forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1) and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex, which associates with both the 3'end of the CCND1 gene and its mRNA. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784 116 PSFELSGALLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQH 195
Cdd:cd22718     1 PNFGLSGALAEDTNTFRGVVIKYSEPPEARKPKKRWRLYPFKGDEALPVLYIHRQSAYLLGRDRKIADIPIDHPSCSKQH 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1253131784 196 AVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHE 264
Cdd:cd22718    81 AVLQYRLVEYTRPDGTKGRRVRPYIIDLESANGTFLNNKKIEPQRYYELKEKDVLKFGFSSREYVLLHE 149

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1) and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex, which associates with both the 3'end of the CCND1 gene and its mRNA. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784 116 PSFELSGALLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQH 195
Cdd:cd22718     1 PNFGLSGALAEDTNTFRGVVIKYSEPPEARKPKKRWRLYPFKGDEALPVLYIHRQSAYLLGRDRKIADIPIDHPSCSKQH 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1253131784 196 AVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHE 264
Cdd:cd22718    81 AVLQYRLVEYTRPDGTKGRRVRPYIIDLESANGTFLNNKKIEPQRYYELKEKDVLKFGFSSREYVLLHE 149

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784 169 RQSAYLLGRHRRiADIPIDHPSCSKQHAVFQYRlveytraDGTVgrrvkpYIIDLGSGNGTFLNNKRIepQRYYELKEKD 248
Cdd:COG1716    19 DGGPLTIGRAPD-NDIVLDDPTVSRRHARIRRD-------GGGW------VLEDLGSTNGTFVNGQRV--TEPAPLRDGD 82

                  ....*
gi 1253131784 249 VLKFG 253
Cdd:COG1716    83 VIRLG 87

transcription termination factor Rho; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784   3 KVKQEREDHPRRGREDRQHREPSEQEHRRARNSERDRHRGHSRQGRSSDERPVSGQDRDRDSQNLQAQEEERDFHNARRR 82
Cdd:PRK12678  144 KAGEGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRREQGDRREERGRRDG 223

                          90
                  ....*....|....*
gi 1253131784  83 EHRQQNESAGSEAQE 97
Cdd:PRK12678  224 GDRRGRRRRRDRRDA 238

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1) and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex, which associates with both the 3'end of the CCND1 gene and its mRNA. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784 116 PSFELSGALLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQH 195
Cdd:cd22718     1 PNFGLSGALAEDTNTFRGVVIKYSEPPEARKPKKRWRLYPFKGDEALPVLYIHRQSAYLLGRDRKIADIPIDHPSCSKQH 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1253131784 196 AVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHE 264
Cdd:cd22718    81 AVLQYRLVEYTRPDGTKGRRVRPYIIDLESANGTFLNNKKIEPQRYYELKEKDVLKFGFSSREYVLLHE 149

forkhead associated (FHA) domain found in Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins; DDL, also called protein DAWDLE, is involved in microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784 136 IKYSEPPEARIPKKRWRLYPFKNDEVL-PVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQHAVFQYRLVEYTRADGTVGR 214
Cdd:cd22719     1 LLFVEPPEARKPSKRWRLYVFKDGEPLnEPLHIHRQSCYLFGRERKVADIPTDHPSCSKQHAVIQYRLTEKEGGDGMMGK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1253131784 215 RVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHE 264
Cdd:cd22719    81 AVRPYIMDLGSTNGTFLNGERIEPQRYYELLEKDTIKFGNSSREYVLLHE 130

forkhead associated (FHA) domain found in kanadaptin and similar proteins; Kanadaptin, also called human lung cancer oncogene 3 protein (HLC-3), kidney anion exchanger adapter protein, or solute carrier family 4 anion exchanger member 1 adapter protein (SLC4A1AP), is a nuclear protein widely expressed in mammalian tissues. It was originally isolated as a kidney Cl-/HCO3- anion exchanger 1 (kAE1)-binding protein. It is a highly mobile nucleocytoplasmic shuttling and multilocalizing protein. Its role in mammalian cells remains unclear. It contains an FHA domain, which is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784 170 QSAYLLGRHRrIADIPIDHPSCSKQHAVFQYRLVEyTRADGTVgrrvkpYIIDLGSGNGTFLNNKRIEPQRYYELKEKDV 249
Cdd:cd22677    21 KSFYVFGRLP-GCDVVLEHPSISRYHAVLQYRGDA-DDHDGGF------YLYDLGSTHGTFLNKQRIPPKQYYRLRVGHV 92

