NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1248026955|ref|NP_001343246|]
View 

translocon-associated protein subunit beta isoform 2 precursor [Mus musculus]

Protein Classification

translocon-associated protein subunit beta( domain architecture ID 12065704)

translocon-associated protein subunit beta is part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins

Gene Ontology:  GO:0006613
PubMed:  28218252

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TRAP_beta pfam05753
Translocon-associated protein beta (TRAPB); This family consists of several eukaryotic ...
 15-179 2.56e-88

Translocon-associated protein beta (TRAPB); This family consists of several eukaryotic translocon-associated protein beta (TRAPB) or signal sequence receptor beta subunit (SSR-beta) proteins. The normal translocation of nascent polypeptides into the lumen of the endoplasmic reticulum (ER) is thought to be aided in part by a translocon-associated protein (TRAP) complex consisting of 4 protein subunits. The association of mature proteins with the ER and Golgi, or other intracellular locales, such as lysosomes, depends on the initial targeting of the nascent polypeptide to the ER membrane. A similar scenario must also exist for proteins destined for secretion.


:

Pssm-ID: 399046  Cd Length: 178  Bit Score: 256.50  E-value: 2.56e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248026955  15 SQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSDDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVV 94
Cdd:pfam05753  12 AQDDAPARLLVKKKILNRYLVEGRDLTVTYTIYNVGSSAAYDVSLVDNSFPEEAFEVVSGSLSASWERLAPGSNVSHIFV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248026955  95 LRPLKAGYFNFTSATITYLAQEDGP-VVIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGIPLLLWYSSKR 173
Cdd:pfam05753  92 VEPKKSGYFNFTAAEVTYRPSEDGAeLQVAYSSPPGEGGIFAERDYGKKFSLHLLDWVAFAVMTLPSLGIPYLLWWVSKS 171


                  ....*.
gi 1248026955 174 KYDTPK 179
Cdd:pfam05753 172 KYETSK 177
 
Name Accession Description Interval E-value
TRAP_beta pfam05753
Translocon-associated protein beta (TRAPB); This family consists of several eukaryotic ...
 15-179 2.56e-88

Translocon-associated protein beta (TRAPB); This family consists of several eukaryotic translocon-associated protein beta (TRAPB) or signal sequence receptor beta subunit (SSR-beta) proteins. The normal translocation of nascent polypeptides into the lumen of the endoplasmic reticulum (ER) is thought to be aided in part by a translocon-associated protein (TRAP) complex consisting of 4 protein subunits. The association of mature proteins with the ER and Golgi, or other intracellular locales, such as lysosomes, depends on the initial targeting of the nascent polypeptide to the ER membrane. A similar scenario must also exist for proteins destined for secretion.


Pssm-ID: 399046  Cd Length: 178  Bit Score: 256.50  E-value: 2.56e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248026955  15 SQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSDDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVV 94
Cdd:pfam05753  12 AQDDAPARLLVKKKILNRYLVEGRDLTVTYTIYNVGSSAAYDVSLVDNSFPEEAFEVVSGSLSASWERLAPGSNVSHIFV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248026955  95 LRPLKAGYFNFTSATITYLAQEDGP-VVIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGIPLLLWYSSKR 173
Cdd:pfam05753  92 VEPKKSGYFNFTAAEVTYRPSEDGAeLQVAYSSPPGEGGIFAERDYGKKFSLHLLDWVAFAVMTLPSLGIPYLLWWVSKS 171


                  ....*.
gi 1248026955 174 KYDTPK 179
Cdd:pfam05753 172 KYETSK 177
 
Name Accession Description Interval E-value
TRAP_beta pfam05753
Translocon-associated protein beta (TRAPB); This family consists of several eukaryotic ...
 15-179 2.56e-88

Translocon-associated protein beta (TRAPB); This family consists of several eukaryotic translocon-associated protein beta (TRAPB) or signal sequence receptor beta subunit (SSR-beta) proteins. The normal translocation of nascent polypeptides into the lumen of the endoplasmic reticulum (ER) is thought to be aided in part by a translocon-associated protein (TRAP) complex consisting of 4 protein subunits. The association of mature proteins with the ER and Golgi, or other intracellular locales, such as lysosomes, depends on the initial targeting of the nascent polypeptide to the ER membrane. A similar scenario must also exist for proteins destined for secretion.


Pssm-ID: 399046  Cd Length: 178  Bit Score: 256.50  E-value: 2.56e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248026955  15 SQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSDDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVV 94
Cdd:pfam05753  12 AQDDAPARLLVKKKILNRYLVEGRDLTVTYTIYNVGSSAAYDVSLVDNSFPEEAFEVVSGSLSASWERLAPGSNVSHIFV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248026955  95 LRPLKAGYFNFTSATITYLAQEDGP-VVIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGIPLLLWYSSKR 173
Cdd:pfam05753  92 VEPKKSGYFNFTAAEVTYRPSEDGAeLQVAYSSPPGEGGIFAERDYGKKFSLHLLDWVAFAVMTLPSLGIPYLLWWVSKS 171


                  ....*.
gi 1248026955 174 KYDTPK 179
Cdd:pfam05753 172 KYETSK 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH