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Conserved domains on  [gi|1191017746|ref|NP_001338487|]
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transducin-like enhancer protein 4 isoform 14 [Homo sapiens]

Protein Classification

WD40 domain-containing protein( domain architecture ID 10511324)

WD40 domain-containing protein similar to Drosophila melanogaster protein groucho and Homo sapiens transducin-like enhancer proteins; also contains a Groucho/TLE N-terminal Q-rich domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 24-103 3.05e-64

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


:

Pssm-ID: 461094  Cd Length: 117  Bit Score: 209.20  E-value: 3.05e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746  24 FKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLS 103
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAICAQVIPFLS 80
WD40 COG2319
WD40 repeat [General function prediction only];
462-747 2.19e-44

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 164.70  E-value: 2.19e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 462 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAa 540
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSAdGTVRLWDLA---TGKLLRTLT--GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA- 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 541 pTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 620
Cdd:COG2319   193 -TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 621 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDK-YQLHLHESCVLSLKFAHCGKWFVSTGKD 698
Cdd:COG2319   272 LWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDD 351

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1191017746 699 NLLNAWRTPYGASIFQSKE-SSSVLSCDISVDDKYIVTGSGDKKATVYEV 747
Cdd:COG2319   352 GTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 24-103 3.05e-64

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 209.20  E-value: 3.05e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746  24 FKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLS 103
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAICAQVIPFLS 80
WD40 COG2319
WD40 repeat [General function prediction only];
462-747 2.19e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 164.70  E-value: 2.19e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 462 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAa 540
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSAdGTVRLWDLA---TGKLLRTLT--GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA- 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 541 pTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 620
Cdd:COG2319   193 -TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 621 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDK-YQLHLHESCVLSLKFAHCGKWFVSTGKD 698
Cdd:COG2319   272 LWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDD 351

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1191017746 699 NLLNAWRTPYGASIFQSKE-SSSVLSCDISVDDKYIVTGSGDKKATVYEV 747
Cdd:COG2319   352 GTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 462-746 4.79e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 146.33  E-value: 4.79e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 462 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLdCLNRDNyIRSCRLLPDGRTLIVGGEASTLSIWDLaa 540
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGdGTIKVWDLE---TGELLRTL-KGHTGP-VRDVAASADGTYLASGSSDKTIRLWDL-- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 541 PTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 620
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 621 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPD-KYQLHLHESCVLSLKFAHCGKWFVSTGKD 698
Cdd:cd00200   161 LWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1191017746 699 NLLNAWRTPYGASIFQ-SKESSSVLSCDISVDDKYIVTGSGDKKATVYE 746
Cdd:cd00200   241 GTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 497-745 2.74e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.32  E-value: 2.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 497 KSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPtprIKAELTSSAPACYALAISPDSKVCF------- 569
Cdd:PLN00181  471 KADLKQGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESI---IKDGRDIHYPVVELASRSKLSGICWnsyiksq 547

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 570 --SCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISN-DGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGY-C 645
Cdd:PLN00181  548 vaSSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpS 627

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 646 PTGEWLAVGMENSNVEVLHVTKPdkyQLHL-----HESCVLSLKFAHCGKwFVSTGKDNLLNAWRTPYGASIFQSKESSS 720
Cdd:PLN00181  628 ESGRSLAFGSADHKVYYYDLRNP---KLPLctmigHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMSISGINETPLHS 703

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1191017746 721 VLS-------CDISVDDKYIVTGSGDKKATVY 745
Cdd:PLN00181  704 FMGhtnvknfVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 584-623 4.65e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 4.65e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1191017746  584 NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 623
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
586-623 5.70e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 5.70e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1191017746 586 TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 623
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 24-103 3.05e-64

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 209.20  E-value: 3.05e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746  24 FKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLS 103
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAICAQVIPFLS 80
WD40 COG2319
WD40 repeat [General function prediction only];
462-747 2.19e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 164.70  E-value: 2.19e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 462 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAa 540
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSAdGTVRLWDLA---TGKLLRTLT--GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA- 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 541 pTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 620
Cdd:COG2319   193 -TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 621 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDK-YQLHLHESCVLSLKFAHCGKWFVSTGKD 698
Cdd:COG2319   272 LWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDD 351

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1191017746 699 NLLNAWRTPYGASIFQSKE-SSSVLSCDISVDDKYIVTGSGDKKATVYEV 747
Cdd:COG2319   352 GTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
429-747 3.32e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.84  E-value: 3.32e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 429 VSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLdclnR 508
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLG----H 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 509 DNYIRSCRLLPDGRTLIVGGEASTLSIWDLAapTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLV 588
Cdd:COG2319    78 TAAVLSVAFSPDGRLLASASADGTVRLWDLA--TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 589 RQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ---HdfTSQIFSLGYCPTGEWLAVGMENSNVEVLHV 665
Cdd:COG2319   156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTltgH--TGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 666 -TKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDISVDDKYIVTGSGDKKAT 743
Cdd:COG2319   234 aTGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLrTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313


                  ....
gi 1191017746 744 VYEV 747
Cdd:COG2319   314 LWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
455-707 2.84e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.14  E-value: 2.84e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 455 RQINTLN-HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEAST 532
Cdd:COG2319   153 KLLRTLTgHSGAVTSVAFSPDGKLLASGSDdGTVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKLLASGSADGT 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 533 LSIWDLAapTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWT 612
Cdd:COG2319   228 VRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 613 GGLDNTVRSWDLREGRQLQQHD-FTSQIFSLGYCPTGEWLAVGMENSNVEVLHV-TKPDKYQLHLHESCVLSLKFAHCGK 690
Cdd:COG2319   306 GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLaTGELLRTLTGHTGAVTSVAFSPDGR 385

