NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|663071143|ref|NP_001284662|]
View 

cytochrome c oxidase assembly protein COX18, mitochondrial isoform 3 [Homo sapiens]

Protein Classification

YidC/Oxa1 family membrane protein insertase( domain architecture ID 15331844)

YidC/Oxa1 family membrane protein insertase functions as a membrane protein chaperone and as an independent insertase for membrane proteins, such as mitochondrial inner membrane protein OXA1/OXA1L and bacterial membrane protein insertase YidC

Gene Ontology:  GO:0016020
PubMed:  23111630|21194367|25947384

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
5TM_Oxa1-like cd20069
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar ...
 1-148 6.82e-56

Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins; This group is composed mostly of the mitochondrial members of the YidC/Oxa1/Alb3 protein family of insertases, including mitochondrial inner membrane proteins Oxa1, Oxa1-like (Oxa1L), cytochrome c oxidase assembly protein 18 (Cox18, also called Oxa2), and Arabidopsis thaliana mitochondrial ALBINO3-like protein 3 (ALB33). It also includes Arabidopsis thaliana chloroplastic ALBINO3-like protein 2 (ALB32). Members of this group mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Oxa1 and Cox18/Oxa2 are essential for the activity and assembly of cytochrome c oxidase, playing central roles in the translocation and export of the N-terminal and C-terminal parts, respectively, of the COX2 protein into the mitochondrial intermembrane space. ALB32 may be involved in the insertion of integral membrane proteins into the chloroplast thylakoid membranes. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


:

Pssm-ID: 410993 [Multi-domain]  Cd Length: 201  Bit Score: 175.02  E-value: 6.82e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143   1 MRRLISELYVRDNCHPFKATVLVWIQLPMWIFMSFALRNLSTGAahsegfsvQEQLATGGILWFPDLTAPDSTWILPISV 80
Cdd:cd20069   62 ARKELKELMKKHNVNPLKSLLLPLVQAPVFISFFFALRKMANLP--------VPSFKTGGLLWFTDLTVPDPYYILPILT 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 663071143  81 GVINLLIVEICALQKIGMSRFQTYITYFVRAMSVLMIPIAATVPSSIVLYWLCSSFVGLSQNLLLRSP 148
Cdd:cd20069  134 SLTFLATIELGAETGTSGSPQSKTMKNVFRGLPVLMIPFTANFPSAVFLYWITSNLFSLAQNLLLRIP 201
 
Name Accession Description Interval E-value
5TM_Oxa1-like cd20069
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar ...
 1-148 6.82e-56

Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins; This group is composed mostly of the mitochondrial members of the YidC/Oxa1/Alb3 protein family of insertases, including mitochondrial inner membrane proteins Oxa1, Oxa1-like (Oxa1L), cytochrome c oxidase assembly protein 18 (Cox18, also called Oxa2), and Arabidopsis thaliana mitochondrial ALBINO3-like protein 3 (ALB33). It also includes Arabidopsis thaliana chloroplastic ALBINO3-like protein 2 (ALB32). Members of this group mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Oxa1 and Cox18/Oxa2 are essential for the activity and assembly of cytochrome c oxidase, playing central roles in the translocation and export of the N-terminal and C-terminal parts, respectively, of the COX2 protein into the mitochondrial intermembrane space. ALB32 may be involved in the insertion of integral membrane proteins into the chloroplast thylakoid membranes. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410993 [Multi-domain]  Cd Length: 201  Bit Score: 175.02  E-value: 6.82e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143   1 MRRLISELYVRDNCHPFKATVLVWIQLPMWIFMSFALRNLSTGAahsegfsvQEQLATGGILWFPDLTAPDSTWILPISV 80
Cdd:cd20069   62 ARKELKELMKKHNVNPLKSLLLPLVQAPVFISFFFALRKMANLP--------VPSFKTGGLLWFTDLTVPDPYYILPILT 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 663071143  81 GVINLLIVEICALQKIGMSRFQTYITYFVRAMSVLMIPIAATVPSSIVLYWLCSSFVGLSQNLLLRSP 148
Cdd:cd20069  134 SLTFLATIELGAETGTSGSPQSKTMKNVFRGLPVLMIPFTANFPSAVFLYWITSNLFSLAQNLLLRIP 201
yidC_oxa1_cterm TIGR03592
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ...
 1-145 1.18e-11

membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274665 [Multi-domain]  Cd Length: 179  Bit Score: 60.19  E-value: 1.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143    1 MRRLISELYVRDNCHPFKATVLVWIQLPMWIFMSFALRNlstgaahsegfsvQEQLATGGILWFPDLTAPDSTWILPISV 80
Cdd:TIGR03592  52 LQQEMMKLYKEEGVNPLGGCLPLLIQMPIFIALYQVLLR-------------SIELRHAPFLWIIDLSSPDPYYILPILM 118

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143   81 GVINLLiveicaLQKIGMSRF-----QTYITYFvraMSVLMIPIAATVPSSIVLYWLCSSFVGLSQNLLL 145
Cdd:TIGR03592 119 GVTMFL------QQKLSPKGPpdpaqQKMMMYF---MPLMFLFFFLSFPAGLVLYWVVSNLFTIIQQLII 179
YidC COG0706
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
25-146 3.26e-10

Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440470 [Multi-domain]  Cd Length: 212  Bit Score: 56.67  E-value: 3.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143  25 IQLPMWIFMSFALRNLstgaahsegfsvqEQLATGGILWFPDLTAPDSTWI-LPISVGVINLLIveicalQKIGMSRF-- 101
Cdd:COG0706  101 IQMPIFIALYRVLRNS-------------IELRHAPFLGIPDLSAPDPYYIfLPILMGVTMFLQ------QKLNPAPAqd 161

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 663071143 102 --QTYITYFvraMSVLMIPIAATVPSSIVLYWLCSSFVGLSQNLLLR 146
Cdd:COG0706  162 pqQKKMMYI---MPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIIN 205
60KD_IMP pfam02096
60Kd inner membrane protein;
25-146 8.15e-09

60Kd inner membrane protein;


Pssm-ID: 460443 [Multi-domain]  Cd Length: 187  Bit Score: 52.47  E-value: 8.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143   25 IQLPMWIFMSFALRNLstgaahsegfsvQEQLATGGILWFPDLTAPDST-----WILPISVGVINLLIVEICALQKIGMS 99
Cdd:pfam02096  75 IQMPIFIALYRVLRNS------------IELRHAPFFLWIADLSAPDPIsilhyYILPILMGVTMFLQQKLTPAPQDQPP 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 663071143  100 RFQTYITYFvraMSVLMIPIAATVPSSIVLYWLCSSFVGLSQNLLLR 146
Cdd:pfam02096 143 QMKMMMLYF---MPLMFLFFFLNFPAGLVLYWVVSNLLSIGQQLIIN 186
PRK00145 PRK00145
putative inner membrane protein translocase component YidC; Provisional
 7-145 3.90e-07

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234665 [Multi-domain]  Cd Length: 223  Bit Score: 48.20  E-value: 3.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143   7 ELYVRDNCHPFKATVLVWIQLPMWIFMSFALRNLS--TGAahsegfsvqeqlatgGILWFPDLTAPDSTWILPISVGVIN 84
Cdd:PRK00145  87 KLYKEKGVNPLGGCLPLLIQWPILIALYYVFNNLTgiNGV---------------SFLWIKDLAKPDITWILPILSGATT 151

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 663071143  85 LLiVEICALQKIGMSRFQTYITYFVraMSVLMIPIAATVPSSIVLYWLCSSFVGLSQNLLL 145
Cdd:PRK00145 152 YL-SGYLMTKADSSQAGQMKTMNIG--MSIFMGVMSWKFKSALVLYWVIGNLIQIIQTYFI 209
 
