NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1274095930|ref|NP_001344607|]
View 

galectin-3 isoform 3 [Homo sapiens]

Protein Classification

galectin family protein( domain architecture ID 10049222)

galectin family protein may exclusively bind beta-galactosides such as lactose in a manner independent of metal ions

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 131-258 7.89e-55

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


:

Pssm-ID: 238025  Cd Length: 127  Bit Score: 172.82  E-value: 7.89e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930 131 PYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGN-DVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESG 209
Cdd:cd00070     1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSsDIALHFNPRFDEN---VIVRNSFLNGNWGPEERSGGFPFQPG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1274095930 210 KPFKIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 258
Cdd:cd00070    78 QPFELTILVEEDKFQIFVNGQHFFSFPHRL-PLESIDYLSINGDVSLTS 125
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 23-127 1.95e-07

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.53  E-value: 1.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  23 DALSGSGNPNPQGWPGAWGNQP-AGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPG 101
Cdd:PRK07764  619 AAPAAPAAPAPAGAAAAPAEASaAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAP 698

                          90       100
                  ....*....|....*....|....*.
gi 1274095930 102 AYPSSGQPSATGAYPATGPYGAPAGP 127
Cdd:PRK07764  699 AQPAPAPAATPPAGQADDPAAQPPQA 724
 
Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 131-258 7.89e-55

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 172.82  E-value: 7.89e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930 131 PYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGN-DVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESG 209
Cdd:cd00070     1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSsDIALHFNPRFDEN---VIVRNSFLNGNWGPEERSGGFPFQPG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1274095930 210 KPFKIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 258
Cdd:cd00070    78 QPFELTILVEEDKFQIFVNGQHFFSFPHRL-PLESIDYLSINGDVSLTS 125
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 132-262 5.98e-54

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 170.49  E-value: 5.98e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  132 YNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGN-DVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESGK 210
Cdd:smart00276   1 FTLPIPGGLKPGQTLTVRGIVLPDAKRFSINLLTGGdDIALHFNPRFNEN---KIVCNSKLNGSWGSEEREGGFPFQPGQ 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1274095930  211 PFKIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTSASYT 262
Cdd:smart00276  78 PFDLTIIVQPDHFQIFVNGVHITTFPHRL-PLESIDYLSINGDVQLTSVSFE 128
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 137-258 1.17e-48

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 157.03  E-value: 1.17e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930 137 PGGVVPRMLITILGTVKPNANRIALDFQRG----NDVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESGKPF 212
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTGvgpsDDIALHFNPRFDEN---VIVRNSRQNGQWGQEEREGGFPFQPGQPF 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1274095930 213 KIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 258
Cdd:pfam00337  78 ELTILVGDDHFKIYVNGQHFTTFKHRL-PPEDIDALQVRGDVKLTS 122
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 23-127 1.95e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.53  E-value: 1.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  23 DALSGSGNPNPQGWPGAWGNQP-AGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPG 101
Cdd:PRK07764  619 AAPAAPAAPAPAGAAAAPAEASaAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAP 698

                          90       100
                  ....*....|....*....|....*.
gi 1274095930 102 AYPSSGQPSATGAYPATGPYGAPAGP 127
Cdd:PRK07764  699 AQPAPAPAATPPAGQADDPAAQPPQA 724
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
16-141 1.85e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 42.43  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  16 ADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYP-GAPAPGVYP 94
Cdd:COG3469    91 STSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATgGTTTTSTTT 170

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1274095930  95 GPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPYNLPLPGGVV 141
Cdd:COG3469   171 TTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPKHVL 217
G_path_suppress pfam15991
G-protein pathway suppressor; This family of proteins inhibits G-protein- and ...
 56-136 5.01e-04

G-protein pathway suppressor; This family of proteins inhibits G-protein- and mitogen-activated protein kinase-mediated signal transduction.


