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Conserved domains on  [gi|597955339|ref|NP_001278048|]
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neuralized-like protein 4 isoform 3 [Mus musculus]

Protein Classification

SPRY_NHR_like domain-containing protein( domain architecture ID 10191474)

SPRY_NHR_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 698-860 2.00e-86

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 278.62  E-value: 2.00e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  698 RFHQLHGSNAVITNGGRTALRhnCRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTMTD 777
Cdd:cd12887     1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  778 IDYDTWMLSGTAIMQDGNTMRNNYGCDLDALGTGARIGMMRTAKGDLHYFINGQDQGAACSGLPPEVYAVVDLYGQCVQV 857
Cdd:cd12887    79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                  ...
gi 597955339  858 SIT 860
Cdd:cd12887   159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 503-664 9.53e-86

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 276.70  E-value: 9.53e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  503 FHPNCGQKAAITHEGRTALRPHatDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTMTNL 582
Cdd:cd12887     2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  583 RSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRREDGTLHFFVNGMTQGPAAWNVPPGVYAVVDLYGQAAQAT 662
Cdd:cd12887    80 KSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVS 159


                  ..
gi 597955339  663 IV 664
Cdd:cd12887   160 IV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 45-207 3.88e-78

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 255.13  E-value: 3.88e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   45 ELHPRTGRLVSLSACGRTARRqqPGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLDFPSSATG 124
Cdd:cd12887     1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  125 LKGGSWVVSGCSVLRDGRSVLEEYGQDLDQLVEGDRVGVERTATGELRLWVNGRDCGVAATGLPARVWAVVDLYGKCTQI 204
Cdd:cd12887    79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                  ...
gi 597955339  205 TVL 207
Cdd:cd12887   159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 300-462 1.66e-77

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 253.20  E-value: 1.66e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  300 FHEKCGTLIKLSNNNKTAERRRplDEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPATMTNL 379
Cdd:cd12887     2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  380 QSGTIMMSGCGILTNGKGTRREYCeFSLDELQEGDHIGLTRKSNSALHFFINGIDQGVATPLTPPVVYGVVDLYGMAVKV 459
Cdd:cd12887    80 KSGTWILSGSSVFKNGNKIRENYG-PDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                  ...
gi 597955339  460 TIV 462
Cdd:cd12887   159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 1110-1269 2.15e-73

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 241.26  E-value: 2.15e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339 1110 EFLENHGKNILLSNGNRTATRVA-SYNQGIVVISQPLVPHMLVQVRIDFLNRQWTSSLVLGVITCPPERLNFPASACALK 1188
Cdd:cd12887     1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339 1189 RAAWLLRGRGVFHNGLKICEKFGPNLDTCPEGTILGLRLDSSGGLHLHINGVDQGVAVPDVPQPCHALVDLYGQCEQVTI 1268
Cdd:cd12887    81 SGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVSI 160


                  .
gi 597955339 1269 V 1269
Cdd:cd12887   161 V 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 893-1061 2.50e-56

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 192.34  E-value: 2.50e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  893 RFHSMCGKNVTLEEDGTRAVRVA-GYAHGLVFSTKELKAEEVFEVKVEELDEKWAGSLRLGLTTLAPEDMGpgagsgpgL 971
Cdd:cd12887     1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLD--------L 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  972 PPSLPELRTKTtWMVSSCEVRRDGHLQRMNYGRNLERLGVGSRVGIRRCADDTMHILVDGEDMGPAAAGIAKNVWAVLDL 1051
Cdd:cd12887    73 PPSATDLKSGT-WILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDL 151

                         170
                  ....*....|
gi 597955339 1052 YGPVRSVAIV 1061
Cdd:cd12887   152 YGQCEQVSIV 161
 
Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 698-860 2.00e-86

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 278.62  E-value: 2.00e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  698 RFHQLHGSNAVITNGGRTALRhnCRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTMTD 777
Cdd:cd12887     1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  778 IDYDTWMLSGTAIMQDGNTMRNNYGCDLDALGTGARIGMMRTAKGDLHYFINGQDQGAACSGLPPEVYAVVDLYGQCVQV 857
Cdd:cd12887    79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                  ...
gi 597955339  858 SIT 860
Cdd:cd12887   159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 503-664 9.53e-86

