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Conserved domains on  [gi|1254064757|ref|NP_001343543|]
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COMM domain-containing protein 8 isoform d [Mus musculus]

Protein Classification

COMM domain-containing protein( domain architecture ID 4715)

COMM (copper metabolism gene MURR1) domain-containing protein is involved in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd super family cl06336
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 5-110 2.79e-50

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


The actual alignment was detected with superfamily member cd04756:

Pssm-ID: 471425 [Multi-domain]  Cd Length: 176  Bit Score: 156.80  E-value: 2.79e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064757   5 QQLNQLNSCHQEAVLKCLKSRRNEIKQALLGEIVDISCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDDKVKPY 84
Cdd:cd04756    71 AQLSDLSSSHQEALLKCVKSRKEEIRQALVNKTNSISSAQLQDFDWQLKLALSSDKLSSLQEPLLNLDLDVKENGILKPV 150

                          90       100
                  ....*....|....*....|....*.
gi 1254064757  85 TVEMSKEELQSLISSLEAANKVVLQL 110
Cdd:cd04756   151 SIEMNKEELQNLISSLEAANKVVLQL 176
 
Name Accession Description Interval E-value
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 5-110 2.79e-50

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 156.80  E-value: 2.79e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064757   5 QQLNQLNSCHQEAVLKCLKSRRNEIKQALLGEIVDISCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDDKVKPY 84
Cdd:cd04756    71 AQLSDLSSSHQEALLKCVKSRKEEIRQALVNKTNSISSAQLQDFDWQLKLALSSDKLSSLQEPLLNLDLDVKENGILKPV 150

                          90       100
                  ....*....|....*....|....*.
gi 1254064757  85 TVEMSKEELQSLISSLEAANKVVLQL 110
Cdd:cd04756   151 SIEMNKEELQNLISSLEAANKVVLQL 176
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 41-103 5.36e-13

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 58.71  E-value: 5.36e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1254064757  41 SCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDD-KVKPYTVEMSKEELQSLISSLEAA 103
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDgSSEEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 5-110 2.79e-50

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 156.80  E-value: 2.79e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064757   5 QQLNQLNSCHQEAVLKCLKSRRNEIKQALLGEIVDISCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDDKVKPY 84
Cdd:cd04756    71 AQLSDLSSSHQEALLKCVKSRKEEIRQALVNKTNSISSAQLQDFDWQLKLALSSDKLSSLQEPLLNLDLDVKENGILKPV 150

                          90       100
                  ....*....|....*....|....*.
gi 1254064757  85 TVEMSKEELQSLISSLEAANKVVLQL 110
Cdd:cd04756   151 SIEMNKEELQNLISSLEAANKVVLQL 176
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 41-103 5.36e-13

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 58.71  E-value: 5.36e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1254064757  41 SCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDD-KVKPYTVEMSKEELQSLISSLEAA 103
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDgSSEEVTFELSKEQLQDLLNELEEA 64
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 21-107 2.11e-10

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 52.70  E-value: 2.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064757  21 CLKSRRNEIKQALLGEivDISCAQLQDFDWQLKLALSSDKIATLQMP--LLNLHLDVKEDDKVKPYTVEMSKEELQSLIS 98
Cdd:cd04748     1 LLTENKAEIEELLSKQ--SLSLPQLVDFDWRLDVQISSSSLAKVKQPtiLVQLKLQVGDNNSSEKICFEMTKEELQNFLN 78


                  ....*....
gi 1254064757  99 SLEAANKVV 107
Cdd:cd04748    79 KLKKIKAQL 87
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 4-103 8.07e-04

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 36.64  E-value: 8.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064757   4 LQQLNqLNSCHQEAVLKCLKSRRNEIKQALLGEIVDIScaQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVK--EDDKV 81
Cdd:cd04752    69 LQQLG-LPKEHATSLCRSYEEKQSKLQESLRANSLRLS--RLESVDWRVDYILSSSELQEVNEPLVQLRLKVRnaDTGEI 145

                          90       100
                  ....*....|....*....|..
gi 1254064757  82 KPYTVEMSKEELQSLISSLEAA 103
Cdd:cd04752   146 TPHPFSVSADKFRVLLAELKQA 167
Commd9 cd04757
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of ...
 40-100 1.18e-03

COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240105  Cd Length: 108  Bit Score: 35.62  E-value: 1.18e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1254064757  40 ISCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDDKVK-------PYTVEMSKEELQSLISSL 100
Cdd:cd04757    29 ISLPKLVDHDWRVDIKTSSDSLGRMAVPTCLLQMKIQEAPSLCgllpplsTLTMELSKETLDTMLDGL 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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