm-ID: 197827  Cd Length: 38  Bit Score: 49.44  E-value: 3.37e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1277529363  393 SRDVKVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVS 430
Cdd:smart00673   1 CESCTIQVSGKVNTISIDKCKKCSIYLGPVSGSPEIVN 38
CARP smart00673
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;
355-392 1.18e-07

Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;


Pssm-ID: 197827  Cd Length: 38  Bit Score: 47.90  E-value: 1.18e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1277529363  355 CVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIIN 392
Cdd:smart00673   1 CESCTIQVSGKVNTISIDKCKKCSIYLGPVSGSPEIVN 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH