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Conserved domains on  [gi|1270813974|ref|NP_001344414.1|]
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phosphatidylinositol-3-phosphatase SAC1 isoform 1x [Mus musculus]

Protein Classification

SAC family polyphosphoinositide phosphatase( domain architecture ID 10493136)

SAC family polyphosphoinositide phosphatase catalyzes the hydrolysis of phosphatidylinositol (PtdIns) phosphates, such as PtdIns(3)P, PtdIns(4)P, and/or PtdIns(3,5)P2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
 58-345 7.35e-125

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


:

Pssm-ID: 460545  Cd Length: 295  Bit Score: 369.98  E-value: 7.35e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974  58 FGILGTIHLVAGNYLVVITKKMKVGECFNHAVWRATDFDV--LSYKKTMLHLTDIQLQDNKTFLAMLNHVLSMDGFYFST 135
Cdd:pfam02383   1 YGILGLIRLLSGYYLIVITKREQVGQIGGHPIYKITDVEFipLNSSLSDTQLAKKEHPDEERLLKLLKLFLSSGSFYFSY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974 136 TYDLTHTLQRLSNTSPEFQEMSLleraDQRFVWNGHLLREL-SAQPEVHRFALPVLHGFITMHSCSINGKYFDWILISRR 214
Cdd:pfam02383  81 DYDLTNSLQRNLTRSRSPSFDSL----DDRFFWNRHLLKPLiDFQLDLDRWILPLIQGFVEQGKLSVFGRSVTLTLISRR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974 215 SCFRAGVRYYVRGIDSEGHAANFVETEQIVHY-----SGNRASFVQTRGSIPIFWSQRPNLKYKPHPQISKVANHMDGFQ 289
Cdd:pfam02383 157 SRKRAGTRYLRRGIDDDGNVANFVETEQIVSLntsnsEGKIFSFVQIRGSIPLFWSQDPNLKYKPKIQITRPEATQPAFK 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1270813974 290 RHFDSQVIIYGKQVIINLVNHKGSEKPLEQTFANMVSSLGSGM---IRYIAFDFHKECK 345
Cdd:pfam02383 237 KHFDDLIERYGPVHIVNLVEKKGRESKLSEAYEEAVKYLNQFLpdkLRYTAFDFHHECK 295
 
Name Accession Description Interval E-value
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
 58-345 7.35e-125

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


Pssm-ID: 460545  Cd Length: 295  Bit Score: 369.98  E-value: 7.35e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974  58 FGILGTIHLVAGNYLVVITKKMKVGECFNHAVWRATDFDV--LSYKKTMLHLTDIQLQDNKTFLAMLNHVLSMDGFYFST 135
Cdd:pfam02383   1 YGILGLIRLLSGYYLIVITKREQVGQIGGHPIYKITDVEFipLNSSLSDTQLAKKEHPDEERLLKLLKLFLSSGSFYFSY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974 136 TYDLTHTLQRLSNTSPEFQEMSLleraDQRFVWNGHLLREL-SAQPEVHRFALPVLHGFITMHSCSINGKYFDWILISRR 214
Cdd:pfam02383  81 DYDLTNSLQRNLTRSRSPSFDSL----DDRFFWNRHLLKPLiDFQLDLDRWILPLIQGFVEQGKLSVFGRSVTLTLISRR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974 215 SCFRAGVRYYVRGIDSEGHAANFVETEQIVHY-----SGNRASFVQTRGSIPIFWSQRPNLKYKPHPQISKVANHMDGFQ 289
Cdd:pfam02383 157 SRKRAGTRYLRRGIDDDGNVANFVETEQIVSLntsnsEGKIFSFVQIRGSIPLFWSQDPNLKYKPKIQITRPEATQPAFK 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1270813974 290 RHFDSQVIIYGKQVIINLVNHKGSEKPLEQTFANMVSSLGSGM---IRYIAFDFHKECK 345
Cdd:pfam02383 237 KHFDDLIERYGPVHIVNLVEKKGRESKLSEAYEEAVKYLNQFLpdkLRYTAFDFHHECK 295
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
57-513 1.15e-124

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 379.43  E-value: 1.15e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974  57 IFGILGTIHLVAGNYLVVITKKMKVGECFNHAVWRATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLSMDGFYFSTT 136
Cdd:COG5329    60 IYGVIGLIKLKGDIYLIVITGASLVGVIPGHSIYKILDVDFISLNNNKWDDELEEDEANYDKLSELKKLLSNGTFYFSYD 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974 137 YDLTHTLQRLSNTSPEFQEMslleRADQRFVWNGHLLREL----SAQPEV----HRFALPVLHGFITMHSCSINGKYFDW 208
Cdd:COG5329   140 FDITNSLQKNLSEGLEASVD----RADLIFMWNSFLLEEFinhrSKLSSLekqfDNFLTTVIRGFAETVDIKVGGNTISL 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974 209 ILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYSGNRASFVQTRGSIPIFWSQRPNLKYKPHpQISKVA-NHMDG 287
Cdd:COG5329   216 TLISRRSSERAGTRYLSRGIDDDGNVSNFVETEQIVTDSQYIFSFTQVRGSIPLFWEQSNLLYGPKI-KVTRSSeAAQSA 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974 288 FQRHFDSQVIIYGKQVIINLVNHKGSEKPLEQTFANMVSSLGSGMIRYIAFDFHKECKNMRWDRLSILLDQVAEMQDELS 367
Cdd:COG5329   295 FDKHFDKLREKYGDVYVVNLLKTKGYEAPLLELYEKHLDLSKKPKIHYTEFDFHKETSQDGFDDVKKLLYLIEQDLLEFG 374

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974 368 YFLVD-SAGKVVTNQDGVFRSNCMDCLDRTNVIQSLLARrSLQAQLQRLGVLHVGQkleeqDEFEKTYKNAWADNANACA 446
Cdd:COG5329   375 YFAYDiNEGKSISEQDGVFRTNCLDCLDRTNVIQSLISR-VLLEQFRSEGVISDGY-----SPFLQIHRELWADNGDAIS 448

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1270813974 447 KQYAGTGALKTDFTRTGKRTQLGLLMDGFNSLLRYYKNNFSDGFRQDSIDLFLGNYSVDELESHSPL 513
Cdd:COG5329   449 RLYTGTGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLGKFRPQEAFSYRPL 515
 
Name Accession Description Interval E-value
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
 58-345 7.35e-125

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


Pssm-ID: 460545  Cd Length: 295  Bit Score: 369.98  E-value: 7.35e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974  58 FGILGTIHLVAGNYLVVITKKMKVGECFNHAVWRATDFDV--LSYKKTMLHLTDIQLQDNKTFLAMLNHVLSMDGFYFST 135
Cdd:pfam02383   1 YGILGLIRLLSGYYLIVITKREQVGQIGGHPIYKITDVEFipLNSSLSDTQLAKKEHPDEERLLKLLKLFLSSGSFYFSY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974 136 TYDLTHTLQRLSNTSPEFQEMSLleraDQRFVWNGHLLREL-SAQPEVHRFALPVLHGFITMHSCSINGKYFDWILISRR 214
Cdd:pfam02383  81 DYDLTNSLQRNLTRSRSPSFDSL----DDRFFWNRHLLKPLiDFQLDLDRWILPLIQGFVEQGKLSVFGRSVTLTLISRR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974 215 SCFRAGVRYYVRGIDSEGHAANFVETEQIVHY-----SGNRASFVQTRGSIPIFWSQRPNLKYKPHPQISKVANHMDGFQ 289
Cdd:pfam02383 157 SRKRAGTRYLRRGIDDDGNVANFVETEQIVSLntsnsEGKIFSFVQIRGSIPLFWSQDPNLKYKPKIQITRPEATQPAFK 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1270813974 290 RHFDSQVIIYGKQVIINLVNHKGSEKPLEQTFANMVSSLGSGM---IRYIAFDFHKECK 345
Cdd:pfam02383 237 KHFDDLIERYGPVHIVNLVEKKGRESKLSEAYEEAVKYLNQFLpdkLRYTAFDFHHECK 295
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
57-513 1.15e-124

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 379.43  E-value: 1.15e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974  57 IFGILGTIHLVAGNYLVVITKKMKVGECFNHAVWRATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLSMDGFYFSTT 136
Cdd:COG5329    60 IYGVIGLIKLKGDIYLIVITGASLVGVIPGHSIYKILDVDFISLNNNKWDDELEEDEANYDKLSELKKLLSNGTFYFSYD 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974 137 YDLTHTLQRLSNTSPEFQEMslleRADQRFVWNGHLLREL----SAQPEV----HRFALPVLHGFITMHSCSINGKYFDW 208
Cdd:COG5329   140 FDITNSLQKNLSEGLEASVD----RADLIFMWNSFLLEEFinhrSKLSSLekqfDNFLTTVIRGFAETVDIKVGGNTISL 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974 209 ILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYSGNRASFVQTRGSIPIFWSQRPNLKYKPHpQISKVA-NHMDG 287
Cdd:COG5329   216 TLISRRSSERAGTRYLSRGIDDDGNVSNFVETEQIVTDSQYIFSFTQVRGSIPLFWEQSNLLYGPKI-KVTRSSeAAQSA 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974 288 FQRHFDSQVIIYGKQVIINLVNHKGSEKPLEQTFANMVSSLGSGMIRYIAFDFHKECKNMRWDRLSILLDQVAEMQDELS 367
Cdd:COG5329   295 FDKHFDKLREKYGDVYVVNLLKTKGYEAPLLELYEKHLDLSKKPKIHYTEFDFHKETSQDGFDDVKKLLYLIEQDLLEFG 374

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270813974 368 YFLVD-SAGKVVTNQDGVFRSNCMDCLDRTNVIQSLLARrSLQAQLQRLGVLHVGQkleeqDEFEKTYKNAWADNANACA 446
Cdd:COG5329   375 YFAYDiNEGKSISEQDGVFRTNCLDCLDRTNVIQSLISR-VLLEQFRSEGVISDGY-----SPFLQIHRELWADNGDAIS 448

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1270813974 447 KQYAGTGALKTDFTRTGKRTQLGLLMDGFNSLLRYYKNNFSDGFRQDSIDLFLGNYSVDELESHSPL 513
Cdd:COG5329   449 RLYTGTGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLGKFRPQEAFSYRPL 515
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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