                          90
                  ....*....|..
gi 1253131784 250 LKFGFSSREYVL 261
Cdd:cd22677    93 LKFGGSTRLYIL 104

forkhead associated (FHA) domain found in Arabidopsis thaliana Protein PARALLEL SPINDLE 1 (PS1) and similar proteins; PS1 is an FHA domain-containing protein required for normal spindle orientation at male meiosis II and normal formation of tetrad of microspores. It is not involved in female meiosis. Mutations in PS1 lead to the production of diploid pollen grains. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784 157 KNDEVLPVMYIHRQSAY-------LLGRHRRiADIPIDHPSCSKQHAvfQYRLVEYTRadgtvgrrvKPYIIDLGSGNGT 229
Cdd:cd22691     8 KNGSVLKNIFLHGKFSKseeedilVVGRHPD-CDIVLDHPSISRFHL--EIRIIPSRR---------KITLTDLSSVHGT 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1253131784 230 FLNNKRIEPQRYYELKEKDVLKFGFSSREYVLL 262
Cdd:cd22691    76 WVNGQRIEPGVPVELEEGDTVRLGASTRVYRLH 108

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784 152 RLYPFKNDEVLPVMYIHRQSaYLLGRHRRiADIPIDHPSCSKQHAVFQYRlveytraDGTVgrrvkpYIIDLGSGNGTFL 231
Cdd:cd00060     1 RLIVLDGDGGGREFPLTKGV-VTIGRSPD-CDIVLDDPSVSRRHARIEVD-------GGGV------YLEDLGSTNGTFV 65

                          90       100
                  ....*....|....*....|..
gi 1253131784 232 NNKRIEPQryYELKEKDVLKFG 253
Cdd:cd00060    66 NGKRITPP--VPLQDGDVIRLG 85

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784 169 RQSAYLLGRHRRiADIPIDHPSCSKQHAVFQYRlveytraDGTVgrrvkpYIIDLGSGNGTFLNNKRIepQRYYELKEKD 248
Cdd:COG1716    19 DGGPLTIGRAPD-NDIVLDDPTVSRRHARIRRD-------GGGW------VLEDLGSTNGTFVNGQRV--TEPAPLRDGD 82

                  ....*
gi 1253131784 249 VLKFG 253
Cdd:COG1716    83 VIRLG 87

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1253131784  173 YLLGRHRRIADIPIDHPSCSKQHAVFQYRlvEYTRAdgtvgrrvkpYIIDLGSGNGTFLNNKRI 236
Cdd:smart00240   1 VTIGRSSEDCDIQLDGPSISRRHAVIVYD--GGGRF----------YLIDLGSTNGTFVNGKRI 52

forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) family; The Cep170 family includes Cep170 and Cep170B. Cep170, also called Cep170A, KARP-1-binding protein, or KARP1-binding protein, is a protein that localizes to centrosomes as well as spindle microtubules and plays a role in microtubule organization and microtubule assembly. It is required for centriole subdistal appendage assembly. Cep170 is phosphorylated during M phase and interacts with Polo-like kinase 1 (Plk1). Cep170B, also called centrosomal protein 170B, plays a role in microtubule organization. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784 168 HR--QSAYLLGRHRriADIPIDHPSCSKQHAVFQYRLVeytradgtvgrRVKPYIIDLGSGNGTFLNNKRIEPQRYYELK 245
Cdd:cd22704    12 HRlpRSMLFVGRED--CDLILQSRSVDKQHAVITYDQI-----------DNEFKIKDLGSLNGTFVNDSRIPEQTYITLK 78