Pssm-ID: 464961 [Multi-domain]  Cd Length: 272  Bit Score: 40.67  E-value: 5.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  56 PGAYPGQapPGAYPGQAPPGAYPGAPGAYPGAPA------PGVYPGPPSGPGAYPSSGQPSA--TGAYPATGPygaPAGP 127
Cdd:pfam15991 147 QQAYYKQ--PAFSPGYAEHGQQKHDDGRRGYDVArfgswnKSTAQYPPSGQLFYPTHQYLPPpqTQGQADARL---QTIY 221


                  ....*....
gi 1274095930 128 LIVPYNLPL 136
Cdd:pfam15991 222 PQPGYALPL 230
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 51-138 6.83e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 37.67  E-value: 6.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  51 PGASYPGAYPGQAPPGAY-PGQAPPGAYPGAPGAYPGAPAPgvyPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLI 129
Cdd:NF041121   16 GRAAAPPSPEGPAPTAASqPATPPPPAAPPSPPGDPPEPPA---PEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALPVR 92


                  ....*....
gi 1274095930 130 VPYNLPLPG 138
Cdd:NF041121   93 VPAPPALPN 101
 
Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 131-258 7.89e-55

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 172.82  E-value: 7.89e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930 131 PYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGN-DVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESG 209
Cdd:cd00070     1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSsDIALHFNPRFDEN---VIVRNSFLNGNWGPEERSGGFPFQPG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1274095930 210 KPFKIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 258
Cdd:cd00070    78 QPFELTILVEEDKFQIFVNGQHFFSFPHRL-PLESIDYLSINGDVSLTS 125
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 132-262 5.98e-54

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 170.49  E-value: 5.98e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  132 YNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGN-DVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESGK 210
Cdd:smart00276   1 FTLPIPGGLKPGQTLTVRGIVLPDAKRFSINLLTGGdDIALHFNPRFNEN---KIVCNSKLNGSWGSEEREGGFPFQPGQ 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1274095930  211 PFKIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTSASYT 262
Cdd:smart00276  78 PFDLTIIVQPDHFQIFVNGVHITTFPHRL-PLESIDYLSINGDVQLTSVSFE 128
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 137-258 8.64e-54

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 170.08  E-value: 8.64e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  137 PGGVVPRMLITILGTVKPNANRIALDFQRG--NDVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESGKPFKI 214
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINLQCGpnADIALHFNPRFDEG---TIVRNSKQNGKWGKEERSGGFPFQPGQPFEL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1274095930  215 QVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 258
Cdd:smart00908  78 EILVEEDEFKVAVNGQHFLEFPHRL-PLESIDTLEISGDVQLTS 120
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 137-258 1.17e-48

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 157.03  E-value: 1.17e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930 137 PGGVVPRMLITILGTVKPNANRIALDFQRG----NDVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESGKPF 212
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTGvgpsDDIALHFNPRFDEN---VIVRNSRQNGQWGQEEREGGFPFQPGQPF 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1274095930 213 KIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 258
Cdd:pfam00337  78 ELTILVGDDHFKIYVNGQHFTTFKHRL-PPEDIDALQVRGDVKLTS 122
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 23-127 1.95e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.53  E-value: 1.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  23 DALSGSGNPNPQGWPGAWGNQP-AGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPG 101
Cdd:PRK07764  619 AAPAAPAAPAPAGAAAAPAEASaAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAP 698

                          90       100
                  ....*....|....*....|....*.
gi 1274095930 102 AYPSSGQPSATGAYPATGPYGAPAGP 127
Cdd:PRK07764  699 AQPAPAPAATPPAGQADDPAAQPPQA 724
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 26-128 1.28e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.21  E-value: 1.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  26 SGSGNPNPQGWPGAWGNQPAGAGGYPGAsypgAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPS 105
Cdd:PRK07764  643 PAPGVAAPEHHPKHVAVPDASDGGDGWP----AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPA 718

