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Concise Results
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histone deacetylase complex subunit SAP130 isoform 3 [Mus musculus]
Protein Classification
List of domain hits
Name
Accession
Description
Interval
E-value
SAP130_C
pfam16014 Histone deacetylase complex subunit SAP130 C-terminus;
654-1059
0e+00
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain]
Cd Length: 371
Bit Score: 550.69
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 654 A Q GSSPRPSILRKKPAT D G mavrktllppqppdvatprvessmrsasgsprpag AKPK SEV HV SI A T PVTV SL E TISN QN 733
Cdd:pfam16014 1 A L GSSPRPSILRKKPAT E G ----------------------------------- AKPK PDI HV AV A P PVTV AV E ALPG QN 45
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 734 A EQ P T VAVP P TA Q Q P PPT IP SMI A A A S PPSQP AIA LST I P G A VP VTPP ---- ITTIA A T PT LS A p VGG T PSTVLGPPV PE 809
Cdd:pfam16014 46 S EQ Q T ASAS P PS Q H P AQA IP TIL A P A A PPSQP SVV LST L P A A MA VTPP ipas MANVV A P PT QP A - ASS T AACAVSSVL PE 124
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 810 IK V K E EAEP V D ITR pvs T VPPL ATNTV SP S L AL LA S NLS M P PS DL P PGASPRKKPRKQQHVISTEEG D MMETNSTD D EKS 889
Cdd:pfam16014 125 IK I K Q EAEP M D TSQ --- S VPPL TPTSI SP A L TS LA N NLS V P AG DL L PGASPRKKPRKQQHVISTEEG E MMETNSTD E EKS 201
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 890 A A K S L LVK AEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKK AM LQ EI ANQKGV S C 969
Cdd:pfam16014 202 A P K P L TSR AEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKK GT LQ DM ANQKGV T C 281
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 970 RAQGWK V HLCAAQLLQLTNLEHDVY E RLT N LQEG I IPKKKA A TDDDLHRINELIQGNMQRCKLVMDQI S EARDSM L KVLD 1049
Cdd:pfam16014 282 RAQGWK I HLCAAQLLQLTNLEHDVY S RLT T LQEG L IPKKKA G TDDDLHRINELIQGNMQRCKLVMDQI T EARDSM M KVLD 361
410
....*....|
gi 1274095663 1050 HKDRVLKLLN 1059
Cdd:pfam16014 362 HKDRVLKLLN 371
PHA03247 super family
cl33720 large tegument protein UL36; Provisional
437-905
3.17e-07
large tegument protein UL36; Provisional
PHA03247 :Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 54.94
E-value: 3.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 437 PRIQPDY PPER SSLI P i SGH R A S PNPV A METRNDNRP S V P V Q fqyfl PTYPPS A Y P laah T YTPI TS SVSTIRQY P VSAQ 516
Cdd:PHA03247 2641 HPPPTVP PPER PRDD P - APG R V S RPRR A RRLGRAAQA S S P P Q ----- RPRRRA A R P ---- T VGSL TS LADPPPPP P TPEP 2710
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 517 AP NSTIT A qtgvgvastvhl N P MQLMTVD A SH A RHIQGIQ PAP ISTQGIQPA P I G tsgiq PA PIGT P GIHSAA P intqgl 596
Cdd:PHA03247 2711 AP HALVS A ------------ T P LPPGPAA A RQ A SPALPAA PAP PAVPAGPAT P G G ----- PA RPAR P PTTAGP P ------ 2767
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 597 Q PA AM A NQQPQ P EGKTSVVLADGATIVANPISN P FSA A PAATT V VQTHSQSASTNT PA QGSS P RP S ILRKK P AT dgmavr 676
Cdd:PHA03247 2768 A PA PP A APAAG P PRRLTRPAVASLSESRESLPS P WDP A DPPAA V LAPAAALPPAAS PA GPLP P PT S AQPTA P PP ------ 2841
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 677 ktll PP Q PP DVAT P R ---- VESSMRSASGSP R PAG AKP KSEVHVSIATPVTVSLET i S NQNAEQ P TVAVPPTA Q QPP P TI 752
Cdd:PHA03247 2842 ---- PP G PP PPSL P L ggsv APGGDVRRRPPS R SPA AKP AAPARPPVRRLARPAVSR - S TESFAL P PDQPERPP Q PQA P PP 2916
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 753 P SMIAAAS PP S QP AIALSTI P GAV P VTP P I T TI A ATP tls A P V G GT P STV LG P ------ P VP EIK V KEE A EPVDI tr P V S 826
Cdd:PHA03247 2917 P QPQPQPP PP P QP QPPPPPP P RPQ P PLA P T T DP A GAG --- E P S G AV P QPW LG A lvpgrv A VP RFR V PQP A PSREA -- P A S 2991
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 827 TV PPL a T NTVSPSLALL AS N L SMPPSDL PP GA S prkkp R KQ QHVIS -- TE EG D MMETNST D D E K S AAKS L LVKAEKRKS P 904
Cdd:PHA03247 2992 ST PPL - T GHSLSRVSSW AS S L ALHEETD PP PV S ----- L KQ TLWPP dd TE DS D ADSLFDS D S E R S DLEA L DPLPPEPHD P 3065
.
gi 1274095663 905 P 905
Cdd:PHA03247 3066 F 3066
PHA03247 super family
cl33720 large tegument protein UL36; Provisional
8-359
2.26e-05
large tegument protein UL36; Provisional
PHA03247 :Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 48.78
E-value: 2.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 8 R L R I P QASGLNVEMSSQQF P RLGTPSPGLSQ PPS QIASSGSAGLINQVATVND E AG RD ADVGT R EHVGPSSSLPP R EEKQ 87
Cdd:PHA03247 2597 R P R A P VDDRGDPRGPAPPS P LPPDTHAPDPP PPS PSPAANEPDPHPPPTVPPP E RP RD DPAPG R VSRPRRARRLG R AAQA 2676
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 88 EPVVV RP YPQVQMLPAHHAVAS A T P VAVTAP P AHLTP A VPLSFSEGLMKPPPKPTM P SR P I APAPP STMS l P P KV PG QVT 167
Cdd:PHA03247 2677 SSPPQ RP RRRAARPTVGSLTSL A D P PPPPPT P EPAPH A LVSATPLPPGPAAARQAS P AL P A APAPP AVPA - G P AT PG GPA 2755
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 168 VTMESSIPQASAI P VATISGQQ G H P SN L HHIMTTNVQM S IIRSNA P GP P LHIG A SH L PR gaaaaavms SSKVTTVLR P TS 247
Cdd:PHA03247 2756 RPARPPTTAGPPA P APPAAPAA G P P RR L TRPAVASLSE S RESLPS P WD P ADPP A AV L AP --------- AAALPPAAS P AG 2826
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 248 Q LP NAAT AQP AVQHLIHQ P IQ sr P PVTTSSTIP P AVVATVSATRAQSPVITTTA A HAADST L S RP TL S IQHPPS A -- AIS 325
Cdd:PHA03247 2827 P LP PPTS AQP TAPPPPPG P PP -- P SLPLGGSVA P GGDVRRRPPSRSPAAKPAAP A RPPVRR L A RP AV S RSTESF A lp PDQ 2904
330 340 350
....*....|....*....|....*....|....
gi 1274095663 326 IQ RP A Q SRDVTTRITL P SH P ALGT P KQQLHTMAQ 359
Cdd:PHA03247 2905 PE RP P Q PQAPPPPQPQ P QP P PPPQ P QPPPPPPPR 2938
Name
Accession
Description
Interval
E-value
SAP130_C
pfam16014 Histone deacetylase complex subunit SAP130 C-terminus;
654-1059
0e+00
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain]
Cd Length: 371
Bit Score: 550.69
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 654 A Q GSSPRPSILRKKPAT D G mavrktllppqppdvatprvessmrsasgsprpag AKPK SEV HV SI A T PVTV SL E TISN QN 733
Cdd:pfam16014 1 A L GSSPRPSILRKKPAT E G ----------------------------------- AKPK PDI HV AV A P PVTV AV E ALPG QN 45
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 734 A EQ P T VAVP P TA Q Q P PPT IP SMI A A A S PPSQP AIA LST I P G A VP VTPP ---- ITTIA A T PT LS A p VGG T PSTVLGPPV PE 809
Cdd:pfam16014 46 S EQ Q T ASAS P PS Q H P AQA IP TIL A P A A PPSQP SVV LST L P A A MA VTPP ipas MANVV A P PT QP A - ASS T AACAVSSVL PE 124
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 810 IK V K E EAEP V D ITR pvs T VPPL ATNTV SP S L AL LA S NLS M P PS DL P PGASPRKKPRKQQHVISTEEG D MMETNSTD D EKS 889