Name Accession Description Interval E-value
5TM_Oxa1-like cd20069
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar ...
 1-148 6.82e-56

Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins; This group is composed mostly of the mitochondrial members of the YidC/Oxa1/Alb3 protein family of insertases, including mitochondrial inner membrane proteins Oxa1, Oxa1-like (Oxa1L), cytochrome c oxidase assembly protein 18 (Cox18, also called Oxa2), and Arabidopsis thaliana mitochondrial ALBINO3-like protein 3 (ALB33). It also includes Arabidopsis thaliana chloroplastic ALBINO3-like protein 2 (ALB32). Members of this group mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Oxa1 and Cox18/Oxa2 are essential for the activity and assembly of cytochrome c oxidase, playing central roles in the translocation and export of the N-terminal and C-terminal parts, respectively, of the COX2 protein into the mitochondrial intermembrane space. ALB32 may be involved in the insertion of integral membrane proteins into the chloroplast thylakoid membranes. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410993 [Multi-domain]  Cd Length: 201  Bit Score: 175.02  E-value: 6.82e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143   1 MRRLISELYVRDNCHPFKATVLVWIQLPMWIFMSFALRNLSTGAahsegfsvQEQLATGGILWFPDLTAPDSTWILPISV 80
Cdd:cd20069   62 ARKELKELMKKHNVNPLKSLLLPLVQAPVFISFFFALRKMANLP--------VPSFKTGGLLWFTDLTVPDPYYILPILT 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 663071143  81 GVINLLIVEICALQKIGMSRFQTYITYFVRAMSVLMIPIAATVPSSIVLYWLCSSFVGLSQNLLLRSP 148
Cdd:cd20069  134 SLTFLATIELGAETGTSGSPQSKTMKNVFRGLPVLMIPFTANFPSAVFLYWITSNLFSLAQNLLLRIP 201
5TM_YidC_Oxa1_Alb3 cd19751
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1 ...
 8-145 1.90e-15

Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1/Alb3 protein family of insertases facilitate the insertion, folding and assembly of proteins of the inner membranes of bacteria and mitochondria, and the thylakoid membrane of plastids. Members include bacterial YidC, mitochondrial Cox18 and Oxa1, and chloroplastic Alb3 and Alb4. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Oxa1 and Cox18/Oxa2 mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Alb3 and Alb3-like proteins, including Alb4, are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410992 [Multi-domain]  Cd Length: 189  Bit Score: 70.66  E-value: 1.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143   8 LYVRDNCHPFKATVLVWIQLPMWIFMSFALRNLstgaahsegfsvqEQLATGGILWFPDLTAPDSTWILPISVGVINLLI 87
Cdd:cd19751   63 LYKKHGVNPMAGCLPLFIQLPIFMAFYFAIMRT-------------EEIRYHTFLWFFDLGQPDYLYILPFVAGITTYFQ 129

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 663071143  88 VEICALQKIGMSRFQTYITYFVRAMSVLMIPIAATVPSSIVLYWLCSSFVGLSQNLLL 145
Cdd:cd19751  130 FKMTMSHQQQMQMMQMQMKVMLYVMPVMIIIAGLSFPSALSLYWIISNLFMIIQTYFI 187
yidC_oxa1_cterm TIGR03592
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ...
 1-145 1.18e-11

membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274665 [Multi-domain]  Cd Length: 179  Bit Score: 60.19  E-value: 1.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143    1 MRRLISELYVRDNCHPFKATVLVWIQLPMWIFMSFALRNlstgaahsegfsvQEQLATGGILWFPDLTAPDSTWILPISV 80
Cdd:TIGR03592  52 LQQEMMKLYKEEGVNPLGGCLPLLIQMPIFIALYQVLLR-------------SIELRHAPFLWIIDLSSPDPYYILPILM 118

