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Conserved domains on  [gi|1241781357|ref|NP_001342182|]
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endothelial transcription factor GATA-2 [Mus musculus]

Protein Classification

GATA-type transcription factor( domain architecture ID 10078896)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
Gene Ontology:  GO:0006355|GO:0008270|GO:0043565
PubMed:  31574210
SCOP:  4003617

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 349-398 1.22e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 82.04  E-value: 1.22e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1241781357 349 CANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNVNRPLTMKKEG-IQTRNR 398
Cdd:cd00202     2 CSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNR 53
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 294-344 7.79e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 77.03  E-value: 7.79e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1241781357 294 ECVNCGATATPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 344
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 349-398 1.22e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 82.04  E-value: 1.22e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1241781357 349 CANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNVNRPLTMKKEG-IQTRNR 398
Cdd:cd00202     2 CSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNR 53
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 294-344 7.79e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 77.03  E-value: 7.79e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1241781357 294 ECVNCGATATPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 344
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
344-393 1.16e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 76.69  E-value: 1.16e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1241781357  344 RAGTCCANCQTTTTTLWRRNANGD-PVCNACGLYYKLHNV-NRPLTMKKEGI 393
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
290-338 2.11e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 67.44  E-value: 2.11e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1241781357  290 SEGRECVNCGATATPLWRRDGTGH-YLCNACGLYHKMNGQ-NRPLIKPKRR 338
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 349-383 3.37e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.49  E-value: 3.37e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1241781357 349 CANCQTTTTTLWRRNANGDP-VCNACGLYYKLHNVN 383
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 295-329 1.49e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 61.57  E-value: 1.49e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1241781357 295 CVNCGATATPLWRRDGTGHY-LCNACGLYHKMNGQN 329
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
297-398 3.38e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 59.11  E-value: 3.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781357 297 NCGATATPLWRR-DGTGHYLCNACGLYHKMNGQNRPLikPKRRLSAARRAGTCCANCQTTTTTLWRRNANGdpvCNACGL 375
Cdd:COG5641   303 LTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNKILSPPTT---SNSPGA 377

                          90       100
                  ....*....|....*....|...
gi 1241781357 376 YYKLHNVNRPLTMKKEGIQTRNR 398
Cdd:COG5641   378 QVKLPNQTRSTGATKKKITRRRM 400
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
295-373 8.96e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 51.41  E-value: 8.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781357 295 CVNCGATATPLWRRD-----GTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTT-TTLWRRNANGDP 368
Cdd:COG5641   161 CSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSNGeNANTESIGNSSA 240


                  ....*
gi 1241781357 369 VCNAC 373
Cdd:COG5641   241 SKLTK 245
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 349-398 1.22e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 82.04  E-value: 1.22e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1241781357 349 CANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNVNRPLTMKKEG-IQTRNR 398
Cdd:cd00202     2 CSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNR 53
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 294-344 7.79e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 77.03  E-value: 7.79e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1241781357 294 ECVNCGATATPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 344
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
344-393 1.16e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 76.69  E-value: 1.16e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1241781357  344 RAGTCCANCQTTTTTLWRRNANGD-PVCNACGLYYKLHNV-NRPLTMKKEGI 393
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
290-338 2.11e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 67.44  E-value: 2.11e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1241781357  290 SEGRECVNCGATATPLWRRDGTGH-YLCNACGLYHKMNGQ-NRPLIKPKRR 338
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 349-383 3.37e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.49  E-value: 3.37e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1241781357 349 CANCQTTTTTLWRRNANGDP-VCNACGLYYKLHNVN 383
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 295-329 1.49e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 61.57  E-value: 1.49e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1241781357 295 CVNCGATATPLWRRDGTGHY-LCNACGLYHKMNGQN 329
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
297-398 3.38e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 59.11  E-value: 3.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781357 297 NCGATATPLWRR-DGTGHYLCNACGLYHKMNGQNRPLikPKRRLSAARRAGTCCANCQTTTTTLWRRNANGdpvCNACGL 375
Cdd:COG5641   303 LTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNKILSPPTT---SNSPGA 377

                          90       100
                  ....*....|....*....|...
gi 1241781357 376 YYKLHNVNRPLTMKKEGIQTRNR 398
Cdd:COG5641   378 QVKLPNQTRSTGATKKKITRRRM 400
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
349-398 8.78e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 57.57  E-value: 8.78e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1241781357 349 CANCQTTTTTLWRR-----NANGDPVCNACGLYYKLHNVNR-PLTMKKEGIQTRNR 398
Cdd:COG5641   161 CSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGSPRaPISLKSDSIKSRSS 216
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
295-373 8.96e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 51.41  E-value: 8.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781357 295 CVNCGATATPLWRRD-----GTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTT-TTLWRRNANGDP 368
Cdd:COG5641   161 CSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSNGeNANTESIGNSSA 240


                  ....*
gi 1241781357 369 VCNAC 373
Cdd:COG5641   241 SKLTK 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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