                          90       100
                  ....*....|....*....|...
gi 1274095930 106 SGQPSATGAYPATGPYGAPAGPL 128
Cdd:PRK07764  719 AQPPQAAQGASAPSPAADDPVPL 741
PHA03378 PHA03378
EBNA-3B; Provisional
 30-143 2.07e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.44  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  30 NPNPQGWPGAWGNQPAGAGGYPGASYPG-AYPGQAPPG-AYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSG 107
Cdd:PHA03378  675 QPSPTGANTMLPIQWAPGTMQPPPRAPTpMRPPAAPPGrAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRA 754

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1274095930 108 QPSATGAYPATGPYGAPAGPLIVPynlPLPGGVVPR 143
Cdd:PHA03378  755 RPPAAAPGRARPPAAAPGAPTPQP---PPQAPPAPQ 787
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 41-127 2.15e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 2.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  41 GNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPG--APGAYPGAPAPGVYPGPPSGPGAYPSSGQPS-ATGAYPA 117
Cdd:PRK07764  384 RLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAApaPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSpPPAAAPS 463

                          90
                  ....*....|
gi 1274095930 118 TGPYGAPAGP 127
Cdd:PRK07764  464 AQPAPAPAAA 473
PHA03378 PHA03378
EBNA-3B; Provisional
 31-153 3.39e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.06  E-value: 3.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  31 PNPQGWPGAwGNQPAGAGGYpgASYPGAYPGQA-PPGAYPGQAPPGAypGAPGAypgAPAPGVYPGPPSGPGAYPSSG-- 107
Cdd:PHA03378  705 RPPAAPPGR-AQRPAAATGR--ARPPAAAPGRArPPAAAPGRARPPA--AAPGR---ARPPAAAPGRARPPAAAPGAPtp 776

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1274095930 108 -QPSATGAYPATGPYGAPAgPLIVPYNLPLPGGVVPRMLITILGTVK 153
Cdd:PHA03378  777 qPPPQAPPAPQQRPRGAPT-PQPPPQAGPTSMQLMPRAAPGQQGPTK 822
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 27-127 3.56e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.59  E-value: 3.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  27 GSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPG--QAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYP 104
Cdd:PRK07764  591 APGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAapAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP 670

                          90       100
                  ....*....|....*....|...
gi 1274095930 105 SSGQPSATGAYPATGPYGAPAGP 127
Cdd:PRK07764  671 AKAGGAAPAAPPPAPAPAAPAAP 693
PHA03247 PHA03247
large tegument protein UL36; Provisional
 29-142 3.70e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 3.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930   29 GNPNPQGWPGAWGNQPAGAggyPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQ 108
Cdd:PHA03247  2752 GGPARPARPPTTAGPPAPA---PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPL 2828

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1274095930  109 PSATGAYPATGPygAPAGPliVPYNLPLPGGVVP 142
Cdd:PHA03247  2829 PPPTSAQPTAPP--PPPGP--PPPSLPLGGSVAP 2858
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 37-127 5.78e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 43.90  E-value: 5.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  37 PGAWGNQPAGAGGYPGASYPGAypGQAPPgayPGQAPPGAYPGAPG-----AYPGAPAPGVYPGP--------------- 96
Cdd:PRK14959  373 PSGGGASAPSGSAAEGPASGGA--ATIPT---PGTQGPQGTAPAAGmtpssAAPATPAPSAAPSPrvpwddappapprsg 447

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1274095930  97 ------PSGPGAYPSSGQPSATGAYPATGP-YGAPAGP 127
Cdd:PRK14959  448 ipprpaPRMPEASPVPGAPDSVASASDAPPtLGDPSDT 485
PHA03378 PHA03378
EBNA-3B; Provisional
 31-164 1.15e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.13  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  31 PNPQGWPGAwGNQPAGAGGYpgASYPGAYPGQA-PPGAYPGQAPPGAypGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQP 109
Cdd:PHA03378  725 RPPAAAPGR-ARPPAAAPGR--ARPPAAAPGRArPPAAAPGRARPPA--AAPGAPTPQPPPQAPPAPQQRPRGAPTPQPP 799