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 276.70  E-value: 9.53e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  503 FHPNCGQKAAITHEGRTALRPHatDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTMTNL 582
Cdd:cd12887     2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  583 RSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRREDGTLHFFVNGMTQGPAAWNVPPGVYAVVDLYGQAAQAT 662
Cdd:cd12887    80 KSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVS 159


                  ..
gi 597955339  663 IV 664
Cdd:cd12887   160 IV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 45-207 3.88e-78

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 255.13  E-value: 3.88e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   45 ELHPRTGRLVSLSACGRTARRqqPGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLDFPSSATG 124
Cdd:cd12887     1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  125 LKGGSWVVSGCSVLRDGRSVLEEYGQDLDQLVEGDRVGVERTATGELRLWVNGRDCGVAATGLPARVWAVVDLYGKCTQI 204
Cdd:cd12887    79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                  ...
gi 597955339  205 TVL 207
Cdd:cd12887   159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 300-462 1.66e-77

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 253.20  E-value: 1.66e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  300 FHEKCGTLIKLSNNNKTAERRRplDEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPATMTNL 379
Cdd:cd12887     2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  380 QSGTIMMSGCGILTNGKGTRREYCeFSLDELQEGDHIGLTRKSNSALHFFINGIDQGVATPLTPPVVYGVVDLYGMAVKV 459
Cdd:cd12887    80 KSGTWILSGSSVFKNGNKIRENYG-PDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                  ...
gi 597955339  460 TIV 462
Cdd:cd12887   159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 1110-1269 2.15e-73

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 241.26  E-value: 2.15e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339 1110 EFLENHGKNILLSNGNRTATRVA-SYNQGIVVISQPLVPHMLVQVRIDFLNRQWTSSLVLGVITCPPERLNFPASACALK 1188
Cdd:cd12887     1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339 1189 RAAWLLRGRGVFHNGLKICEKFGPNLDTCPEGTILGLRLDSSGGLHLHINGVDQGVAVPDVPQPCHALVDLYGQCEQVTI 1268
Cdd:cd12887    81 SGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVSI 160


                  .
gi 597955339 1269 V 1269
Cdd:cd12887   161 V 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 893-1061 2.50e-56

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 192.34  E-value: 2.50e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  893 RFHSMCGKNVTLEEDGTRAVRVA-GYAHGLVFSTKELKAEEVFEVKVEELDEKWAGSLRLGLTTLAPEDMGpgagsgpgL 971
Cdd:cd12887     1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLD--------L 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  972 PPSLPELRTKTtWMVSSCEVRRDGHLQRMNYGRNLERLGVGSRVGIRRCADDTMHILVDGEDMGPAAAGIAKNVWAVLDL 1051
Cdd:cd12887    73 PPSATDLKSGT-WILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDL 151

                         170
                  ....*....|
gi 597955339 1052 YGPVRSVAIV 1061
Cdd:cd12887   152 YGQCEQVSIV 161
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 699-861 3.78e-55

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 188.51  E-value: 3.78e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   699 FHQLHGSNAVITNGGRTALRHNcrsEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLE---FPNTM 775
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTN---SFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   776 TDIDYDTWMLSgtaimQDGNTmrnnygcdldaLGTGARIGMMRTAKGDLHYFINGQDQGAACSGLPP--EVYAVVDLYGQ 853
Cdd:pfam07177   78 TDLRPGYWVVA-----LSGSY-----------LQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDsqPLWAVFDLYGQ 141


                   ....*...
gi 597955339   854 CVQVSITN 861
Cdd:pfam07177  142 TTQVSILG 149
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 300-462 1.70e-54

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 186.97  E-value: 1.70e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   300 FHEKCGTLIKLSNNNKTAERRRpldEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLE---YPATM 376
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTN---SFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   377 TNLQSGTIMMSgcgiltngkgtrreyceFSLDELQEGDHIGLTRKSNSALHFFINGIDQGVATPLTPP--VVYGVVDLYG 454
Cdd:pfam07177   78 TDLRPGYWVVA-----------------LSGSYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDsqPLWAVFDLYG 140


                   ....*...
gi 597955339   455 MAVKVTIV 462
Cdd:pfam07177  141 QTTQVSIL 148
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 503-665 1.12e-53

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 184.27  E-value: 1.12e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   503 FHPNCGQKAAITHEGRTALRphaTDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQ---LPSTM 579
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARR---TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   580 TNLRSGTWMMtgngvmhngttILDEYghnldRLKAGDTVGVVRREDGTLHFFVNGMTQGPAAWNVPPG--VYAVVDLYGQ 657
Cdd:pfam07177   78 TDLRPGYWVV-----------ALSGS-----YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDLYGQ 141


                   ....*...
gi 597955339   658 AAQATIVD 665
Cdd:pfam07177  142 TTQVSILG 149
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 47-207 8.47e-51

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 176.19  E-value: 8.47e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339    47 HPRTGRLVSLSACGRTARRqqpGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVL---DFPSSAT 123
Cdd:pfam07177    2 HPVHGKNVRLSNDGRTARR---TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLrpkALPDLAT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   124 GLKGGSWVVSgcsvlRDGRsvleeygqdldQLVEGDRVGVERTATGELRLWVNGRDCGVAATGLP--ARVWAVVDLYGKC 201
Cdd:pfam07177   79 DLRPGYWVVA-----LSGS-----------YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYGQT 142


                   ....*.
gi 597955339   202 TQITVL 207
Cdd:pfam07177  143 TQVSIL 148
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 1111-1270 7.21e-46

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 161.93  E-value: 7.21e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  1111 FLENHGKNILLSNGNRTATRVASYNQGIVVISQPLVPHMLVQVRIDFLNRQWTSSLVLGVITCPPERLN---FPASACAL 1187
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLATDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  1188 KRAAWLlrgrgvfhngLKICEKfgpnldTCPEGTILGLRLDSSGGLHLHINGVDQGVAVPDVP--QPCHALVDLYGQCEQ 1265
Cdd:pfam07177   81 RPGYWV----------VALSGS------YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYGQTTQ 144


                   ....*
gi 597955339  1266 VTIVS 1270
Cdd:pfam07177  145 VSILG 149
NEUZ smart00588
domain in neuralized proteins;
296-417 1.10e-43

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 154.78  E-value: 1.10e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339    296 DALLFHEKCGTLIKLSNNNKTAerRRPLDEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPAT 375
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVA--RRSASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|..
gi 597955339    376 MTNLQSGTIMMSGCGILTNGKGTRREYCEFSLDELQEGDHIG 417
Cdd:smart00588   79 PTNACPDLVDMSGFWAKALGEGLAEQGGILGLDVLAEGEVVG 120
NEUZ smart00588
domain in neuralized proteins;
500-622 4.76e-39

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 141.68  E-value: 4.76e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339    500 RLLFHPNCGQKAAITHEGRTALRPHatDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTM 579
Cdd:smart00588    2 PLRFHHRHGSNIRLSDSGRVARRSA--SDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLP 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 597955339    580 TNLRSGTWMMTGNGVMHNGTTILDEYG-HNLDRLKAGDTVGVVR 622
Cdd:smart00588   80 TNACPDLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
696-818 1.81e-33

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 125.50  E-value: 1.81e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339    696 DLRFHQLHGSNAVITNGGRTALRHncRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTM 775
Cdd:smart00588    2 PLRFHHRHGSNIRLSDSGRVARRS--ASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLP 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 597955339    776 TDIDYDTWMLSGTAIMQDGNTMRNNYGC-DLDALGTGARIGMMR 818
Cdd:smart00588   80 TNACPDLVDMSGFWAKALGEGLAEQGGIlGLDVLAEGEVVGVIN 123
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 894-1062 7.26e-33

