DNA-directed RNA polymerases I and III subunit RPAC1 isoform 2 [Homo sapiens]
Protein Classification
DNA-directed RNA polymerases I and III subunit RPAC1( domain architecture ID 10161717)
DNA-directed RNA polymerases I and III subunit RPAC1 is a common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| RNAP_I_II_AC40 | cd07032 | AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III; The eukaryotic AC40 subunit ... |
49-307 | 8.58e-174 | |||||
AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III; The eukaryotic AC40 subunit of RNA polymerase (RNAP) I and RNAP III is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. At least three distinct RNAP complexes are found in eukaryotic nuclei: RNAP I, RNAP II, and RNAP III. RNAP I is responsible for the synthesis of ribosomal RNA precursor, while RNAP III functions in the synthesis of 5S and tRNA. The AC40 subunit is the equivalent of the RPB3 subunit of RNAP II. The RPB3 subunit is similar to the bacterial RNAP alpha subunit in that it contains two subdomains: one subdomain is similar the eukaryotic Rpb11/AC19/archaeal L subunit which is involved in dimerization; and the other is an inserted beta sheet subdomain. The RPB3 subunit heterodimerizes with the RPB11 subunit, and together with RPB10 and RPB12, anchors the two largest subunits, RPB1 and RPB2, and stabilizes their association. The homology of AC40 to RPB3 suggests a similar function. The AC40 subunit is likely to associate with the RPB11 counterpart, AC19, to form a heterodimer, which stabilizes the association of the two largest subunits of RNAP I and RNAP III. : Pssm-ID: 132910 [Multi-domain] Cd Length: 291 Bit Score: 484.02 E-value: 8.58e-174
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| Name | Accession | Description | Interval | E-value | |||||
| RNAP_I_II_AC40 | cd07032 | AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III; The eukaryotic AC40 subunit ... |
49-307 | 8.58e-174 | |||||
AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III; The eukaryotic AC40 subunit of RNA polymerase (RNAP) I and RNAP III is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. At least three distinct RNAP complexes are found in eukaryotic nuclei: RNAP I, RNAP II, and RNAP III. RNAP I is responsible for the synthesis of ribosomal RNA precursor, while RNAP III functions in the synthesis of 5S and tRNA. The AC40 subunit is the equivalent of the RPB3 subunit of RNAP II. The RPB3 subunit is similar to the bacterial RNAP alpha subunit in that it contains two subdomains: one subdomain is similar the eukaryotic Rpb11/AC19/archaeal L subunit which is involved in dimerization; and the other is an inserted beta sheet subdomain. The RPB3 subunit heterodimerizes with the RPB11 subunit, and together with RPB10 and RPB12, anchors the two largest subunits, RPB1 and RPB2, and stabilizes their association. The homology of AC40 to RPB3 suggests a similar function. The AC40 subunit is likely to associate with the RPB11 counterpart, AC19, to form a heterodimer, which stabilizes the association of the two largest subunits of RNAP I and RNAP III. Pssm-ID: 132910 [Multi-domain] Cd Length: 291 Bit Score: 484.02 E-value: 8.58e-174
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| RPOLD | smart00662 | RNA polymerases D; DNA-directed RNA polymerase subunit D and bacterial alpha chain |
61-267 | 2.02e-66 | |||||
RNA polymerases D; DNA-directed RNA polymerase subunit D and bacterial alpha chain Pssm-ID: 214766 [Multi-domain] Cd Length: 224 Bit Score: 208.62 E-value: 2.02e-66
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| PRK00783 | PRK00783 | DNA-directed RNA polymerase subunit D; Provisional |
49-266 | 3.46e-42 | |||||
DNA-directed RNA polymerase subunit D; Provisional Pssm-ID: 234837 [Multi-domain] Cd Length: 263 Bit Score: 147.34 E-value: 3.46e-42
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| RNA_pol_L | pfam01193 | RNA polymerase Rpb3/Rpb11 dimerization domain; The two eukaryotic subunits Rpb3 and Rpb11 ... |