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1274095930 110 satgaypatgPYGAPAGPLIVPYNLPLPGGVVPRMLITILgTVKPNANRIALDFQ 164
Cdd:PHA03378  800 ----------PQAGPTSMQLMPRAAPGQQGPTKQILRQLL-TGGVKRGRPSLKKP 843
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 18-153 1.47e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  18 NFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPP 97
Cdd:PRK07764  386 GVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQ 465

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1274095930  98 SGPGAYPS-----SGQPSATGAYPATGPYGAPAGPliVPYNLPLPGGVVPRMLITILGTVK 153
Cdd:PRK07764  466 PAPAPAAApeptaAPAPAPPAAPAPAAAPAAPAAP--AAPAGADDAATLRERWPEILAAVP 524
PHA03247 PHA03247
large tegument protein UL36; Provisional
 31-142 1.52e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930   31 PNPQGWPGAWGNQPAGAGGypGASYPGAYPGQAPPGAYPGQAPPG--AYPGAPGAYPGAPAPGVYPGPPSGPGayPSSGQ 108
Cdd:PHA03247  2710 PAPHALVSATPLPPGPAAA--RQASPALPAAPAPPAVPAGPATPGgpARPARPPTTAGPPAPAPPAAPAAGPP--RRLTR 2785

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1274095930  109 PSATGAYPATGPYGAPAGPLIVPYNLPLPGGVVP 142
Cdd:PHA03247  2786 PAVASLSESRESLPSPWDPADPPAAVLAPAAALP 2819
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 24-127 1.68e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  24 ALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAyPGQAPPGayPGQAPPGAYPGA--------PGAYPGAPAPGVYPG 95
Cdd:PRK07764  671 AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP-AATPPAG--QADDPAAQPPQAaqgasapsPAADDPVPLPPEPDD 747

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1274095930  96 PPSGPGAYPSSGQPSATGAYPATGPYGAPAGP 127
Cdd:PRK07764  748 PPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPP 779
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 51-125 1.77e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 1.77e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1274095930  51 PGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVyPGPPSGPGAYPSSGQPSATGAYPATGPYGAPA 125
Cdd:PRK14951  366 PAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAP-AAAASAPAAPPAAAPPAPVAAPAAAAPAAAPA 439
PHA03247 PHA03247
large tegument protein UL36; Provisional
 56-139 1.78e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930   56 PGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSG---PGAYPSSGQPSATGAYPATGPYGAPAGPliVPY 132
Cdd:PHA03247  2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpatPGGPARPARPPTTAGPPAPAPPAAPAAG--PPR 2781


                   ....*..
gi 1274095930  133 NLPLPGG 139
Cdd:PHA03247  2782 RLTRPAV 2788
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
16-141 1.85e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 42.43  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  16 ADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYP-GAPAPGVYP 94
Cdd:COG3469    91 STSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATgGTTTTSTTT 170

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1274095930  95 GPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPYNLPLPGGVV 141
Cdd:COG3469   171 TTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPKHVL 217
dnaA PRK14086
chromosomal replication initiator protein DnaA;
23-127 2.59e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 42.12  E-value: 2.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  23 DALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPgAPAPGVYPGPPSgpgA 102
Cdd:PRK14086   89 DPSAGEPAPPPPHARRTSEPELPRPGRRPYEGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQ-RPEPGAWPRAAD---D 164

                          90       100
                  ....*....|....*....|....*
gi 1274095930 103 YPSSGQPSatgAYPATGPYGAPAGP 127
Cdd:PRK14086  165 YGWQQQRL---GFPPRAPYASPASY 186
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
27-137 3.25e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 3.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  27 GSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPG-APGAYPGAPAPGVYPGPPSGPGAYPS 105
Cdd:PRK12323  368 SGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAaAPARRSPAPEALAAARQASARGPGGA 447