Cdd:pfam16014 125 IK I K Q EAEP M D TSQ --- S VPPL TPTSI SP A L TS LA N NLS V P AG DL L PGASPRKKPRKQQHVISTEEG E MMETNSTD E EKS 201
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 890 A A K S L LVK AEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKK AM LQ EI ANQKGV S C 969
Cdd:pfam16014 202 A P K P L TSR AEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKK GT LQ DM ANQKGV T C 281
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 970 RAQGWK V HLCAAQLLQLTNLEHDVY E RLT N LQEG I IPKKKA A TDDDLHRINELIQGNMQRCKLVMDQI S EARDSM L KVLD 1049
Cdd:pfam16014 282 RAQGWK I HLCAAQLLQLTNLEHDVY S RLT T LQEG L IPKKKA G TDDDLHRINELIQGNMQRCKLVMDQI T EARDSM M KVLD 361
410
....*....|
gi 1274095663 1050 HKDRVLKLLN 1059
Cdd:pfam16014 362 HKDRVLKLLN 371
PHA03247
PHA03247 large tegument protein UL36; Provisional
437-905
3.17e-07
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 54.94
E-value: 3.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 437 PRIQPDY PPER SSLI P i SGH R A S PNPV A METRNDNRP S V P V Q fqyfl PTYPPS A Y P laah T YTPI TS SVSTIRQY P VSAQ 516
Cdd:PHA03247 2641 HPPPTVP PPER PRDD P - APG R V S RPRR A RRLGRAAQA S S P P Q ----- RPRRRA A R P ---- T VGSL TS LADPPPPP P TPEP 2710
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 517 AP NSTIT A qtgvgvastvhl N P MQLMTVD A SH A RHIQGIQ PAP ISTQGIQPA P I G tsgiq PA PIGT P GIHSAA P intqgl 596
Cdd:PHA03247 2711 AP HALVS A ------------ T P LPPGPAA A RQ A SPALPAA PAP PAVPAGPAT P G G ----- PA RPAR P PTTAGP P ------ 2767
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 597 Q PA AM A NQQPQ P EGKTSVVLADGATIVANPISN P FSA A PAATT V VQTHSQSASTNT PA QGSS P RP S ILRKK P AT dgmavr 676
Cdd:PHA03247 2768 A PA PP A APAAG P PRRLTRPAVASLSESRESLPS P WDP A DPPAA V LAPAAALPPAAS PA GPLP P PT S AQPTA P PP ------ 2841
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 677 ktll PP Q PP DVAT P R ---- VESSMRSASGSP R PAG AKP KSEVHVSIATPVTVSLET i S NQNAEQ P TVAVPPTA Q QPP P TI 752
Cdd:PHA03247 2842 ---- PP G PP PPSL P L ggsv APGGDVRRRPPS R SPA AKP AAPARPPVRRLARPAVSR - S TESFAL P PDQPERPP Q PQA P PP 2916
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 753 P SMIAAAS PP S QP AIALSTI P GAV P VTP P I T TI A ATP tls A P V G GT P STV LG P ------ P VP EIK V KEE A EPVDI tr P V S 826
Cdd:PHA03247 2917 P QPQPQPP PP P QP QPPPPPP P RPQ P PLA P T T DP A GAG --- E P S G AV P QPW LG A lvpgrv A VP RFR V PQP A PSREA -- P A S 2991
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 827 TV PPL a T NTVSPSLALL AS N L SMPPSDL PP GA S prkkp R KQ QHVIS -- TE EG D MMETNST D D E K S AAKS L LVKAEKRKS P 904
Cdd:PHA03247 2992 ST PPL - T GHSLSRVSSW AS S L ALHEETD PP PV S ----- L KQ TLWPP dd TE DS D ADSLFDS D S E R S DLEA L DPLPPEPHD P 3065
.
gi 1274095663 905 P 905
Cdd:PHA03247 3066 F 3066
PHA03247
PHA03247 large tegument protein UL36; Provisional
557-868
5.21e-06
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 51.09
E-value: 5.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 557 P APISTQGIQ P APIGTSGIQ PA PIGTPGIHS A A P INTQGLQ P AAMANQQPQ P EGKTSVVLADG A tivan P ISN P F S AA PA 636
Cdd:PHA03247 2560 P PAAPDRSVP P PRPAPRPSE PA VTSRARRPD A P P QSARPRA P VDDRGDPRG P APPSPLPPDTH A ----- P DPP P P S PS PA 2634
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 637 A TTVVQTHSQSA - STNT P AQGSS P RPSILRKKPATD G M A VRKTLL P PQ P PDV A TPRVES S M r SASGS P R P AGAK P KSEV H 715
Cdd:PHA03247 2635 A NEPDPHPPPTV p PPER P RDDPA P GRVSRPRRARRL G R A AQASSP P QR P RRR A ARPTVG S L - TSLAD P P P PPPT P EPAP H 2713
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 716 VSIATPVTVSLETISN Q NAEQPTV A VP P T A QQPP P TI P SMI A AASP P SQP A IALSTI P G A V P VT -- P PIT T IA A TPT LS A 793
Cdd:PHA03247 2714 ALVSATPLPPGPAAAR Q ASPALPA A PA P P A VPAG P AT P GGP A RPAR P PTT A GPPAPA P P A A P AA gp P RRL T RP A VAS LS E 2793
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1274095663 794 PVGGT PS TVLGPPV P EIKVKEE A EPVDITR P VSTV PP LATNT - VS P SLALLASNL S M P P - SDLP PG ASP R KK P RKQQ 868
Cdd:PHA03247 2794 SRESL PS PWDPADP P AAVLAPA A ALPPAAS P AGPL PP PTSAQ p TA P PPPPGPPPP S L P L g GSVA PG GDV R RR P PSRS 2870
PHA03247
PHA03247 large tegument protein UL36; Provisional
8-359
2.26e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 48.78
E-value: 2.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 8 R L R I P QASGLNVEMSSQQF P RLGTPSPGLSQ PPS QIASSGSAGLINQVATVND E AG RD ADVGT R EHVGPSSSLPP R EEKQ 87
Cdd:PHA03247 2597 R P R A P VDDRGDPRGPAPPS P LPPDTHAPDPP PPS PSPAANEPDPHPPPTVPPP E RP RD DPAPG R VSRPRRARRLG R AAQA 2676
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 88 EPVVV RP YPQVQMLPAHHAVAS A T P VAVTAP P AHLTP A VPLSFSEGLMKPPPKPTM P SR P I APAPP STMS l P P KV PG QVT 167
Cdd:PHA03247 2677 SSPPQ RP RRRAARPTVGSLTSL A D P PPPPPT P EPAPH A LVSATPLPPGPAAARQAS P AL P A APAPP AVPA - G P AT PG GPA 2755
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 168 VTMESSIPQASAI P VATISGQQ G H P SN L HHIMTTNVQM S IIRSNA P GP P LHIG A SH L PR gaaaaavms SSKVTTVLR P TS 247
Cdd:PHA03247 2756 RPARPPTTAGPPA P APPAAPAA G P P RR L TRPAVASLSE S RESLPS P WD P ADPP A AV L AP --------- AAALPPAAS P AG 2826
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 248 Q LP NAAT AQP AVQHLIHQ P IQ sr P PVTTSSTIP P AVVATVSATRAQSPVITTTA A HAADST L S RP TL S IQHPPS A -- AIS 325
Cdd:PHA03247 2827 P LP PPTS AQP TAPPPPPG P PP -- P SLPLGGSVA P GGDVRRRPPSRSPAAKPAAP A RPPVRR L A RP AV S RSTESF A lp PDQ 2904
330 340 350
....*....|....*....|....*....|....
gi 1274095663 326 IQ RP A Q SRDVTTRITL P SH P ALGT P KQQLHTMAQ 359
Cdd:PHA03247 2905 PE RP P Q PQAPPPPQPQ P QP P PPPQ P QPPPPPPPR 2938
Atrophin-1
pfam03154 Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
473-848
1.83e-04
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain]
Cd Length: 991
Bit Score: 45.53
E-value: 1.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 473 P SVPV Q FQYFL P TY PP SAYPLA A H T YT P IT S SV S TIR Q - Y P VSA Q A PN S T I - TA QTGVGVAS T VH L N P MQ L MT vdashar 550
Cdd:pfam03154 172 P VLQA Q SGAAS P PS PP PPGTTQ A A T AG P TP S AP S VPP Q g S P ATS Q P PN Q T Q s TA APHTLIQQ T PT L H P QR L PS ------- 244
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 551 hiqgiq P A P ISTQGI QP A P IGTSGI QP A P ig T P GI H SAA P INTQG LQ PAAMAN Q Q P Q P E gktsvvladg ATIVAN P I S NP 630
Cdd:pfam03154 245 ------ P H P PLQPMT QP P P PSQVSP QP L P -- Q P SL H GQM P PMPHS LQ TGPSHM Q H P V P P ---------- QPFPLT P Q S SQ 306
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 631 FSAA P AATTVVQTH SQ SASTNT P A Q GSSPRPSIL R KK P ATDG - MAVRKTLL PP QP P DVAT P RVE S SMRSASG S ------- 702
Cdd:pfam03154 307 SQVP P GPSPAAPGQ SQ QRIHTP P S Q SQLQSQQPP R EQ P LPPA p LSMPHIKP PP TT P IPQL P NPQ S HKHPPHL S gpspfqm 386
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 703 ---- P R P AGA KP K S EV --- H VSI A T P VTVS L ETI S N Q ---- N A EQ P TVAVPPTAQQ P PPTI P SMIAAASP PSQ PAIAL - S 770
Cdd:pfam03154 387 nsnl P P P PAL KP L S SL sth H PPS A H P PPLQ L MPQ S Q Q lppp P A QP P VLTQSQSLPP P AASH P PTSGLHQV PSQ SPFPQ h P 466
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 771 TI PG AV P V ----- T PP IT T IA A T P TLSA P VGGTP S T ------ VLGP P V P EIKV KEEA e PVDITR P V S TV PP LATNTVS P S 839
Cdd:pfam03154 467 FV PG GP P P itpps G PP TS T SS A M P GIQP P SSASV S S sgpvpa AVSC P L P PVQI KEEA - LDEAEE P E S PP PP PRSPSPE P T 545
....*....
