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Conserved domains on  [gi|657406261|ref|NP_001280686|]
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dynactin subunit 6 isoform 1 [Mus musculus]

Protein Classification

LbH_Dynactin_6 domain-containing protein( domain architecture ID 10140303)

LbH_Dynactin_6 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LbH_Dynactin_6 cd04646
Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that ...
 36-184 6.14e-84

Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping protein Arp1, and dynamatin. In vitro binding experiments show that dynactin enhances dynein-dependent motility, possibly through interaction with microtubules and vesicles. Subunit p27 is part of the pointed-end subcomplex in dynactin that also includes p25, p26, and Arp11. This subcomplex interacts with membranous cargoes. p25 and p27 contain the imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), indicating a left-handed parallel beta helix (LbH) structural domain. Proteins containing hexapeptide repeats are often enzymes showing acyltransferase activity.


:

Pssm-ID: 100052 [Multi-domain]  Cd Length: 164  Bit Score: 245.31  E-value: 6.14e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657406261  36 PRTVIHPKARIIAEAGPIIIGEGNLIEEQALIINAHPDNIipdtedTEPKPMIIGTNNVFEVGCHSQAMKMGDNNVIESK 115
Cdd:cd04646   22 PGTVVHPRATIIAEAGPIIIGENNIIEEQVTIVNKKPKDP------AEPKPMIIGSNNVFEVGCKCEALKIGNNNVFESK 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 657406261 116 AYVGRNVILTSGCIIGACCSLNTFEAIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKK 184
Cdd:cd04646   96 SFVGKNVIITDGCIIGAGCKLPSSEILPENTVIYGADCLRRTQTDRPKPQTLQLDFLRKILPNYHHLKK 164
 
Name Accession Description Interval E-value
LbH_Dynactin_6 cd04646
Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that ...
 36-184 6.14e-84

Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping protein Arp1, and dynamatin. In vitro binding experiments show that dynactin enhances dynein-dependent motility, possibly through interaction with microtubules and vesicles. Subunit p27 is part of the pointed-end subcomplex in dynactin that also includes p25, p26, and Arp11. This subcomplex interacts with membranous cargoes. p25 and p27 contain the imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), indicating a left-handed parallel beta helix (LbH) structural domain. Proteins containing hexapeptide repeats are often enzymes showing acyltransferase activity.


Pssm-ID: 100052 [Multi-domain]  Cd Length: 164  Bit Score: 245.31  E-value: 6.14e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657406261  36 PRTVIHPKARIIAEAGPIIIGEGNLIEEQALIINAHPDNIipdtedTEPKPMIIGTNNVFEVGCHSQAMKMGDNNVIESK 115
Cdd:cd04646   22 PGTVVHPRATIIAEAGPIIIGENNIIEEQVTIVNKKPKDP------AEPKPMIIGSNNVFEVGCKCEALKIGNNNVFESK 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 657406261 116 AYVGRNVILTSGCIIGACCSLNTFEAIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKK 184
Cdd:cd04646   96 SFVGKNVIITDGCIIGAGCKLPSSEILPENTVIYGADCLRRTQTDRPKPQTLQLDFLRKILPNYHHLKK 164
lpxD PRK00892
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional
 31-154 2.30e-04

UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional


Pssm-ID: 234858 [Multi-domain]  Cd Length: 343  Bit Score: 40.89  E-value: 2.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657406261  31 SQLFcprtviHPKARIIAEAGpiiigegnlIEEQALIinaHPDNIIPDTedtepkpMIIGTNNVFEVGChsqamKMGDNN 110
Cdd:PRK00892  88 AQLF------DPPATPSPAAG---------IHPSAVI---DPSAKIGEG-------VSIGPNAVIGAGV-----VIGDGV 137

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 657406261 111 VIESKAYVGRNVILTSGCIIGACCSLNtfeaipENTVIyGADCL 154
Cdd:PRK00892 138 VIGAGAVIGDGVKIGADCRLHANVTIY------HAVRI-GNRVI 174
PaaY COG0663
Carbonic anhydrase or acetyltransferase, isoleucine patch superfamily [General function ...
 42-189 1.00e-03

Carbonic anhydrase or acetyltransferase, isoleucine patch superfamily [General function prediction only];


Pssm-ID: 440427 [Multi-domain]  Cd Length: 170  Bit Score: 38.08  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657406261  42 PKARIIAEAGPIIIGEGNLIEEQALIinaHPDniipdtedtEPKPMIIGtNNVFeVGcHsQAM----KMGDNNVIESKAY 117
Cdd:COG0663   39 PGAVLRGDVGPIRIGEGSNIQDGVVL---HVD---------PGYPLTIG-DDVT-IG-H-GAIlhgcTIGDNVLIGMGAI 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 657406261 118 VGRNVILTSGCIIGACC--SLNTFeaIPENTVIYG--ADCLRRVQTErpqpqtlQLDFLMKILPNYHHLKKTMKGS 189
Cdd:COG0663  103 VLDGAVIGDGSIVGAGAlvTEGKV--VPPGSLVVGspAKVVRELTEE-------EIAFLRESAENYVELARRYLAE 169
 
Name Accession Description Interval E-value
LbH_Dynactin_6 cd04646
Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that ...
 36-184 6.14e-84

Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping protein Arp1, and dynamatin. In vitro binding experiments show that dynactin enhances dynein-dependent motility, possibly through interaction with microtubules and vesicles. Subunit p27 is part of the pointed-end subcomplex in dynactin that also includes p25, p26, and Arp11. This subcomplex interacts with membranous cargoes. p25 and p27 contain the imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), indicating a left-handed parallel beta helix (LbH) structural domain. Proteins containing hexapeptide repeats are often enzymes showing acyltransferase activity.