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1274095930 106 SGQPSATGAYPATGPYGAPAGPLIVPYNLPLP 137
Cdd:PRK12323  448 PAPAPAPAAAPAAAARPAAAGPRPVAAAAAAA 479
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
26-137 4.29e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 4.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  26 SGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAP----PGAYPGAPGAYPGAPAPGVYPGPPSGPG 101
Cdd:PRK12323  376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAParrsPAPEALAAARQASARGPGGAPAPAPAPA 455

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1274095930 102 AYPSSGQPSATGAYPATGPYGAPAGPLIVPYNLPLP 137
Cdd:PRK12323  456 AAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAP 491
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
24-127 4.36e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 4.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  24 ALSGSGNPnpqgwPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAY 103
Cdd:PRK07003  361 AVTGGGAP-----GGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPAT 435

                          90       100
                  ....*....|....*....|....
gi 1274095930 104 PSSGQPSATGAYPATGPYGAPAGP 127
Cdd:PRK07003  436 ADRGDDAADGDAPVPAKANARASA 459
PHA03247 PHA03247
large tegument protein UL36; Provisional
 51-143 4.65e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 4.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930   51 PGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATgayPATGPYGAPAGPLIV 130
Cdd:PHA03247  2575 PRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAN---EPDPHPPPTVPPPER 2651

                           90
                   ....*....|...
gi 1274095930  131 PYNLPLPGGVVPR 143
Cdd:PHA03247  2652 PRDDPAPGRVSRP 2664
G_path_suppress pfam15991
G-protein pathway suppressor; This family of proteins inhibits G-protein- and ...
 56-136 5.01e-04

G-protein pathway suppressor; This family of proteins inhibits G-protein- and mitogen-activated protein kinase-mediated signal transduction.


Pssm-ID: 464961 [Multi-domain]  Cd Length: 272  Bit Score: 40.67  E-value: 5.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  56 PGAYPGQapPGAYPGQAPPGAYPGAPGAYPGAPA------PGVYPGPPSGPGAYPSSGQPSA--TGAYPATGPygaPAGP 127
Cdd:pfam15991 147 QQAYYKQ--PAFSPGYAEHGQQKHDDGRRGYDVArfgswnKSTAQYPPSGQLFYPTHQYLPPpqTQGQADARL---QTIY 221


                  ....*....
gi 1274095930 128 LIVPYNLPL 136
Cdd:pfam15991 222 PQPGYALPL 230
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 24-127 5.37e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 41.20  E-value: 5.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  24 ALSGSGNPNPQGW-------PGAWGNQPA--GAGGYPGASYPGA-YPGQAPPGAYP-GQAPPGAYPGAPGAYPGAPAPGV 92
Cdd:PRK14959  380 APSGSAAEGPASGgaatiptPGTQGPQGTapAAGMTPSSAAPATpAPSAAPSPRVPwDDAPPAPPRSGIPPRPAPRMPEA 459

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1274095930  93 YPGPPSGPGAYPSSGQPSATGAYPATGPYgAPAGP 127
Cdd:PRK14959  460 SPVPGAPDSVASASDAPPTLGDPSDTAEH-TPSGP 493
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 31-127 6.02e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 6.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  31 PNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPG--AYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQ 108
Cdd:PRK07764  590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAapAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGW 669

                          90
                  ....*....|....*....
gi 1274095930 109 PSATGAYPATGPYGAPAGP 127
Cdd:PRK07764  670 PAKAGGAAPAAPPPAPAPA 688
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 33-127 7.59e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 7.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  33 PQGWPGAWGnQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVyPGPPSGPGAYPSSGQPSAT 112
Cdd:PRK07764  666 GDGWPAKAG-GAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQA-AQGASAPSPAADDPVPLPP 743