gi 1274095663 840 LALLA S NL S 848
Cdd:pfam03154 546 VVNTP S HA S 554
Name
Accession
Description
Interval
E-value
SAP130_C
pfam16014 Histone deacetylase complex subunit SAP130 C-terminus;
654-1059
0e+00
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain]
Cd Length: 371
Bit Score: 550.69
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 654 A Q GSSPRPSILRKKPAT D G mavrktllppqppdvatprvessmrsasgsprpag AKPK SEV HV SI A T PVTV SL E TISN QN 733
Cdd:pfam16014 1 A L GSSPRPSILRKKPAT E G ----------------------------------- AKPK PDI HV AV A P PVTV AV E ALPG QN 45
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 734 A EQ P T VAVP P TA Q Q P PPT IP SMI A A A S PPSQP AIA LST I P G A VP VTPP ---- ITTIA A T PT LS A p VGG T PSTVLGPPV PE 809
Cdd:pfam16014 46 S EQ Q T ASAS P PS Q H P AQA IP TIL A P A A PPSQP SVV LST L P A A MA VTPP ipas MANVV A P PT QP A - ASS T AACAVSSVL PE 124
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 810 IK V K E EAEP V D ITR pvs T VPPL ATNTV SP S L AL LA S NLS M P PS DL P PGASPRKKPRKQQHVISTEEG D MMETNSTD D EKS 889
Cdd:pfam16014 125 IK I K Q EAEP M D TSQ --- S VPPL TPTSI SP A L TS LA N NLS V P AG DL L PGASPRKKPRKQQHVISTEEG E MMETNSTD E EKS 201
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 890 A A K S L LVK AEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKK AM LQ EI ANQKGV S C 969
Cdd:pfam16014 202 A P K P L TSR AEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKK GT LQ DM ANQKGV T C 281
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 970 RAQGWK V HLCAAQLLQLTNLEHDVY E RLT N LQEG I IPKKKA A TDDDLHRINELIQGNMQRCKLVMDQI S EARDSM L KVLD 1049
Cdd:pfam16014 282 RAQGWK I HLCAAQLLQLTNLEHDVY S RLT T LQEG L IPKKKA G TDDDLHRINELIQGNMQRCKLVMDQI T EARDSM M KVLD 361
410
....*....|
gi 1274095663 1050 HKDRVLKLLN 1059
Cdd:pfam16014 362 HKDRVLKLLN 371
PHA03247
PHA03247 large tegument protein UL36; Provisional
437-905
3.17e-07
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 54.94
E-value: 3.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 437 PRIQPDY PPER SSLI P i SGH R A S PNPV A METRNDNRP S V P V Q fqyfl PTYPPS A Y P laah T YTPI TS SVSTIRQY P VSAQ 516
Cdd:PHA03247 2641 HPPPTVP PPER PRDD P - APG R V S RPRR A RRLGRAAQA S S P P Q ----- RPRRRA A R P ---- T VGSL TS LADPPPPP P TPEP 2710
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 517 AP NSTIT A qtgvgvastvhl N P MQLMTVD A SH A RHIQGIQ PAP ISTQGIQPA P I G tsgiq PA PIGT P GIHSAA P intqgl 596
Cdd:PHA03247 2711 AP HALVS A ------------ T P LPPGPAA A RQ A SPALPAA PAP PAVPAGPAT P G G ----- PA RPAR P PTTAGP P ------ 2767
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 597 Q PA AM A NQQPQ P EGKTSVVLADGATIVANPISN P FSA A PAATT V VQTHSQSASTNT PA QGSS P RP S ILRKK P AT dgmavr 676
Cdd:PHA03247 2768 A PA PP A APAAG P PRRLTRPAVASLSESRESLPS P WDP A DPPAA V LAPAAALPPAAS PA GPLP P PT S AQPTA P PP ------ 2841
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 677 ktll PP Q PP DVAT P R ---- VESSMRSASGSP R PAG AKP KSEVHVSIATPVTVSLET i S NQNAEQ P TVAVPPTA Q QPP P TI 752
Cdd:PHA03247 2842 ---- PP G PP PPSL P L ggsv APGGDVRRRPPS R SPA AKP AAPARPPVRRLARPAVSR - S TESFAL P PDQPERPP Q PQA P PP 2916
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 753 P SMIAAAS PP S QP AIALSTI P GAV P VTP P I T TI A ATP tls A P V G GT P STV LG P ------ P VP EIK V KEE A EPVDI tr P V S 826