Pssm-ID: 100052 [Multi-domain]  Cd Length: 164  Bit Score: 245.31  E-value: 6.14e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657406261  36 PRTVIHPKARIIAEAGPIIIGEGNLIEEQALIINAHPDNIipdtedTEPKPMIIGTNNVFEVGCHSQAMKMGDNNVIESK 115
Cdd:cd04646   22 PGTVVHPRATIIAEAGPIIIGENNIIEEQVTIVNKKPKDP------AEPKPMIIGSNNVFEVGCKCEALKIGNNNVFESK 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 657406261 116 AYVGRNVILTSGCIIGACCSLNTFEAIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKK 184
Cdd:cd04646   96 SFVGKNVIITDGCIIGAGCKLPSSEILPENTVIYGADCLRRTQTDRPKPQTLQLDFLRKILPNYHHLKK 164
LbetaH cd00208
Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each ...
 36-119 9.00e-12

Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes showing acyltransferase activity, however, some subfamilies in this hierarchy also show activities related to ion transport or translation initiation. Many are trimeric in their active forms.


Pssm-ID: 100038 [Multi-domain]  Cd Length: 78  Bit Score: 58.41  E-value: 9.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657406261  36 PRTVIHPKARIIaeaGPIIIGEGNLIEEQALIINAhpdniipdTEDTEPKPMIIGTNNVFEVGCH-SQAMKMGDNNVIES 114
Cdd:cd00208    5 EGVKIHPKAVIR---GPVVIGDNVNIGPGAVIGAA--------TGPNEKNPTIIGDNVEIGANAViHGGVKIGDNAVIGA 73


                 ....*
gi 657406261 115 KAYVG 119
Cdd:cd00208   74 GAVVT 78
lpxD PRK00892
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional
 31-154 2.30e-04

UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional


Pssm-ID: 234858 [Multi-domain]  Cd Length: 343  Bit Score: 40.89  E-value: 2.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657406261  31 SQLFcprtviHPKARIIAEAGpiiigegnlIEEQALIinaHPDNIIPDTedtepkpMIIGTNNVFEVGChsqamKMGDNN 110
Cdd:PRK00892  88 AQLF------DPPATPSPAAG---------IHPSAVI---DPSAKIGEG-------VSIGPNAVIGAGV-----VIGDGV 137

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 657406261 111 VIESKAYVGRNVILTSGCIIGACCSLNtfeaipENTVIyGADCL 154
Cdd:PRK00892 138 VIGAGAVIGDGVKIGADCRLHANVTIY------HAVRI-GNRVI 174
LbH_Dynactin_5 cd03359
Dynactin 5 (or subunit p25); Dynactin is a major component of the activator complex that ...
 37-148 7.05e-04

Dynactin 5 (or subunit p25); Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping protein Arp1, and dynamatin. In vitro binding experiments show that dynactin enhances dynein-dependent motility, possibly through interaction with microtubules and vesicles. Subunit p25 is part of the pointed-end subcomplex in dynactin that also includes p26, p27, and Arp11. This subcomplex interacts with membranous cargoes. p25 and p27 contain imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), indicating a left-handed parallel beta helix (LbH) structural domain. Proteins containing hexapeptide repeats are often enzymes showing acyltransferase activity.


Pssm-ID: 100049 [Multi-domain]  Cd Length: 161  Bit Score: 38.35  E-value: 7.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657406261  37 RTVIHPKARIIAEAGPIIIGEGNLIEEQALIINahPDNIIPDTEDTepKPMIIGTNNVFEVGCHSQAMKMGDNNVIESKA 116
Cdd:cd03359   27 KTIIQSDVIIRGDLATVSIGRYCILSEGCVIRP--PFKKFSKGVAF--FPLHIGDYVFIGENCVVNAAQIGSYVHIGKNC 102

                         90       100       110
                 ....*....|....*....|....*....|..
gi 657406261 117 YVGRNVILTSGCIIGAccslNTfeAIPENTVI 148
Cdd:cd03359  103 VIGRRCIIKDCVKILD----GT--VVPPDTVI 128
PaaY COG0663
Carbonic anhydrase or acetyltransferase, isoleucine patch superfamily [General function ...
 42-189 1.00e-03

Carbonic anhydrase or acetyltransferase, isoleucine patch superfamily [General function prediction only];