63-156 | 1.07e-27 | |||||
RNA polymerase Rpb3/Rpb11 dimerization domain; The two eukaryotic subunits Rpb3 and Rpb11 dimerize to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerization domain of the alpha subunit/Rpb3 is interrupted by an insert domain (pfam01000). Some of the alpha subunits also contain iron-sulphur binding domains (pfam00037). Rpb11 is found as a continuous domain. Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp. Pssm-ID: 460104 [Multi-domain] Cd Length: 191 Bit Score: 107.11 E-value: 1.07e-27
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| Name | Accession | Description | Interval | E-value | |||||
| RNAP_I_II_AC40 | cd07032 | AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III; The eukaryotic AC40 subunit ... |
49-307 | 8.58e-174 | |||||
AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III; The eukaryotic AC40 subunit of RNA polymerase (RNAP) I and RNAP III is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. At least three distinct RNAP complexes are found in eukaryotic nuclei: RNAP I, RNAP II, and RNAP III. RNAP I is responsible for the synthesis of ribosomal RNA precursor, while RNAP III functions in the synthesis of 5S and tRNA. The AC40 subunit is the equivalent of the RPB3 subunit of RNAP II. The RPB3 subunit is similar to the bacterial RNAP alpha subunit in that it contains two subdomains: one subdomain is similar the eukaryotic Rpb11/AC19/archaeal L subunit which is involved in dimerization; and the other is an inserted beta sheet subdomain. The RPB3 subunit heterodimerizes with the RPB11 subunit, and together with RPB10 and RPB12, anchors the two largest subunits, RPB1 and RPB2, and stabilizes their association. The homology of AC40 to RPB3 suggests a similar function. The AC40 subunit is likely to associate with the RPB11 counterpart, AC19, to form a heterodimer, which stabilizes the association of the two largest subunits of RNAP I and RNAP III. Pssm-ID: 132910 [Multi-domain] Cd Length: 291 Bit Score: 484.02 E-value: 8.58e-174
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| RNAP_RPB3_like | cd07028 | RPB3 subunit of RNA polymerase; The eukaryotic RPB3 subunit of RNA polymerase (RNAP), as well ... |
49-237 | 3.42e-90 | |||||
RPB3 subunit of RNA polymerase; The eukaryotic RPB3 subunit of RNA polymerase (RNAP), as well as its archaeal (D subunit) and bacterial (alpha subunit) counterparts, is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. At least three distinct RNAP complexes are found in eukaryotic nuclei: RNAP I, RNAP II, and RNAP III, for the synthesis of ribosomal RNA precursor, mRNA precursor, and 5S and tRNA, respectively. A single distinct RNAP complex is found in prokaryotes and archaea, which may be responsible for the synthesis of all RNAs. The RPB3 subunit is similar to the bacterial RNAP alpha subunit in that it contains two subdomains: one subdomain is similar to the eukaryotic Rpb11/AC19/archaeal L subunit which is involved in dimerization; and the other is an inserted beta sheet subdomain. The assembly of the two largest eukaryotic RNAP subunits that provide most of the enzyme's catalytic functions depends on the presence of RPB3/RPB11 heterodimer subunits. This is also true for the archaeal (D/L subunits) and bacterial (alpha subunit) counterparts. Pssm-ID: 132906 [Multi-domain] Cd Length: 212 Bit Score: 269.05 E-value: 3.42e-90
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| RPOLD | smart00662 | RNA polymerases D; DNA-directed RNA polymerase subunit D and bacterial alpha chain |
61-267 | 2.02e-66 | |||||
RNA polymerases D; DNA-directed RNA polymerase subunit D and bacterial alpha chain Pssm-ID: 214766 [Multi-domain] Cd Length: 224 Bit Score: 208.62 E-value: 2.02e-66
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| RNAP_II_RPB3 | cd07031 | RPB3 subunit of Eukaryotic RNA polymerase II; The eukaryotic RPB3 subunit of RNA polymerase ... |
