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Conserved domains on  [gi|694869814|ref|NP_001289179|]
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polymeric immunoglobulin receptor precursor [Danio rerio]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10146027)

immunoglobulin (Ig) domain-containing protein with one or more Ig domains, which adopt a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition; similar to polymeric immunoglobulin receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 134-227 2.30e-25

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 97.85  E-value: 2.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694869814 134 SVVNGMVSAEEGKSVSVQCLYSKNLRSSEKRWCRSGNWNSCLLTDSEGTFS-GKNVHIHDDKNSVFTVTLQRLEMRDSGW 212
Cdd:cd05716    1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPgGRISLTDDPDNGVFTVTLNQLRKEDAGW 80

                         90       100
                 ....*....|....*....|
gi 694869814 213 YWCGAGQQN-----VAVHVS 227
Cdd:cd05716   81 YWCGVGDDGdrgltVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 28-115 3.34e-21

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 86.68  E-value: 3.34e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694869814  28 VAVLEGGSVTVPCHYNPQYISNVKYWCSGRmREFCSSLARTDdpesAPNGNRKVTIADDPTQHVFTVNMRNLTEDDSGWY 107
Cdd:cd05716    7 VTGVEGGSVTIQCPYPPKYASSRKYWCKWG-SEGCQTLVSSE----GVVPGGRISLTDDPDNGVFTVTLNQLRKEDAGWY 81


                 ....*...
gi 694869814 108 WCGVELGG 115
Cdd:cd05716   82 WCGVGDDG 89
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 134-227 2.30e-25

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 97.85  E-value: 2.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694869814 134 SVVNGMVSAEEGKSVSVQCLYSKNLRSSEKRWCRSGNWNSCLLTDSEGTFS-GKNVHIHDDKNSVFTVTLQRLEMRDSGW 212
Cdd:cd05716    1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPgGRISLTDDPDNGVFTVTLNQLRKEDAGW 80

                         90       100
                 ....*....|....*....|
gi 694869814 213 YWCGAGQQN-----VAVHVS 227
Cdd:cd05716   81 YWCGVGDDGdrgltVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 28-115 3.34e-21

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 86.68  E-value: 3.34e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694869814  28 VAVLEGGSVTVPCHYNPQYISNVKYWCSGRmREFCSSLARTDdpesAPNGNRKVTIADDPTQHVFTVNMRNLTEDDSGWY 107
Cdd:cd05716    7 VTGVEGGSVTIQCPYPPKYASSRKYWCKWG-SEGCQTLVSSE----GVVPGGRISLTDDPDNGVFTVTLNQLRKEDAGWY 81


                 ....*...
gi 694869814 108 WCGVELGG 115
Cdd:cd05716   82 WCGVGDDG 89
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 28-127 8.71e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 58.24  E-value: 8.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694869814   28 VAVLEGGSVTVPCHYNPQYISNV--KYWC---SGRMREFCSSLARTDDPESAPNGnrKVTIADDPTQHVFTVNMRNLTED 102
Cdd:pfam07686   6 VTVALGGSVTLPCTYSSSMSEAStsVYWYrqpPGKGPTFLIAYYSNGSEEGVKKG--RFSGRGDPSNGDGSLTIQNLTLS 83

                          90       100
                  ....*....|....*....|....*
gi 694869814  103 DSGWYWCGVELGGMWVSDSTASLYI 127
Cdd:pfam07686  84 DSGTYTCAVIPSGEGVFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 135-229 1.10e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 43.99  E-value: 1.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694869814  135 VVNGMVSAEEGKSVSVQCLY--SKNLRSSEKRWCR--SGNWNSCLL---TDSEGTFSGKN-VHIHDDK-NSVFTVTLQRL 205
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYssSMSEASTSVYWYRqpPGKGPTFLIayySNGSEEGVKKGrFSGRGDPsNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....*....
gi 694869814  206 EMRDSGWYWCGAGQQNV-----AVHVSVT 229
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEgvfgkGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-127 2.09e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.49  E-value: 2.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694869814    26 GDVAVLEGGSVTVPCHYNpQYISNVKYWcsgrmrefcsslaRTDDPESAPNGNRkVTIADDPTQHVFTvnMRNLTEDDSG 105
Cdd:smart00410   2 PSVTVKEGESVTLSCEAS-GSPPPEVTW-------------YKQGGKLLAESGR-FSVSRSGSTSTLT--ISNVTPEDSG 64