                          90
                  ....*....|....*.
gi 1253131784 246 EKDVLKFGFSSREYVL 261
Cdd:cd22704    79 LGDSIRFGYDTNVYRF 94

forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also called cell cycle regulatory protein p95, or Nijmegen breakage syndrome protein 1 (NBS1), is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. Nibrin modulates the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. Nibrin also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. Nibrin is a major player in the control of intra-S-phase checkpoint. This subfamily also includes Schizosaccharomyces pombe DNA repair and telomere maintenance protein Nbs1 and Arabidopsis thaliana AtNbs1. SpNbs1 is an FHA domain-containing protein required for DNA damage repair and S-phase DNA damage checkpoint. It is involved in telomere length maintenance and maintenance of chromatin structure. AtNbs1 is a component of MRN complex. It also functions in the very early stages of meiosis. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784 151 WRLYPFKNDEVLPVmYIHRQSAYLLGRhrRIADIPIDH-PSCSKQHAVFQyrLVEYTRADGTVGRRVKPYIIDLgSGNGT 229
Cdd:cd22667     1 WWLLSEQDGAGTSY-YLLPGGEYTVGR--KDCDIIIVDdSSISRKHATLT--VLHPEANLSDPDTRPELTLKDL-SKYGT 74

                          90       100
                  ....*....|....*....|....
gi 1253131784 230 FLNNKRIEPQRYYELKEKDVLKFG 253
Cdd:cd22667    75 FVNGEKLKGGSEVTLKDGDVITFG 98

forkhead associated (FHA) domain found in Arabidopsis thaliana protein phosphatase 2C 70 (AtPP2C70) and similar proteins; AtPP2C70, also called kinase-associated protein phosphatase, or protein ROOT ATTENUATED GROWTH 1, dephosphorylates the serine/threonine receptor-like kinase RLK5. It may function as a signaling component in a pathway involving RLK5. It acts as a negative regulator of the CLAVATA1 signaling in plant development by binding and dephosphorylating CLAVATA1. It is also a component of a signaling pathway which mediates adaptation to NaCl stress. It contains an FHA domain, which is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784 175 LGRHRRiADIPIDHPSCSKQHAVFQYrlveytraDGTVGRRvkpYIIDLGSGNGTFLNNKRIEPQ-RYYELKEKDVLKFG 253
Cdd:cd22678    27 IGRIQR-GDIALKDDEVSGKHARIEW--------NSTGSKW---ELVDLGSLNGTLVNGESISPNgRPVVLSSGDVITLG 94

                  ....*..
gi 1253131784 254 FSSREYV 260
Cdd:cd22678    95 SETKILV 101

forkhead associated (FHA) domain found in centrosomal protein of 170 kDa (Cep170) and similar proteins; Cep170, also called Cep170A, KARP-1-binding protein, or KARP1-binding protein, is a protein that localizes to centrosomes as well as spindle microtubules and plays a role in microtubule organization and microtubule assembly. It is required for centriole subdistal appendage assembly. Cep170 is phosphorylated during M phase and interacts with Polo-like kinase 1 (Plk1). The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1253131784 190 SCSKQHAVFQYRlveytraDGTVGRRVKpyiiDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLL 262
Cdd:cd22724    38 SVDKQHAVINYD-------ASTDEHKVK----DLGSLNGTFVNDVRIPEQTYITLKLDDKLRFGYDTNLFTVV 99

forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar proteins; Ki-67, also called antigen identified by monoclonal antibody Ki-67, antigen KI-67, or antigen Ki67, acts as a biological surfactant to disperse mitotic chromosomes. It is required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Ki-67 binds DNA with a preference for supercoiled DNA and AT-rich DNA. It may also play a role in chromatin organization. Ki-67 contains an FHA domain at its N-terminus. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784 173 YLLGRHRRiADIPIDHPSCSKQHAVFqyrlveytradgTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRyyELKEKDVLKF 252
Cdd:cd22673    23 CTFGRDLS-CDIRIQLPGVSREHCRI------------EVDENGKAYLENLSTTNPTLVNGKAIEKSA--ELKDGDVITI 87

                  .
gi 1253131784 253 G 253
Cdd:cd22673    88 G 88

forkhead associated (FHA) domain found in RING finger protein 8 (RNF8) and similar proteins; RNF8 is a telomere-associated E3 ubiquitin-protein ligase that plays an important role in DNA double-strand break (DSB) repair via histone ubiquitination. It is localized in the nucleus and interacts with class III E2s (UBE2E2, UbcH6, and UBE2E3), but not with other E2s (UbcH5, UbcH7, UbcH10, hCdc34, and hBendless). It recruits UBC13 for lysine 63-based self polyubiquitylation. Its deficiency causes neuronal pathology and cognitive decline, and its loss results in neuron degeneration. RNF8, together with RNF168, catalyzes a series of ubiquitylation events on substrates such as H2A and H2AX, with the H2AK13/15 ubiquitylation being particularly important for recruitment of repair factors p53-binding protein 1 (53BP1) or the RAP80-BRCA1 complex to sites of DSBs. Specially, RNF8 mediates the ubiquitination of gammaH2AX, and recruits 53BP1 and BRCA1 to DNA damage sites which promotes DNA damage response (DDR) and inhibits chromosomal instability. Moreover, RNF8 interacts with retinoid X receptor alpha (RXR alpha) and enhances its transcription-stimulating activity. It also regulates the rate of exit from mitosis and cytokinesis. RNF8 contains an N-terminal FHA domain, which is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784 184 IPIDHPSCSKQHAVFQYRlveytrADGTVgrrvkpYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFG 253
Cdd:cd22663    36 VSTCPLMISRNHCVLKKN------DEGQW------TIKDNKSLNGVWVNGERIEPLKPYPLNEGDLIQLG 93

forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaA and similar proteins; FhaA regulates cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis. It contains an FHA domain, which is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784 169 RQSAYLLGRHRRiADIPIDHPSCSKQHAVFQYrlveytraDGTVGrrvkpYIIDLGSGNGTFLNNKRIEPQryYELKEKD 248
Cdd:cd22668    16 REGSNIIGRGSD-ADFRLPDTGVSRRHAEIRW--------DGQVA-----HLTDLGSTNGTTVNNAPVTPE--WRLADGD 79

                  ....*...
gi 1253131784 249 VLKFGFSS 256
Cdd:cd22668    80 VITLGHSE 87

forkhead associated (FHA) domain found in Saccharomyces cerevisiae DNA damage response protein kinase DUN1 and similar proteins; DUN1 is a protein kinase that controls the DNA damage response in yeast. It phosphorylates SML1 on serine residues and cooperates with the PAN deadenylation complex in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress. It contains an FHA domain, which is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784 163 PVMYIHRQSAYLLGRHRRIaDIPIDHPSCSKQHAVFQyrlVEYTRAdgtvgrrvkpYIIDLGSGNGTFLNNKRIEpQRYY 242
Cdd:cd22683    13 QKISITNRNVTTIGRSRSC-DLVLSDPSISRFHAELR---LEQNGI----------NVIDNNSANGTFINGKRIK-GKTY 77

                          90
                  ....*....|.
gi 1253131784 243 ELKEKDVLKFG 253
Cdd:cd22683    78 ILKNGDIIVFG 88

first forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the first FHA domain. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1253131784 170 QSAYLLGRHRRiADIPIDHPSCSKQHAVFQYRLVEYTradgtvgrrvkpyIIDLGSGNGTFLNNKRI 236
Cdd:cd22694    15 GSSVRIGRDPD-ADVRLDDPRVSRRHALLEFDGDGWV-------------YTDLGSRNGTYLNGRRV 67

transcription termination factor Rho; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784   6 QEREDHPRRGREDRQHREPSEQEHRRARNSERDRHRghSRQGRSSDERPVS-GQDRDRDSQNLQAQEEERDFHNARRREH 84
Cdd:PRK12678  174 RRGDREDRQAEAERGERGRREERGRDGDDRDRRDRR--EQGDRREERGRRDgGDRRGRRRRRDRRDARGDDNREDRGDRD 251