50-251 | 3.07e-47 | |||||
RPB3 subunit of Eukaryotic RNA polymerase II; The eukaryotic RPB3 subunit of RNA polymerase (RNAP) II is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. At least three distinct RNAP complexes are found in eukaryotic nuclei: RNAP I, RNAP II, and RNAP III. RNAP II is responsible for the synthesis of mRNA precursor. The RPB3 subunit is similar to the bacterial RNAP alpha subunit in that it contains two subdomains: one subdomain is similar the eukaryotic Rpb11/AC19/archaeal L subunit which is involved in dimerization, and the other is an inserted beta sheet subdomain. The RPB3 subunit heterodimerizes with the RPB11 subunit, and together with RPB10 and RPB12, anchors the two largest subunits, RPB1 and RPB2, and stabilizes their association. Pssm-ID: 132909 [Multi-domain] Cd Length: 265 Bit Score: 160.46 E-value: 3.07e-47
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| PRK00783 | PRK00783 | DNA-directed RNA polymerase subunit D; Provisional |
49-266 | 3.46e-42 | |||||
DNA-directed RNA polymerase subunit D; Provisional Pssm-ID: 234837 [Multi-domain] Cd Length: 263 Bit Score: 147.34 E-value: 3.46e-42
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| RNAP_D | cd07030 | D subunit of Archaeal RNA polymerase; The D subunit of archaeal RNA polymerase (RNAP) is ... |
49-252 | 1.26e-40 | |||||
D subunit of Archaeal RNA polymerase; The D subunit of archaeal RNA polymerase (RNAP) is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. A single distinct RNAP complex is found in archaea, which may be responsible for the synthesis of all RNAs. The archaeal RNAP harbors homologues of all eukaryotic RNAP II subunits with two exceptions (RPB8 and RPB9). The 12 archaeal subunits are designated by letters and can be divided into three functional groups that are engaged in: (I) catalysis (A'/A", B'/B" or B); (II) assembly (L, N, D and P); and (III) auxiliary functions (F, E, H and K). The D subunit is equivalent to the RPB3 subunit of eukaryotic RNAP II. It contains two subdomains: one subdomain is similar the eukaryotic Rpb11/AC19/archaeal L subunit which is involved in dimerization, and the other is an inserted beta sheet subdomain. The assembly of the two largest archaeal RNAP subunits that provide most of the enzyme's catalytic functions depends on the presence of the archaeal D/L heterodimer. Pssm-ID: 132908 [Multi-domain] Cd Length: 259 Bit Score: 143.18 E-value: 1.26e-40
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| RNA_pol_L | pfam01193 | RNA polymerase Rpb3/Rpb11 dimerization domain; The two eukaryotic subunits Rpb3 and Rpb11 ... |
63-156 | 1.07e-27 | |||||
RNA polymerase Rpb3/Rpb11 dimerization domain; The two eukaryotic subunits Rpb3 and Rpb11 dimerize to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerization domain of the alpha subunit/Rpb3 is interrupted by an insert domain (pfam01000). Some of the alpha subunits also contain iron-sulphur binding domains (pfam00037). Rpb11 is found as a continuous domain. Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp. Pssm-ID: 460104 [Multi-domain] Cd Length: 191 Bit Score: 107.11 E-value: 1.07e-27
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| PRK14979 | PRK14979 | DNA-directed RNA polymerase subunit D; Provisional |
73-238 | 1.84e-20 | |||||
DNA-directed RNA polymerase subunit D; Provisional Pssm-ID: 237878 [Multi-domain] Cd Length: 195 Bit Score: 87.59 E-value: 1.84e-20
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| RNA_pol_A_bac | pfam01000 | RNA polymerase Rpb3/RpoA insert domain; Members of this family include: alpha subunit from ... |
106-238 | 1.13e-17 | |||||
RNA polymerase Rpb3/RpoA insert domain; Members of this family include: alpha subunit from eubacteria alpha subunits from chloroplasts Rpb3 subunits from eukaryotes RpoD subunits from archaeal Pssm-ID: 425983 Cd Length: 117 Bit Score: 77.68 E-value: 1.13e-17
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