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Conserved domains on  [gi|1216866331|ref|NP_001340478|]
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zinc finger protein 44 isoform 3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
164-575 5.43e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 5.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 164 PYKCELCGKAFFWPSLLRMHERTHTGEKPYECKQCSKA---FPVYSSYLRHEKIHTGEKPYECKQCSKAFPDYSSYLRHE 240
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksfSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 241 RTHTGEKPYKCKQCGKAFSVSGSLRVHERIHTGEKPYTCKQCGKAFCH----LGSFQRHMIMHSGDGPHKCKicgkgfdf 316
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNL-------- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 317 pgSARIHEGTHTLEKPYECKQCGKLLSHRSSFRRHMMAHTGDGPHKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQCGK 396
Cdd:COG5048   185 --SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 397 AFRT------SSSLRKHETTHTG-EQPYKCK-CGKAFSDLFSFQSH--ETTHSEE--EPYECKE--CGKAFSSFKYFCRH 462
Cdd:COG5048   263 SSLPtassqsSSPNESDSSSEKGfSLPIKSKqCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 463 ERTHSEEKSYEC--QICGKAFSRFSYLKTHERTH-----TAEKPYEC--KQCRKAFFWPSFLLRHERTHTGERPYECK-- 531
Cdd:COG5048   343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1216866331 532 HCGKAFSRSSFCREHERTHTGEKPYECKECGKAFSSLSSFNRHK 575
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
164-575 5.43e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 5.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 164 PYKCELCGKAFFWPSLLRMHERTHTGEKPYECKQCSKA---FPVYSSYLRHEKIHTGEKPYECKQCSKAFPDYSSYLRHE 240
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksfSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 241 RTHTGEKPYKCKQCGKAFSVSGSLRVHERIHTGEKPYTCKQCGKAFCH----LGSFQRHMIMHSGDGPHKCKicgkgfdf 316
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNL-------- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 317 pgSARIHEGTHTLEKPYECKQCGKLLSHRSSFRRHMMAHTGDGPHKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQCGK 396
Cdd:COG5048   185 --SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 397 AFRT------SSSLRKHETTHTG-EQPYKCK-CGKAFSDLFSFQSH--ETTHSEE--EPYECKE--CGKAFSSFKYFCRH 462
Cdd:COG5048   263 SSLPtassqsSSPNESDSSSEKGfSLPIKSKqCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 463 ERTHSEEKSYEC--QICGKAFSRFSYLKTHERTH-----TAEKPYEC--KQCRKAFFWPSFLLRHERTHTGERPYECK-- 531
Cdd:COG5048   343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1216866331 532 HCGKAFSRSSFCREHERTHTGEKPYECKECGKAFSSLSSFNRHK 575
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
376-400 7.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.02e-04
                          10        20
                  ....*....|....*....|....*
gi 1216866331 376 FQRHERTHTGEKPYECKQCGKAFRT 400
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
164-575 5.43e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 5.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 164 PYKCELCGKAFFWPSLLRMHERTHTGEKPYECKQCSKA---FPVYSSYLRHEKIHTGEKPYECKQCSKAFPDYSSYLRHE 240
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksfSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 241 RTHTGEKPYKCKQCGKAFSVSGSLRVHERIHTGEKPYTCKQCGKAFCH----LGSFQRHMIMHSGDGPHKCKicgkgfdf 316
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNL-------- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 317 pgSARIHEGTHTLEKPYECKQCGKLLSHRSSFRRHMMAHTGDGPHKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQCGK 396
Cdd:COG5048   185 --SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 397 AFRT------SSSLRKHETTHTG-EQPYKCK-CGKAFSDLFSFQSH--ETTHSEE--EPYECKE--CGKAFSSFKYFCRH 462
Cdd:COG5048   263 SSLPtassqsSSPNESDSSSEKGfSLPIKSKqCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 463 ERTHSEEKSYEC--QICGKAFSRFSYLKTHERTH-----TAEKPYEC--KQCRKAFFWPSFLLRHERTHTGERPYECK-- 531
Cdd:COG5048   343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1216866331 532 HCGKAFSRSSFCREHERTHTGEKPYECKECGKAFSSLSSFNRHK 575
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-578 9.86e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 9.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 191 KPYECKQCSKAFPVYSSYLRHEKIHTGEKPYEC--KQCSKAFPDYSSYLRHERTHTGEKPYKC-KQCGKAFSVSGSLRVH 267
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 268 ERIHTGEKPYTCKQCGKAFCHLGSFQRHMIMHSGDGPHKCKIC-GKGFDFPGSARIHEGTHTLEKPyeckqcgKLLSHRS 346
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 347 SFRRHMMAHTGDGPHKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQCGKAFRTSSSLR-------KHETTHTGEQPYKC 419
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQspsslssSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 420 KCGKAFSDLFSFQSHETTHS-EEEPYECKECGKAFSSFKYFCRHERT--HSEEKSYECQ----ICGKAFSRFSYLKTHER 492
Cdd:COG5048   265 LPTASSQSSSPNESDSSSEKgFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFScpysLCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 493 THTAEKPYECKQCR-------KAFFWPSFLLRHERTHTGERPYECKH--CGKAFSRSSFCREHERTHTGEKPYECK--EC 561
Cdd:COG5048   345 LHTSISPAKEKLLNssskfspLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                         410
                  ....*....|....*..