Pssm-ID: 440427 [Multi-domain]  Cd Length: 170  Bit Score: 38.08  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657406261  42 PKARIIAEAGPIIIGEGNLIEEQALIinaHPDniipdtedtEPKPMIIGtNNVFeVGcHsQAM----KMGDNNVIESKAY 117
Cdd:COG0663   39 PGAVLRGDVGPIRIGEGSNIQDGVVL---HVD---------PGYPLTIG-DDVT-IG-H-GAIlhgcTIGDNVLIGMGAI 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 657406261 118 VGRNVILTSGCIIGACC--SLNTFeaIPENTVIYG--ADCLRRVQTErpqpqtlQLDFLMKILPNYHHLKKTMKGS 189
Cdd:COG0663  103 VLDGAVIGDGSIVGAGAlvTEGKV--VPPGSLVVGspAKVVRELTEE-------EIAFLRESAENYVELARRYLAE 169
LbH_AT_putative cd03360
Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is ...
 38-150 1.38e-03

Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes showing acyltransferase activity. A few members are identified as NeuD, a sialic acid (Sia) O-acetyltransferase that is required for Sia synthesis and surface polysaccharide sialylation.


Pssm-ID: 100050 [Multi-domain]  Cd Length: 197  Bit Score: 37.85  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657406261  38 TVIHPKARIIAEAgpiIIGEGNLIeeqaliinaHPDNII-PDTEdtepkpmiIGTNNVFEVGC----HSqamKMGDNN-- 110
Cdd:cd03360   85 TLIHPSAVVSPSA---VIGEGCVI---------MAGAVInPDAR--------IGDNVIINTGAvighDC---VIGDFVhi 141

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 657406261 111 ----------VIESKAYVG------RNVILTSGCIIGACCSLntFEAIPENTVIYG 150
Cdd:cd03360  142 apgvvlsggvTIGEGAFIGagatiiQGVTIGAGAIIGAGAVV--TKDVPDGSVVVG 195
PRK12461 PRK12461
UDP-N-acetylglucosamine acyltransferase; Provisional
 37-131 3.01e-03

UDP-N-acetylglucosamine acyltransferase; Provisional


Pssm-ID: 183539 [Multi-domain]  Cd Length: 255  Bit Score: 37.31  E-value: 3.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657406261  37 RTVIHPKARIIaeaGPIIIGEGNLIEEQAlIINAHPDNIipdTEDTEPKPMIIGTNNVFEVGC--H-----SQAMKMGDN 109
Cdd:PRK12461  35 GTWIGPHAVIL---GPTRIGKNNKIHQGA-VVGDEPQDF---TYKGEESRLEIGDRNVIREGVtiHrgtkgGGVTRIGND 107

                         90       100
                 ....*....|....*....|..
gi 657406261 110 NVIESKAYVGRNVILTSGCIIG 131
Cdd:PRK12461 108 NLLMAYSHVAHDCQIGNNVILV 129
WbbJ COG0110
Acetyltransferase, isoleucine patch superfamily [General function prediction only];
37-122 4.49e-03

Acetyltransferase, isoleucine patch superfamily [General function prediction only];


Pssm-ID: 439880 [Multi-domain]  Cd Length: 140  Bit Score: 36.00  E-value: 4.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657406261  37 RTVIHPKARIIAeAGPIIIGEGNLIEEQALIINAHPDNIIPDTEDTEPKPMIIGtNNVFeVGCHSQAM---KMGDNNVIE 113
Cdd:COG0110   33 NVYIGPGVTIDD-PGGITIGDNVLIGPGVTILTGNHPIDDPATFPLRTGPVTIG-DDVW-IGAGATILpgvTIGDGAVVG 109


                 ....*....
gi 657406261 114 SKAYVGRNV 122
Cdd:COG0110  110 AGSVVTKDV 118
LpxD COG1044
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [Cell wall/membrane/envelope ...
 94-154 4.67e-03

UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [Cell wall/membrane/envelope biogenesis]; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase is part of the Pathway/BioSystem: Lipid A biosynthesis


Pssm-ID: 440666 [Multi-domain]  Cd Length: 335  Bit Score: 36.92  E-value: 4.67e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 657406261  94 VFEVGCHSQAM-----KMGDNNVIESKAYVGRNVILTSGCIIGACCSlntfeaIPENTVIyGADCL 154
Cdd:COG1044   94 APAPGIHPSAVidpsaKIGEGVSIGPFAVIGAGVVIGDGVVIGPGVV------IGDGVVI-GDDCV 152
LpxD COG1044
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [Cell wall/membrane/envelope ...
 105-154 8.35e-03

UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [Cell wall/membrane/envelope biogenesis]; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase is part of the Pathway/BioSystem: Lipid A biosynthesis


Pssm-ID: 440666 [Multi-domain]  Cd Length: 335  Bit Score: 36.15  E-value: 8.35e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 657406261 105 KMGDNNVIESKAYVGRNVILTSGCIIGACCSlntfeaIPENTVIyGADCL 154
Cdd:COG1044  128 VIGDGVVIGPGVVIGDGVVIGDDCVLHPNVT------IYERCVI-GDRVI 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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