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 124.95  E-value: 7.26e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   894 FHSMCGKNVTLEEDGTRAVRVAGYAHGLVFSTKELKAEEVFEVKVEELDEKWAGSLRLGLTTLAPEDMGPGAgsgpglPP 973
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRPKA------LP 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   974 SLPELRTKTTWMVSSCEvrrdghlqrmnygrnlERLGVGSRVGIRRCADDTMHILVDGEDMGPAAAGIAKN--VWAVLDL 1051
Cdd:pfam07177   75 DLATDLRPGYWVVALSG----------------SYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDL 138

                          170
                   ....*....|.
gi 597955339  1052 YGPVRSVAIVS 1062
Cdd:pfam07177  139 YGQTTQVSILG 149
NEUZ smart00588
domain in neuralized proteins;
47-165 1.01e-29

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 115.10  E-value: 1.01e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339     47 HPRTGRLVSLSACGRTARRQQpgQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLDFPSSATGLK 126
Cdd:smart00588    6 HHRHGSNIRLSDSGRVARRSA--SDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLPTNAC 83

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 597955339    127 GGSWVVSGCSVLRDGRSVLEEYG-QDLDQLVEGDRVGVER 165
Cdd:smart00588   84 PDLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
1107-1224 2.01e-14

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 71.19  E-value: 2.01e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   1107 TALEFLENHGKNILLSNGNRTATRVAS-YNQGIVVISQPLVPHMLVQVRIDFLNRQWTSSLVLGVITCPPERLNFPASAC 1185
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVARRSASdFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLPT 80

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 597955339   1186 ALKRAAWLLRGRGVFHNGLKICEKFGP-NLDTCPEGTILG 1224
Cdd:smart00588   81 NACPDLVDMSGFWAKALGEGLAEQGGIlGLDVLAEGEVVG 120
NEUZ smart00588
domain in neuralized proteins;
893-1019 2.10e-12

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 65.41  E-value: 2.10e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339    893 RFHSMCGKNVTLEEDGTRAVRVAG-YAHGLVFSTKELKAEEVFEVKVEELDEKWAGSLRLGLTTLAPEDMGPgagsgPGL 971
Cdd:smart00588    4 RFHHRHGSNIRLSDSGRVARRSASdFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRP-----ASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*....
gi 597955339    972 PPSLPElrtkTTWMVSSCEVRRDGHLQRMNYG-RNLERLGVGSRVGIRR 1019
Cdd:smart00588   79 PTNACP----DLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
 
Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 698-860 2.00e-86

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 278.62  E-value: 2.00e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  698 RFHQLHGSNAVITNGGRTALRhnCRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTMTD 777
Cdd:cd12887     1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  778 IDYDTWMLSGTAIMQDGNTMRNNYGCDLDALGTGARIGMMRTAKGDLHYFINGQDQGAACSGLPPEVYAVVDLYGQCVQV 857
Cdd:cd12887    79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                  ...
gi 597955339  858 SIT 860
Cdd:cd12887   159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 503-664 9.53e-86

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 276.70  E-value: 9.53e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  503 FHPNCGQKAAITHEGRTALRPHatDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTMTNL 582
Cdd:cd12887     2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  583 RSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRREDGTLHFFVNGMTQGPAAWNVPPGVYAVVDLYGQAAQAT 662
Cdd:cd12887    80 KSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVS 159


                  ..
gi 597955339  663 IV 664
Cdd:cd12887   160 IV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 45-207 3.88e-78

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 255.13  E-value: 3.88e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   45 ELHPRTGRLVSLSACGRTARRqqPGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLDFPSSATG 124
Cdd:cd12887     1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  125 LKGGSWVVSGCSVLRDGRSVLEEYGQDLDQLVEGDRVGVERTATGELRLWVNGRDCGVAATGLPARVWAVVDLYGKCTQI 204
Cdd:cd12887    79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                  ...
gi 597955339  205 TVL 207
Cdd:cd12887   159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 300-462 1.66e-77

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 253.20  E-value: 1.66e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  300 FHEKCGTLIKLSNNNKTAERRRplDEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPATMTNL 379
Cdd:cd12887     2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  380 QSGTIMMSGCGILTNGKGTRREYCeFSLDELQEGDHIGLTRKSNSALHFFINGIDQGVATPLTPPVVYGVVDLYGMAVKV 459
Cdd:cd12887    80 KSGTWILSGSSVFKNGNKIRENYG-PDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                  ...
gi 597955339  460 TIV 462
Cdd:cd12887   159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 1110-1269 2.15e-73

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 241.26  E-value: 2.15e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339 1110 EFLENHGKNILLSNGNRTATRVA-SYNQGIVVISQPLVPHMLVQVRIDFLNRQWTSSLVLGVITCPPERLNFPASACALK 1188
Cdd:cd12887     1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339 1189 RAAWLLRGRGVFHNGLKICEKFGPNLDTCPEGTILGLRLDSSGGLHLHINGVDQGVAVPDVPQPCHALVDLYGQCEQVTI 1268
Cdd:cd12887    81 SGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVSI 160


                  .
gi 597955339 1269 V 1269
Cdd:cd12887   161 V 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 893-1061 2.50e-56

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 192.34  E-value: 2.50e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  893 RFHSMCGKNVTLEEDGTRAVRVA-GYAHGLVFSTKELKAEEVFEVKVEELDEKWAGSLRLGLTTLAPEDMGpgagsgpgL 971
Cdd:cd12887     1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLD--------L 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  972 PPSLPELRTKTtWMVSSCEVRRDGHLQRMNYGRNLERLGVGSRVGIRRCADDTMHILVDGEDMGPAAAGIAKNVWAVLDL 1051
Cdd:cd12887    73 PPSATDLKSGT-WILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDL 151

                         170
                  ....*....|
gi 597955339 1052 YGPVRSVAIV 1061
Cdd:cd12887   152 YGQCEQVSIV 161
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 699-861 3.78e-55

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 188.51  E-value: 3.78e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   699 FHQLHGSNAVITNGGRTALRHNcrsEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLE---FPNTM 775
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTN---SFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   776 TDIDYDTWMLSgtaimQDGNTmrnnygcdldaLGTGARIGMMRTAKGDLHYFINGQDQGAACSGLPP--EVYAVVDLYGQ 853
Cdd:pfam07177   78 TDLRPGYWVVA-----LSGSY-----------LQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDsqPLWAVFDLYGQ 141


                   ....*...
gi 597955339   854 CVQVSITN 861
Cdd:pfam07177  142 TTQVSILG 149
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 300-462 1.70e-54

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 186.97  E-value: 1.70e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   300 FHEKCGTLIKLSNNNKTAERRRpldEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLE---YPATM 376
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTN---SFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   377 TNLQSGTIMMSgcgiltngkgtrreyceFSLDELQEGDHIGLTRKSNSALHFFINGIDQGVATPLTPP--VVYGVVDLYG 454
Cdd:pfam07177   78 TDLRPGYWVVA-----------------LSGSYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDsqPLWAVFDLYG 140


                   ....*...
gi 597955339   455 MAVKVTIV 462
Cdd:pfam07177  141 QTTQVSIL 148
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 503-665 1.12e-53

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 184.27  E-value: 1.12e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   503 FHPNCGQKAAITHEGRTALRphaTDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQ---LPSTM 579
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARR---TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   580 TNLRSGTWMMtgngvmhngttILDEYghnldRLKAGDTVGVVRREDGTLHFFVNGMTQGPAAWNVPPG--VYAVVDLYGQ 657
Cdd:pfam07177   78 TDLRPGYWVV-----------ALSGS-----YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDLYGQ 141


                   ....*...
gi 597955339   658 AAQATIVD 665
Cdd:pfam07177  142 TTQVSILG 149
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 47-207 8.47e-51

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 176.19  E-value: 8.47e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339    47 HPRTGRLVSLSACGRTARRqqpGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVL---DFPSSAT 123
Cdd:pfam07177    2 HPVHGKNVRLSNDGRTARR---TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLrpkALPDLAT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   124 GLKGGSWVVSgcsvlRDGRsvleeygqdldQLVEGDRVGVERTATGELRLWVNGRDCGVAATGLP--ARVWAVVDLYGKC 201
Cdd:pfam07177   79 DLRPGYWVVA-----LSGS-----------YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYGQT 142


                   ....*.
gi 597955339   202 TQITVL 207
Cdd:pfam07177  143 TQVSIL 148
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 1111-1270 7.21e-46