gi 1216866331 562 GKAFSSLSSFNRHKRTH 578
Cdd:COG5048   425 SKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
81-284 4.86e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 4.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331  81 MGHSSLNCYIRVDTGHKHRecHEYAEKSYTHKQCGKGLSYRHSFQTCERPHTGK-KPYDCKECGKTFSSPGNLRRHM--- 156
Cdd:COG5048   235 LSPKSLLSQSPSSLSSSDS--SSSASESPRSSLPTASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLrsv 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 157 -VVKGGDGPYKC--ELCGKAFFWPSLLRMHERTHTGEKPYECK--QCSKAFPVYS-----SYLRHEKIHTGEKPYEC--K 224
Cdd:COG5048   313 nHSGESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsN 392

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1216866331 225 QCSKAFPDYSSYLRHERTHTGEKP--YKCKQCGKAFSVSGSLRVHERIHTGEKPYTCKQCGK 284
Cdd:COG5048   393 SCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
247-581 8.91e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 8.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 247 KPYKCKQCGKAFSVSGSLRVHERIHTGEKPYTC--KQCGKAFCHLGSFQRHMIMHSGDGPHKCKICGKG--FDFPGSARI 322
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 323 HEGTHTLEKPYECkQCGKLLSHRSSFRRHMMAHTGDGPHKCTVC-GKAFDSPSVFQRHERTHTGEkpyeckQCGKAFRTS 401
Cdd:COG5048   112 SSSSNSNDNNLLS-SHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANS------LSKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 402 SSLRKHETTHTGEQPYKCKCGKAFSDLFSFQSHETTHSEEEPYECkecgkafssfkyfcrHERTHSEEKSYECQicgkaf 481
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPL---------------TTNSQLSPKSLLSQ------ 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1216866331 482 sRFSYLKTHERTHTAEKPYECKQCRKAFFWPSFLLRHERTHTGER-PYECKHCGKAFSRSSFCREHERT--HTGE--KPY 556
Cdd:COG5048   244 -SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPF 322

                         330       340
                  ....*....|....*....|....*..
gi 1216866331 557 ECKE--CGKAFSSLSSFNRHKRTHWKD 581
Cdd:COG5048   323 SCPYslCGKLFSRNDALKRHILLHTSI 349
zf-H2C2_2 pfam13465
Zinc-finger double domain;
376-400 7.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.02e-04
                          10        20
                  ....*....|....*....|....*
gi 1216866331 376 FQRHERTHTGEKPYECKQCGKAFRT 400
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
515-539 1.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....*
gi 1216866331 515 LLRHERTHTGERPYECKHCGKAFSR 539
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
180-202 1.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.28e-03
                          10        20
                  ....*....|....*....|...
gi 1216866331 180 LRMHERTHTGEKPYECKQCSKAF 202
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
544-567 1.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.40e-03
                          10        20
                  ....*....|....*....|....
gi 1216866331 544 REHERTHTGEKPYECKECGKAFSS 567
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
238-259 1.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.40e-03
                          10        20
                  ....*....|....*....|..
gi 1216866331 238 RHERTHTGEKPYKCKQCGKAFS 259
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
263-286 1.97e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.97e-03
                          10        20
                  ....*....|....*....|....
gi 1216866331 263 SLRVHERIHTGEKPYTCKQCGKAF 286
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-230 6.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.59e-03
                          10        20
                  ....*....|....*....|.
gi 1216866331 210 RHEKIHTGEKPYECKQCSKAF 230
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
486-509 6.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.72e-03
                          10        20
                  ....*....|....*....|....
gi 1216866331 486 YLKTHERTHTAEKPYECKQCRKAF 509
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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