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Conserved domains on  [gi|1241781279|ref|NP_001342009|]
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peptidyl-prolyl cis-trans isomerase FKBP7 isoform 3 [Mus musculus]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 1000101)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FRQ1 super family cl34916
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
29-108 8.16e-07

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5126:

Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 44.40  E-value: 8.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781279  29 LYAVTKGPRSIETFKQIDTDNDRQLSKAEIELYLqkdfekdanpRDKSYQKAVLEDIFKKNDHNGDGFISPKEYNVHQHD 108
Cdd:COG5126    62 LFEATVEPFARAAFDLLDTDGDGKISADEFRRLL----------TALGVSEEEADELFARLDTDGDGKISFEEFVAAVRD 131
FkpA super family cl29492
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 13-32 4.41e-04

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG0545:

Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 36.70  E-value: 4.41e-04
                          10        20
                  ....*....|....*....|
gi 1241781279  13 AEGKIPPNATLMFEIELYAV 32
Cdd:COG0545    85 AGGVIPPNSTLVFEVELLDV 104
 
Name Accession Description Interval E-value
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
29-108 8.16e-07

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 44.40  E-value: 8.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781279  29 LYAVTKGPRSIETFKQIDTDNDRQLSKAEIELYLqkdfekdanpRDKSYQKAVLEDIFKKNDHNGDGFISPKEYNVHQHD 108
Cdd:COG5126    62 LFEATVEPFARAAFDLLDTDGDGKISADEFRRLL----------TALGVSEEEADELFARLDTDGDGKISFEEFVAAVRD 131
EFh_CREC_cab45 cd16225
EF-hand, calcium binding motif, found in 45 kDa calcium-binding protein (Cab45); Cab45, also ...
 39-105 9.73e-07

EF-hand, calcium binding motif, found in 45 kDa calcium-binding protein (Cab45); Cab45, also termed stromal cell-derived factor 4 (SDF-4), is a soluble, lumenal Golgi resident low-affinity Ca2+-binding protein that contains six copies of the EF-hand Ca2+-binding motif. It is required for secretory pathway calcium ATPase1 (SPCA1)-dependent Ca2+ import into the trans-Golgi network (TGN) and plays an essential role in Ca2+-dependent secretory cargo sorting at the TGN.


Pssm-ID: 320023 [Multi-domain]  Cd Length: 278  Bit Score: 45.37  E-value: 9.73e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1241781279  39 IETFKQIDTDNDRQLSKAEIELYLQKDFEkdanprdKSYQKAVLED--IFKKNDHNGDGFISPKEYNVH 105
Cdd:cd16225    37 KEIFKKVDVNTDGFLSAEELEDWIMEKTQ-------EHFQEAVEENeqIFKAVDTDKDGNVSWEEYRVH 98
EF-hand_7 pfam13499
EF-hand domain pair;
40-102 2.12e-06

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 41.86  E-value: 2.12e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1241781279  40 ETFKQIDTDNDRQLSKAEIELYLQKdFEKDANPRDKSyqkavLEDIFKKNDHNGDGFISPKEY 102
Cdd:pfam13499   6 EAFKLLDSDGDGYLDVEELKKLLRK-LEEGEPLSDEE-----VEELFKEFDLDKDGRISFEEF 62
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 13-32 4.41e-04

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 36.70  E-value: 4.41e-04
                          10        20
                  ....*....|....*....|
gi 1241781279  13 AEGKIPPNATLMFEIELYAV 32
Cdd:COG0545    85 AGGVIPPNSTLVFEVELLDV 104
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
12-29 5.79e-04

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 36.02  E-value: 5.79e-04
                          10
                  ....*....|....*...
gi 1241781279  12 CAEGKIPPNATLMFEIEL 29
Cdd:pfam00254  76 LAGPVIPPNATLVFEVEL 93
 
Name Accession Description Interval E-value
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
29-108 8.16e-07

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 44.40  E-value: 8.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781279  29 LYAVTKGPRSIETFKQIDTDNDRQLSKAEIELYLqkdfekdanpRDKSYQKAVLEDIFKKNDHNGDGFISPKEYNVHQHD 108
Cdd:COG5126    62 LFEATVEPFARAAFDLLDTDGDGKISADEFRRLL----------TALGVSEEEADELFARLDTDGDGKISFEEFVAAVRD 131
EFh_CREC_cab45 cd16225
EF-hand, calcium binding motif, found in 45 kDa calcium-binding protein (Cab45); Cab45, also ...
 39-105 9.73e-07

EF-hand, calcium binding motif, found in 45 kDa calcium-binding protein (Cab45); Cab45, also termed stromal cell-derived factor 4 (SDF-4), is a soluble, lumenal Golgi resident low-affinity Ca2+-binding protein that contains six copies of the EF-hand Ca2+-binding motif. It is required for secretory pathway calcium ATPase1 (SPCA1)-dependent Ca2+ import into the trans-Golgi network (TGN) and plays an essential role in Ca2+-dependent secretory cargo sorting at the TGN.