                         250
                  ....*....|....*..
gi 1191017746 691 WFVSTGKDNLLNAWRTP 707
Cdd:COG2319   386 TLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 462-746 4.79e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 146.33  E-value: 4.79e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 462 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLdCLNRDNyIRSCRLLPDGRTLIVGGEASTLSIWDLaa 540
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGdGTIKVWDLE---TGELLRTL-KGHTGP-VRDVAASADGTYLASGSSDKTIRLWDL-- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 541 PTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 620
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 621 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPD-KYQLHLHESCVLSLKFAHCGKWFVSTGKD 698
Cdd:cd00200   161 LWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1191017746 699 NLLNAWRTPYGASIFQ-SKESSSVLSCDISVDDKYIVTGSGDKKATVYE 746
Cdd:cd00200   241 GTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 510-747 1.39e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.98  E-value: 1.39e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 510 NYIRSCRLLPDGRTLIVGGEASTLSIWDLAapTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVR 589
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLE--TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 590 QFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMENSNVEV--LHVT 666
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTlRGHTDWVNSVAFSPDGTFVASSSQDGTIKLwdLRTG 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 667 KPdKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASI--FQSKEsSSVLSCDISVDDKYIVTGSGDKKATV 744
Cdd:cd00200   168 KC-VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLgtLRGHE-NGVNSVAFSPDGYLLASGSEDGTIRV 245


                  ...
gi 1191017746 745 YEV 747
Cdd:cd00200   246 WDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 587-747 3.45e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 3.45e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 587 LVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREG---RQLQQHdfTSQIFSLGYCPTGEWLAVGMENSNVEVL 663
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGellRTLKGH--TGPVRDVAASADGTYLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 664 HVTKPDK-YQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASI--FQSKEsSSVLSCDISVDDKYIVTGSGDK 740
Cdd:cd00200    79 DLETGECvRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLttLRGHT-DWVNSVAFSPDGTFVASSSQDG 157


                  ....*..
gi 1191017746 741 KATVYEV 747
Cdd:cd00200   158 TIKLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
455-584 1.21e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.41  E-value: 1.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 455 RQINTLN-HGEVVCAVTISNPTRHVYTGGKGC-VKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEAST 532
Cdd:COG2319   279 ELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKTLASGSDDGT 353

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1191017746 533 LSIWDLAapTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHN 584
Cdd:COG2319   354 VRLWDLA--TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 497-745 2.74e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.32  E-value: 2.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 497 KSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPtprIKAELTSSAPACYALAISPDSKVCF------- 569
Cdd:PLN00181  471 KADLKQGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESI---IKDGRDIHYPVVELASRSKLSGICWnsyiksq 547

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 570 --SCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISN-DGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGY-C 645
Cdd:PLN00181  548 vaSSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpS 627

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 646 PTGEWLAVGMENSNVEVLHVTKPdkyQLHL-----HESCVLSLKFAHCGKwFVSTGKDNLLNAWRTPYGASIFQSKESSS 720
Cdd:PLN00181  628 ESGRSLAFGSADHKVYYYDLRNP---KLPLctmigHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMSISGINETPLHS 703

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1191017746 721 VLS-------CDISVDDKYIVTGSGDKKATVY 745
Cdd:PLN00181  704 FMGhtnvknfVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 584-623 4.65e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 4.65e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1191017746  584 NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 623
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
586-623 5.70e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 5.70e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1191017746 586 TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 623
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 547-628 1.09e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 41.98  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 547 AELTSSAPACYALAISPDSKVCFSCcsdGNiavWD-------LHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTV 619
Cdd:pfam20426  75 AENVELGAQCFATLQTPSENFLISC---GN---WEnsfqvisLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTV 148


                  ....*....
gi 1191017746 620 RSWDLREGR 628
Cdd:pfam20426 149 MVWEVLRGR 157
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 542-581 1.09e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.09e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1191017746  542 TPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWD 581
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
COG5276 COG5276
Uncharacterized secreted protein, contains LVIVD repeats, choice-of-anchor domain [Function ...
 477-623 8.89e-03

Uncharacterized secreted protein, contains LVIVD repeats, choice-of-anchor domain [Function unknown];


Pssm-ID: 444087 [Multi-domain]  Cd Length: 320  Bit Score: 38.77  E-value: 8.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191017746 477 HVYTG-GKGCVKVWDISHPGNKSPVSQLDCLNRDNYirscRLLPDGRTLIVGGEAST-LSIWDLAAPT-PRIKAELTSSA 553
Cdd:COG5276    31 YAYVAgGSNGLAIVDVSDPANPVLVGSLPTPGGTWR----DVKVSGDYLYVASEGSEgLQIFDISDPAnPKLVGRYDTGG 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1191017746 554 PACYALAISpDSKVCFSCCSDGNIAVWDLHNQT---LVRQFQgHTDGASCIDISNDGTKLWTGGLDNTVRSWD 623
Cdd:COG5276   107 SGAHNIAVD-GNYAYVAGGSDNGLVIVDISDPTnpvLVGRYS-LPGQAYLHDVQVVGDYAYVADWEDGLVIVD 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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