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143   81 GVINLLiveicaLQKIGMSRF-----QTYITYFvraMSVLMIPIAATVPSSIVLYWLCSSFVGLSQNLLL 145
Cdd:TIGR03592 119 GVTMFL------QQKLSPKGPpdpaqQKMMMYF---MPLMFLFFFLSFPAGLVLYWVVSNLFTIIQQLII 179
5TM_YidC_Alb3 cd20070
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ...
 25-146 4.68e-11

Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410994 [Multi-domain]  Cd Length: 181  Bit Score: 58.54  E-value: 4.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143  25 IQLPMWIFMSFALRNlsTGAAHSEGFsvqeqlatggILWFPDLTAPDSTWILPISVGVINLLiveicaLQKIGMSR---- 100
Cdd:cd20070   74 IQMPIFIALYQVLRN--SIELRGAPF----------LWWILDLSAPDPYYILPILMGVTMFL------QQKLTPTPtddq 135

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 663071143 101 --FQTYITYFvraMSVLMIPIAATVPSSIVLYWLCSSFVGLSQNLLLR 146
Cdd:cd20070  136 apQQKMMMYF---MPVMFTFIFLSFPSGLVLYWLVSNLFSIIQQLIIN 180
YidC COG0706
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
25-146 3.26e-10

Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440470 [Multi-domain]  Cd Length: 212  Bit Score: 56.67  E-value: 3.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143  25 IQLPMWIFMSFALRNLstgaahsegfsvqEQLATGGILWFPDLTAPDSTWI-LPISVGVINLLIveicalQKIGMSRF-- 101
Cdd:COG0706  101 IQMPIFIALYRVLRNS-------------IELRHAPFLGIPDLSAPDPYYIfLPILMGVTMFLQ------QKLNPAPAqd 161

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 663071143 102 --QTYITYFvraMSVLMIPIAATVPSSIVLYWLCSSFVGLSQNLLLR 146
Cdd:COG0706  162 pqQKKMMYI---MPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIIN 205
60KD_IMP pfam02096
60Kd inner membrane protein;
25-146 8.15e-09

60Kd inner membrane protein;


Pssm-ID: 460443 [Multi-domain]  Cd Length: 187  Bit Score: 52.47  E-value: 8.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143   25 IQLPMWIFMSFALRNLstgaahsegfsvQEQLATGGILWFPDLTAPDST-----WILPISVGVINLLIVEICALQKIGMS 99
Cdd:pfam02096  75 IQMPIFIALYRVLRNS------------IELRHAPFFLWIADLSAPDPIsilhyYILPILMGVTMFLQQKLTPAPQDQPP 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 663071143  100 RFQTYITYFvraMSVLMIPIAATVPSSIVLYWLCSSFVGLSQNLLLR 146
Cdd:pfam02096 143 QMKMMMLYF---MPLMFLFFFLNFPAGLVLYWVVSNLLSIGQQLIIN 186
PRK00145 PRK00145
putative inner membrane protein translocase component YidC; Provisional
 7-145 3.90e-07

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234665 [Multi-domain]  Cd Length: 223  Bit Score: 48.20  E-value: 3.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143   7 ELYVRDNCHPFKATVLVWIQLPMWIFMSFALRNLS--TGAahsegfsvqeqlatgGILWFPDLTAPDSTWILPISVGVIN 84
Cdd:PRK00145  87 KLYKEKGVNPLGGCLPLLIQWPILIALYYVFNNLTgiNGV---------------SFLWIKDLAKPDITWILPILSGATT 151

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 663071143  85 LLiVEICALQKIGMSRFQTYITYFVraMSVLMIPIAATVPSSIVLYWLCSSFVGLSQNLLL 145
Cdd:PRK00145 152 YL-SGYLMTKADSSQAGQMKTMNIG--MSIFMGVMSWKFKSALVLYWVIGNLIQIIQTYFI 209
PRK01001 PRK01001
putative inner membrane protein translocase component YidC; Provisional
 5-141 1.22e-04