Pssm-ID: 320023 [Multi-domain]  Cd Length: 278  Bit Score: 45.37  E-value: 9.73e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1241781279  39 IETFKQIDTDNDRQLSKAEIELYLQKDFEkdanprdKSYQKAVLED--IFKKNDHNGDGFISPKEYNVH 105
Cdd:cd16225    37 KEIFKKVDVNTDGFLSAEELEDWIMEKTQ-------EHFQEAVEENeqIFKAVDTDKDGNVSWEEYRVH 98
EFh_CREC_RCN2 cd16224
EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2); RCN2, also termed ...
 37-108 1.28e-06

EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2); RCN2, also termed calcium-binding protein ERC-55, or E6-binding protein (E6BP), or TCBP-49, is an endoplasmic reticulum resident low-affinity Ca2+-binding protein that has been implicated in immunity, redox homeostasis, cell cycle regulation and coagulation. It is associated with tumorigenesis, in particular with transformation of cells of the cervix induced by human papillomavirus (HPV), through binding to human papillomavirus (HPV) E6 oncogenic protein. It specifically interacts with vitamin D receptor among nuclear receptors. RCN2 contains an N-terminal signal sequence followed by six copies of the EF-hand Ca2+-binding motif, and a C-terminal His-Asp-Glu-Leu (HDEL) tetrapeptide that is required for retention of RCN2 in the endoplasmic reticulum (ER).


Pssm-ID: 320022 [Multi-domain]  Cd Length: 268  Bit Score: 45.12  E-value: 1.28e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1241781279  37 RSIETFKQIDTDNDRQLSKAEIELYLQKDFekdanprdKSYQKAVLEDIFKKNDHNGDGFISPKEYNVHQHD 108
Cdd:cd16224    37 RLKSIIKKIDTDSDGFLTEEELSSWIQQSF--------RHYALEDAKQQFPEYDKDGDGAVTWDEYNMQMYD 100
EF-hand_7 pfam13499
EF-hand domain pair;
40-102 2.12e-06

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 41.86  E-value: 2.12e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1241781279  40 ETFKQIDTDNDRQLSKAEIELYLQKdFEKDANPRDKSyqkavLEDIFKKNDHNGDGFISPKEY 102
Cdd:pfam13499   6 EAFKLLDSDGDGYLDVEELKKLLRK-LEEGEPLSDEE-----VEELFKEFDLDKDGRISFEEF 62
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
42-102 6.39e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 39.39  E-value: 6.39e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1241781279  42 FKQIDTDNDRQLSKAEIELYLQKDFEKDANPRdksyqkavLEDIFKKNDHNGDGFISPKEY 102
Cdd:COG5126    39 FSEADTDGDGRISREEFVAGMESLFEATVEPF--------ARAAFDLLDTDGDGKISADEF 91
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 40-101 3.91e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 35.99  E-value: 3.91e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1241781279  40 ETFKQIDTDNDRQLSKAEIELYLQKDFEKdanprdksYQKAVLEDIFKKNDHNGDGFISPKE 101
Cdd:cd00051     4 EAFRLFDKDGDGTISADELKAALKSLGEG--------LSEEEIDEMIREVDKDGDGKIDFEE 57
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 13-32 4.41e-04

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 36.70  E-value: 4.41e-04
                          10        20
                  ....*....|....*....|
gi 1241781279  13 AEGKIPPNATLMFEIELYAV 32
Cdd:COG0545    85 AGGVIPPNSTLVFEVELLDV 104
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
12-29 5.79e-04

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 36.02  E-value: 5.79e-04
                          10
                  ....*....|....*...
gi 1241781279  12 CAEGKIPPNATLMFEIEL 29
Cdd:pfam00254  76 LAGPVIPPNATLVFEVEL 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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