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 161.93  E-value: 7.21e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  1111 FLENHGKNILLSNGNRTATRVASYNQGIVVISQPLVPHMLVQVRIDFLNRQWTSSLVLGVITCPPERLN---FPASACAL 1187
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLATDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  1188 KRAAWLlrgrgvfhngLKICEKfgpnldTCPEGTILGLRLDSSGGLHLHINGVDQGVAVPDVP--QPCHALVDLYGQCEQ 1265
Cdd:pfam07177   81 RPGYWV----------VALSGS------YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYGQTTQ 144


                   ....*
gi 597955339  1266 VTIVS 1270
Cdd:pfam07177  145 VSILG 149
NEUZ smart00588
domain in neuralized proteins;
296-417 1.10e-43

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 154.78  E-value: 1.10e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339    296 DALLFHEKCGTLIKLSNNNKTAerRRPLDEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPAT 375
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVA--RRSASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|..
gi 597955339    376 MTNLQSGTIMMSGCGILTNGKGTRREYCEFSLDELQEGDHIG 417
Cdd:smart00588   79 PTNACPDLVDMSGFWAKALGEGLAEQGGILGLDVLAEGEVVG 120
NEUZ smart00588
domain in neuralized proteins;
500-622 4.76e-39

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 141.68  E-value: 4.76e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339    500 RLLFHPNCGQKAAITHEGRTALRPHatDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTM 579
Cdd:smart00588    2 PLRFHHRHGSNIRLSDSGRVARRSA--SDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLP 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 597955339    580 TNLRSGTWMMTGNGVMHNGTTILDEYG-HNLDRLKAGDTVGVVR 622
Cdd:smart00588   80 TNACPDLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
696-818 1.81e-33

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 125.50  E-value: 1.81e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339    696 DLRFHQLHGSNAVITNGGRTALRHncRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTM 775
Cdd:smart00588    2 PLRFHHRHGSNIRLSDSGRVARRS--ASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLP 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 597955339    776 TDIDYDTWMLSGTAIMQDGNTMRNNYGC-DLDALGTGARIGMMR 818
Cdd:smart00588   80 TNACPDLVDMSGFWAKALGEGLAEQGGIlGLDVLAEGEVVGVIN 123
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 894-1062 7.26e-33

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 124.95  E-value: 7.26e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   894 FHSMCGKNVTLEEDGTRAVRVAGYAHGLVFSTKELKAEEVFEVKVEELDEKWAGSLRLGLTTLAPEDMGPGAgsgpglPP 973
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRPKA------LP 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   974 SLPELRTKTTWMVSSCEvrrdghlqrmnygrnlERLGVGSRVGIRRCADDTMHILVDGEDMGPAAAGIAKN--VWAVLDL 1051
Cdd:pfam07177   75 DLATDLRPGYWVVALSG----------------SYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDL 138

                          170
                   ....*....|.
gi 597955339  1052 YGPVRSVAIVS 1062
Cdd:pfam07177  139 YGQTTQVSILG 149
NEUZ smart00588
domain in neuralized proteins;
47-165 1.01e-29

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 115.10  E-value: 1.01e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339     47 HPRTGRLVSLSACGRTARRQQpgQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLDFPSSATGLK 126
Cdd:smart00588    6 HHRHGSNIRLSDSGRVARRSA--SDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLPTNAC 83

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 597955339    127 GGSWVVSGCSVLRDGRSVLEEYG-QDLDQLVEGDRVGVER 165
Cdd:smart00588   84 PDLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
1107-1224 2.01e-14

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 71.19  E-value: 2.01e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   1107 TALEFLENHGKNILLSNGNRTATRVAS-YNQGIVVISQPLVPHMLVQVRIDFLNRQWTSSLVLGVITCPPERLNFPASAC 1185
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVARRSASdFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLPT 80

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 597955339   1186 ALKRAAWLLRGRGVFHNGLKICEKFGP-NLDTCPEGTILG 1224
Cdd:smart00588   81 NACPDLVDMSGFWAKALGEGLAEQGGIlGLDVLAEGEVVG 120
NEUZ smart00588
domain in neuralized proteins;
893-1019 2.10e-12