                          90
                  ....*....|....*
gi 1274095930 113 GAYPATGPYGAPAGP 127
Cdd:PRK07764  744 EPDDPPDPAGAPAQP 758
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
43-143 7.73e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 7.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  43 QPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYG 122
Cdd:PRK12323  364 RPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARG 443

                          90       100
                  ....*....|....*....|.
gi 1274095930 123 APAGPLIVPYNLPLPGGVVPR 143
Cdd:PRK12323  444 PGGAPAPAPAPAAAPAAAARP 464
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 30-145 1.79e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 39.31  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  30 NPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGP-------GA 102
Cdd:PRK14951  382 ARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPaqaapetVA 461

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1274095930 103 YPSSGQPSATGAYPATGPYGAPAGPLIVPYNL-PLPGGVVPRML 145
Cdd:PRK14951  462 IPVRVAPEPAVASAAPAPAAAPAAARLTPTEEgDVWHATVQQLA 505
PHA03247 PHA03247
large tegument protein UL36; Provisional
 31-154 2.06e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 2.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930   31 PNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPgqAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPS 110
Cdd:PHA03247  2723 PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPP--TTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS 2800

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1274095930  111 ----------ATGAYPATGPYGAPAGPL-----IVPYNLPLPGGVVPRMLiTILGTVKP 154
Cdd:PHA03247  2801 pwdpadppaaVLAPAAALPPAASPAGPLppptsAQPTAPPPPPGPPPPSL-PLGGSVAP 2858
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 45-142 2.13e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.20  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  45 AGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAyPGAPGAyPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAP 124
Cdd:PRK07764  586 AVVGPAPGAAGGEGPPAPASSGPPEEAARPAA-PAAPAA-PAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDAS 663

                          90
                  ....*....|....*...
gi 1274095930 125 AGPLIVPYNLPLPGGVVP 142
Cdd:PRK07764  664 DGGDGWPAKAGGAAPAAP 681
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
43-125 2.31e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.06  E-value: 2.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  43 QPA-GAGGYPGASYPGAYPGQAP-PGAYPGQAPPGAYPGAPGAYPGAPA-----PGVYPGPPSGPGAYPSSGQPSATGA- 114
Cdd:PRK07003  359 EPAvTGGGAPGGGVPARVAGAVPaPGARAAAAVGASAVPAVTAVTGAAGaalapKAAAAAAATRAEAPPAAPAPPATADr 438

                          90
                  ....*....|...
gi 1274095930 115 --YPATGPYGAPA 125
Cdd:PRK07003  439 gdDAADGDAPVPA 451
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 51-131 2.50e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 39.10  E-value: 2.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930   51 PGASYPGAYPGQAPPGAYPGQAP-PGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLI 129
Cdd:PRK12270    38 PGSTAAPTAAAAAAAAAASAPAAaPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDEV 117


                   ..
gi 1274095930  130 VP 131
Cdd:PRK12270   118 TP 119
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 26-128 3.54e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.43  E-value: 3.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  26 SGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGA----YPGAPGAYPGAPAPGVYPGPPSGPG 101
Cdd:PRK07764  692 APAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPpepdDPPDPAGAPAQPPPPPAPAPAAAPA 771

                          90       100
                  ....*....|....*....|....*..
gi 1274095930 102 AYPSSGQPSATGAYPATGPYGAPAGPL 128
Cdd:PRK07764  772 AAPPPSPPSEEEEMAEDDAPSMDDEDR 798
PHA03185 PHA03185
UL14 tegument protein; Provisional
 89-127 4.33e-03

UL14 tegument protein; Provisional


Pssm-ID: 177553 [Multi-domain]  Cd Length: 214  Bit Score: 37.31  E-value: 4.33e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1274095930  89 APGVYPGPPSGPGAYPSS-----GQPSATGAYPATGPYGAPAGP 127
Cdd:PHA03185  157 APAVRPGDLSGPGSRPTSgpvagGLPGGGAPAPPTPPRPGPTDP 200
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 27-131 4.58e-03