                           90       100
                   ....*....|....*....|..
gi 694869814   106 WYWCGVELGGMWVSdSTASLYI 127
Cdd:smart00410  65 TYTCAATNSSGSAS-SGTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 140-228 3.23e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.33  E-value: 3.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694869814   140 VSAEEGKSVSVQCLYSKNlRSSEKRWCRSGNwnsclltdsEGTFSGKNVHIHDDKNSvFTVTLQRLEMRDSGWYWCGA-- 217
Cdd:smart00410   4 VTVKEGESVTLSCEASGS-PPPEVTWYKQGG---------KLLAESGRFSVSRSGST-STLTISNVTPEDSGTYTCAAtn 72

                           90
                   ....*....|...
gi 694869814   218 --GQQNVAVHVSV 228
Cdd:smart00410  73 ssGSASSGTTLTV 85
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 134-227 2.30e-25

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 97.85  E-value: 2.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694869814 134 SVVNGMVSAEEGKSVSVQCLYSKNLRSSEKRWCRSGNWNSCLLTDSEGTFS-GKNVHIHDDKNSVFTVTLQRLEMRDSGW 212
Cdd:cd05716    1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPgGRISLTDDPDNGVFTVTLNQLRKEDAGW 80

                         90       100
                 ....*....|....*....|
gi 694869814 213 YWCGAGQQN-----VAVHVS 227
Cdd:cd05716   81 YWCGVGDDGdrgltVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 28-115 3.34e-21

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 86.68  E-value: 3.34e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694869814  28 VAVLEGGSVTVPCHYNPQYISNVKYWCSGRmREFCSSLARTDdpesAPNGNRKVTIADDPTQHVFTVNMRNLTEDDSGWY 107
Cdd:cd05716    7 VTGVEGGSVTIQCPYPPKYASSRKYWCKWG-SEGCQTLVSSE----GVVPGGRISLTDDPDNGVFTVTLNQLRKEDAGWY 81


                 ....*...
gi 694869814 108 WCGVELGG 115
Cdd:cd05716   82 WCGVGDDG 89
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 28-127 8.71e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 58.24  E-value: 8.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694869814   28 VAVLEGGSVTVPCHYNPQYISNV--KYWC---SGRMREFCSSLARTDDPESAPNGnrKVTIADDPTQHVFTVNMRNLTED 102
Cdd:pfam07686   6 VTVALGGSVTLPCTYSSSMSEAStsVYWYrqpPGKGPTFLIAYYSNGSEEGVKKG--RFSGRGDPSNGDGSLTIQNLTLS 83

                          90       100
                  ....*....|....*....|....*
gi 694869814  103 DSGWYWCGVELGGMWVSDSTASLYI 127
Cdd:pfam07686  84 DSGTYTCAVIPSGEGVFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 135-229 1.10e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 43.99  E-value: 1.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694869814  135 VVNGMVSAEEGKSVSVQCLY--SKNLRSSEKRWCR--SGNWNSCLL---TDSEGTFSGKN-VHIHDDK-NSVFTVTLQRL 205
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYssSMSEASTSVYWYRqpPGKGPTFLIayySNGSEEGVKKGrFSGRGDPsNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....*....
gi 694869814  206 EMRDSGWYWCGAGQQNV-----AVHVSVT 229
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEgvfgkGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-127 2.09e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.49  E-value: 2.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694869814    26 GDVAVLEGGSVTVPCHYNpQYISNVKYWcsgrmrefcsslaRTDDPESAPNGNRkVTIADDPTQHVFTvnMRNLTEDDSG 105
Cdd:smart00410   2 PSVTVKEGESVTLSCEAS-GSPPPEVTW-------------YKQGGKLLAESGR-FSVSRSGSTSTLT--ISNVTPEDSG 64

                           90       100
                   ....*....|....*....|..
gi 694869814   106 WYWCGVELGGMWVSdSTASLYI 127
Cdd:smart00410  65 TYTCAATNSSGSAS-SGTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 140-228 3.23e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.33  E-value: 3.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694869814   140 VSAEEGKSVSVQCLYSKNlRSSEKRWCRSGNwnsclltdsEGTFSGKNVHIHDDKNSvFTVTLQRLEMRDSGWYWCGA-- 217
Cdd:smart00410   4 VTVKEGESVTLSCEASGS-PPPEVTWYKQGG---------KLLAESGRFSVSRSGST-STLTISNVTPEDSGTYTCAAtn 72

                           90
                   ....*....|...
gi 694869814   218 --GQQNVAVHVSV 228
Cdd:smart00410  73 ssGSASSGTTLTV 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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