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 65.41  E-value: 2.10e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339    893 RFHSMCGKNVTLEEDGTRAVRVAG-YAHGLVFSTKELKAEEVFEVKVEELDEKWAGSLRLGLTTLAPEDMGPgagsgPGL 971
Cdd:smart00588    4 RFHHRHGSNIRLSDSGRVARRSASdFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRP-----ASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*....
gi 597955339    972 PPSLPElrtkTTWMVSSCEVRRDGHLQRMNYG-RNLERLGVGSRVGIRR 1019
Cdd:smart00588   79 PTNACP----DLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
SPRY cd11709
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 89-207 5.17e-09

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


Pssm-ID: 293931  Cd Length: 118  Bit Score: 55.51  E-value: 5.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339   89 FTVRIDrkvNSWSGSIEIGVTalDPSVLDFPSSATGLKGGSWVVSGCSVlRDGRSVLEEYGQDldQLVEGDRVGVER-TA 167
Cdd:cd11709     5 WEVRVD---SGNGGLIQVGWA--TKSFSLDGEGGVGDDEESWGYDGSRL-RKGHGGSSGPGGR--PWKSGDVVGCLLdLD 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 597955339  168 TGELRLWVNGRDCGVAATGLPA---RVWAVVDLYGKCtQITVL 207
Cdd:cd11709    77 EGTLSFSLNGKDLGVAFTNLFLkggGLYPAVSLGSGQ-GVTIN 118
SPRY cd11709
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 546-659 1.21e-04

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


Pssm-ID: 293931  Cd Length: 118  Bit Score: 43.19  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597955339  546 FQVRIDKMVDkwaGSIEIGVTTHNPAYLQLPSTMTNLRSgtWMMTGNGVmHNGTTILDEYGhnLDRLKAGDTVGV-VRRE 624
Cdd:cd11709     5 WEVRVDSGNG---GLIQVGWATKSFSLDGEGGVGDDEES--WGYDGSRL-RKGHGGSSGPG--GRPWKSGDVVGClLDLD 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 597955339  625 DGTLHFFVNGMTQGPAAWNV---PPGVYAVVDLYGQAA 659
Cdd:cd11709    77 EGTLSFSLNGKDLGVAFTNLflkGGGLYPAVSLGSGQG 114
SPRY_SOCS_Fbox cd12875
SPRY domain in Fbxo45 and suppressors of cytokine signaling (SOCS) proteins; This family ...
 587-658 6.25e-03

SPRY domain in Fbxo45 and suppressors of cytokine signaling (SOCS) proteins; This family consists of the SPRY domain-containing SOCS box protein family (SPSB1-4, also known as SSB-1 to -4) as well as F-box protein 45 (Fbxo45), a novel synaptic E3 and ubiquitin ligase. The SPSB protein is composed of a central SPRY protein interaction domain and a C-terminal SOCS box. SPSB1, SPSB2, and SPSB4 interact with prostate apoptosis response protein 4 (Par-4) and are negative regulators that recruit the ECS E3 ubiquitin ligase complex to polyubiquitinate inducible nitric-oxide synthase (iNOS), resulting in its proteasomal degradation. Fbxo45 is related to this family; it is located N-terminal to the SPRY domain, and known to induce the degradation of a synaptic vesicle-priming factor, Munc13-1, via the SPRY domain, thus playing an important role in the regulation of neurotransmission by modulating Munc13-1 at the synapse. Suppressor of cytokine signaling (SOCS) proteins negatively regulate signaling from JAK-associated cytokine receptor complexes, and play key roles in the regulation of immune homeostasis.


Pssm-ID: 293935  Cd Length: 169  Bit Score: 39.36  E-value: 6.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 597955339  587 WMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVV-RREDGTLHFFVNGMTQGPAAWNVP-----PGVYAVvdlYGQA 658
Cdd:cd12875    88 WDLGDNKLYHNGKKVIGSYPAKSENYQVPDRILVIlDMEDGTLAFEANGEYLGVAFRGLPgkllyPAVSAV---YGNC 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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