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Conserved domains on  [gi|1241781433|ref|NP_001342143|]
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phosphopantothenate--cysteine ligase isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05579 super family cl35341
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
 5-100 2.28e-09

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated


The actual alignment was detected with superfamily member PRK05579:

Pssm-ID: 235513 [Multi-domain]  Cd Length: 399  Bit Score: 53.99  E-value: 2.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781433   5 AAAVSDfYIPVSEMpEHKIHSSGGPLQITMKMVPKMLSPLVKDWAPKAFVVSFKLETDPdiIISRARNALEVYQHQVVVA 84
Cdd:PRK05579  274 AAAVAD-YRPATVA-EGKIKKGEGELTLELVPNPDILAEVAALKDKRPFVVGFAAETGD--VLEYARAKLKRKGLDLIVA 349

                          90       100
                  ....*....|....*....|..
gi 1241781433  85 NILESIKSF------VIIVTKD 100
Cdd:PRK05579  350 NDVSAGGGFgsddneVTLIWSD 371
 
Name Accession Description Interval E-value
PRK05579 PRK05579
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
 5-100 2.28e-09

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated


Pssm-ID: 235513 [Multi-domain]  Cd Length: 399  Bit Score: 53.99  E-value: 2.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781433   5 AAAVSDfYIPVSEMpEHKIHSSGGPLQITMKMVPKMLSPLVKDWAPKAFVVSFKLETDPdiIISRARNALEVYQHQVVVA 84
Cdd:PRK05579  274 AAAVAD-YRPATVA-EGKIKKGEGELTLELVPNPDILAEVAALKDKRPFVVGFAAETGD--VLEYARAKLKRKGLDLIVA 349

                          90       100
                  ....*....|....*....|..
gi 1241781433  85 NILESIKSF------VIIVTKD 100
Cdd:PRK05579  350 NDVSAGGGFgsddneVTLIWSD 371
DFP pfam04127
DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4. ...
 5-85 7.67e-08

DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.


Pssm-ID: 461186 [Multi-domain]  Cd Length: 183  Bit Score: 48.56  E-value: 7.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781433   5 AAAVSDFYipVSEMPEHKI--HSSGGPLQITMKMVPKMLSPLVKDwAPKAFVVSFKLETDPdiIISRARNALEVYQHQVV 82
Cdd:pfam04127  89 AAAVADYR--PAEVADGKIkkSSGGEELTLELVKNPDILAELGKR-KPGQLLVGFAAETED--LLENARAKLERKNLDLI 163


                  ...
gi 1241781433  83 VAN 85
Cdd:pfam04127 164 VAN 166
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 5-62 5.79e-06

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 44.25  E-value: 5.79e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1241781433   5 AAAVSDFYipVSEMPEHKIHSSGGPLQITMKMVPKMLSPLVKDWAPKAFVVSFKLETD 62
Cdd:COG0452   273 AAAVADYR--PAEVADQKIKKTDDPLTLELVKNPDILAELGARKKPGQFLVGFAAETE 328
 
Name Accession Description Interval E-value
PRK05579 PRK05579
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
 5-100 2.28e-09

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated


Pssm-ID: 235513 [Multi-domain]  Cd Length: 399  Bit Score: 53.99  E-value: 2.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781433   5 AAAVSDfYIPVSEMpEHKIHSSGGPLQITMKMVPKMLSPLVKDWAPKAFVVSFKLETDPdiIISRARNALEVYQHQVVVA 84
Cdd:PRK05579  274 AAAVAD-YRPATVA-EGKIKKGEGELTLELVPNPDILAEVAALKDKRPFVVGFAAETGD--VLEYARAKLKRKGLDLIVA 349

                          90       100
                  ....*....|....*....|..
gi 1241781433  85 NILESIKSF------VIIVTKD 100
Cdd:PRK05579  350 NDVSAGGGFgsddneVTLIWSD 371
DFP pfam04127
DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4. ...
 5-85 7.67e-08

DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.


Pssm-ID: 461186 [Multi-domain]  Cd Length: 183  Bit Score: 48.56  E-value: 7.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781433   5 AAAVSDFYipVSEMPEHKI--HSSGGPLQITMKMVPKMLSPLVKDwAPKAFVVSFKLETDPdiIISRARNALEVYQHQVV 82
Cdd:pfam04127  89 AAAVADYR--PAEVADGKIkkSSGGEELTLELVKNPDILAELGKR-KPGQLLVGFAAETED--LLENARAKLERKNLDLI 163


                  ...
gi 1241781433  83 VAN 85
Cdd:pfam04127 164 VAN 166
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 5-62 5.79e-06

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 44.25  E-value: 5.79e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1241781433   5 AAAVSDFYipVSEMPEHKIHSSGGPLQITMKMVPKMLSPLVKDWAPKAFVVSFKLETD 62
Cdd:COG0452   273 AAAVADYR--PAEVADQKIKKTDDPLTLELVKNPDILAELGARKKPGQFLVGFAAETE 328
PRK09620 PRK09620
hypothetical protein; Provisional
 4-92 7.29e-06

hypothetical protein; Provisional


Pssm-ID: 181997  Cd Length: 229  Bit Score: 43.73  E-value: 7.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781433   4 LAAAVSDFYIP--------VSEMpEHKIHSSGGPLqITMKMVPKMLSPlVKDWAPKAFVVSFKLETDPD--IIISRARNA 73
Cdd:PRK09620   93 MAAAGSDWVVDkicdqegnVLDM-NGKISSDIAPI-IHFQKAPKVLKQ-IKQWDPETVLVGFKLESDVNeeELFERAKNR 169

                          90
                  ....*....|....*....
gi 1241781433  74 LEVYQHQVVVANILESIKS 92
Cdd:PRK09620  170 MEEAKASVMIANSPHSLYS 188
PRK06732 PRK06732
phosphopantothenate--cysteine ligase; Validated
 20-92 2.21e-04

phosphopantothenate--cysteine ligase; Validated


Pssm-ID: 235856 [Multi-domain]  Cd Length: 229  Bit Score: 39.59  E-value: 2.21e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1241781433  20 EHKIHSSGGPLQITMKMVPKMLSpLVKDWAPKAFVVSFKLETD--PDIIISRARNALEVYQHQVVVANILESIKS 92
Cdd:PRK06732  121 EAKISSASDYQVLFLKKTPKVIS-YVKKWNPNITLVGFKLLVNvsKEELIKVARASLIKNQADYILANDLTDISA 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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