                          90
                  ....*....|
gi 1253131784  85 RQQNESAGSE 94
Cdd:PRK12678  252 GDDGEGRGGR 261

forkhead associated (FHA) domain found in transcription factor 19 (TCF-19) and similar proteins; TCF-19, also called transcription factor SC1, was identified as a putative trans-activating factor with expression beginning at the late G1-S boundary in dividing cells. It also functions as a novel islet factor necessary for proliferation and survival in the INS-1 beta cell line. It plays an important role in susceptibility to both Type 1 Diabetes Mellitus (T1DM) and Type 2 Diabetes Mellitus (T2DM); it has been suggested that it may positively impact beta cell mass under conditions of beta cell stress and increased insulin demand. TCF-19 contains an N-terminal fork head association domain (FHA), a proline rich region, and a C-terminal plant homeodomain (PHD) finger. The FHA domain may serve as a nuclear signaling domain or as a phosphoprotein binding domain. The proline rich region is a common characteristic of trans-activating factors. The PHD finger may allow TCF-19 to interact with chromatin via methylated histone H3.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784 170 QSAYLLGRHRRIADIPIdhpsCSKQHAVFQYRLVEYTRADGTVGRRVKPYIIDLgSGNGTFLNNKRIEPQRYYELKEKDV 249
Cdd:cd22685    27 LCEYRIGRNPEVCDVFL----CSSQHPNLISREHAEIHAERDGNGNWKVLIEDR-STNGTYVNDVRLQDGQRRELSDGDT 101

                          90       100
                  ....*....|....*....|.
gi 1253131784 250 LKFGFSSREYVLLHESSDTSE 270
Cdd:cd22685   102 ITFGHKNGRRVKQWPYQKSSE 122

transcription termination factor Rho; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253131784   6 QEREDHPRRGREDRQHREPSEQEHRRARNSERDRHRGHSRQGRSSDERPVS---GQDRDRDSQNLQAQEEERDFHNARRR 82
Cdd:PRK12678  182 QAEAERGERGRREERGRDGDDRDRRDRREQGDRREERGRRDGGDRRGRRRRrdrRDARGDDNREDRGDRDGDDGEGRGGR 261

                  ...
gi 1253131784  83 EHR 85
Cdd:PRK12678  262 RGR 264

forkhead associated (FHA) domain found in Myxococcus xanthus EspA and similar proteins; EspA is a histidine protein kinase with a fork head-associated (FHA) domain at the N-terminus and a receiver domain at the C-terminus. It functions as an inhibitor of sporulation during early fruiting body development while cells are aggregating into raised mounds. EspA is part of a two-component signal transduction system that regulates the timing of sporulation initiation. The FHA domain is a small phosphopeptide recognition module.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1253131784 182 ADIPIDHPSCSKQHAvfqyrlvEYTRADGtvgrrvKPYIIDLGSGNGTFLNNKRIEPqryYELKEKDVLKFGFS 255
Cdd:cd22698    31 NDIRLNDHSVSRHHA-------RIVRQGD------KCNLTDLGSTNGTFLNGIRVGT---HELKHGDRIQLGET 88

second forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the second FHA domain, which has a circularly permuted FHA domain fold with a conserved pThr-binding interface.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1253131784 183 DIPIDHPSCSKQHAvfqyrlvEYTRADGtvgrrvKPYIIDLGSGNGTFLNNKRIEPqryYELKEKDVLKFG 253
Cdd:cd22737    32 DIVIPEGSVSRHHA-------TLVPTPG------GTQIRDLRSTNGTFVNGLRVDA---ALLHDGDVVTIG 86