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Conserved domains on  [gi|1015158151|ref|NP_001308988|]
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dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 5 [Homo sapiens]

Protein Classification

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1( domain architecture ID 10763433)

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1 (PDE1) is a cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
362-590 7.52e-113

3'5'-cyclic nucleotide phosphodiesterase;


:

Pssm-ID: 459723  Cd Length: 238  Bit Score: 341.84  E-value: 7.52e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015158151 362 YHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAY 441
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015158151 442 RLLQdDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQ-------PEAIEKPKAL-SLMLHTADIS 513
Cdd:pfam00233  81 QILQ-DEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESkktldflENEEDRRLLLlSMLIKAADIS 159
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1015158151 514 HPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR-KSTMVAQSQVGFIDFIVEPTFTVLTDMTEKiVSPLID 590
Cdd:pfam00233 160 NPTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDReKKTSLPKSQIGFIDFIVLPLFEALAKLFPE-LQPLLD 236
PDEase_I_N pfam08499
3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of ...
217-277 2.63e-34

3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of the calcium/calmodulin-dependent 3'5'-cyclic nucleotide phosphodiesterase domain (pfam00233).


:

Pssm-ID: 462497 [Multi-domain]  Cd Length: 61  Bit Score: 124.76  E-value: 2.63e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1015158151 217 RLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER 277
Cdd:pfam08499   1 RLLDEEDELSEIQSDAVPSEVRDWLASTFTRQMAAHKRRSEEKPKFRSVAHAVQAGIFVER 61
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
362-590 7.52e-113

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 341.84  E-value: 7.52e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015158151 362 YHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAY 441
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015158151 442 RLLQdDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQ-------PEAIEKPKAL-SLMLHTADIS 513
Cdd:pfam00233  81 QILQ-DEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESkktldflENEEDRRLLLlSMLIKAADIS 159
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1015158151 514 HPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR-KSTMVAQSQVGFIDFIVEPTFTVLTDMTEKiVSPLID 590
Cdd:pfam00233 160 NPTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDReKKTSLPKSQIGFIDFIVLPLFEALAKLFPE-LQPLLD 236
PDEase_I_N pfam08499
3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of ...
217-277 2.63e-34

3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of the calcium/calmodulin-dependent 3'5'-cyclic nucleotide phosphodiesterase domain (pfam00233).


Pssm-ID: 462497 [Multi-domain]  Cd Length: 61  Bit Score: 124.76  E-value: 2.63e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1015158151 217 RLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER 277
Cdd:pfam08499   1 RLLDEEDELSEIQSDAVPSEVRDWLASTFTRQMAAHKRRSEEKPKFRSVAHAVQAGIFVER 61
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
362-534 1.37e-14

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 71.60  E-value: 1.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015158151 362 YHNLMHAADVTQTVHYLLYKTGvanwLTELEIFAIIFSAAIHDYEHTGTTNNFhiqtrsdpailYNDRSVLENHHLSAAY 441
Cdd:cd00077     1 EHRFEHSLRVAQLARRLAEELG----LSEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGA 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015158151 442 RLLQDDEemnilinlskddWREFRTLVIEMVMATDmSCHFQQIKAMKTALQqpEAIEKPKALSLMLHTADISHPAKA--W 519
Cdd:cd00077    66 EILRELL------------LEEVIKLIDELILAVD-ASHHERLDGLGYPDG--LKGEEITLEARIVKLADRLDALRRdsR 130
                         170
                  ....*....|....*
gi 1015158151 520 DLHHRWTMSLLEEFF 534
Cdd:cd00077   131 EKRRRIAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
360-525 9.33e-12

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 62.70  E-value: 9.33e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015158151  360 NPYHNLMHAADVTQTVHYLLYKTGvanwltELEIFAIIFSAAIHDYEHTGTTNNFHIQTrsdpailyndrSVLENHHLSA 439
Cdd:smart00471   1 SDYHVFEHSLRVAQLAAALAEELG------LLDIELLLLAALLHDIGKPGTPDSFLVKT-----------SVLEDHHFIG 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015158151  440 AYRLLQDDEEmNILINLSKddwrefrtlviemvmaTDMSCHFQQIKAMKTALQQPEAiekpkalsLMLHTADISHPAKAW 519
Cdd:smart00471  64 AEILLEEEEP-RILEEILR----------------TAILSHHERPDGLRGEPITLEA--------RIVKVADRLDALRAD 118

                   ....*.
gi 1015158151  520 DLHHRW 525
Cdd:smart00471 119 RRYRRV 124
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
362-590 7.52e-113

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 341.84  E-value: 7.52e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015158151 362 YHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAY 441
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015158151 442 RLLQdDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQ-------PEAIEKPKAL-SLMLHTADIS 513
Cdd:pfam00233  81 QILQ-DEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESkktldflENEEDRRLLLlSMLIKAADIS 159
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1015158151 514 HPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR-KSTMVAQSQVGFIDFIVEPTFTVLTDMTEKiVSPLID 590
Cdd:pfam00233 160 NPTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDReKKTSLPKSQIGFIDFIVLPLFEALAKLFPE-LQPLLD 236
PDEase_I_N pfam08499
3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of ...
217-277 2.63e-34

3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of the calcium/calmodulin-dependent 3'5'-cyclic nucleotide phosphodiesterase domain (pfam00233).


Pssm-ID: 462497 [Multi-domain]  Cd Length: 61  Bit Score: 124.76  E-value: 2.63e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1015158151 217 RLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER 277
Cdd:pfam08499   1 RLLDEEDELSEIQSDAVPSEVRDWLASTFTRQMAAHKRRSEEKPKFRSVAHAVQAGIFVER 61
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
362-534 1.37e-14

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 71.60  E-value: 1.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015158151 362 YHNLMHAADVTQTVHYLLYKTGvanwLTELEIFAIIFSAAIHDYEHTGTTNNFhiqtrsdpailYNDRSVLENHHLSAAY 441
Cdd:cd00077     1 EHRFEHSLRVAQLARRLAEELG----LSEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGA 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015158151 442 RLLQDDEemnilinlskddWREFRTLVIEMVMATDmSCHFQQIKAMKTALQqpEAIEKPKALSLMLHTADISHPAKA--W 519
Cdd:cd00077    66 EILRELL------------LEEVIKLIDELILAVD-ASHHERLDGLGYPDG--LKGEEITLEARIVKLADRLDALRRdsR 130
                         170
                  ....*....|....*
gi 1015158151 520 DLHHRWTMSLLEEFF 534
Cdd:cd00077   131 EKRRRIAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
360-525 9.33e-12

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 62.70  E-value: 9.33e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015158151  360 NPYHNLMHAADVTQTVHYLLYKTGvanwltELEIFAIIFSAAIHDYEHTGTTNNFHIQTrsdpailyndrSVLENHHLSA 439
Cdd:smart00471   1 SDYHVFEHSLRVAQLAAALAEELG------LLDIELLLLAALLHDIGKPGTPDSFLVKT-----------SVLEDHHFIG 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015158151  440 AYRLLQDDEEmNILINLSKddwrefrtlviemvmaTDMSCHFQQIKAMKTALQQPEAiekpkalsLMLHTADISHPAKAW 519
Cdd:smart00471  64 AEILLEEEEP-RILEEILR----------------TAILSHHERPDGLRGEPITLEA--------RIVKVADRLDALRAD 118

                   ....*.
gi 1015158151  520 DLHHRW 525
Cdd:smart00471 119 RRYRRV 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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