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234887 [Multi-domain]  Cd Length: 795  Bit Score: 41.71  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143   5 ISELYVRDNCHPFKATVLVWIQLPMWIFM------SFALRnlstGAAHSEGfsvqeqlatggilWFPDLTAPDS--TW-- 74
Cdd:PRK01001 630 IMALYKTNKVNPITGCLPLLIQLPFLIAMfdllksSFLLR----GASFIPG-------------WIDNLTAPDVlfSWet 692

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143  75 ----------ILPISVGVINLLIVEICALQKIG-MSRFQTYityfVRAMSVLMIPIAATV----PSSIVLYWLCSSFVGL 139
Cdd:PRK01001 693 piwfignefhLLPILLGVVMFAQQKISSLKRKGpVTDQQRQ----QEAMGTMMALLFTFMfynfPSGLNIYWLSSMLLGV 768


                 ..
gi 663071143 140 SQ 141
Cdd:PRK01001 769 IQ 770
PRK01318 PRK01318
membrane protein insertase; Provisional
 61-146 1.40e-04

membrane protein insertase; Provisional


Pssm-ID: 234942 [Multi-domain]  Cd Length: 521  Bit Score: 41.40  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143  61 ILWFPDLTAPDSTWILPISVGVInLLIVEICALQKIGMS---RFQTYITYFvraMSVLMIPIAATVPSSIVLYWLCSSFV 137
Cdd:PRK01318 421 IGWIHDLSAPDPYFILHIGLLPI-LMGITMFLQQKLNPTptdPMQAKIMKF---MPLIFTFFFLSFPAGLVLYWIVNNLL 496


                 ....*....
gi 663071143 138 GLSQNLLLR 146
Cdd:PRK01318 497 TIIQQYLIN 505
PRK01622 PRK01622
membrane protein insertase YidC;
5-146 5.23e-04

membrane protein insertase YidC;


Pssm-ID: 179310  Cd Length: 256  Bit Score: 39.35  E-value: 5.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143   5 ISELYVRDNCHPFKATVL-VWIQLPMWIFMSFALRNLSTGAAHSegfsvqeqlatggILWFpDLTAPDstWILPISVGVI 83
Cdd:PRK01622 123 MMELYKSGNINPLAMGCLpLLIQMPILSAFYYAIRRTEEIASHS-------------FLWF-NLGHAD--HILPIIAGLT 186

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 663071143  84 NLLIVEIcaLQKIGMSRFQTYITYFVRAMSVLMIPIAA-TVPSSIVLYWLCSSFVGLSQNLLLR 146
Cdd:PRK01622 187 YFIQMKV--SQSNGTSPEQVQMLKIQGIMMPAMILFMSfAAPSALVLYWITGGLFLMGQTIVLR 248
PRK02463 PRK02463
OxaA-like protein precursor; Provisional
 25-144 7.05e-03

OxaA-like protein precursor; Provisional


Pssm-ID: 235040  Cd Length: 307  Bit Score: 36.25  E-value: 7.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071143  25 IQLPMWIFMSFAlrnlstgAAHSEGfsvqeqLATGGILWFpDLTAPDstWILPISVGVINLLIVEICALQKIGMSRFQTY 104
Cdd:PRK02463 145 IQMPFFSALYFA-------AQYTKG------VSTSTFLGI-DLGSPS--LVLTAIIGVLYFFQSWLSMMGVPEEQREQMK 208

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 663071143 105 ITYFVraMSVLMIPIAATVPSSIVLYWLCSSFVGLSQNLL 144
Cdd:PRK02463 209 AMMYM--MPIMMVVFSFSSPAGVGLYWLVGGFFSIIQQLI 246
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH