C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236812  25 GTKDPLFLTGVTFppDYPIYEETRIKLTVYDVKDKSHDtirtsvlPEHKDplpevarsFLGCASFKVGELLKSKEQLLSL 104
Cdd:cd04048   48 NNLNPDFVTTFTV--DYYFEEVQKLRFEVYDVDSKSKD-------LSDHD--------FLGEAECTLGEIVSSPGQKLTL 110

                         90
                 ....*....|
gi 662236812 105 SLRTSDGGKV 114
Cdd:cd04048  111 PLKGGKGKGT 120

C2 domain first repeat in Copine; There are 2 copies of the C2 domain present in copine, a protein involved in membrane trafficking, protein-protein interactions, and perhaps even cell division and growth. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the first C2 repeat, C2A, and has a type-I topology.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236812  25 GTKDPLFLTGVTFppDYPIYEETRIKLTVYDVKDKSHDtirtsvlPEHKDplpevarsFLGCASFKVGELLKSKEQLLSL 104
Cdd:cd04048   48 NNLNPDFVTTFTV--DYYFEEVQKLRFEVYDVDSKSKD-------LSDHD--------FLGEAECTLGEIVSSPGQKLTL 110

                         90
                 ....*....|
gi 662236812 105 SLRTSDGGKV 114
Cdd:cd04048  111 PLKGGKGKGT 120

C2 domain first repeat in Copine; There are 2 copies of the C2 domain present in copine, a protein involved in membrane trafficking, protein-protein interactions, and perhaps even cell division and growth. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the first C2 repeat, C2A, and has a type-I topology.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236812  25 GTKDPLFLTGVTFppDYPIYEETRIKLTVYDVKDKSHDtirtsvlPEHKDplpevarsFLGCASFKVGELLKSKEQLLSL 104
Cdd:cd04048   48 NNLNPDFVTTFTV--DYYFEEVQKLRFEVYDVDSKSKD-------LSDHD--------FLGEAECTLGEIVSSPGQKLTL 110

                         90
                 ....*....|
gi 662236812 105 SLRTSDGGKV 114
Cdd:cd04048  111 PLKGGKGKGT 120