Cdd:PHA03247 2917 P QPQPQPP PP P QP QPPPPPP P RPQ P PLA P T T DP A GAG --- E P S G AV P QPW LG A lvpgrv A VP RFR V PQP A PSREA -- P A S 2991
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 827 TV PPL a T NTVSPSLALL AS N L SMPPSDL PP GA S prkkp R KQ QHVIS -- TE EG D MMETNST D D E K S AAKS L LVKAEKRKS P 904
Cdd:PHA03247 2992 ST PPL - T GHSLSRVSSW AS S L ALHEETD PP PV S ----- L KQ TLWPP dd TE DS D ADSLFDS D S E R S DLEA L DPLPPEPHD P 3065
.
gi 1274095663 905 P 905
Cdd:PHA03247 3066 F 3066
PHA03247
PHA03247 large tegument protein UL36; Provisional
557-868
5.21e-06
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 51.09
E-value: 5.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 557 P APISTQGIQ P APIGTSGIQ PA PIGTPGIHS A A P INTQGLQ P AAMANQQPQ P EGKTSVVLADG A tivan P ISN P F S AA PA 636
Cdd:PHA03247 2560 P PAAPDRSVP P PRPAPRPSE PA VTSRARRPD A P P QSARPRA P VDDRGDPRG P APPSPLPPDTH A ----- P DPP P P S PS PA 2634
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 637 A TTVVQTHSQSA - STNT P AQGSS P RPSILRKKPATD G M A VRKTLL P PQ P PDV A TPRVES S M r SASGS P R P AGAK P KSEV H 715
Cdd:PHA03247 2635 A NEPDPHPPPTV p PPER P RDDPA P GRVSRPRRARRL G R A AQASSP P QR P RRR A ARPTVG S L - TSLAD P P P PPPT P EPAP H 2713
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 716 VSIATPVTVSLETISN Q NAEQPTV A VP P T A QQPP P TI P SMI A AASP P SQP A IALSTI P G A V P VT -- P PIT T IA A TPT LS A 793
Cdd:PHA03247 2714 ALVSATPLPPGPAAAR Q ASPALPA A PA P P A VPAG P AT P GGP A RPAR P PTT A GPPAPA P P A A P AA gp P RRL T RP A VAS LS E 2793
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1274095663 794 PVGGT PS TVLGPPV P EIKVKEE A EPVDITR P VSTV PP LATNT - VS P SLALLASNL S M P P - SDLP PG ASP R KK P RKQQ 868
Cdd:PHA03247 2794 SRESL PS PWDPADP P AAVLAPA A ALPPAAS P AGPL PP PTSAQ p TA P PPPPGPPPP S L P L g GSVA PG GDV R RR P PSRS 2870
PHA03247
PHA03247 large tegument protein UL36; Provisional
8-359
2.26e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 48.78
E-value: 2.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 8 R L R I P QASGLNVEMSSQQF P RLGTPSPGLSQ PPS QIASSGSAGLINQVATVND E AG RD ADVGT R EHVGPSSSLPP R EEKQ 87
Cdd:PHA03247 2597 R P R A P VDDRGDPRGPAPPS P LPPDTHAPDPP PPS PSPAANEPDPHPPPTVPPP E RP RD DPAPG R VSRPRRARRLG R AAQA 2676
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 88 EPVVV RP YPQVQMLPAHHAVAS A T P VAVTAP P AHLTP A VPLSFSEGLMKPPPKPTM P SR P I APAPP STMS l P P KV PG QVT 167
Cdd:PHA03247 2677 SSPPQ RP RRRAARPTVGSLTSL A D P PPPPPT P EPAPH A LVSATPLPPGPAAARQAS P AL P A APAPP AVPA - G P AT PG GPA 2755
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 168 VTMESSIPQASAI P VATISGQQ G H P SN L HHIMTTNVQM S IIRSNA P GP P LHIG A SH L PR gaaaaavms SSKVTTVLR P TS 247
Cdd:PHA03247 2756 RPARPPTTAGPPA P APPAAPAA G P P RR L TRPAVASLSE S RESLPS P WD P ADPP A AV L AP --------- AAALPPAAS P AG 2826
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 248 Q LP NAAT AQP AVQHLIHQ P IQ sr P PVTTSSTIP P AVVATVSATRAQSPVITTTA A HAADST L S RP TL S IQHPPS A -- AIS 325
Cdd:PHA03247 2827 P LP PPTS AQP TAPPPPPG P PP -- P SLPLGGSVA P GGDVRRRPPSRSPAAKPAAP A RPPVRR L A RP AV S RSTESF A lp PDQ 2904
330 340 350
....*....|....*....|....*....|....
gi 1274095663 326 IQ RP A Q SRDVTTRITL P SH P ALGT P KQQLHTMAQ 359
Cdd:PHA03247 2905 PE RP P Q PQAPPPPQPQ P QP P PPPQ P QPPPPPPPR 2938
PHA03247
PHA03247 large tegument protein UL36; Provisional
118-512
9.23e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 46.86
E-value: 9.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 118 PP AH L T PA --------- VP LSFSEGLMKP P PKPTMPS RP I AP APPSTMSL P PKVP G QVTVTMES S - I P QASAI P VATISG 187
Cdd:PHA03247 2551 PP PP L P PA appaapdrs VP PPRPAPRPSE P AVTSRAR RP D AP PQSARPRA P VDDR G DPRGPAPP S p L P PDTHA P DPPPPS 2630
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 188 QQGHPSNLHHIMTTN V QMSIIRSNA P G P P ------------ LHIG AS HL P RGAAAA A VMSS - SKV T TVLR P TSQL P NAAT 254
Cdd:PHA03247 2631 PSPAANEPDPHPPPT V PPPERPRDD P A P G rvsrprrarrlg RAAQ AS SP P QRPRRR A ARPT v GSL T SLAD P PPPP P TPEP 2710
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 255 A QP A VQHLIHQ P IQSRPPVTT S STI P P A VVATVSATRAQS P V - ITTT A AHAADSTLSR P TLSIQHPPSAAISIQ RPA QSR 333
Cdd:PHA03247 2711 A PH A LVSATPL P PGPAAARQA S PAL P A A PAPPAVPAGPAT P G g PARP A RPPTTAGPPA P APPAAPAAGPPRRLT RPA VAS 2790
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 334 DVTT R IT LPS ------ H PA LGTPKQQLHTM A QKTIFSTGT P VA A ATV AP ILATNTL P STTTA G SVSHTQAP tsti V TMTM 407
Cdd:PHA03247 2791 LSES R ES LPS pwdpad P PA AVLAPAAALPP A ASPAGPLPP P TS A QPT AP PPPPGPP P PSLPL G GSVAPGGD ---- V RRRP 2866
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 408 PS H S SH A TAVTTSNI PV AKV vpqqithts P R IQPDYPP E RSS L I P ISGH R ASPNPVAMETRNDNR P SV P V Q F Q YFL P TY P 487
Cdd:PHA03247 2867 PS R S PA A KPAAPARP PV RRL --------- A R PAVSRST E SFA L P P DQPE R PPQPQAPPPPQPQPQ P PP P P Q P Q PPP P PP P 2937
410 420
....*....|....*....|....*
gi 1274095663 488 PSAY PLA AH T YTPITSSV S TIRQY P 512
Cdd:PHA03247 2938 RPQP PLA PT T DPAGAGEP S GAVPQ P 2962
Atrophin-1
pfam03154 Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
473-848
1.83e-04
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain]
Cd Length: 991
Bit Score: 45.53
E-value: 1.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 473 P SVPV Q FQYFL P TY PP SAYPLA A H T YT P IT S SV S TIR Q - Y P VSA Q A PN S T I - TA QTGVGVAS T VH L N P MQ L MT vdashar 550
Cdd:pfam03154 172 P VLQA Q SGAAS P PS PP PPGTTQ A A T AG P TP S AP S VPP Q g S P ATS Q P PN Q T Q s TA APHTLIQQ T PT L H P QR L PS ------- 244
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 551 hiqgiq P A P ISTQGI QP A P IGTSGI QP A P ig T P GI H SAA P INTQG LQ PAAMAN Q Q P Q P E gktsvvladg ATIVAN P I S NP 630
Cdd:pfam03154 245 ------ P H P PLQPMT QP P P PSQVSP QP L P -- Q P SL H GQM P PMPHS LQ TGPSHM Q H P V P P ---------- QPFPLT P Q S SQ 306
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 631 FSAA P AATTVVQTH SQ SASTNT P A Q GSSPRPSIL R KK P ATDG - MAVRKTLL PP QP P DVAT P RVE S SMRSASG S ------- 702
Cdd:pfam03154 307 SQVP P GPSPAAPGQ SQ QRIHTP P S Q SQLQSQQPP R EQ P LPPA p LSMPHIKP PP TT P IPQL P NPQ S HKHPPHL S gpspfqm 386
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 703 ---- P R P AGA KP K S EV --- H VSI A T P VTVS L ETI S N Q ---- N A EQ P TVAVPPTAQQ P PPTI P SMIAAASP PSQ PAIAL - S 770
Cdd:pfam03154 387 nsnl P P P PAL KP L S SL sth H PPS A H P PPLQ L MPQ S Q Q lppp P A QP P VLTQSQSLPP P AASH P PTSGLHQV PSQ SPFPQ h P 466
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 771 TI PG AV P V ----- T PP IT T IA A T P TLSA P VGGTP S T ------ VLGP P V P EIKV KEEA e PVDITR P V S TV PP LATNTVS P S 839
Cdd:pfam03154 467 FV PG GP P P itpps G PP TS T SS A M P GIQP P SSASV S S sgpvpa AVSC P L P PVQI KEEA - LDEAEE P E S PP PP PRSPSPE P T 545
....*....
gi 1274095663 840 LALLA S NL S 848
Cdd:pfam03154 546 VVNTP S HA S 554
PRK14950
PRK14950 DNA polymerase III subunits gamma and tau; Provisional
760-880
4.12e-03
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237864 [Multi-domain]
Cd Length: 585
Bit Score: 40.95
E-value: 4.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 760 SPPS Q PAIA L ST I PGAVPVT P PITTIAA T PTLSA PV GG TP STVLG P PVPEIKVKEEA EPV -- DI T R P VSTVP P L A TNTVS 837
Cdd:PRK14950 344 TSYG Q LPLE L AV I EALLVPV P APQPAKP T AAAPS PV RP TP APSTR P KAAAAANIPPK EPV re TA T P P PVPPR P V A PPVPH 423
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1274095663 838 PSLALLASNLSMP P S D LP P GAS P r KK P R K QQHVISTEE GD MM E 880
Cdd:PRK14950 424 TPESAPKLTRAAI P V D EK P KYT P - PA P P K EEEKALIAD GD VL E 465
PHA02732
PHA02732 hypothetical protein; Provisional
257-486
5.17e-03
hypothetical protein; Provisional
Pssm-ID: 165099 [Multi-domain]
Cd Length: 1467
Bit Score: 40.89
E-value: 5.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 257 PA V Q H L IHQPIQSRPPVTTSST -- IPP AVVA ---- TVSATR A QSPVITTTAAHA A DS T LSR P TL S IQHPPSAA IS IQ r P A 330
Cdd:PHA02732 1182 PA P Q L L SSYIPTGSVLYQDPIF ty IPP GIIG msgt NTFTFK A AQLQLSAASSPP A AT T PTP P PS S SSSSSAQS IS TS - P G 1260
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 331 Q SR ----- DV T TR I TLPSH PAL G TPK qqlhtmaqktifs T G TPV A AAT V apilatntlp STTT A GSVSHTQAPT S TIVTM 405
Cdd:PHA02732 1261 Q IQ ivlng ST T IH I NFLFF PAL S TPK ------------- I G QIL A MPI V ---------- NSSG A FISLYVNSAI S ANFNV 1317
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095663 406 T MPSHS S HA T AVTTSNIPVAKVV P QQITHTSPRIQPDYPP E r S SLIP IS GHRASPNPV A MET RN DNRP S V P VQ F QY F L P T 485
Cdd:PHA02732 1318 T IEYVF S NG T VIKRFTDEPGQIF P LPLINGDEEVIISVEN E - S TTFN IS ANNLGSAQL A LQL RN AISA S L P GP F AF F G P I 1396
.
gi 1274095663 486 Y 486
Cdd:PHA02732 1397 L 1397
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
