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Conserved domains on  [gi|902763375|ref|NP_001298070|]
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interleukin-12 receptor subunit beta-2 isoform 2 [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10440918)

fibronectin type III (FN3) domain-containing protein similar to human Target of Nesh-SH3 (Tarsh) and Drosophila melanogaster cytokine receptor (protein domeless)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
104-192 2.30e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.34  E-value: 2.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763375  104 APHQVSAKSENMDNILVTWQPPKKADSAVREYIVEWRALQPGSitkfPPHWLRIPPDNMSALISeNIKPYICYEIRVHAL 183
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGE----PWNEITVPGTTTSVTLT-GLKPGTEYEVRVQAV 76


                  ....*....
gi 902763375  184 SESQGGCSS 192
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 202-296 2.03e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 2.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763375 202 PVSGPHITAITekKERLFISWThiPFPEQRGCILHYRIYWKERDSTaQPELCEIQyRRSQNSHPISSLQPRVTYVLWMTA 281
Cdd:cd00063    3 PPTNLRVTDVT--STSVTLSWT--PPEDDGGPITGYVVEYREKGSG-DWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRA 76

                         90
                 ....*....|....*
gi 902763375 282 VTAAGESPQGNEREF 296
Cdd:cd00063   77 VNGGGESPPSESVTV 91
 
Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
104-192 2.30e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.34  E-value: 2.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763375  104 APHQVSAKSENMDNILVTWQPPKKADSAVREYIVEWRALQPGSitkfPPHWLRIPPDNMSALISeNIKPYICYEIRVHAL 183
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGE----PWNEITVPGTTTSVTLT-GLKPGTEYEVRVQAV 76


                  ....*....
gi 902763375  184 SESQGGCSS 192
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 202-296 2.03e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 2.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763375 202 PVSGPHITAITekKERLFISWThiPFPEQRGCILHYRIYWKERDSTaQPELCEIQyRRSQNSHPISSLQPRVTYVLWMTA 281
Cdd:cd00063    3 PPTNLRVTDVT--STSVTLSWT--PPEDDGGPITGYVVEYREKGSG-DWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRA 76

                         90
                 ....*....|....*
gi 902763375 282 VTAAGESPQGNEREF 296
Cdd:cd00063   77 VNGGGESPPSESVTV 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 104-191 3.80e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763375 104 APHQVSAKSENMDNILVTWQPPKKADSAVREYIVEWRALQPGSITKFPPHwlriPPDNMSALISeNIKPYICYEIRVHAl 183
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVT----PGSETSYTLT-GLKPGTEYEFRVRA- 76


                 ....*...
gi 902763375 184 sESQGGCS 191
Cdd:cd00063   77 -VNGGGES 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 202-288 1.44e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 1.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763375   202 PVSGPHITAITekKERLFISWTHIPFPEQRGCILHYRIYWKERDSTAQpelcEIQYRRSQNSHPISSLQPRVTYVLWMTA 281
Cdd:smart00060   3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWK----EVNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 902763375   282 VTAAGES 288
Cdd:smart00060  77 VNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
202-289 1.85e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 1.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763375  202 PVSGPHITAITEKKerLFISWTHIPFPeqRGCILHYRIYWKERDSTaQPELcEIQYRRSQNSHPISSLQPRVTYVLWMTA 281
Cdd:pfam00041   2 APSNLTVTDVTSTS--LTVSWTPPPDG--NGPITGYEVEYRPKNSG-EPWN-EITVPGTTTSVTLTGLKPGTEYEVRVQA 75


                  ....*...
gi 902763375  282 VTAAGESP 289
Cdd:pfam00041  76 VNGGGEGP 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
73-293 7.49e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.85  E-value: 7.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763375  73 AWTASVSAANSKGASAPTHINIVDLCGTGLLAPHQVSAKSENMDNILVTWQPPKKADsaVREYIVEWRALQPGSitkfpp 152
Cdd:COG3401  204 TYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGDGP------ 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763375 153 hWLRIPPDNMSALISENIKP---YiCYEIRVHALSESQGGCS---SIRGDSKHKAPVSGPHITAITEKKERLfiSWThip 226
Cdd:COG3401  276 -FTKVATVTTTSYTDTGLTNgttY-YYRVTAVDAAGNESAPSnvvSVTTDLTPPAAPSGLTATAVGSSSITL--SWT--- 348

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 902763375 227 fPEQRGCILHYRIYWKERDSTAQPELCEIqyrRSQNSHPISSLQPRVTYVLWMTAVTAAG-ESPQGNE 293
Cdd:COG3401  349 -ASSDADVTGYNVYRSTSGGGTYTKIAET---VTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEE 412
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 104-185 8.76e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 38.36  E-value: 8.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763375   104 APHQVSAKSENMDNILVTWQPPKkaDSAVREYIVEWRALQPGSitkfPPHWLRIP-PDNMSALISENIKPYICYEIRVHA 182
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPP--DDGITGYIVGYRVEYREE----GSEWKEVNvTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ...
gi 902763375   183 LSE 185
Cdd:smart00060  77 VNG 79
 
Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
104-192 2.30e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.34  E-value: 2.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763375  104 APHQVSAKSENMDNILVTWQPPKKADSAVREYIVEWRALQPGSitkfPPHWLRIPPDNMSALISeNIKPYICYEIRVHAL 183
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGE----PWNEITVPGTTTSVTLT-GLKPGTEYEVRVQAV 76


                  ....*....
gi 902763375  184 SESQGGCSS 192
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 202-296 2.03e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 2.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763375 202 PVSGPHITAITekKERLFISWThiPFPEQRGCILHYRIYWKERDSTaQPELCEIQyRRSQNSHPISSLQPRVTYVLWMTA 281
Cdd:cd00063    3 PPTNLRVTDVT--STSVTLSWT--PPEDDGGPITGYVVEYREKGSG-DWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRA 76

                         90
                 ....*....|....*
gi 902763375 282 VTAAGESPQGNEREF 296
Cdd:cd00063   77 VNGGGESPPSESVTV 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 104-191 3.80e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763375 104 APHQVSAKSENMDNILVTWQPPKKADSAVREYIVEWRALQPGSITKFPPHwlriPPDNMSALISeNIKPYICYEIRVHAl 183
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVT----PGSETSYTLT-GLKPGTEYEFRVRA- 76


                 ....*...
gi 902763375 184 sESQGGCS 191
Cdd:cd00063   77 -VNGGGES 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 202-288 1.44e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 1.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763375   202 PVSGPHITAITekKERLFISWTHIPFPEQRGCILHYRIYWKERDSTAQpelcEIQYRRSQNSHPISSLQPRVTYVLWMTA 281
Cdd:smart00060   3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWK----EVNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 902763375   282 VTAAGES 288
Cdd:smart00060  77 VNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
202-289 1.85e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 1.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763375  202 PVSGPHITAITEKKerLFISWTHIPFPeqRGCILHYRIYWKERDSTaQPELcEIQYRRSQNSHPISSLQPRVTYVLWMTA 281
Cdd:pfam00041   2 APSNLTVTDVTSTS--LTVSWTPPPDG--NGPITGYEVEYRPKNSG-EPWN-EITVPGTTTSVTLTGLKPGTEYEVRVQA 75


                  ....*...
gi 902763375  282 VTAAGESP 289
Cdd:pfam00041  76 VNGGGEGP 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
73-293 7.49e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.85  E-value: 7.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763375  73 AWTASVSAANSKGASAPTHINIVDLCGTGLLAPHQVSAKSENMDNILVTWQPPKKADsaVREYIVEWRALQPGSitkfpp 152
Cdd:COG3401  204 TYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGDGP------ 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763375 153 hWLRIPPDNMSALISENIKP---YiCYEIRVHALSESQGGCS---SIRGDSKHKAPVSGPHITAITEKKERLfiSWThip 226
Cdd:COG3401  276 -FTKVATVTTTSYTDTGLTNgttY-YYRVTAVDAAGNESAPSnvvSVTTDLTPPAAPSGLTATAVGSSSITL--SWT--- 348

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 902763375 227 fPEQRGCILHYRIYWKERDSTAQPELCEIqyrRSQNSHPISSLQPRVTYVLWMTAVTAAG-ESPQGNE 293
Cdd:COG3401  349 -ASSDADVTGYNVYRSTSGGGTYTKIAET---VTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEE 412
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 104-185 8.76e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 38.36  E-value: 8.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763375   104 APHQVSAKSENMDNILVTWQPPKkaDSAVREYIVEWRALQPGSitkfPPHWLRIP-PDNMSALISENIKPYICYEIRVHA 182
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPP--DDGITGYIVGYRVEYREE----GSEWKEVNvTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ...
gi 902763375   183 LSE 185
Cdd:smart00060  77 VNG 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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