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 37.66  E-value: 4.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  27 GSGNPNPQGWPGAWGNQPAGAGGYP-GASYPGAYPGQAPPGAYPGQAPpgayPGAPGAYPGAPAPGVYPGPPSGPGAYps 105
Cdd:pfam15822 128 APTDPAAAAPSGPWGSMSSGPWAPGmGGQYPAPNMPYPSPGPYPAVPP----PQSPGAAPPVPWGTVPPGPWGPPAPY-- 201

                          90       100
                  ....*....|....*....|....*.
gi 1274095930 106 sgqPSATGAYPATGPYGAPAGPLIVP 131
Cdd:pfam15822 202 ---PDPTGSYPMPGLYPTPNNPFQVP 224
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
33-143 5.19e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 37.93  E-value: 5.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  33 PQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAypgAPGAYPGAPAPGVYPGPPS-GPGAYPSSGQPSA 111
Cdd:PRK12323  365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAA---APAAAAAARAVAAAPARRSpAPEALAAARQASA 441

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1274095930 112 TGAYPATGPYGAPAgPLIVPYNLPLPGGVVPR 143
Cdd:PRK12323  442 RGPGGAPAPAPAPA-AAPAAAARPAAAGPRPV 472
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
44-127 5.19e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 37.93  E-value: 5.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  44 PAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPgAPGAYPGAPAPgvyPGPPSGPGAYPSSGQPSATGAYPATGPYGA 123
Cdd:PRK12323  473 AAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFA-SPAPAQPDAAP---AGWVAESIPDPATADPDDAFETLAPAPAAA 548


                  ....
gi 1274095930 124 PAGP 127
Cdd:PRK12323  549 PAPR 552
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 33-125 6.17e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 37.95  E-value: 6.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930   33 PQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPgvyPGPPSGPGAYPSSGQPSAT 112
Cdd:PRK12270    39 GSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAP---AAPPAAAAAAAPAAAAVED 115

                           90
                   ....*....|...
gi 1274095930  113 GAYPATGPYGAPA 125
Cdd:PRK12270   116 EVTPLRGAAAAVA 128
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 51-138 6.83e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 37.67  E-value: 6.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  51 PGASYPGAYPGQAPPGAY-PGQAPPGAYPGAPGAYPGAPAPgvyPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLI 129
Cdd:NF041121   16 GRAAAPPSPEGPAPTAASqPATPPPPAAPPSPPGDPPEPPA---PEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALPVR 92


                  ....*....
gi 1274095930 130 VPYNLPLPG 138
Cdd:NF041121   93 VPAPPALPN 101
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 43-127 7.53e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 37.66  E-value: 7.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  43 QPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPG--APAPGVYPGPPSGPGAYPSSGQPSATGAYPATGP 120
Cdd:PRK07764  587 VVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAgaAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGG 666


                  ....*..
gi 1274095930 121 YGAPAGP 127
Cdd:PRK07764  667 DGWPAKA 673
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
45-127 8.62e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 37.16  E-value: 8.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095930  45 AGAGGYPGASYPGAYPGQAPPgayPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAP 124
Cdd:PRK12323  439 ASARGPGGAPAPAPAPAAAPA---AAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPD 515


                  ...
gi 1274095930 125 AGP 127
Cdd:PRK12323  516 AAP 518
PRK12438 PRK12438
hypothetical protein; Provisional
 42-106 9.13e-03

hypothetical protein; Provisional


Pssm-ID: 171499 [Multi-domain]  Cd Length: 991  Bit Score: 37.15  E-value: 9.13e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1274095930  42 NQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGayPGAPGAYPGAPAPgvypgPPSGPGAYPSS 106
Cdd:PRK12438  892 DQVFGPGTGRVATAPGGDAASAPPPGAGPPAPPQ--AVPPPRTTQPPAA-----PPRGPDVPPAA 949
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH